Cervus canadensis (wapiti): 122446827 Help Entry 122446827         CDS       T07554                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ccad  Cervus canadensis (wapiti) Pathway ccad04020   Calcium signaling pathway ccad04024   cAMP signaling pathway ccad04260   Cardiac muscle contraction ccad04261   Adrenergic signaling in cardiomyocytes ccad04371   Apelin signaling pathway ccad04713   Circadian entrainment ccad04911   Insulin secretion ccad04921   Oxytocin signaling pathway ccad04972   Pancreatic secretion ccad05020   Prion disease ccad05022   Pathways of neurodegeneration - multiple diseases ccad05410   Hypertrophic cardiomyopathy ccad05412   Arrhythmogenic right ventricular cardiomyopathy ccad05414   Dilated cardiomyopathy ccad05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ccad00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122446827 (RYR2)    04020 Calcium signaling pathway     122446827 (RYR2)    04024 cAMP signaling pathway     122446827 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     122446827 (RYR2)    04921 Oxytocin signaling pathway     122446827 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     122446827 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     122446827 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     122446827 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     122446827 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     122446827 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     122446827 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     122446827 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     122446827 (RYR2)    05414 Dilated cardiomyopathy     122446827 (RYR2)    05415 Diabetic cardiomyopathy     122446827 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ccad04040]     122446827 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ccad04990]     122446827 (RYR2) Ion channels [BR:ccad04040]  Voltage-gated cation channels   Ryanodine receptor    122446827 (RYR2) Domain-containing proteins not elsewhere classified [BR:ccad04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    122446827 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 FYDLN_acid EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  122446827 NCBI-ProteinID:  XP_043333238 LinkDB All DBs Position 8:complement(82887474..83482544) Genome browser AA seq 5012 aa AA seqDB search MGTQLLRILKPMLLAVFILPVPSHPDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLES TSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGKVDVEKWKFMMKTAQGGGHR TLLYGHAVLLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSE GEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGG DVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRW GQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGT SEIKYGDSVCYIQHISTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHE ESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLE HEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILN SLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKE GHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNH VSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGE EWGGNGVGDDLFSYGFDGLHLWSGCIARTVNSPNQHLLRTDDVISCCLDLSAPSISFRIN GQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEK LKVEHSREYKQERSYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHE LWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVG ISDEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDR IRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDH AARADVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSD ERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELA FKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWL SKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQSSSTDIMFYRLSMPIECA EVFSKPAAGGIPGTGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDKDKEAAKPEFN NHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVR IFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAG ESLSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPN VFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRI SERQGWLVQCVEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHR VAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTE ETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSINTEGYQYSPEFPLDILKAKT IQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHVLQLIEPSVF KEAASPEEESEVVEKEPCMEDSKLEGAAEEESKGGKRPKEGLLQMKLPEPVKLQMCLLLQ YLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQE QINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNNDLTIRGRLLS LVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQ YDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMN NKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQ KAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAG CGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECF GPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTTGSSKTPDTDEEEDDTIHMGNAIMTF YAALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNV VEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATD MALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEV CLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFG AASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEK QSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGWIYGEIYSDSS KVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTS QVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLL VPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIR YVDEAHQYILEFVFEVQHVPKKLFMSTDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFK NHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHIL GQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINY TTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALG ECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLME EIVDLAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMNTL LGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSE EDHLKSEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLF RMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKG DRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNVHLQ GKLEDPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLV EHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYF EDKLIEDLAKPGAEPPEEDEGAKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMA KSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASK GETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAF ERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTV NIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPC TGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEG NVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDF HKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEH MPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSVNKEESEKEKPEE QGPRMGFFSIVTVKSALFALRYNILILMRMLSLKSLKKQMKKVKKMTVKDMITAFFTSYW GILMSLLHFVASVFRGFSRIIGSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGYGEE GERKTLEGALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSN PVPIPEVQEKFQVTYLQSQQLSGLQEQKAKEEEKEEKEESKSEPEKAEGEDGEKEEKAKE DKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINF ILLFYKVSTSSVVEGKELPTRSSSENAKVSSLDSSSPRIIAVHYVLEESSGYMEPTLRIL AILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVI NTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLS AVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRT ILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMF HMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRD QQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTG QESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15039 nt NT seq  +upstreamnt  +downstreamnt atgggaactcagctactgcgaattctgaagcccatgcttcttgctgtgttcatattgcct gtgccaagtcatcctgatgatgaagtggttctacagtgtaccgcaaccatccacaaagaa caacagaaactatgtttggcagcagaaggatttggcaacagactttgcttcttggagtcc acttcgaattccaagaatgtccctccagacctctccatctgcaccttcgtgctggagcag tccctgtctgtccgggccttgcaggagatgctggctaacactgtggaaaagtctgaaggg aaggttgatgtggaaaaatggaaattcatgatgaagactgctcagggtggcggccaccga acgctcctctatggccatgcagtactgctgcggcattcctacagtggcatgtatctgtgc tgcctgtccacctctcggtcttcaactgataagctggcttttgatgttggcttgcaagag gatacaacaggtgaagcttgttggtggaccatccatcctgcctctaagcagcgctcagaa ggagaaaaggtgcgggttggagatgacctcatcttagtgagtgtgtcctctgaaaggtac ctgcacttgtcttacggtaacggcagcttgcacgtggatgctgctttccagcagaccctc tggagcgtggcccccatcagctcaggaagtgaagcagcccaagggtatctgattggtggt gacgtcctcaggttgcttcatggacacatggatgaatgcctcactgtcccttcaggagaa cacggtgaagagcagcggagaactgttcattacgaaggtggtgctgtatccgttcacgca cgttccctgtggcgactagagacactaagagttgcgtggagtggaagccacataagatgg ggacaaccttttcgactacgccatgtcacaacaggaaaatacttgagtctcatggaagac aaaagccttctactcatggacaaagagaaagctgatgtcaaatcaactgcatttaccttc agatcttccaaggaaaaattggatgtaggagtgagaaaagaagtcgatggcatgggaacc tctgaaataaaatatggagactcagtgtgttatatacagcacatcagtacaggcttgtgg ctaacttaccagtctgtggatgtgaaatcggtgagaatgggatccatacaacgcaaggct attatgcatcatgaaggacacatggatgatggcctaaatttatccagatctcagcatgaa gaatcacggacagcacgtgtcatccggagcacagtctttctttttaatagatttattagg ggccttgatgctctcagcaaaaaggtgaaggcttccacagtagacttacctatagagtct gtaagtctgagtctgcaggaccttattggctacttccacccaccagatgagcatttagag catgaagataagcagaacagattacgagctctgaagaacaggcagaatctcttccaggaa gagggaatgatcaacctcgtgctcgagtgtatagacagactgcacgtgtatagcagcgcc gctcacttcgcggatgttgctgggagagaagcaggggaatcttggaaatcgattctgaat tctttgtatgagttgttggctgcactaattagaggaaatcgtaaaaactgtgctcaattt tctggctcccttgactggttaatcagccgactggaaagactggaagcttcttctggtatt cttgaagttttacactgtgtgttagtagaaagtccagaagctctcaatattattaaagaa ggccatataaaatccattatctcacttttagacaagcatggaagaaatcacaaggttctg gatgtcttatgctctctctgtgtttgccatggagtggcagtccgttctaaccagcatctc atctgtgacaatcttctgccaggaagagacctgttattgcagacacgccttgtgaaccat gtgagcagcatgagacccaatatttttctgggtgtcagtgaaggctctgcacagtataag aagtggtactatgagttgatggtggaccacacggagccgttcgtgactgctgaagccact cacctgcgcgtgggctgggcttccacagagggctactcaccctaccccggcgggggcgag gaatggggtgggaatggcgtcggagacgacctcttctcctacggattcgatggccttcac ctctggtcaggttgtattgcccggactgtcaactcaccaaaccagcatctcttgagaact gatgatgtcatcagttgctgtttagatctaagtgccccaagcatctccttccgaattaat ggacaacctgttcaaggcatgtttgagaatttcaacattgatggcctcttctttccagtt gtcagtttctctgcaggaatcaaagtacgctttctgcttggggggagacatggagaattt aaattccttcctccgcctgggtacgctccttgttacgaagctgttctgccaaaagagaag ttgaaagtggagcacagccgagagtacaagcaagaaaggagttacacgcgggacctcctg ggccccacagtttccctgacacaagccgccttcacaccaatcccagtggacaccagccag attgtgttgcctccccacctggagaggatacgagaaaaactggcagagaatatccatgag ctctgggtgatgaataaaattgaacttggctggcagtatggtccggttagagacgacaat aagagacagcacccgtgtctggtggagttctccaagctgcctgaacaggaacgcaattac aatttacagatgtctcttgagaccctgaagacgttgttggctttaggatgtcatgtgggt atatcagatgaacatgctgaagaaaaggtgaaaaaaatgaagctgccaaagaattaccaa ctgacaagtggatacaagcctgccccaatggacctgagctttatcaaactcaccccatct caagaggctatggtggacaagttggcggaaaatgctcataacgtgtgggctcgggatcgg attcgacagggctggacctacggcatccaacaggatgtaaagaacagaagaaaccctcgg cttgttccctatgcccttctagatgacagaactaagaaatccaataaggatagcctccgt gaggctgtacgcacactcctgggatatggctacaacctggaggcacctgatcaggatcat gctgccagagcagacgtgtgcagcggcacgggagagaggttccggatcttccgggcagag aagacgtacgctgtgaaggctggaaggtggtattttgaattcgaggcggtcactgctgga gacatgcgagttggctggagcaggccaggctgtcaacctgatcaggagcttggctcagat gaacgtgcctttgcttttgatggcttcaaggcccagcgatggcaccagggcaatgagcac tatggacgctcttggcaagccggcgatgttgtggggtgtatggttgacatgacagaacac accatgatgttcacactgaacggcgaaatcctccttgatgattcaggttcagaactggct ttcaaggactttgacgttggtgatggattcatacctgtgtgtagccttggagtggctcaa gtgggcaggatgaactttggaaaggatgtcagcaccttgaaatatttcaccatctgtggc ttacaagagggctatgagccatttgccgttaacacaaatagggatattaccatgtggctg agcaagaggcttcctcaatttctccaagttccatcaaaccatgaacatattgaggtgacc agaatagatggcaccatcgacagttccccatgtttaaaggtcactcagaagtcctttggt tctcagagcagcagcacggatatcatgttttatcgtctgagcatgcccatcgagtgtgca gaggtcttctccaagcctgcagctggagggatccctggcaccggcctctttgggcccaag aatgatctggaggattatgatgtggattcagactttgaggttctcatgaagacagctcac ggccatctggtgccagatcgaggagacaaagacaaagaagctgcaaaaccagagtttaat aaccacaaagattatgctcaggaaaaaccctctcgtctgaaacagaggtttttgcttcga agaacaaagccagattatagcaccagccattctgcaagactcactgaagacgtccttgca gatgagagggatgactacgattacttgatgcaaacgtccacgtactattactcagtgaga atctttcctggacaagaacctgccaatgtctgggtgggctggatcacatccgatttccat cagtacgatacaggctttgacttggacagagttcgtacagtgaccgtgactctgggagat gaaaaaggaaaggtgcacgaaagcatcaaacgcagcaattgctatatggtgtgtgcgggg gagagcctgagcccggggcaaggacgcaacaacaacggcctggagattggctgcgtggtg gatgccgccagtgggctgctcaccttcacggccaacggcaaggaactgagcacctattat caggtggagccaagcacaaagttattccctgcagtttttgcacaagctacaagtcccaat gtttttcagtttgagttgggaagaataaagaatgtgatgcctctctcagcgggattattc aagagtgagcacaaaaaccctgtgccacagtgtcccccacgtctccatgtgcagtttctc tcacatgtcctgtggagcagaatgcccaaccagttcttgaaggtagatgtctctcgaata agtgaacgccagggctggctggtgcagtgcgtggagcctctgcagttcatgtcacttcat atcccagaggagaacaggtctgtggacattctggaactgacagagcaggaggagctgctc aagttccactaccacactctccggctctactcggctgtctgcgcgctcgggaaccaccgc gtggcccacgccctgtgcagccacgtggacgagccgcagctgctgtacgccatcgagaac aagtacatgcccggcttgctgcgcgccggctactacgacctgctcattgacatccacctc agttcctacgccaccgccaggctcatgatgaacaacgagttcatcgtccccatgaccgag gagacgaagagcatcaccctcttcccggatgagaacaaaaaacacgggctgccgggcatc ggcctcagcacctccctccggccgcggatgcagttttcctccccgagctttgtcagcatt aatacggagggttaccagtatagcccggagttcccgctggacatcctgaaggccaagacc atccagatgctgacagaagccgtgaaagagggcagccttcatgcgcgagaccccgttggg ggcaccaccgagttcctctttgtccctctcatcaagctgttctataccctgctcatcatg ggtgtcttccacaacgaggacttgaaacacgtcttgcagttgattgagcctagtgtgttc aaggaggccgccagccccgaggaggaaagcgaggtggtggagaaggagccctgcatggaa gactccaagctggaaggagccgcagaggaagaaagcaaaggcggtaagaggcccaaggag ggcctgctccaaatgaaactgccagagccagtaaaattacagatgtgcctgctacttcaa tacctctgtgactgccaggtccggcaccgaatagaagccattgtggccttttcagatgac tttgtagccaagctccaagacaatcaacgattccgatataacgaagttatgcaagcctta aacatgtcggctgcactcacagccaggaaaacaaaggaattcagatccccgcctcaagaa cagatcaatatgcttctcaattttaaggatgacaaaagtgaatgtccatgtcctgaagaa atccgagaccaactcttggattttcacgaagatttgatgacacattgtggaattgagttg gatgaagataggtctctggatggaaacaatgatttaactattagaggacgcctgctgtcc ttggtagaaaaggtgacgtacctaaagaagaagcaagctgaaaagccagttgagagtgac tccaagaagtcatccactcttcagcagttgatttctgagaccatggtccgatgggctcaa gagtctgttattgaagaccctgagttggtgagggccatgtttgtattgctccatcgacag tatgatggcattgggggtctggtacgggctctgccaaagacctatactataaatggtgtt tctgtggaggataccatcaatctgctggcatctcttggtcagattcgttccctgctaagt gtgagaatgggcaaagaagaagagaaacttatgattcgtgggttaggggatatcatgaac aataaagtgttttaccagcatcctaatctcatgagggcacttgggatgcatgagacagtg atggaggtcatggtcaatgtccttggaggtggagagtccaaggaaatcacttttccaaag atggtggccaactgttgccgttttctctgttacttctgtcgtataagtaggcagaatcag aaagctatgtttgatcatctcagttatttactggaaaacagcagtgttggtcttgcctca ccagctatgagagggtcaacaccattggatgtggcagcagcctcagtgatggataataat gaactagctttagctttgcgggagccagatctggaaaaggtagttcgatacttggctggt tgtggactgcagagttgccagatgctagtgtcaaagggttatccagacattgggtggaat ccagttgaaggagagagatatcttgactttctcagatttgctgtcttctgtaatggggag agcgtggaggagaatgcaaatgttgtggtgagattgctcattcggaggcctgagtgtttc ggtcctgccttgaggggggaaggtgggaatggcctgctcgcagccatggaagaagccata aaaatagccgaggatccctctcgagatggtccctcaccaactaccggatccagcaaaaca cctgatacagacgaggaagaggatgacaccatccacatgggaaatgccatcatgaccttc tatgcagctttgattgacctgttaggacgctgtgctcccgagatgcatttgattcatgct gccaagggggaagccatcagaatcaggtctattttgagatctctgattccattgggagat ttggtgggagtgatcagcatcgcttttcagatgcccacaatagccaaagatgggaatgtg gtggagcctgacatgtctgcagggttttgtccagatcacaaggcagccatggttttgttc cttgacagggtctatggaattgaggttcaggatttcctcctccatcttcttgaggttggc tttctgccagatctccgggctgctgcctccttagacacggctgctttgagtgccacagac atggccctggccctcaatcggtacctctgcacagctgtgctccccttgttgacaaggtgc gctcctctttttgcgggcaccgagcaccatgcttctctcattgactcgttgcttcacact gtgtaccggctttcgaagggctgctcactcaccaaagctcaacgggattccatagaagtg tgtttactctctatctgtggccaattgagaccttctatgatgcaacacttactcagacga ttagtatttgatgtcccattattaaatgaacacgcaaagatgcctcttaagctgctgaca aatcattatgaaagatgctggaaatattactgcctgcctggagggtggggaaacttcgga gctgcctcagaagaagaacttcatttatcaagaaagctgttctggggcatctttgatgcc ctgtctcaaaagaaatatgaacaagaacttttcaaactggcactgccttgcctgagtgca gttgcgggagctttgcctccagactacatggagtcaaattatgtcagtatgatggaaaaa cagtcatcaatggattctgaagggaactttaatccacaacctgttgatacctcaaatatt acaattcctgagaagttggaatacttcattaacaaatatgcagaacatgcccatgacaag tggtcaatggataagttggcaaatggatggatttatggagaaatatattcagactcatct aaagttcaaccattaatgaagccatataaactgttatctgaaaaggaaaaagaaatttat cgctggccaatcaaagaatctttaaaaactatgctggcttggggatggagaattgaaagg acacgggaaggagacagcatggccctttataaccgtacccgtcgtatttctcagacaagt caggtttctgtagatgccgcccatgggtatagcccacgagccattgacatgagcaatgtt acactatccagagatctgcatgctatggcagaaatgatggctgaaaactaccataatata tgggcaaagaaaaagaaactggaactggaggccaaaggaggtggaaaccatcccctactg gtgccttacgatacactgacggccaaagagaaagccaaggatagggagaaagcacaggac atcctcaagttcctgcagatcaacggctatgctgtgtccagagggttcaaagacctggaa ctggacacgccttctattgagaaacgatttgcctatagtttccttcagcaactcattcgc tatgtggatgaagcccatcagtatatcctggagtttgtgtttgaagtgcaacatgtacct aaaaaactcttcatgtctacagatggtggcagcagaagcaaaggagagcatttcccttat gagcaagaaatcaagttctttgctaaagtcgttcttcctttaattgatcagtatttcaaa aaccaccgtttatacttcttatctgcagcaagcagacctctctgttctggaggacatgcg tcaaacaaagagaaagaaatggtgactagcctattctgcaaacttggagttcttgtcagg cataggatttcactatttgggaatgatgcaacatcaattgtcaactgtcttcatattttg ggtcagactttggatgcaaggactgtgatgaagactggcctggagagtgttaaaagtgca ctcagagctttcctggacaatgccgcagaggatctggagaagacaatggagaatcttaag cagggccagttcacccacacccgaaaccagcccaaaggtgttactcagattatcaattat accacggtggcactcttgccaatgctgtcatcattatttgagcatattggccagcatcaa ttcggagaagatctaatattggaagatgtacaggtgtcatgttatagaattctgactagc ttgtatgctttgggaaccagcaagagtatttatgtggaaaggcaacgttctgcattggga gaatgtctggctgcttttgctggtgcctttcctgtagcatttttagaaactcacctggac aagcacaatatttactccatctacaatacaaagtcttcgagagagagagcagctcttaat ttgcctactaacgtggaagatgtttgtccaaatataccatctttggagaagctcatggaa gaaattgtggacttggctgagtccggtattcgctacactcagatgccacacgtaatggaa gttatcctgcccatgctttgtagctacatgtctcgttggtgggagcatggacctgagaat aatccgggaagggctgagatgtgctgtacggctctgaactcagagcacatgaacacactt ctgggcaatatcctgaaaatcatatataataacttgggtattgatgagggagcctggatg aagaggttagcagtgttttcccagcctattataaataaagtgaaacctcagctcttgaaa actcatttcttgccattaatggagaagctcaagaaaaaggcagcgatggtggtatcagaa gaggaccatctgaaatctgaggccaggggagatatgtctgaagctgaacttctcatccta gatgagttcaccacactggccagagatctctatgccttctatccactcctgattagattt gtggactataacagggcaaagtggctgaaagagcctaaccaagaagcagaagatcttttc cgcatggttgctgaggtgtttatctactggtcaaaatcccataatttcaaaagggaggag cagaacttcgtggtgcagaatgaaatcaacaatatgtctttccttattatggacaccaag tcaaagatgtccaaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggg gaccgatattccatgcagacctctcttattgtggccgctctgaagcggttactacccatt gggttgaacatctgtgcccctggggaccaggagctcattgctctggccaaaaatcgcttt agtctgaaagacactgaggatgaagttcgagatataatccgcagtaatgttcacttacaa ggcaagttggaggatcctgctattagatggcaaatggctctttacaaagacttacccaac aggaccgaagacacttcagatcctgagaagacagtggaaagggtcttggatatagcaaat gtgctttttcatcttgaacagaaatctacatgtatgcgccggagatattacaatctggtt gagcatcctcagagatccaaaaaggccgtgtggcacaaactgctctctaagcagaggaaa cgtgctgtggttgcttgcttccgaatggctcctttatataatctgccgaggcatcgggct gtcaatctctttcttcagggatatgaaaagtcttggattgagacagaagaacattacttt gaagataaattgatagaagatttagcgaaacctggagcagaacctccagaagaagatgaa ggagctaagagggttgatcctcttcatcagctgatccttctgtttagtcgaacagcttta acggagaaatgcaaactggaggaagattttttatatatggcttatgcagatattatggca aagagttgtcatgatgaggaagatgacgatggggaagaggaagtgaagagttttgaagtc acaggatcccaacgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccagcaa gccaggctccacgaccgcggtgctgctgagatggtgctacagaccatcagtgccagcaaa ggtgaaactggacccatggtggctgctactttgaaacttggaattgctatcttaaatgga gggaactctaccgtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggc ttctttcagagcctggctggcctgatgcagtcatgcagtgtcctcgacctaaatgcattt gagcgacaaaacaaagctgaaggacttgggatggtgactgaggaaggatcaggagagaag gttctgcaggatgacgaattcacctgtgacctcttccgcttcctgcaactgctttgtgag ggacacaactcagattttcaaaattatctgagaactcagactggcaataatacaactgtc aacataatcatctctactgtagactatcttctgagagttcaggaatcaattagtgatttc tattggtattactctgggaaagatgtcattgatgaacaaggacaaaggaatttctccaaa gctattcaagtagcaaaacaagtctttaacactcttacagagtatattcagggtccttgc actggcaaccagcagagtttggcccacagcaggctctgggatgctgtggtgggctttctt catgtgtttgcccacatgcagatgaagctgtctcaggactccagtcaaattgagctacta aaagaattgatggatcttcagaaggatatggtggtcatgttgctgtccatgttggaaggg aatgttgttaatggcaccattggcaaacagatggttgatatgctcgtggaatcttccaac aacgtggagatgattctcaagttttttgacatgttcttaaaactcaaggacttgacgtct tctgatactttcaaagagtatgaccctgatggtaagggagttatttccaagagggacttt cacaaagccatggagagccataaacactacacccagtccgagactgagtttctcctgtcc tgtgcagagacagatgaaaatgaaaccctggactatgaagaatttgtcaaacggttccac gagcctgccaaggacattggcttcaacgtggcagtgcttctgacaaacctctccgaacac atgcccaatgatacccggctgcagacttttctggaactggccgagagtgtgctcaattac ttccagcccttcctgggccgcatcgagatcatgggcagtgccaagcgcatagagagggtg tattttgaaatcagtgagtccagccgaacccagtgggagaagccccaggttaaggagtcc aaaaggcaatttatatttgatgtggtcaatgaagggggggaaaaggagaagatggagctc ttcgtgaacttctgtgaggacaccatcttcgagatgcagctggcggctcagatatcagaa tcagatctgaacgagaggtcagtgaataaagaggagagtgagaaggagaagccggaggag cagggtccaaggatgggtttcttttccatcgtgacggtcaagtccgccctgtttgccctc aggtacaatatcttgatccttatgcggatgctcagcctgaaaagcttgaagaagcagatg aagaaggtgaagaagatgacagtgaaggacatgatcacagccttctttacatcctactgg ggtattttgatgagcctcctgcactttgtagccagcgttttcagaggcttctctcgcatc atcggcagcctcctgctgggaggaagcctggtcgaaggtgcaaagaagattaaagtggca gagctcctggccaacatgccagaccccacacaggatgaggttcgaggatacggggaggag ggggagaggaaaaccctggaaggggccctgccctctgaagatctgacggatttaaaggaa ctgacagaggagagtgacctgctttccgatatctttggcttggacctgaagcgagaagga gggcagtacaaactgattcctcacaatcccaatgctggcctgagtgacctcatgagcaac cccgtccccatcccagaggtgcaagaaaagttccaggtaacttacctccagtcacagcag ctctctggacttcaggaacagaaggcaaaagaagaagaaaaggaagaaaaagaagaaagt aaatccgaacctgagaaagctgaaggagaagatggagaaaaagaagaaaaagccaaagaa gacaagggtaaacaaaagctgagacagctccacacacacagatatggagagccagaagtt cctgagtcagcattctggaagaaaatcatagcctatcaacagaaacttctaaactatttt gctcgcaacttctacaacatgagaatgttagccttatttgtcgcatttgcaatcaatttc atcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggagctacccact cgcagttcaagtgaaaacgccaaagttagcagcttggacagcagctcgcccagaatcatc gcagtgcattacgtgctggaggagagcagtggctacatggagcccacactgcggatatta gccatcctgcacacggtcatctctttcttctgcatcatcggatactactgcttgaaagtc ccactggttatttttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctt tatattacagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatc aacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggat aaatatggagagttctatggccgagacagaatcagcgagttacttggcatggacaaagct gccttggacttcagtgatgcccgggaaaagaagaagccaaagaaagacagctccctgtca gctgtactgaactctattgatgtgaagtatcagatgtggaaactaggagtcgttttcact gacaactccttcctctaccttgcctggtatatgaccatgtccattcttggacactacaat aactttttttttgctgctcatcttctggacattgctatgggattcaagacattaagaacc atcttgtcatcagtaactcacaatggcaaacagcttgtattaactgttggcttattggct gttgttgtatacctatatactgtcgtggcattcaattttttccgaaaattctacaataaa agtgaagatggcgatacaccagacatgaaatgtgatgacatgctaacgtgctatatgttc cacatgtatgttggagtacgtgccggagggggtattggtgatgaaatcgaagatccagct ggtgatgaatatgagatatatcgaatcatctttgacatcaccttcttcttttttgtaatt gtcattctcttggccataatacaaggtttaatcatcgatgcttttggggaactaagagac caacaggaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaat gattactttgacaccgtgccacatggctttgaaacccacactttacaggaacacaacttg gccaattatctgttttttctgatgtatcttataaacaaagatgaaacggagcacacagga caggaatcttatgtttggaagatgtatcaagaaaggtgctgggaatttttcccagccgga gactgtttccggaaacaatatgaagaccagctaaattaa

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