KEGG   Cervus canadensis (wapiti): 122424748
Entry
122424748         CDS       T07554                                 
Symbol
PRKCA
Name
(RefSeq) protein kinase C alpha type isoform X1
  KO
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01521  EGFR tyrosine kinase inhibitor resistance
ccad04010  MAPK signaling pathway
ccad04012  ErbB signaling pathway
ccad04014  Ras signaling pathway
ccad04015  Rap1 signaling pathway
ccad04020  Calcium signaling pathway
ccad04066  HIF-1 signaling pathway
ccad04070  Phosphatidylinositol signaling system
ccad04071  Sphingolipid signaling pathway
ccad04072  Phospholipase D signaling pathway
ccad04082  Neuroactive ligand signaling
ccad04150  mTOR signaling pathway
ccad04151  PI3K-Akt signaling pathway
ccad04261  Adrenergic signaling in cardiomyocytes
ccad04270  Vascular smooth muscle contraction
ccad04310  Wnt signaling pathway
ccad04360  Axon guidance
ccad04370  VEGF signaling pathway
ccad04510  Focal adhesion
ccad04517  IgSF CAM signaling
ccad04540  Gap junction
ccad04613  Neutrophil extracellular trap formation
ccad04650  Natural killer cell mediated cytotoxicity
ccad04664  Fc epsilon RI signaling pathway
ccad04666  Fc gamma R-mediated phagocytosis
ccad04670  Leukocyte transendothelial migration
ccad04713  Circadian entrainment
ccad04720  Long-term potentiation
ccad04723  Retrograde endocannabinoid signaling
ccad04724  Glutamatergic synapse
ccad04725  Cholinergic synapse
ccad04726  Serotonergic synapse
ccad04727  GABAergic synapse
ccad04728  Dopaminergic synapse
ccad04730  Long-term depression
ccad04750  Inflammatory mediator regulation of TRP channels
ccad04911  Insulin secretion
ccad04912  GnRH signaling pathway
ccad04916  Melanogenesis
ccad04918  Thyroid hormone synthesis
ccad04919  Thyroid hormone signaling pathway
ccad04921  Oxytocin signaling pathway
ccad04925  Aldosterone synthesis and secretion
ccad04926  Relaxin signaling pathway
ccad04928  Parathyroid hormone synthesis, secretion and action
ccad04929  GnRH secretion
ccad04933  AGE-RAGE signaling pathway in diabetic complications
ccad04935  Growth hormone synthesis, secretion and action
ccad04960  Aldosterone-regulated sodium reabsorption
ccad04961  Endocrine and other factor-regulated calcium reabsorption
ccad04970  Salivary secretion
ccad04971  Gastric acid secretion
ccad04972  Pancreatic secretion
ccad05017  Spinocerebellar ataxia
ccad05022  Pathways of neurodegeneration - multiple diseases
ccad05031  Amphetamine addiction
ccad05032  Morphine addiction
ccad05143  African trypanosomiasis
ccad05146  Amoebiasis
ccad05161  Hepatitis B
ccad05163  Human cytomegalovirus infection
ccad05164  Influenza A
ccad05170  Human immunodeficiency virus 1 infection
ccad05171  Coronavirus disease - COVID-19
ccad05200  Pathways in cancer
ccad05205  Proteoglycans in cancer
ccad05206  MicroRNAs in cancer
ccad05207  Chemical carcinogenesis - receptor activation
ccad05214  Glioma
ccad05223  Non-small cell lung cancer
ccad05225  Hepatocellular carcinoma
ccad05231  Choline metabolism in cancer
ccad05415  Diabetic cardiomyopathy
ccad05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122424748 (PRKCA)
   04012 ErbB signaling pathway
    122424748 (PRKCA)
   04014 Ras signaling pathway
    122424748 (PRKCA)
   04015 Rap1 signaling pathway
    122424748 (PRKCA)
   04310 Wnt signaling pathway
    122424748 (PRKCA)
   04370 VEGF signaling pathway
    122424748 (PRKCA)
   04066 HIF-1 signaling pathway
    122424748 (PRKCA)
   04020 Calcium signaling pathway
    122424748 (PRKCA)
   04070 Phosphatidylinositol signaling system
    122424748 (PRKCA)
   04072 Phospholipase D signaling pathway
    122424748 (PRKCA)
   04071 Sphingolipid signaling pathway
    122424748 (PRKCA)
   04151 PI3K-Akt signaling pathway
    122424748 (PRKCA)
   04150 mTOR signaling pathway
    122424748 (PRKCA)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    122424748 (PRKCA)
   04517 IgSF CAM signaling
    122424748 (PRKCA)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122424748 (PRKCA)
   04540 Gap junction
    122424748 (PRKCA)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122424748 (PRKCA)
   04650 Natural killer cell mediated cytotoxicity
    122424748 (PRKCA)
   04664 Fc epsilon RI signaling pathway
    122424748 (PRKCA)
   04666 Fc gamma R-mediated phagocytosis
    122424748 (PRKCA)
   04670 Leukocyte transendothelial migration
    122424748 (PRKCA)
  09152 Endocrine system
   04911 Insulin secretion
    122424748 (PRKCA)
   04929 GnRH secretion
    122424748 (PRKCA)
   04912 GnRH signaling pathway
    122424748 (PRKCA)
   04921 Oxytocin signaling pathway
    122424748 (PRKCA)
   04926 Relaxin signaling pathway
    122424748 (PRKCA)
   04935 Growth hormone synthesis, secretion and action
    122424748 (PRKCA)
   04918 Thyroid hormone synthesis
    122424748 (PRKCA)
   04919 Thyroid hormone signaling pathway
    122424748 (PRKCA)
   04928 Parathyroid hormone synthesis, secretion and action
    122424748 (PRKCA)
   04916 Melanogenesis
    122424748 (PRKCA)
   04925 Aldosterone synthesis and secretion
    122424748 (PRKCA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122424748 (PRKCA)
   04270 Vascular smooth muscle contraction
    122424748 (PRKCA)
  09154 Digestive system
   04970 Salivary secretion
    122424748 (PRKCA)
   04971 Gastric acid secretion
    122424748 (PRKCA)
   04972 Pancreatic secretion
    122424748 (PRKCA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122424748 (PRKCA)
   04961 Endocrine and other factor-regulated calcium reabsorption
    122424748 (PRKCA)
  09156 Nervous system
   04724 Glutamatergic synapse
    122424748 (PRKCA)
   04727 GABAergic synapse
    122424748 (PRKCA)
   04725 Cholinergic synapse
    122424748 (PRKCA)
   04728 Dopaminergic synapse
    122424748 (PRKCA)
   04726 Serotonergic synapse
    122424748 (PRKCA)
   04720 Long-term potentiation
    122424748 (PRKCA)
   04730 Long-term depression
    122424748 (PRKCA)
   04723 Retrograde endocannabinoid signaling
    122424748 (PRKCA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122424748 (PRKCA)
  09158 Development and regeneration
   04360 Axon guidance
    122424748 (PRKCA)
  09159 Environmental adaptation
   04713 Circadian entrainment
    122424748 (PRKCA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122424748 (PRKCA)
   05206 MicroRNAs in cancer
    122424748 (PRKCA)
   05205 Proteoglycans in cancer
    122424748 (PRKCA)
   05207 Chemical carcinogenesis - receptor activation
    122424748 (PRKCA)
   05231 Choline metabolism in cancer
    122424748 (PRKCA)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    122424748 (PRKCA)
   05214 Glioma
    122424748 (PRKCA)
   05223 Non-small cell lung cancer
    122424748 (PRKCA)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122424748 (PRKCA)
   05161 Hepatitis B
    122424748 (PRKCA)
   05171 Coronavirus disease - COVID-19
    122424748 (PRKCA)
   05164 Influenza A
    122424748 (PRKCA)
   05163 Human cytomegalovirus infection
    122424748 (PRKCA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122424748 (PRKCA)
   05143 African trypanosomiasis
    122424748 (PRKCA)
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    122424748 (PRKCA)
   05022 Pathways of neurodegeneration - multiple diseases
    122424748 (PRKCA)
  09165 Substance dependence
   05031 Amphetamine addiction
    122424748 (PRKCA)
   05032 Morphine addiction
    122424748 (PRKCA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122424748 (PRKCA)
   05415 Diabetic cardiomyopathy
    122424748 (PRKCA)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122424748 (PRKCA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122424748 (PRKCA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122424748 (PRKCA)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccad04131]
    122424748 (PRKCA)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     122424748 (PRKCA)
Protein kinases [BR:ccad01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   122424748 (PRKCA)
Membrane trafficking [BR:ccad04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    122424748 (PRKCA)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr C2 Pkinase_C ABC1 Kinase-like
Other DBs
NCBI-GeneID: 122424748
NCBI-ProteinID: XP_043298876
LinkDB
Position
1:complement(492415..547953)
AA seq 505 aa
MDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIW
DWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKF
EKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELY
AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL
MYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC
KEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDE
LFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRIDWEKL
ENREIQPPFKPKVTFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPPDQLVIANID
QSDFEGFSYVNPQFVHPILQSAVEA
NT seq 1518 nt   +upstreamnt  +downstreamnt
atggatccaaatgggctttcagatccttacgtgaagctgaagcttattcctgaccccaag
aacgagagcaaacagaaaaccaaaaccatccgctccacgctgaacccccagtggaacgag
tccttcacgttcaaattaaaaccttctgataaagaccggcgactgtccgtggagatctgg
gactgggatcgaaccacacggaacgacttcatggggtccctttcctttggggtctcggag
ctgatgaagatgccggccagcggatggtacaagctgctgaaccaagaggagggtgagtac
tacaacgtgccgatccccgaaggcgacgaggaaggcaacgtggagctcaggcagaaattc
gagaaagccaagcttggccctgccggcaacaaagtcatcagtccctccgaggacaggaga
cagccttccaacaacctggacagagtgaagctcactgacttcaacttcctcatggtgctg
ggcaaaggcagctttgggaaggtgatgctggccgaccggaaggggaccgaggagctgtac
gccatcaagatcctgaagaaggatgtggtcatccaggacgacgacgtggagtgcaccatg
gtggagaagcgggtgttggccctgctcgacaagccgccgttcctgacacagctgcactcc
tgcttccagacggtggaccggctctacttcgtcatggagtacgtcaacggcggggacctc
atgtaccacatccagcaggtcgggaagttcaaggagccgcaggcagtgttctatgcggca
gagatttccatcgggctgttctttcttcataaaagaggaatcatttatcgggacctgaag
ttagacaacgtcatgctggactcggaagggcacatcaagatcgcggactttgggatgtgc
aaggagcacatgatggacggcgtcacgaccaggaccttctgtgggacccccgactacatc
gccccggagataatcgcctatcagccgtatgggaagtccgtggactggtgggcctatggc
gtcctgttgtacgagatgttggccgggcagcccccgttcgacggcgaggatgaagacgag
ctgttccagtccatcatggagcacaacgtctcgtaccccaagtccttgtccaaggaggcc
gtgtccatctgcaaagggctgatgaccaagcacccggggaagcggctgggctgcgggccc
gagggcgagcgggacgtgcgggagcacgccttcttccggaggatcgactgggagaagctg
gagaaccgtgagatccagccgcccttcaagcccaaagtgactttctgcaccaaaatgcac
tggcttcagtgggcatccaggccttcgtgcggcaaaggagcagagaactttgacaagttc
ttcacgcgagggcagcctgtcttgacgccgcccgaccagttggtcatcgctaacattgac
cagtctgattttgaaggcttctcatacgtcaacccccagttcgtgcaccccatcttgcag
agcgcggtggaggcctga

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