Cervus canadensis (wapiti): 122427106
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Entry
122427106 CDS
T07554
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
ccad
Cervus canadensis (wapiti)
Pathway
ccad05012
Parkinson disease
ccad05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
ccad00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
122427106 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
122427106 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ccad01001
]
122427106 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ccad04131
]
122427106 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ccad04147
]
122427106 (LRRK2)
Enzymes [BR:
ccad01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
122427106 (LRRK2)
Protein kinases [BR:
ccad01001
]
Serine/threonine kinases: TKL group
LRRK family
122427106 (LRRK2)
Membrane trafficking [BR:
ccad04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
122427106 (LRRK2)
Exosome [BR:
ccad04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
122427106 (LRRK2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
LRR_4
Roc
COR-B
Ras
COR-A
LRR_14
LRR_9
ARMC6
WD40_CDC20-Fz
Arf
Beta-prop_IFT122_1st
Beta-prop_EML_2
Beta-prop_NOL10_N
Beta-prop_WDR36-Utp21_1st
LRR_13
Ank_2
T2SSE
Kdo
Beta-prop_RIG_2nd
nSTAND3
G-alpha
GTP_EFTU
AAA_22
AAA_16
ABC_tran
PduV-EutP
LRR_6
MobB
Beta-prop_THOC3
AAA_7
WD40_Prp19
NACHT
MMR_HSR1
AAA_29
Beta-prop_BBS7
TrwB_AAD_bind
FtsK_SpoIIIE
NB-ARC
nSTAND_NTPase5
TniB
AAA_23
Motif
Other DBs
NCBI-GeneID:
122427106
NCBI-ProteinID:
XP_043302275
LinkDB
All DBs
Position
25:15993447..16188007
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSSQGCEEDEESLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQDKNV
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPHDIGHDWEVLGVHQLILK
MLTVHNASVNLTTVGLKALDLLLTSGKISLLILDEENDIFLLIFDAMRTFSASDEVQKLG
CKVLHVLFERVSEEQLTEFVENKDYMILLSALKNFEDEEEIVLHVLHCLHSLAIPCSNVE
VLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
RYSENAVLQIAALSCLALLTETIFLNQDLEEKNENQENDDDEEEEKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHMHSPEVAESGCKMLNHLFEESSTSLDTM
AAVVPKIITVMKSHETSLSVQLEALRALLHFIVPGIPEEYREDTEYQHKLNMIEKQCFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSITHFPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCTVTGYLLAKILISTLQRFKDVGEVQIKGFQTVLTILELSV
SFSKLLVHHSFDSVIFHQLSSSIMEQKDQQFLNLCCKCFAKLTIDNELKSVLLEKACDQN
NSIMVECLLLLGADANRAKEATSLICQVCEKASNPKLVELLLNSGSHEQDVRKALTISIG
KGNSQIISLLLRRLALDLANNSICLGGFCMGKIEPSWLGPLFPDKTSYLRKETNIGSTLA
RMVLRYQMKSSVEEGAGSGSNGNFSEEMVDKFDEWTFIPESYIDSVFGQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDPALQRCSPNLQRHSSSLGPIFDHEDLLKRKRKIFSSDDSLR
ASKFQSHMRHSESISSLPSEREYITSLDLSANELRDVDALSQNSCISGHLEHLEKLELHQ
NSLTSFPQQLCETLKCLTHLDLHSNKFTSFPTYLLKMNCIANLDVSRNDIGPSVVLDPAV
TCPTLKQFNLSYNQISSLPANLGDVVEKLEQLVLEGNKISEICSPLSLKELKILNLSKNH
ISSLSEDFLETCPKVEILSARMNFLAAMPFLPSSITSLKLSQNRFTCVPEAILHLPHLRS
LDMSSNDIRYLPGPVHWRSLNLRELLFSHNQISILDLSEKACAWSRIEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKIKKSDLGMQGATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVTDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQSVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGFPK
HPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDHHAESFLKITVPSCRKGCVLLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDNLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYKGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKTSLTRTLQHRIVLHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRRISVPKSFTVECMVAMNH
NSKNVRIWLGCGHTDKGQLSCLDLNTERYTPEEVTDSRILCLALVYLPVEKESWIVSGTQ
SGMLLVINTEDGRKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGATPLKILNIGNVSTPLMCLSESVNLTEKNIMWGGCGTKVFSFSDDFTIQKLIETRT
NQRFSNTSFSDSNIIAVVVDTVLYVAKKNSPCVEVWDKKTEKRCELIDCVHFLKEELVRV
SKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLGSLKNVMLVLGYNRKSAEGTQHQKEIQSCLSVWDVNLPHEVQNLEKHIEVRKELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagcagccaggggtgcgaggaggacgaggaatctctgaagaagttgata
gttaggctgaacaatgtccaggaaggaaaacagatagagacgctggttcaaatcctggag
gatatgctggtgtttacttacgccgatcacgcctccaagttatttcaagacaaaaatgtc
cacgtgcctctgttgatcgtcttggactcgtatatgagagtcgctagtgtgcagcaggtg
ggttggtcacttttatgcaaattaatagaaatctgtccaaatacaatgcaaagcttaatg
ggaccccatgatattggacatgattgggaagtccttggggttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtcaacctgacaacagttggattgaaggccttagat
cttctcctaacttcaggtaaaatcagtttgctgatactggatgaagaaaatgatattttc
ttgttaatcttcgatgccatgcgcacattttcagccagtgatgaagtccagaaacttgga
tgtaaagttttacatgtgctgtttgagagagtttcagaggagcaactgactgaatttgtt
gaaaataaagattatatgatattgctaagtgcgttaaaaaattttgaagatgaagaggaa
attgtgcttcatgtactgcactgtttacattccttagcaattccttgtagtaatgttgaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgaaagcattc
cctatcagtgaaaaaattcaagaagtgagttgctgcttgctccataggcttacgttaggt
aatttctttaatatcttggtattaaatgaggtgcatgagtttgtggtgaaggctgtgcag
cggtattcagaaaatgcagtattacagatcgcagccctcagctgcttagcactcctcact
gagaccattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgacgat
gatgaagaagaagaaaaattgttttggctggaagcctgttacaaagcattaacttggcat
aggaagaacaagcatgtgcaggaggctgcctgttgggccctgaataatctccttatgtat
caaaacagtttacacgagaagattggagatgaagatggccagttcccagctcacagggaa
gtgatgctgtccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gctttgtcaactctgttagaacaaaatgttaattttagaaagatcctgttgtcaaaagga
atatatctgaatgtattggagttaatgcagaagcatatgcattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatcttttcgaagaaagtagcacttccctggatacaatg
gcagccgtggtccccaaaataataacagtcatgaaaagtcatgagacatcattatcggtg
cagctggaagcacttcgagctctgttacattttatagttccaggcatcccagaagaatac
agggaagatactgaatatcagcataagctaaatatgattgaaaagcagtgtttcaggaat
gatattcacaaattggtcctggcagctttgaacaggttcattggaaatcctgggattcag
aagtgtggattaaaagtaatttcgtctataacacattttcctgatgcattagaggtgtta
tccctggaaggtgctattgattcggtgcttcatacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgtttgattacaaagaagaatttatgc
acggtaactgggtatctgctggcgaaaattctgatttccaccctacaacgatttaaggat
gttggtgaagtacagataaaaggatttcaaacagtcttgacaatactggaattgtcagtg
tctttttccaagctactggtgcatcactcctttgattcagtaatattccatcagttgtcc
tccagtatcatggagcaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattgactattgataatgagttaaaaagtgtgttgctggagaaagcatgtgatcagaat
aacagcatcatggttgaatgcttgcttctgttgggagcggatgccaatcgagcaaaagaa
gcaacttctttgatttgtcaggtatgtgagaaagcaagcaatcccaaactggtagaattg
ttactgaatagtggatctcatgagcaggatgtccggaaagctctgacaatcagcattggg
aaaggcaacagccaaatcatcagcttactcttgaggaggcttgccctggatctggccaat
aatagcatctgtcttggaggattttgtatgggaaaaattgaaccttcctggcttggtcct
ttatttccagataagacatcttatttaagaaaagagacaaatataggatccaccctggca
aggatggtgctcagatatcagatgaaaagttctgtggaggaaggagctggctcaggcagc
aatgggaatttttctgaagaaatggttgataaatttgatgaatggaccttcattcctgag
tcttacattgacagtgtgtttggtcaaagtgatgatctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagcgtgggagaattttaccgagatcct
gccttgcaacgttgctcaccaaatttgcaaagacattctagttcattgggacccattttt
gatcatgaagatttactaaagagaaaaagaaaaatattttcatcagatgattcactcaga
gcatcaaaattccagtcccatatgaggcattcagagagcatttcttccctgccttctgag
agagaatatattacatcgttagacctttcagcaaatgaactaagagatgttgatgccctg
agccagaactcctgtataagtggtcatttggagcatcttgaaaagctggaacttcaccag
aattcactcacaagctttccacaacagctgtgtgaaactctgaaatgtttaacacatttg
gatctgcatagtaataaatttacatcgtttcccacttacttgttgaaaatgaattgtatt
gctaaccttgatgtctctcgaaatgatattggaccctcggtagttttggaccctgctgtg
acgtgcccgaccttgaaacagtttaacttgtcgtataatcagatatcttctcttcctgca
aaccttggggacgtggtagagaaattggaacagctcgttttagaaggaaataaaatatca
gaaatatgttcccctttgagcctgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatctctatcagaggacttccttgagacttgtcctaaagtggagattttaagtgcc
agaatgaattttcttgctgctatgccttttttgccttcttctatcacaagcctaaaatta
tctcaaaacagattcacgtgtgtcccagaagcaattttacatctcccacatctgcggtcc
ttagatatgagcagcaatgatattcgatatctaccaggtcctgtgcactggagatctttg
aacttaagggaactcttgtttagtcataaccagatcagtatcttggacttgagtgagaaa
gcatgtgcatggtctagaatagagaaactacatctctctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctcttgatgttagttacaacttggaa
ctgagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcatcttaattttgattttaaacatgtaggatgtaaagccaaagacatcataagg
tttcttcagcagcggctgaaaaaggctgtgccctataaccgaatgaaacttatgattgtg
ggaaatactgggagtggcaagaccaccttattgcagcaattgatgaaaatcaagaaatca
gatcttgggatgcaaggcgccacagttggcattgatgtgaaagactggcccatccaaata
agaggcaaagggaagaaagacctcattctgaatgtatgggattttgcaggtcgtgaggag
ttctacagcactcatccccactttatgacccaacgagccttgtatcttgcggtctatgac
ctcagcaaagggcaagctgaagttgatgccatgaagccttggcttttcaatataaaggcc
cgtgcttcttcttcccctgtgattcttgttggcacacatttagatgttactgatgagaag
cagcgcaaagcctgtatcagtaaaattaccaaggaactcttgaacaaacgagggtttcct
gcaatacgggattaccactttgtgaatgccactgaggaatccgatgctttggcaaaactt
cggaaaaccatcatcaatgagagccttaatttcaagatccgagatcagtctgttgttggg
cagctgattccagactgctacgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccaattgaatttcctgtaattgaccggaaacgattattacaacttgtgagagaacac
cagctgcagttagatgaaaatgagcttcctcatgcagttcactttctaaatgaatcaggg
gtccttcttcattttcaagacccagcgctgcagctaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggctcagattttgacagtgaaagtggaaggctttccaaaa
catcctaagggaattatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatggcacagtactttaaactcctagaaaaattccagattgccttg
ccaattggagaagaatatttactggttccaagcagtttgtctgaccacaggcctgtaata
gagcttccccattgtgagaactctgaaattatcattcgactgtatgaaatgccttatttt
ccaatgggcttttggtcgagattaatcaatcggttgcttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgtccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttactgcttagtaggatctgaagttttagatcatcacgcagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtgttcttctgggccaagtt
gtggaccacattgattctctcatggaagagtggtttcctggattattagagattgatatt
tgtggtgaaggagaaactctgctgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatattgcttgacaacttgatgaagaaagcagaagaaggagacctctta
gtaaatccagatcaaccaaggctcacaattccaatatctcagattgctcctgacttgatt
ttggctgatcttcctagaaatattatgctgaataatgatgaattggaatttgaacaagct
ccagagtttctcttaggtgacggcagttttggatctgtatatcgagctgcgtacaaagga
gaagaagtggctgtgaagatttttaataaacatacatcacttaggctgttaagacaagag
ctggtggtgctctgccaccttcaccatcccagcttaatatctttgctggcagctgggatt
cgtcctcggatgttggtgatggaattagcctccaagggttccctggaccgcctgcttcag
caagacaaaaccagtcttaccagaaccctgcagcacagaatcgtgctacatgtggccgat
ggcctgagatacctccattcggccatgattatataccgtgacttgaagccccacaacgtg
ttgcttttcaccctgtatcccaatgctgccatcatcgccaagattgcggactatgggatt
gctcagtactgctgtagaatggggataaaaacatcagagggcactccaggttttcgtgca
cctgaagttgctagaggaaatgttatttataaccaacaagctgatgtttattcatttggt
ttgctactttatgacattttgacaactggaggtagaatagcagaaggtctgaagtttcca
aatgagtttgatgaattggcaatacaagggaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaagttaattaaaaaatgtttgaaagaaaatcctcaa
gaaagacctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacgtatatcagtccctaaaagctttactgttgaatgcatggttgctatgaatcac
aacagcaagaatgtgaggatttggctgggctgtgggcacacggacaaaggacagctctca
tgtctggacttaaatacagaaagatacactcctgaggaagttactgatagtagaatactg
tgccttgccttggtgtatcttcctgttgaaaaggaaagttggattgtgtctggaacacag
tctggcatgctccttgtcattaatactgaagatgggagaaagaggcatactcttgaaaag
atgactgattctgtaacttgcttgtattgcaattccttttccaagcaaagcaagcaaaaa
aatttccttttagtgggaactgctgatggcaacttagcaatttttgaagataaaactgtt
aagtgtaaaggagccactcctttgaagatactcaacataggaaatgtcagcactccactg
atgtgtctgagtgaatctgtgaacttaactgaaaaaaacattatgtggggaggatgtggt
acaaaagttttctcattttctgatgatttcaccattcagaaactcattgagaccaggaca
aatcagcgattttctaatacatctttcagtgattccaacatcatcgcagtggtggtagac
acagttctttatgttgctaagaaaaatagcccatgtgtggaagtgtgggataagaagact
gaaaaacgctgtgaactgatagattgtgtgcactttttaaaggaagaactcgtcagagta
agcaaggaatcgaaacacaaaatgtcttattctgggagagtgaagactctctgccttcag
aagaacactgctctctggataggaactggaggaggccatatcttactccttgatctttca
actcgtcgaattatacgtataattcacaacttttgtgattctgttagagtcatgatgact
gcacagttaggaagccttaaaaatgtcatgctggttttggggtataaccggaaaagtgct
gaaggtacgcaacaccaaaaagagatacagtcttgcctgtctgtttgggacgtcaatctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgaaaaa
atgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
