KEGG   Cervus canadensis (wapiti): 122434589
Entry
122434589         CDS       T07554                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01521  EGFR tyrosine kinase inhibitor resistance
ccad01522  Endocrine resistance
ccad04010  MAPK signaling pathway
ccad04012  ErbB signaling pathway
ccad04068  FoxO signaling pathway
ccad04270  Vascular smooth muscle contraction
ccad04650  Natural killer cell mediated cytotoxicity
ccad04720  Long-term potentiation
ccad04726  Serotonergic synapse
ccad04730  Long-term depression
ccad04810  Regulation of actin cytoskeleton
ccad04910  Insulin signaling pathway
ccad04914  Progesterone-mediated oocyte maturation
ccad04928  Parathyroid hormone synthesis, secretion and action
ccad05010  Alzheimer disease
ccad05022  Pathways of neurodegeneration - multiple diseases
ccad05034  Alcoholism
ccad05160  Hepatitis C
ccad05161  Hepatitis B
ccad05200  Pathways in cancer
ccad05205  Proteoglycans in cancer
ccad05208  Chemical carcinogenesis - reactive oxygen species
ccad05210  Colorectal cancer
ccad05211  Renal cell carcinoma
ccad05212  Pancreatic cancer
ccad05213  Endometrial cancer
ccad05214  Glioma
ccad05215  Prostate cancer
ccad05218  Melanoma
ccad05219  Bladder cancer
ccad05220  Chronic myeloid leukemia
ccad05221  Acute myeloid leukemia
ccad05223  Non-small cell lung cancer
ccad05224  Breast cancer
ccad05225  Hepatocellular carcinoma
ccad05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122434589 (ARAF)
   04012 ErbB signaling pathway
    122434589 (ARAF)
   04068 FoxO signaling pathway
    122434589 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122434589 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    122434589 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122434589 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    122434589 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    122434589 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122434589 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    122434589 (ARAF)
   04720 Long-term potentiation
    122434589 (ARAF)
   04730 Long-term depression
    122434589 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122434589 (ARAF)
   05205 Proteoglycans in cancer
    122434589 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    122434589 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122434589 (ARAF)
   05212 Pancreatic cancer
    122434589 (ARAF)
   05225 Hepatocellular carcinoma
    122434589 (ARAF)
   05226 Gastric cancer
    122434589 (ARAF)
   05214 Glioma
    122434589 (ARAF)
   05221 Acute myeloid leukemia
    122434589 (ARAF)
   05220 Chronic myeloid leukemia
    122434589 (ARAF)
   05218 Melanoma
    122434589 (ARAF)
   05211 Renal cell carcinoma
    122434589 (ARAF)
   05219 Bladder cancer
    122434589 (ARAF)
   05215 Prostate cancer
    122434589 (ARAF)
   05213 Endometrial cancer
    122434589 (ARAF)
   05224 Breast cancer
    122434589 (ARAF)
   05223 Non-small cell lung cancer
    122434589 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    122434589 (ARAF)
   05160 Hepatitis C
    122434589 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122434589 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    122434589 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    122434589 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122434589 (ARAF)
   01522 Endocrine resistance
    122434589 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122434589 (ARAF)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122434589 (ARAF)
Protein kinases [BR:ccad01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   122434589 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 122434589
NCBI-ProteinID: XP_043314060
LinkDB
Position
X:50094634..50105217
AA seq 611 aa
MEPPRGPPANGAEPSRSVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGSSRQHEVPSNRPLNEPL
TPQSPSLSPTSSCTQHCDPEHFSFPAQANTPLQRIRSTSTPNVHMVSTTAPMDSGLIQLT
GQNFNTDAAGNRGGGDGAPRGSPNPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARLVP
NT seq 1836 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccatcccggtcagtgggcact
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggatggcatgagt
gtctatgactctctagacaaggccctcaaggtgcggggtctcaatcaagattgctgtgtg
gtttaccggctcatcaaggggcgaaagacagtcaccgcctgggacacagccattgccccc
ctggatggcgaggagctcattgtggaggtccttgaagatgtccccctgaccatgcacaat
tttgtacggaagacgttcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccggaagctccagacagcacgaagttccctcaaaccgccccctgaatgagccactc
acccctcagagtcccagcctttcccctaccagctcctgcacccagcactgcgaccccgag
cacttctccttccctgcccaggccaacacccctctccagcgcatccgctccacatccacc
cccaatgtccacatggtcagcaccacagcccccatggactccggcctcatccagctcact
ggccagaatttcaacactgatgctgctgggaatagaggtggtggtgatggagccccccgg
gggagccccaacccagccagcgtgtcctcgggaaggaagtccccacattccaagtcccca
tcagagcagcgggaacggaagtccttggctgatgacaagaagaaagtgaagaatttgggg
taccgggactcgggctattactgggaggtgccacccagtgaggtgcagttgctgaagagg
atcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggtgatgtggccgtg
aaggtgctcaaggtggcccaacccacagctgagcaggcccaggccttcaagaacgagatg
caggtgctcaggaagacacgtcacgtcaacatcttgctgttcatgggcttcatgacccgg
ccaggatttgccatcatcacacagtggtgtgagggctccagtctctaccaccaccttcat
gtggctgacacacgcttcgacatggtccagctcattgatgtggcccgccagactgctcag
ggcatggactacctccatgccaagaacatcattcaccgagatctgaagtctaacaacatc
ttcctgcacgaggggctcacggtgaagattggggacttcggcctggccacagtaaagacg
cgctggagtggggcccagcccttggagcaaccctcgggctctgtgctatggatggcagct
gaagtgatccgtatgcaggacccgaacccctacagcttccagtcagatgtctacgcctat
ggggttgtgctctatgagctcatgaccggctcactgccttacagccacattggcagccga
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaattgccccaaggccatgaggcgcctgctgtctgactgcctgaagttccagcgagag
gagcggcccctttttccccagatcctggccacgattgagctgctgcagcggtcactcccc
aagattgagcggagtgcctccgaaccctccttgcaccgtacccaggctgatgagttgcct
gcctgcctactcagcgcagcccgccttgtgccttag

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