KEGG   Cervus canadensis (wapiti): 122425059
Entry
122425059         CDS       T07554                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01521  EGFR tyrosine kinase inhibitor resistance
ccad01522  Endocrine resistance
ccad04010  MAPK signaling pathway
ccad04012  ErbB signaling pathway
ccad04014  Ras signaling pathway
ccad04015  Rap1 signaling pathway
ccad04022  cGMP-PKG signaling pathway
ccad04024  cAMP signaling pathway
ccad04062  Chemokine signaling pathway
ccad04068  FoxO signaling pathway
ccad04071  Sphingolipid signaling pathway
ccad04072  Phospholipase D signaling pathway
ccad04140  Autophagy - animal
ccad04150  mTOR signaling pathway
ccad04151  PI3K-Akt signaling pathway
ccad04210  Apoptosis
ccad04218  Cellular senescence
ccad04270  Vascular smooth muscle contraction
ccad04360  Axon guidance
ccad04370  VEGF signaling pathway
ccad04371  Apelin signaling pathway
ccad04510  Focal adhesion
ccad04540  Gap junction
ccad04550  Signaling pathways regulating pluripotency of stem cells
ccad04613  Neutrophil extracellular trap formation
ccad04625  C-type lectin receptor signaling pathway
ccad04630  JAK-STAT signaling pathway
ccad04650  Natural killer cell mediated cytotoxicity
ccad04660  T cell receptor signaling pathway
ccad04662  B cell receptor signaling pathway
ccad04664  Fc epsilon RI signaling pathway
ccad04666  Fc gamma R-mediated phagocytosis
ccad04720  Long-term potentiation
ccad04722  Neurotrophin signaling pathway
ccad04726  Serotonergic synapse
ccad04730  Long-term depression
ccad04810  Regulation of actin cytoskeleton
ccad04910  Insulin signaling pathway
ccad04912  GnRH signaling pathway
ccad04914  Progesterone-mediated oocyte maturation
ccad04915  Estrogen signaling pathway
ccad04916  Melanogenesis
ccad04917  Prolactin signaling pathway
ccad04919  Thyroid hormone signaling pathway
ccad04921  Oxytocin signaling pathway
ccad04926  Relaxin signaling pathway
ccad04928  Parathyroid hormone synthesis, secretion and action
ccad04929  GnRH secretion
ccad04935  Growth hormone synthesis, secretion and action
ccad05010  Alzheimer disease
ccad05022  Pathways of neurodegeneration - multiple diseases
ccad05034  Alcoholism
ccad05132  Salmonella infection
ccad05152  Tuberculosis
ccad05160  Hepatitis C
ccad05161  Hepatitis B
ccad05163  Human cytomegalovirus infection
ccad05164  Influenza A
ccad05165  Human papillomavirus infection
ccad05167  Kaposi sarcoma-associated herpesvirus infection
ccad05170  Human immunodeficiency virus 1 infection
ccad05200  Pathways in cancer
ccad05205  Proteoglycans in cancer
ccad05206  MicroRNAs in cancer
ccad05207  Chemical carcinogenesis - receptor activation
ccad05208  Chemical carcinogenesis - reactive oxygen species
ccad05210  Colorectal cancer
ccad05211  Renal cell carcinoma
ccad05212  Pancreatic cancer
ccad05213  Endometrial cancer
ccad05214  Glioma
ccad05215  Prostate cancer
ccad05218  Melanoma
ccad05219  Bladder cancer
ccad05220  Chronic myeloid leukemia
ccad05221  Acute myeloid leukemia
ccad05223  Non-small cell lung cancer
ccad05224  Breast cancer
ccad05225  Hepatocellular carcinoma
ccad05226  Gastric cancer
ccad05230  Central carbon metabolism in cancer
ccad05231  Choline metabolism in cancer
ccad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122425059 (RAF1)
   04012 ErbB signaling pathway
    122425059 (RAF1)
   04014 Ras signaling pathway
    122425059 (RAF1)
   04015 Rap1 signaling pathway
    122425059 (RAF1)
   04370 VEGF signaling pathway
    122425059 (RAF1)
   04371 Apelin signaling pathway
    122425059 (RAF1)
   04630 JAK-STAT signaling pathway
    122425059 (RAF1)
   04068 FoxO signaling pathway
    122425059 (RAF1)
   04072 Phospholipase D signaling pathway
    122425059 (RAF1)
   04071 Sphingolipid signaling pathway
    122425059 (RAF1)
   04024 cAMP signaling pathway
    122425059 (RAF1)
   04022 cGMP-PKG signaling pathway
    122425059 (RAF1)
   04151 PI3K-Akt signaling pathway
    122425059 (RAF1)
   04150 mTOR signaling pathway
    122425059 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122425059 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    122425059 (RAF1)
   04218 Cellular senescence
    122425059 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122425059 (RAF1)
   04540 Gap junction
    122425059 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122425059 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122425059 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122425059 (RAF1)
   04625 C-type lectin receptor signaling pathway
    122425059 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    122425059 (RAF1)
   04660 T cell receptor signaling pathway
    122425059 (RAF1)
   04662 B cell receptor signaling pathway
    122425059 (RAF1)
   04664 Fc epsilon RI signaling pathway
    122425059 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    122425059 (RAF1)
   04062 Chemokine signaling pathway
    122425059 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122425059 (RAF1)
   04929 GnRH secretion
    122425059 (RAF1)
   04912 GnRH signaling pathway
    122425059 (RAF1)
   04915 Estrogen signaling pathway
    122425059 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    122425059 (RAF1)
   04917 Prolactin signaling pathway
    122425059 (RAF1)
   04921 Oxytocin signaling pathway
    122425059 (RAF1)
   04926 Relaxin signaling pathway
    122425059 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    122425059 (RAF1)
   04919 Thyroid hormone signaling pathway
    122425059 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    122425059 (RAF1)
   04916 Melanogenesis
    122425059 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122425059 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    122425059 (RAF1)
   04720 Long-term potentiation
    122425059 (RAF1)
   04730 Long-term depression
    122425059 (RAF1)
   04722 Neurotrophin signaling pathway
    122425059 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    122425059 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122425059 (RAF1)
   05206 MicroRNAs in cancer
    122425059 (RAF1)
   05205 Proteoglycans in cancer
    122425059 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    122425059 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122425059 (RAF1)
   05230 Central carbon metabolism in cancer
    122425059 (RAF1)
   05231 Choline metabolism in cancer
    122425059 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122425059 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122425059 (RAF1)
   05212 Pancreatic cancer
    122425059 (RAF1)
   05225 Hepatocellular carcinoma
    122425059 (RAF1)
   05226 Gastric cancer
    122425059 (RAF1)
   05214 Glioma
    122425059 (RAF1)
   05221 Acute myeloid leukemia
    122425059 (RAF1)
   05220 Chronic myeloid leukemia
    122425059 (RAF1)
   05218 Melanoma
    122425059 (RAF1)
   05211 Renal cell carcinoma
    122425059 (RAF1)
   05219 Bladder cancer
    122425059 (RAF1)
   05215 Prostate cancer
    122425059 (RAF1)
   05213 Endometrial cancer
    122425059 (RAF1)
   05224 Breast cancer
    122425059 (RAF1)
   05223 Non-small cell lung cancer
    122425059 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122425059 (RAF1)
   05161 Hepatitis B
    122425059 (RAF1)
   05160 Hepatitis C
    122425059 (RAF1)
   05164 Influenza A
    122425059 (RAF1)
   05163 Human cytomegalovirus infection
    122425059 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122425059 (RAF1)
   05165 Human papillomavirus infection
    122425059 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122425059 (RAF1)
   05152 Tuberculosis
    122425059 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122425059 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    122425059 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    122425059 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122425059 (RAF1)
   01522 Endocrine resistance
    122425059 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122425059 (RAF1)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122425059 (RAF1)
Protein kinases [BR:ccad01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   122425059 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 122425059
NCBI-ProteinID: XP_043299302
LinkDB
Position
22:complement(4094488..4165971)
AA seq 668 aa
MEHIQGAWKTISNGFGFKDTVFDGTSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDGGVPALPSLTMRRMRESVSRIPPGSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDNRMIENNSLNASPRAWSRRFCVRGRDA
IRSHSESGSPSALSSSPNNLSPTGWSQPKTPAPAQRERAPSSSTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKENLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacacg
gtgtttgatggcaccagctgcatctcccctacaatagttcagcaatttggctatcagcgt
cgggcatcagatgatggcaaacttacggacccttctaagacaagcaacactatccgtgtg
tttttgccaaacaaacaaagaacagtggtcaatgtgcggaatggaatgagcttgcatgac
tgccttatgaaagctctcaaggtgaggggtctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaagggtaaaaaagcacggttagattggaatactgatgctgcctca
ttgatcggagaggaacttcaagtggatttcctggatcatgttcccctcacaacacacaac
tttgctcggaaaaccttcctgaagcttgccttctgtgacatctgtcagaagttcttgcta
aatggatttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cccactatgtgtgtggactggagtaatatcagacagctcttattgttcccaaattccact
gttggtgatggtggggtcccagcgctgccttctttgacgatgcgtcggatgcgagagtct
gtttcccggatacctcctggttcccagcacagatactccacaccccacgctttcacattc
aacacctccagcccctcctctgaaggttcgctctcccagaggcagaggtcgacgtccaca
cctaacgtccacatggtcagcaccactctgcctgtggacaacaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtgtgaggggaagagatgca
attcgaagtcacagtgaatcaggctccccttcagccttgtccagcagccccaacaatctg
agcccgacaggctggtcacagcccaaaacccctgcgccggcacagagagagcgggcgccg
agctccagcacccaggagaagaacaaaattaggcctcgtggacagagagattcgagttat
tactgggagatagaagccagtgaagtgatgctgtccactcggattgggtcaggctccttt
gggactgtttataagggcaagtggcatggagacgttgcagtaaagattctgaaggtcgtg
gaccccaccccagagcagttccaggccttcaggaacgaggtggctgtcctccgcaaaacc
cggcacgtgaacatcctgctctttatgggctacatgacgaaggagaacctggccatcgtg
acgcagtggtgtgagggcagcagcctctacaagcacctgcacgtccaggagaccaagttc
cagatgttccagctgatcgacatcgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccacgaaggcctg
acggtgaaaatcggcgattttggattggccacggtgaagtcgcgctggagtggttctcag
caggtcgagcagcccaccggctccatcctgtggatggccccagaggtgatccggatgcag
gacaacaacccgttcagcttccagtccgacgtctactcctacggcatcgtcctgtacgag
ctcatgacgggggagctcccctactcccacatcaacaaccgtgaccagatcatcttcatg
gtgggccgcggctacgcctccccagacctcagcaagctctacaagaactgccccaaagcc
atgaagaggctggtagccgactgtgtgaagaaagtgaaggaagagaggcctctctttccc
cagatcctgtcttccatcgagctgctccagcactctctgcccaagatcaaccggagtgcc
tcggagccctccttgcaccgggcagcccacaccgaggacatcaacgcctgcacgctgacc
acgtcccctcggctgcccgtcttctag

DBGET integrated database retrieval system