KEGG   Cervus canadensis (wapiti): 122446321
Entry
122446321         CDS       T07554                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01522  Endocrine resistance
ccad04010  MAPK signaling pathway
ccad04012  ErbB signaling pathway
ccad04014  Ras signaling pathway
ccad04024  cAMP signaling pathway
ccad04068  FoxO signaling pathway
ccad04071  Sphingolipid signaling pathway
ccad04137  Mitophagy - animal
ccad04140  Autophagy - animal
ccad04141  Protein processing in endoplasmic reticulum
ccad04210  Apoptosis
ccad04215  Apoptosis - multiple species
ccad04217  Necroptosis
ccad04310  Wnt signaling pathway
ccad04380  Osteoclast differentiation
ccad04510  Focal adhesion
ccad04530  Tight junction
ccad04620  Toll-like receptor signaling pathway
ccad04621  NOD-like receptor signaling pathway
ccad04622  RIG-I-like receptor signaling pathway
ccad04625  C-type lectin receptor signaling pathway
ccad04657  IL-17 signaling pathway
ccad04658  Th1 and Th2 cell differentiation
ccad04659  Th17 cell differentiation
ccad04660  T cell receptor signaling pathway
ccad04664  Fc epsilon RI signaling pathway
ccad04668  TNF signaling pathway
ccad04722  Neurotrophin signaling pathway
ccad04723  Retrograde endocannabinoid signaling
ccad04728  Dopaminergic synapse
ccad04750  Inflammatory mediator regulation of TRP channels
ccad04910  Insulin signaling pathway
ccad04912  GnRH signaling pathway
ccad04914  Progesterone-mediated oocyte maturation
ccad04917  Prolactin signaling pathway
ccad04920  Adipocytokine signaling pathway
ccad04926  Relaxin signaling pathway
ccad04930  Type II diabetes mellitus
ccad04931  Insulin resistance
ccad04932  Non-alcoholic fatty liver disease
ccad04933  AGE-RAGE signaling pathway in diabetic complications
ccad04935  Growth hormone synthesis, secretion and action
ccad04936  Alcoholic liver disease
ccad05010  Alzheimer disease
ccad05012  Parkinson disease
ccad05016  Huntington disease
ccad05017  Spinocerebellar ataxia
ccad05020  Prion disease
ccad05022  Pathways of neurodegeneration - multiple diseases
ccad05132  Salmonella infection
ccad05133  Pertussis
ccad05135  Yersinia infection
ccad05142  Chagas disease
ccad05145  Toxoplasmosis
ccad05152  Tuberculosis
ccad05161  Hepatitis B
ccad05162  Measles
ccad05166  Human T-cell leukemia virus 1 infection
ccad05167  Kaposi sarcoma-associated herpesvirus infection
ccad05169  Epstein-Barr virus infection
ccad05170  Human immunodeficiency virus 1 infection
ccad05171  Coronavirus disease - COVID-19
ccad05200  Pathways in cancer
ccad05208  Chemical carcinogenesis - reactive oxygen species
ccad05210  Colorectal cancer
ccad05212  Pancreatic cancer
ccad05231  Choline metabolism in cancer
ccad05415  Diabetic cardiomyopathy
ccad05417  Lipid and atherosclerosis
ccad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    122446321 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122446321 (MAPK8)
   04012 ErbB signaling pathway
    122446321 (MAPK8)
   04014 Ras signaling pathway
    122446321 (MAPK8)
   04310 Wnt signaling pathway
    122446321 (MAPK8)
   04668 TNF signaling pathway
    122446321 (MAPK8)
   04068 FoxO signaling pathway
    122446321 (MAPK8)
   04071 Sphingolipid signaling pathway
    122446321 (MAPK8)
   04024 cAMP signaling pathway
    122446321 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122446321 (MAPK8)
   04137 Mitophagy - animal
    122446321 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    122446321 (MAPK8)
   04215 Apoptosis - multiple species
    122446321 (MAPK8)
   04217 Necroptosis
    122446321 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122446321 (MAPK8)
   04530 Tight junction
    122446321 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    122446321 (MAPK8)
   04621 NOD-like receptor signaling pathway
    122446321 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    122446321 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    122446321 (MAPK8)
   04660 T cell receptor signaling pathway
    122446321 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    122446321 (MAPK8)
   04659 Th17 cell differentiation
    122446321 (MAPK8)
   04657 IL-17 signaling pathway
    122446321 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    122446321 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122446321 (MAPK8)
   04920 Adipocytokine signaling pathway
    122446321 (MAPK8)
   04912 GnRH signaling pathway
    122446321 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    122446321 (MAPK8)
   04917 Prolactin signaling pathway
    122446321 (MAPK8)
   04926 Relaxin signaling pathway
    122446321 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    122446321 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    122446321 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    122446321 (MAPK8)
   04722 Neurotrophin signaling pathway
    122446321 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122446321 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122446321 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122446321 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    122446321 (MAPK8)
   05231 Choline metabolism in cancer
    122446321 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122446321 (MAPK8)
   05212 Pancreatic cancer
    122446321 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122446321 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    122446321 (MAPK8)
   05161 Hepatitis B
    122446321 (MAPK8)
   05171 Coronavirus disease - COVID-19
    122446321 (MAPK8)
   05162 Measles
    122446321 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122446321 (MAPK8)
   05169 Epstein-Barr virus infection
    122446321 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122446321 (MAPK8)
   05135 Yersinia infection
    122446321 (MAPK8)
   05133 Pertussis
    122446321 (MAPK8)
   05152 Tuberculosis
    122446321 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122446321 (MAPK8)
   05142 Chagas disease
    122446321 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122446321 (MAPK8)
   05012 Parkinson disease
    122446321 (MAPK8)
   05016 Huntington disease
    122446321 (MAPK8)
   05017 Spinocerebellar ataxia
    122446321 (MAPK8)
   05020 Prion disease
    122446321 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    122446321 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122446321 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    122446321 (MAPK8)
   05415 Diabetic cardiomyopathy
    122446321 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122446321 (MAPK8)
   04936 Alcoholic liver disease
    122446321 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    122446321 (MAPK8)
   04931 Insulin resistance
    122446321 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122446321 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    122446321 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122446321 (MAPK8)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     122446321 (MAPK8)
Protein kinases [BR:ccad01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   122446321 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 RIO1 Kinase-like Kdo FTA2 APH DUF530
Other DBs
NCBI-GeneID: 122446321
NCBI-ProteinID: XP_043332301
LinkDB
Position
8:complement(57421520..57513220)
AA seq 439 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNADISENWNLSTEIIGLLNVFTPQKSLEEFQDVYIVM
ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL
DFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGT
DHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNK
LKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHT
IEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTL
ASDTDSSLEASAGPLGCCR
NT seq 1320 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattc
acagtcctgaaacggtatcagaatttaaaaccaataggttcaggagcccaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaacgttgcaatcaagaagctaagccggcca
tttcagaatcaaactcatgctaagcgtgcttacagagaactagttcttatgaaatgtgta
aatcacaaaaatgctgacatttcagaaaactggaaccttagcacagagataattggcctt
ttgaatgtttttacaccacagaaatccctagaagaatttcaagatgtttacatagtcatg
gagctcatggatgcaaatctttgtcaagtgattcagatggaactagatcatgaaagaatg
tcctaccttctctatcagatgctgtgtggaatcaagcaccttcactctgctggaattatt
catcgggacttaaagcccagtaatatagtagtaaaatcagactgcactttgaagattctt
gactttggactggccaggactgcaggaactagttttatgatgacaccttacgtagtgact
cgctactacagagcacctgaggtcatcctaggcatgggctacaaagaaaacgttgacatt
tggtcagttgggtgcatcatgggagaaatgatcaaaggtggtgttttgttcccaggtaca
gatcatattgatcagtggaataaagttattgaacagcttggaacaccatgtcctgaattc
atgaagaaactgcagccaacagtaaggacttacgttgaaaacagacctaaatatgctgga
tatagctttgagaaactcttccctgatgtacttttcccagctgactcggaacacaacaaa
cttaaagccagtcaggcaagggatttgttatccaaaatgctggtaattgatgcatctaaa
aggatttctgtagatgaagctctccagcacccgtatatcaatgtctggtatgatccttct
gaagcagaagctcccccaccaaagatacctgacaagcagttagatgaaagggaacacaca
atagaagagtggaaagaattgatatacaaagaagttatggacttggaggaaagaaccaag
aatggagttatacgggggcagccctctcctttaggtgcagcagtgatcaatggctctcag
catccatcatcatcatcatctgtcaatgatgtgtcttcaatgtcaacagatccgactttg
gcctcggatacagacagcagtctagaagcatcagctgggcctctgggctgctgtagatga

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