KEGG   Cervus canadensis (wapiti): 122443383
Entry
122443383         CDS       T07554                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad00562  Inositol phosphate metabolism
ccad01100  Metabolic pathways
ccad04015  Rap1 signaling pathway
ccad04020  Calcium signaling pathway
ccad04022  cGMP-PKG signaling pathway
ccad04062  Chemokine signaling pathway
ccad04070  Phosphatidylinositol signaling system
ccad04071  Sphingolipid signaling pathway
ccad04072  Phospholipase D signaling pathway
ccad04081  Hormone signaling
ccad04082  Neuroactive ligand signaling
ccad04261  Adrenergic signaling in cardiomyocytes
ccad04270  Vascular smooth muscle contraction
ccad04310  Wnt signaling pathway
ccad04371  Apelin signaling pathway
ccad04540  Gap junction
ccad04611  Platelet activation
ccad04613  Neutrophil extracellular trap formation
ccad04621  NOD-like receptor signaling pathway
ccad04713  Circadian entrainment
ccad04720  Long-term potentiation
ccad04723  Retrograde endocannabinoid signaling
ccad04724  Glutamatergic synapse
ccad04725  Cholinergic synapse
ccad04726  Serotonergic synapse
ccad04728  Dopaminergic synapse
ccad04730  Long-term depression
ccad04742  Taste transduction
ccad04750  Inflammatory mediator regulation of TRP channels
ccad04911  Insulin secretion
ccad04912  GnRH signaling pathway
ccad04915  Estrogen signaling pathway
ccad04916  Melanogenesis
ccad04918  Thyroid hormone synthesis
ccad04919  Thyroid hormone signaling pathway
ccad04921  Oxytocin signaling pathway
ccad04922  Glucagon signaling pathway
ccad04924  Renin secretion
ccad04925  Aldosterone synthesis and secretion
ccad04926  Relaxin signaling pathway
ccad04927  Cortisol synthesis and secretion
ccad04928  Parathyroid hormone synthesis, secretion and action
ccad04929  GnRH secretion
ccad04933  AGE-RAGE signaling pathway in diabetic complications
ccad04934  Cushing syndrome
ccad04935  Growth hormone synthesis, secretion and action
ccad04961  Endocrine and other factor-regulated calcium reabsorption
ccad04970  Salivary secretion
ccad04971  Gastric acid secretion
ccad04972  Pancreatic secretion
ccad04973  Carbohydrate digestion and absorption
ccad05010  Alzheimer disease
ccad05016  Huntington disease
ccad05017  Spinocerebellar ataxia
ccad05022  Pathways of neurodegeneration - multiple diseases
ccad05142  Chagas disease
ccad05143  African trypanosomiasis
ccad05146  Amoebiasis
ccad05163  Human cytomegalovirus infection
ccad05200  Pathways in cancer
ccad05415  Diabetic cardiomyopathy
ccad05417  Lipid and atherosclerosis
Module
ccad_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122443383 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    122443383 (PLCB2)
   04310 Wnt signaling pathway
    122443383 (PLCB2)
   04371 Apelin signaling pathway
    122443383 (PLCB2)
   04020 Calcium signaling pathway
    122443383 (PLCB2)
   04070 Phosphatidylinositol signaling system
    122443383 (PLCB2)
   04072 Phospholipase D signaling pathway
    122443383 (PLCB2)
   04071 Sphingolipid signaling pathway
    122443383 (PLCB2)
   04022 cGMP-PKG signaling pathway
    122443383 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    122443383 (PLCB2)
   04081 Hormone signaling
    122443383 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    122443383 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122443383 (PLCB2)
   04613 Neutrophil extracellular trap formation
    122443383 (PLCB2)
   04621 NOD-like receptor signaling pathway
    122443383 (PLCB2)
   04062 Chemokine signaling pathway
    122443383 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    122443383 (PLCB2)
   04922 Glucagon signaling pathway
    122443383 (PLCB2)
   04929 GnRH secretion
    122443383 (PLCB2)
   04912 GnRH signaling pathway
    122443383 (PLCB2)
   04915 Estrogen signaling pathway
    122443383 (PLCB2)
   04921 Oxytocin signaling pathway
    122443383 (PLCB2)
   04926 Relaxin signaling pathway
    122443383 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    122443383 (PLCB2)
   04918 Thyroid hormone synthesis
    122443383 (PLCB2)
   04919 Thyroid hormone signaling pathway
    122443383 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    122443383 (PLCB2)
   04916 Melanogenesis
    122443383 (PLCB2)
   04924 Renin secretion
    122443383 (PLCB2)
   04925 Aldosterone synthesis and secretion
    122443383 (PLCB2)
   04927 Cortisol synthesis and secretion
    122443383 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122443383 (PLCB2)
   04270 Vascular smooth muscle contraction
    122443383 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    122443383 (PLCB2)
   04971 Gastric acid secretion
    122443383 (PLCB2)
   04972 Pancreatic secretion
    122443383 (PLCB2)
   04973 Carbohydrate digestion and absorption
    122443383 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    122443383 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    122443383 (PLCB2)
   04725 Cholinergic synapse
    122443383 (PLCB2)
   04728 Dopaminergic synapse
    122443383 (PLCB2)
   04726 Serotonergic synapse
    122443383 (PLCB2)
   04720 Long-term potentiation
    122443383 (PLCB2)
   04730 Long-term depression
    122443383 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    122443383 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    122443383 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    122443383 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    122443383 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122443383 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    122443383 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122443383 (PLCB2)
   05142 Chagas disease
    122443383 (PLCB2)
   05143 African trypanosomiasis
    122443383 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122443383 (PLCB2)
   05016 Huntington disease
    122443383 (PLCB2)
   05017 Spinocerebellar ataxia
    122443383 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    122443383 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122443383 (PLCB2)
   05415 Diabetic cardiomyopathy
    122443383 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122443383 (PLCB2)
   04934 Cushing syndrome
    122443383 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccad04131]
    122443383 (PLCB2)
Enzymes [BR:ccad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     122443383 (PLCB2)
Membrane trafficking [BR:ccad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    122443383 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    122443383 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh C2 EF-hand_like FAM184 Gp58
Other DBs
NCBI-GeneID: 122443383
NCBI-ProteinID: XP_043327391
LinkDB
Position
6:complement(36882932..36904585)
AA seq 1186 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMELLD
ITSIRDTRFGKFAKMPKSQKLREVFNMNIPDNFLLKTLTVVSGPDMVDLTFHNFVSYKEN
VGKDWAEDVLALAKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRV
EAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHL
AKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENS
VLAQDKLLLHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDCW
KGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMA
EYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASSGKEPDGEA
EGSSPPNAPVGEDTVWAGEEGAELEEEEVEEEEEESGNLDEEGIKKMQSDEGTAGLEVTA
YEEMSSLVNYIQPTKFISFELSAQKNRSYVISSFTELKAYDLLSKSSVQFVDYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR
RSDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKL
SPNTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPISALNSGYHHLCL
HNESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKSVKLKEAMGGQPE
SPFPLGNHPANQVNGASAPTSNGSAAAGAKAREEATKEAAEPQTASLEELRELKGVVKLQ
RRQEKELRELGRRGVRRWEELLQRGAAQLAGLGPPSAGGGGGCRGRKLGPGKGSRKKRTL
PGEDTAGAASAEGPEGEDVRLRELRDSLELELLQLGEEQCECVLKLKEQHAAQQMTKMME
LAREKQAAERKTLKETLETDTKEMKKKLEAKRLERIQAMMKVTTDKMAQERLKREINNSH
IQEVVQVIKQMTENLERHQEKLEEKQAACLEQIQEMEKQFQQEAMAEYEAKMKGLEMEVK
ESVRTCLQACFPSEEEDKPERPCVVSRELCEQDTLAEQAETQESHL
NT seq 3561 nt   +upstreamnt  +downstreamnt
atgtctcttctgaaccccgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaacgacgatagcctctccggttatccttcgagtg
gatcccaagggctactacttgtactggacctatcagagtaaggagatggagcttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggaagtcttcaacatgaacatccccgacaacttcctgctgaagacgctcacagtg
gtatccggtcctgacatggtggacctcaccttccataacttcgtctcctacaaggagaac
gtgggcaaggactgggctgaagatgtactggctctggccaagcatccgctgacggccaac
gcctcccgcagcaccttcctggacaagatccttgtgaagctcaagatgcagcttaaccct
gagggcaagattcccgtgaagaattttttccagatgttccctgctgaccgcaagcgggtg
gaagctgccctcagtgcctgccacctccccaaaggcaagaacgatgccatcaatcccgag
gacttcccagagtccgtgtacaagagcttcctcatgagcctctgtcctcggccagaaata
gatgagatcttcacttcctaccactccaaggccaaaccctatatgactaaggagcacctg
gccaaattcatcaaccagaaacagcgcgactccaggctcaattccctgctgtttccgcca
gcgcgtcctgaccaagtgcagggcctcatcgacaagtacgagcccagcggcatcaacgtg
cagcggggccagctgtcccccgagggcatggtgtggtttctctgcgggccggagaacagt
gtgctggcccaggacaagctgctgctgcaccaggacatgacccagccgctcaaccattac
ttcatcaactcctcccacaacacctacctgacagccggccagttctcaggcctttcctct
gctgagatgtaccgccaagtgctgctggcaggctgccgctgcgtggagctggactgctgg
aaggggaagccccccgacgaggagcccatcatcacccacggtttcaccatgaccacagac
atctatttcaaggaagcaatcgaagccattgcagaaagtgcctttaagacctccccttat
ccggtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggctaagatggcc
gagtactgccggacgatgtttggggatatgctgctcacagaacccctggagaagttcccg
ctgaaacctggcatccccctgcccagccctgaggatctccgaggcaagatcctaatcaag
aacaagaagaaccagttttctggccctgcatcctccggcaaggagccggatggggaggct
gagggtagcagcccacccaatgcccctgtgggtgaggatacagtgtgggctggtgaggaa
ggggctgagctggaggaggaggaggtagaagaagaagaggaggagtcgggaaacctggat
gaagaagggataaagaagatgcaatcagatgagggcacagcgggcctggaggtgacggcc
tatgaggagatgtccagcctagtcaattacatccagcccaccaagttcatctccttcgag
ctctctgcccagaagaaccgaagttatgttatctcctccttcacggagctcaaggcttac
gatctgctctccaagtcctcagtgcagtttgtggactacaacaagcgccagatgagccgc
atctaccccaaggggacccgcatggactcctccaactacatgccccagatgttctggaac
gctggttgtcagatggttgccctcaacttccagacgatggacctgcccatgcagcagaac
atggcgcttttcgagttcaacgggcagagtggctacctcctcaagcatgagttcatgcgt
cggtcggacaagcagttcaatcccttctcagtggaccgcatcgacgtggtggtagccacc
accctttccattacggtgatctctgggcagttcctgtcagaacgcagtgtgcgcacttat
gtggaagtggagctgtttggccttccgggagatcccaagaggcgctatcgcaccaagctg
tcacccaataccaactccatcaatccggtctggaaggaggagccctttgtctttgagaag
atcttgatgcctgagctggcttccctcagagtcgctgtgatggaggaaggcaataagttt
cttggacaccgcatcatccccatcagtgccctgaattctggataccaccatctctgtctg
cacaatgagagcaacatgccgctcaccatgcccgcgctgtttgtcttcctggagatgaag
gactatgtgcctgacacctgggcagatctcacggtggccctcgctaaccctatcaagttc
ttcagtgcccatgataagaagtctgtgaagctcaaggaagccatgggaggccagcccgag
agtcccttccctcttgggaatcaccctgccaaccaggtcaatggggcatcggctccaaca
agcaatgggtcagcagcagccggggccaaggccagggaggaggccacgaaagaagctgcg
gaaccgcagaccgccagcctggaggagctgcgggagctgaagggcgtcgtgaagctgcag
cggcgccaggagaaggagctgcgggaactggggcggcgcggcgtgcggcgctgggaggag
ctgctgcagaggggcgcggcgcagctggccgggctcgggcctccgagcgcggggggcggc
ggcgggtgtcggggccgtaagctcggcccgggcaagggatcccgcaaaaagaggaccctg
cccggcgaggacaccgccggggcggcatcggccgaaggcccggagggcgaggacgtgcgc
ctgcgagagctgagggacagtctggagctggagctgctgcagctgggcgaagagcagtgc
gagtgtgtcctgaagctcaaggagcagcacgcggcccagcaaatgaccaagatgatggag
ctggccagggagaaacaggctgcagagcggaagaccctcaaggagaccttggagactgac
accaaagagatgaagaagaagctggaggccaagaggctggagcggatccaggccatgatg
aaggtcaccacagacaagatggctcaggagaggttgaagagagagattaacaactcccac
atccaggaggtggtgcaggtgatcaagcagatgacggagaacctggagaggcaccaggag
aagttggaggagaagcaggcagcctgcctggaacagatccaggagatggaaaaacagttc
cagcaggaggcgatggcagagtacgaggccaagatgaagggcctggagatggaagtgaag
gagtcagtgaggacctgcctccaggcctgcttcccctctgaggaggaggacaagcctgag
agaccctgcgtggtctccagggagctgtgtgagcaggacacactcgcagagcaggcagag
acccaggagagccacctctga

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