KEGG   Cervus canadensis (wapiti): 122452858
Entry
122452858         CDS       T07554                                 
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01521  EGFR tyrosine kinase inhibitor resistance
ccad04062  Chemokine signaling pathway
ccad04081  Hormone signaling
ccad04148  Efferocytosis
ccad04151  PI3K-Akt signaling pathway
ccad04217  Necroptosis
ccad04550  Signaling pathways regulating pluripotency of stem cells
ccad04630  JAK-STAT signaling pathway
ccad04658  Th1 and Th2 cell differentiation
ccad04659  Th17 cell differentiation
ccad04725  Cholinergic synapse
ccad04917  Prolactin signaling pathway
ccad04920  Adipocytokine signaling pathway
ccad04933  AGE-RAGE signaling pathway in diabetic complications
ccad04935  Growth hormone synthesis, secretion and action
ccad05140  Leishmaniasis
ccad05145  Toxoplasmosis
ccad05152  Tuberculosis
ccad05161  Hepatitis B
ccad05164  Influenza A
ccad05167  Kaposi sarcoma-associated herpesvirus infection
ccad05168  Herpes simplex virus 1 infection
ccad05200  Pathways in cancer
ccad05207  Chemical carcinogenesis - receptor activation
ccad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccad05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    122452858 (JAK2)
   04151 PI3K-Akt signaling pathway
    122452858 (JAK2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122452858 (JAK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    122452858 (JAK2)
  09143 Cell growth and death
   04217 Necroptosis
    122452858 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    122452858 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    122452858 (JAK2)
   04659 Th17 cell differentiation
    122452858 (JAK2)
   04062 Chemokine signaling pathway
    122452858 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    122452858 (JAK2)
   04917 Prolactin signaling pathway
    122452858 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    122452858 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    122452858 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122452858 (JAK2)
   05207 Chemical carcinogenesis - receptor activation
    122452858 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122452858 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    122452858 (JAK2)
   05164 Influenza A
    122452858 (JAK2)
   05168 Herpes simplex virus 1 infection
    122452858 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122452858 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    122452858 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122452858 (JAK2)
   05140 Leishmaniasis
    122452858 (JAK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122452858 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122452858 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122452858 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122452858 (JAK2)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     122452858 (JAK2)
Protein kinases [BR:ccad01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   122452858 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M
Other DBs
NCBI-GeneID: 122452858
NCBI-ProteinID: XP_043342535
LinkDB
Position
14:32631461..32746875
AA seq 1132 aa
MGMACLTMTEMEEASTSPVHQNGDISGNASSVKQIDPVLQVYLYHSLGKAEGDYLKFPTG
EYVAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF
PYWYCNGSNRTYRHGISRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGSNESRIVTIHKQDGKSLEIELKSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI
RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYVIMTECWNNNVSQRPSFRDLAVRVDQIRDNMTG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttacaatgacagaaatggaagaagcatccacatcccctgtacat
cagaatggtgatatttctggaaatgctagttctgtgaagcaaatagatccagtcctacag
gtctatctttatcattcccttgggaaagctgagggggattatctgaagtttccaactgga
gagtatgttgctgaagagatttgtgttgctgcttctaaagcttgtggaatcacacctgtg
tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgaatcaaccaggcaaaatgtactctacagaatcagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcgacatggaatatctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaagaatcaaaccccactggacatc
tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag
tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcagtttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt
cctgatattattgatatcagtattaaacaagcaaatcaagaaggctcaaatgaaagcaga
attgtaactattcataagcaggatggtaaaagtctagaaattgagcttaagtcattaaga
gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat
cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt
catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct
gttgagcgagaaaatgtaattgaatataagcactgtttgattacgaaaaatgagaatgga
gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc
taccagatggaaactgttcgctcggacagtataattttccaatttactaaatgctgtccc
ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtatttctgatgta
ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt
agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt
aaaggtataagaagagaaataggagactatggtcagctgcatgaaacagaagttctttta
aaagttctggataaagcgcatagaaactattcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag
gagaatattctggttcaggaatttgtaaaatttggatcactagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatattctt
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt
accacattgtgggaaatctgtagtggaggagataagcctctgagtgctttggattctcaa
agaaaactacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgcatggattatgaaccagattttagaccttctttcagagcc
attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgagaataggtgccctagggttttctggtgcttttgaagaccgagac
cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt
gggagtgtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtggct
gtgaaaaagctccagcacagtactgaagagcacctcagagacttcgaaagagaaattgaa
atccttaaatccttgcagcatgacaacattgtgaagtacaaaggagtctgctacagtgct
ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtacacatctcagata
tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcgacaagg
aatatactagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc
ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg
tatgcaccagagtcactgacagagagcaagttttccgtggcctcagatgtttggagcttc
ggagtggttctctatgaactcttcacgtacattgagaagagtaaaagcccgccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaa
ctcctgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatgtg
attatgacagaatgctggaacaataatgtaagccagcgcccctctttcagagacctagct
gttcgagttgatcaaataagggacaacatgactggatga

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