KEGG   Cervus canadensis (wapiti): 122444906
Entry
122444906         CDS       T07554                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad00562  Inositol phosphate metabolism
ccad01100  Metabolic pathways
ccad01521  EGFR tyrosine kinase inhibitor resistance
ccad01522  Endocrine resistance
ccad01524  Platinum drug resistance
ccad04012  ErbB signaling pathway
ccad04014  Ras signaling pathway
ccad04015  Rap1 signaling pathway
ccad04024  cAMP signaling pathway
ccad04062  Chemokine signaling pathway
ccad04066  HIF-1 signaling pathway
ccad04068  FoxO signaling pathway
ccad04070  Phosphatidylinositol signaling system
ccad04071  Sphingolipid signaling pathway
ccad04072  Phospholipase D signaling pathway
ccad04081  Hormone signaling
ccad04140  Autophagy - animal
ccad04145  Phagocytosis
ccad04150  mTOR signaling pathway
ccad04151  PI3K-Akt signaling pathway
ccad04152  AMPK signaling pathway
ccad04210  Apoptosis
ccad04211  Longevity regulating pathway
ccad04213  Longevity regulating pathway - multiple species
ccad04218  Cellular senescence
ccad04360  Axon guidance
ccad04370  VEGF signaling pathway
ccad04380  Osteoclast differentiation
ccad04510  Focal adhesion
ccad04517  IgSF CAM signaling
ccad04518  Integrin signaling
ccad04550  Signaling pathways regulating pluripotency of stem cells
ccad04611  Platelet activation
ccad04613  Neutrophil extracellular trap formation
ccad04620  Toll-like receptor signaling pathway
ccad04625  C-type lectin receptor signaling pathway
ccad04630  JAK-STAT signaling pathway
ccad04650  Natural killer cell mediated cytotoxicity
ccad04660  T cell receptor signaling pathway
ccad04662  B cell receptor signaling pathway
ccad04664  Fc epsilon RI signaling pathway
ccad04666  Fc gamma R-mediated phagosome formation
ccad04668  TNF signaling pathway
ccad04670  Leukocyte transendothelial migration
ccad04722  Neurotrophin signaling pathway
ccad04725  Cholinergic synapse
ccad04750  Inflammatory mediator regulation of TRP channels
ccad04810  Regulation of actin cytoskeleton
ccad04910  Insulin signaling pathway
ccad04914  Progesterone-mediated oocyte maturation
ccad04915  Estrogen signaling pathway
ccad04917  Prolactin signaling pathway
ccad04919  Thyroid hormone signaling pathway
ccad04923  Regulation of lipolysis in adipocytes
ccad04926  Relaxin signaling pathway
ccad04929  GnRH secretion
ccad04930  Type II diabetes mellitus
ccad04931  Insulin resistance
ccad04932  Non-alcoholic fatty liver disease
ccad04933  AGE-RAGE signaling pathway in diabetic complications
ccad04935  Growth hormone synthesis, secretion and action
ccad04960  Aldosterone-regulated sodium reabsorption
ccad04973  Carbohydrate digestion and absorption
ccad05010  Alzheimer disease
ccad05017  Spinocerebellar ataxia
ccad05020  Prion disease
ccad05100  Bacterial invasion of epithelial cells
ccad05132  Salmonella infection
ccad05135  Yersinia infection
ccad05142  Chagas disease
ccad05146  Amoebiasis
ccad05160  Hepatitis C
ccad05161  Hepatitis B
ccad05162  Measles
ccad05163  Human cytomegalovirus infection
ccad05164  Influenza A
ccad05165  Human papillomavirus infection
ccad05166  Human T-cell leukemia virus 1 infection
ccad05167  Kaposi sarcoma-associated herpesvirus infection
ccad05168  Herpes simplex virus 1 infection
ccad05169  Epstein-Barr virus infection
ccad05170  Human immunodeficiency virus 1 infection
ccad05171  Coronavirus disease
ccad05200  Pathways in cancer
ccad05203  Viral carcinogenesis
ccad05205  Proteoglycans in cancer
ccad05206  MicroRNAs in cancer
ccad05207  Chemical carcinogenesis - receptor activation
ccad05208  Chemical carcinogenesis - reactive oxygen species
ccad05210  Colorectal cancer
ccad05211  Renal cell carcinoma
ccad05212  Pancreatic cancer
ccad05213  Endometrial cancer
ccad05214  Glioma
ccad05215  Prostate cancer
ccad05218  Melanoma
ccad05220  Chronic myeloid leukemia
ccad05221  Acute myeloid leukemia
ccad05222  Small cell lung cancer
ccad05223  Non-small cell lung cancer
ccad05224  Breast cancer
ccad05225  Hepatocellular carcinoma
ccad05226  Gastric cancer
ccad05230  Central carbon metabolism in cancer
ccad05231  Choline metabolism in cancer
ccad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccad05415  Diabetic cardiomyopathy
ccad05417  Lipid and atherosclerosis
ccad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122444906 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122444906 (PIK3CA)
   04014 Ras signaling pathway
    122444906 (PIK3CA)
   04015 Rap1 signaling pathway
    122444906 (PIK3CA)
   04370 VEGF signaling pathway
    122444906 (PIK3CA)
   04630 JAK-STAT signaling pathway
    122444906 (PIK3CA)
   04668 TNF signaling pathway
    122444906 (PIK3CA)
   04066 HIF-1 signaling pathway
    122444906 (PIK3CA)
   04068 FoxO signaling pathway
    122444906 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    122444906 (PIK3CA)
   04072 Phospholipase D signaling pathway
    122444906 (PIK3CA)
   04071 Sphingolipid signaling pathway
    122444906 (PIK3CA)
   04024 cAMP signaling pathway
    122444906 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    122444906 (PIK3CA)
   04152 AMPK signaling pathway
    122444906 (PIK3CA)
   04150 mTOR signaling pathway
    122444906 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122444906 (PIK3CA)
   04517 IgSF CAM signaling
    122444906 (PIK3CA)
   04518 Integrin signaling
    122444906 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    122444906 (PIK3CA)
   04140 Autophagy - animal
    122444906 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    122444906 (PIK3CA)
   04218 Cellular senescence
    122444906 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122444906 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    122444906 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122444906 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122444906 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    122444906 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    122444906 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    122444906 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    122444906 (PIK3CA)
   04660 T cell receptor signaling pathway
    122444906 (PIK3CA)
   04662 B cell receptor signaling pathway
    122444906 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    122444906 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    122444906 (PIK3CA)
   04670 Leukocyte transendothelial migration
    122444906 (PIK3CA)
   04062 Chemokine signaling pathway
    122444906 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122444906 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    122444906 (PIK3CA)
   04929 GnRH secretion
    122444906 (PIK3CA)
   04915 Estrogen signaling pathway
    122444906 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    122444906 (PIK3CA)
   04917 Prolactin signaling pathway
    122444906 (PIK3CA)
   04926 Relaxin signaling pathway
    122444906 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    122444906 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    122444906 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122444906 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122444906 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    122444906 (PIK3CA)
   04722 Neurotrophin signaling pathway
    122444906 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122444906 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    122444906 (PIK3CA)
   04380 Osteoclast differentiation
    122444906 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    122444906 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    122444906 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122444906 (PIK3CA)
   05206 MicroRNAs in cancer
    122444906 (PIK3CA)
   05205 Proteoglycans in cancer
    122444906 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    122444906 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    122444906 (PIK3CA)
   05203 Viral carcinogenesis
    122444906 (PIK3CA)
   05230 Central carbon metabolism in cancer
    122444906 (PIK3CA)
   05231 Choline metabolism in cancer
    122444906 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122444906 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122444906 (PIK3CA)
   05212 Pancreatic cancer
    122444906 (PIK3CA)
   05225 Hepatocellular carcinoma
    122444906 (PIK3CA)
   05226 Gastric cancer
    122444906 (PIK3CA)
   05214 Glioma
    122444906 (PIK3CA)
   05221 Acute myeloid leukemia
    122444906 (PIK3CA)
   05220 Chronic myeloid leukemia
    122444906 (PIK3CA)
   05218 Melanoma
    122444906 (PIK3CA)
   05211 Renal cell carcinoma
    122444906 (PIK3CA)
   05215 Prostate cancer
    122444906 (PIK3CA)
   05213 Endometrial cancer
    122444906 (PIK3CA)
   05224 Breast cancer
    122444906 (PIK3CA)
   05222 Small cell lung cancer
    122444906 (PIK3CA)
   05223 Non-small cell lung cancer
    122444906 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122444906 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    122444906 (PIK3CA)
   05161 Hepatitis B
    122444906 (PIK3CA)
   05160 Hepatitis C
    122444906 (PIK3CA)
   05171 Coronavirus disease
    122444906 (PIK3CA)
   05164 Influenza A
    122444906 (PIK3CA)
   05162 Measles
    122444906 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    122444906 (PIK3CA)
   05163 Human cytomegalovirus infection
    122444906 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122444906 (PIK3CA)
   05169 Epstein-Barr virus infection
    122444906 (PIK3CA)
   05165 Human papillomavirus infection
    122444906 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122444906 (PIK3CA)
   05135 Yersinia infection
    122444906 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    122444906 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122444906 (PIK3CA)
   05142 Chagas disease
    122444906 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122444906 (PIK3CA)
   05017 Spinocerebellar ataxia
    122444906 (PIK3CA)
   05020 Prion disease
    122444906 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122444906 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    122444906 (PIK3CA)
   05415 Diabetic cardiomyopathy
    122444906 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122444906 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    122444906 (PIK3CA)
   04931 Insulin resistance
    122444906 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122444906 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122444906 (PIK3CA)
   01524 Platinum drug resistance
    122444906 (PIK3CA)
   01522 Endocrine resistance
    122444906 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccad04131]
    122444906 (PIK3CA)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     122444906 (PIK3CA)
Membrane trafficking [BR:ccad04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122444906 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 122444906
NCBI-ProteinID: XP_043329611
LinkDB
Position
7:complement(63431961..63517302)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttattaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acgttaataactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaaatatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcatattccagacgcatctccacagctacgccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtgaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgtgaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaactctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaagcctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcggtgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtactaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcattaactaat
caaaggatcggtcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggaatcctattgccgtgcatgtgggatgtatctgaag
caccttaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctccagggctttctgtctcctctaaaccctgctcatcag
ctgggaaacctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacccttcagattattcgcatcatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggatgtctgtca
attggtgactgtgtgggactgattgaggtggtgagaaattctcacactataatgcagatt
cagtgtaaaggaggcctgaaaggtgctctgcagttcaacagccacaccctccatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccatcgatctgtttacacgatca
tgtgctggatattgtgttgccaccttcattttgggaattggagatcgtcacaatagtaat
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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