Ceratina calcarata (carpenter bee): 108623053 Help Entry 108623053         CDS       T06061                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism ccal  Ceratina calcarata (carpenter bee) Brite KEGG Orthology (KO) [BR:ccal00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ccal04040]     108623053    04990 Domain-containing proteins not elsewhere classified [BR:ccal04990]     108623053 Ion channels [BR:ccal04040]  Voltage-gated cation channels   Ryanodine receptor    108623053 Domain-containing proteins not elsewhere classified [BR:ccal04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    108623053 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  108623053 NCBI-ProteinID:  XP_017876796 UniProt:  A0AAJ7N459 LinkDB All DBs Position Unknown AA seq 5153 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETQQESLGKGTGSGHRTLLYGNAILLRHLNSDMYLA CLSTSSSNDKLAFDVGLQQHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSSW STTPSQNIVIYEGGSVMSQARSLWRLELARTKWAGGFINWLHPMRIRHLTTGRYLGVKEN NELYLVDRNEATIESSTFWLRQEKDDQKIILEDKDLEVIGLPIIKYGDSTVIMQHATTCL WVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQF ITGLETLQVDRRASMFFQNVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRFRALRNRQD LFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQAWDQISGYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRPNIFVGR VEGSALYQKWYFEVTVDHIEQTTHMMPHLRIGWANTSGYVPYPGGGEKWGGNGVGDDLYS FSFDGAHLWTGGRKTQVMQNATEPYIRKSDVIGCALDLTVPIITFTFNGAPIMGSFRNFN LDGMFFPAISCSSKLSCRFLLGGDHGRLKYQPPEEFSPLVESLLPQQILSLDPCFYFGNM NKVVLAGPWLVEDDTAFVPAPVDTSMINLPSYVEQIRDKLAENIHEMWAMNKIEAGWIYG EHRDDLRKIHPCIVQFERLPAAEKRYDTQLAVQTLKTILALGYYITMDKPPSRIKTLRLP NEPFLQSSGYKPAPLDLSAITLTPKMEELVDQLAENTHNLWAKERISQGWTYGLNEDSEM RRSPHLVPYPKVDEAIKKANRDTASETVRTLLVYGYMLEPPTGEQHEALLLEASRLRQLY FRTYRVEKHYAVSSGKWYFEFEVLTAGPMRVGWAKADCMPGSMLGSDENTWAFDGYNEEK VYSGTAETFGKQWQVGDVVGVFLDLIDRTISFSLNGELLMDALGGETSFADVQGDCFVPA FTLGVGQRAKLTFGQDVNTLKFFTTCGLQEGYEPFCVNMNRHVTFWFTKDQPIFENTDDM ADTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSTFVSESEKLRRW QEIKMRQNKLLYEQMEQAQPTVPSAHMEQIMKSGFSMSDIKGLQRNYSEDAVEADEMMKE SPLPMQRNKPARPPRKGGSVYGSRGGNMDNAISEADMNGYVDMNGDVKDDKKKRGRSPFR KLSKEMEDVPFFSRKAKSPDAKSKTPEPPVRSDVSDKSTKTLPMNKASSRIPQVRISNTD LKVVPPQIPERNAPKAMSVLSGSGVESIGNEIFDADCLKLMNEYFYGVRIFPGQDPTHVY VGWVTSQYHLHTKDFNLSRVRKGSVVITDDYDRPIEQVDRQSCIMVRADELYNEVTQDAS GKGASQGMFVGCFVDTATGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSKEILQIEL GRTSTTLPLSAAVLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDIRGW SMLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHALC QHVDQKQLLYAIRAEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYIIPLGQGLKDLY ENEEMKHSLRYLETESVRPQMKMTDIRDIPSSDQTIENIRSLYSPHFPLDVVRDYVMTAL NEAVEVNQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRNEDIMKLLIMIHPETWDPTF DKEGKDEHKKGLLHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIISFSHDFVGDLQSDQL RRYIEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKNVDYADDPDNIPCGEDLISRMN DFHNNLMSYVSLHALQEAADAENEPAEEVQKPGPIKRLFNFINAVKELEEEPKPELEPER KTPEEVFRKVLIKTIVSWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYVTNSK TRDDVALMWVGLSQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRIHENV MAIMINTLGRRSQAQSDAQTQPQTTEGEPVSKEKDTSHEMVVACCRFLCYFCRTSRQNQK AMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRC GLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLG PALRGEGEGLLRAIIDANKMSERIADRRKVHDEAEGTTVMQFEHPLPESDDDEDYIDTGA AILNFYCTLVDLLGRCAPDSSVIEQEASTESVGKNESLRARAILRSLVPLDDLQGVLSLR FTLLNPAAGEEKPKSDMPSGLIPGHKQSIVLFLERVYGIETQELFFKILEEAFLPDLRAA TMLDRNDGYESDMALAMNRYIGNSILPLLIKHSKFYNEADNYASLLDATLHTVYRLSKNR MLTKGQREAVSDFLVALTREVHELNVSQMQPSMLLKLLRKLTVDVSKLSEYTTVALRLLT LHYERCAKYYGSTGGQGAYGASSDEEKRLTMVLFSNIFDSLSKMDYDPELFGKALPCLTA IGCALPPDYSLSKNYDDEWYGSKSASAQSPDGPYNPQPINTSSVVLNNDLNQIVQKFSEH YHDAWASRKLENGWTFGEQWSDANKNHPRLKPYNMLNDYERERYKEPVRESLKALLAIGW SVEHAEVDVPSTNRSSMRRSSKSQGDSANPFNYNPHPVDMTNLTLSREMQNMAERLADNA HDIWAKKKKEELITCGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKPNR GGESEVATAGASVELRFAYSLLEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDIKF FSKVVLPLMEKYFSTHKNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFG PDVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYSHL RGTHLKTSTSLSYINSVVLPVLTAMFDHLAACEYGSDLLLDEIQVASYKMLASLYTLGVD SSLTHDRKYLKTEIERNKPNLGSCLGAFSSCFPVAFLEPHLNKHNPFSLLNRIADHSLEA QDIMAKMESSMPTLETILNEVDQFVESDKTYNDIPHVVDIILPLLCSYLPFWWAQGPDNV NPTEGTYVSMVTSDHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELLKD PFLPLAERVRKRTDNMFHKEESLRGFIKSSTDDTSQVEAQIQEDWQLLVRDIYSFYPLLI KYVDLQRNHWLRNNIPEAEDLYNHVAAIFNIWSKSQYFLREEQNFISANEIDNMVLIMPT ATRRPAAISDGTTPSGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQ ELVQHCKDRFLKKMPEYEIAEFAKTQLTLPDKIDPADEMSWQHYLYSKLGQQKDTMEPVK AQQLEDVVARITDMAKVLYGLHMIDHPQQQSKGQYRSVVSIQRKRAVIACFRQISLHSLP RHRAINIFARTYYELWLQDENVGQEVMIEDLTQSFEDAELKKMDKDEDESKPDPLTQLVT TFCRGAMTERSGALQEDPLYMSYAQIISKSCGEEEEEGEDEGGGGEEEAAASIHKRSHKP LMRPMHKLMEQEMEKQKLLFHQARLANRGVAEMVLLHISACKGLPSEMVMKTLELGISIL RGGNIEIQRGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEGAAG EKNMHDAEFTCALFRFIQLTCEGHNLGTLRYSQAGNTTTVNVVICTVDYLLRLQESIMDF YWHYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCAQNQQALAHSRLWDAVGGFL FLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESAG NVELILKYFDMFLKLKDLVSSPSFLEVDLNSDGWVYPKDFKEKMEQQKSYTDEEIEFLLA CCETNHDGKINYVAFMDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNY FEPYLGRIEILGGNKKIERVYFEIKESNIEQWEKPQIKESKRTYFYNTVVEAGEKEKLET FINFCEDAIFEMQHASALMAVEESGGIGKARESSYTYMTEDDEERNKDPIRRSIQTCKDS IYFFFSIFSPSNIKHKIAEMQQMTFLEIFICFFKMIFYAFYYSGFGCGCVIGYFMKLLLA LMRGPHVEEPVVEVKEEEEKPSRHLPALPPTPDESNLQVQAFGMDITKEEGGQIKIAPHE SATSTPQSSIDQETGESTPEEMTGEEGARAEGGGDTEPPVSLVDLLGGEQARAQAAAAAE AAAAQQAAMAAVEAEAKQETTAEPSGSSIDFSEYTHRIVSFLARNFYNLKYVALVLAFCI NFMLLFYKVSSLGDDGEEEGSGQIVDMLAEMSGEGESGSGNGSGVELGSGSGEVESEEEE DAYALEYVEVSEDFYYMAHVIRLMAMLHAMVSLAMLVAYYHLKVPLAIFKREKEIARRVE FDGLYIAETPEEDDIKAHWDKMVISAKTFPVNYWDKFVKKKVRQKYSETYDFDYISNLLG MEKTSFSQQEEEGSGLVHFIVNIDWRYQVWKAGVTITDNAFLYSLWYFTFSILGNYNNFF FAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIVVYIYTVIAFNFFRKFYIQEED DEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGEPDGDDYEVYRIMFDITFFFFVIVILL AIIQGLIIDAFGELRDQLENVKTNMESNCFICGLGKEYFDTVPHGFDTHVQQEHNLANYM FFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQNEAVEEEAKKK NT seq 15462 nt NT seq  +upstreamnt  +downstreamnt atggctgacagcgagggtggttccgagcaggatgacgtatcattccttcgcacggaggac atggtatgtttgtcctgcacagcgactggtgaaagggtttgtctagcagccgagggtttc ggtaacaggcactgtttcctcgagaatatagcagacaagaatataccgcctgacctgtcg caatgcgtattcgtaatagagcaagctctctcggtgagagctttacaggaattggtcact gctgccggttccgagacgcagcaagaaagtttaggaaaggggacgggatcagggcacagg acgctactttatggcaacgctattctactgaggcacctgaacagcgacatgtacttggct tgcctatcgaccagctcgtccaacgacaagttggctttcgacgttggtctccaacaacat tctcaaggcgaggcctgctggtggaccgtgcacccagcgtccaagcagaggtcagagggt gaaaaagttcgagtcggtgacgatcttatcttggtatcagtagccaccgaaagatacttg cacacgacgaaggaaaacgacttgtcagtggtgaatgcatcgttccacgtgacgcactgg tcggtgcaaccgtacggcactggaatcagccggatgaaatacgtcggctacgtgttcggc ggcgacgttttacgatttttccacggcggcgacgaatgtctcactataccgtcctcatgg agcacgacccccagtcaaaacatagtgatctacgagggaggcagcgtaatgagccaagct cgctcgctttggaggctggagcttgcgaggacgaaatgggctggtggctttatcaactgg ttgcatccgatgaggatcagacatttaacaaccggacgttatctcggtgtcaaagagaac aacgaattatacctggttgataggaatgaggcgacgatcgaaagctcgacgttctggctg aggcaagagaaagatgatcagaaaatcattcttgaagacaaggatctcgaagtaattgga ttgcccattatcaaatacggtgactcgactgttatcatgcaacacgctaccacttgcctc tgggtttcatacaagtcgtatgagacgaaaaagaagggtgtgggcaaagtggaggaaaag caagcagtccttcacgaggaaggcaagatggacgatggtctagatttctcacggtcgcag gaagaggaatcccggacggctcgcgtgatccggaagtgcagcagtttgttcacacagttt atcacaggcctagagacgctgcaagtcgataggagagcgtctatgttcttccaaaatgtg aatctcaacgaaatggtgatgtgtctggaagacttgattaattattttgctcaacccgag gacgacatggaacacgaggagaagcaaaacagattccgtgccctaagaaatcgtcaagac ttgttccaagaagaaggcatcctaaatctaatcctagaagccatcgacaaaatcaacgtg atcacctctcaaggatttctagtagcactttctggtgacgaaagcggccaggcttgggac caaatatccggttacctgtatcaactactggcagccataatcaaagggaatcacacgaat tgcgcacaatttgccaacagtaatcggttgaactggctgttcagtcgactgggttcgcaa gcttccagcgagggcactgggatgttagacgtgcttcactgcgttcttatcgactcgccc gaagctttgaacatgatgagagatgaacacattaaagtcatcatttcgttgctggagaaa cacgggagagatccaaaagtcttggacgttctctgctcactttgcgtgggtaacggcgtc gcggtcagatcatcgcagaacaacatctgcgattttctcctacctgggaagaatcttctt ttacaaacgcaactggtggaccacgtggccagcgtcagaccaaatatattcgtcggcaga gttgaagggtcagcactttatcagaagtggtacttcgaagttactgtggatcacattgaa cagacaactcatatgatgcctcatttgaggattggctgggcaaacacctctggatacgtg ccatatcccggtggtggtgaaaaatggggaggcaacggtgtcggcgacgacctttactcc ttcagcttcgacggtgcacatttgtggacaggtggtagaaaaacccaagtgatgcagaac gcaacggaaccgtatatcaggaagagcgacgtgatcggctgcgcgttggatctcacagtg cccataatcacgttcaccttcaatggagcacccatcatgggatcatttaggaattttaat ctggacggcatgttcttcccagcaattagctgttcctccaaactgtcttgcagattcctg ttaggcggtgatcatggccggcttaagtaccaaccaccagaagaattctcacccttggtg gagagtttgctaccgcaacaaattttatccttggatccttgtttctattttggtaacatg aacaaagtggtcttggctggtccatggctggtcgaagacgacacggccttcgttcctgcc ccggtcgacacgtccatgatcaatttaccatcgtacgtcgagcagattagggataaattg gcagagaacattcacgaaatgtgggcgatgaataaaatcgaagccggttggatatatgga gaacacagagacgatctaagaaagatccatccgtgtatcgttcaattcgagagactacca gctgcagaaaaacgttacgatacacaattggcagtgcaaacgttaaaaacgattttggct ctgggatattatataacaatggataaaccaccttctagaattaaaaccttgaggcttccg aacgagccctttctacagagcagtggatacaaaccagcaccactggacctcagcgctatt accttaactcccaaaatggaagaattggtcgatcaactcgcggagaacactcataactta tgggcgaaggagagaatcagtcagggttggacttacggtctgaacgaagattcagaaatg agacgaagcccgcacttggtgccgtaccctaaagttgacgaagccattaagaaagctaat cgtgacactgctagtgaaacagtgagaacgcttttggtttatggatacatgctggaacca cccactggagaacagcatgaagcattgcttctggaggcgagcagactgaggcaattatac ttcagaacttatcgcgtggaaaaacactatgcagtgagcagcggcaaatggtacttcgaa tttgaagtgctaactgctggtcccatgagggtaggctgggctaaagcagattgcatgcct ggaagcatgctgggaagcgacgagaacacctgggcattcgacggttacaatgaggaaaaa gtatattcgggcacagccgagacttttggcaaacaatggcaggttggagacgttgtcggg gttttcctggatctaattgaccgaacaattagcttctctttgaatggggaactgcttatg gacgctcttggcggtgaaacatccttcgctgacgttcaaggcgactgcttcgtgccagct tttactctcggcgttggtcaaagggcaaagttaacttttgggcaagacgtgaatacgttg aaattctttacgacttgtggtttgcaggagggatacgagccattctgcgtaaacatgaac cgtcatgtaacgttctggttcacgaaagaccagccgatattcgagaacaccgacgacatg gctgatactaggatagacgtagccagaatcccagcgggttccgacactccaccatgtcta aaaatctcccataatacatttgaaacgatggaaaaagcgaactgggaattccttcgatta tctctgcctgttatttgccaatcgactttcgtctcggagagcgagaagctcaggaggtgg caggagataaaaatgcgtcagaacaaactcttatatgaacagatggagcaagctcagcca actgtgccgtcggctcatatggagcagatcatgaaatctggcttcagcatgagcgatatc aaaggattgcaaagaaattattcggaagacgctgtggaggctgacgagatgatgaaagaa tcgccgcttcctatgcaaaggaacaagccagctagacctccgaggaagggaggatccgta tatggatcgaggggtgggaacatggacaacgcgattagcgaggctgatatgaatggctat gtcgatatgaacggggatgttaaggatgacaagaagaagcgagggcgttcaccgttccgc aaacttagcaaagagatggaggatgtcccgttcttctcgcgcaaggcgaagtctccggat gcgaaatcaaagacgcccgaaccacctgtgcggtctgacgtctccgacaaaagtaccaag accctgccgatgaacaaagcaagtagccggattccccaagttcgcatatcaaacacggat ttgaaagtggtaccacctcaaatcccggagcgcaatgcacccaaagctatgtcagtttta agtggaagcggagtcgaatcgattgggaatgaaatattcgatgcagattgcttgaaactg atgaatgaatacttttatggtgtgagaatcttccctggacaggatccaacacacgtttat gtgggctgggtcacgtctcagtatcatttgcacacgaaggactttaatttgtctcgtgtg agaaagggttctgtggttatcactgatgattatgatcgtcccatagaacaagtcgacaga cagagttgtatcatggtcagagccgacgaactgtacaacgaagtaactcaagacgcgtca ggaaagggtgcatcccaagggatgttcgtgggctgtttcgtggatacagcaactggttgg gtgtccttcacctgcgagggcaaggaaactagccacaagttcaagatggaacccgataca aaattattcccagccatattcgtcgaagctaccagcaaagagatacttcaaatcgaatta ggaagaacttctacaacattgccgttgtctgctgctgttttacaaaattcagagcgtcat gtgataccacagtttccgcctagattgaaggttcaatgtttaaagcctcatcaatgggcg agggttcctaatcaatcactacaagtgcatgctttgaaattgtctgatatcagaggctgg tccatgctctgcgaggatgctatatcgatgctagccttgcatattcctgaagaagatcga tgcatcgatatcttggagcttatcgaaatggacaaactcctcagtttccacgcacacacg ttaacactgtatgcagccctgtgctaccagtcgaattacagagccgcacatgctctatgc caacacgttgatcagaaacaattactatatgctattcgagcggaatacatgtctgggccc ctacgacaaggattctacgatttgctgatcgcattacatctcgaatcgcacgcgaccacg atggaagtgtgcaaaaacgagtacataattcctttaggtcaaggattgaaggatctttac gaaaacgaagaaatgaagcacagtctcagatacttagagaccgagtccgttcgtccgcag atgaagatgacagacatcagggatattccttctagtgaccagacgatcgagaacataagg agcctctacagtcctcatttcccgctggacgttgtacgggactatgtgatgacggctttg aacgaagccgtcgaggtgaatcaagtgcacaatcgagaccccattggcggcagcaatgaa aacctgttcttgccacttttgaagctcgtggacaggttgctgttggtagggatgctccga aacgaagatatcatgaagcttcttatcatgattcatcctgagacttgggatccgaccttt gataaagaaggcaaagacgagcacaagaagggacttcttcatatgaaaatggctgaggga gcaaaactacagatgtgttatcttctacatcatctaaacgatattcaacttcgacatcga gtggaatccatcatatctttcagccacgacttcgttggtgacttacagtcggatcagctt cgtcgttacattgaaatcaaacagtctgacttgccatcggcagtggcggcgaagaaaacg agagagttcagatgtccacctcgtgaacagatgaacgcaattctaagcttcaagaatgtt gactatgctgacgatcctgacaatattccttgtggagaggatctgataagtcggatgaac gattttcataacaatctcatgtcgtacgtgtccttgcacgcgcttcaggaagccgccgac gctgaaaacgagccagcagaggaagtgcagaagcctggtccaattaaaagactgtttaac tttattaatgcagtaaaagagttagaggaagaacctaaaccggagcttgaaccggagagg aagactcctgaagaggtgttccggaaggtgcttataaaaacaatcgtcagctgggctgag gaatcccaaatcgagactccaaaactagtccgagaaatgttcagtttactggttcgccaa tacgacaccgtaggcgagctaatcagagcattagaaaaaacctatgtaactaacagcaag acaagggacgacgttgctttaatgtgggtcggtctcagtcaaatccgagccttgctgccc gtacagatgtctcaagaagaagaagaactcgtgagagaacgattatggaaactggtgaac aatcatacattcttccagcatccagatttgattagagtactgagaattcatgaaaacgtc atggcgatcatgataaacacgctgggtagacgatctcaggctcaatctgatgctcaaact cagcctcaaactactgaaggagagccagtttctaaagaaaaggacacatctcacgagatg gtggtggcttgctgtagattcctttgctatttctgtcggacttccagacaaaatcaaaag gcgatgttcgatcatttcgattttctattggagaacagcaacattttgttgtcgaggcca tcgttgagaggctcaacgccattggacgtggcctattcttctcttatggagaacacggag ctcgctttagctctcagagagcattatctcgagaagatagctatctacctatctcgctgt ggattgcaatctaactcagagttggtggagaaaggctaccctgatttaggatgggatcca gtggaaggtgaacgatacttggacttcctgcggttctgtgtctgggttaacggtgaaagt gtggaagagaacgcaaacttggtgatacgtttactaatcaggagaccagagtgtttagga ccggctcttcgcggtgagggcgaaggtttgctgagggcaattatagacgctaataaaatg tctgaacggatcgctgatagaaggaaagtacacgatgaggctgagggtacaaccgtgatg cagttcgagcatcctttgcccgaatcagatgacgatgaagattacatagacacaggcgca gctattttgaacttctactgcactctggtagacctattaggtcgttgcgctcctgattct tctgttatagagcaagaggcttctacagaatccgttgggaagaacgaatctcttcgagcg agagccattctgcggtctctagtacctctcgacgatctgcaaggcgtactatctttgaga tttacgttgcttaatccagcagcgggtgaagagaaaccgaaaagcgacatgccttctggc ttaattcctggacacaagcaaagcatagtcttgtttctggaacgcgtttacggtatcgag acgcaggaattgttcttcaaaatacttgaggaagctttcttgcctgacctgagggccgct accatgttggacaggaacgatggatacgagtcagatatggcgctggcgatgaaccgttac ataggaaacagtattctacctttattaatcaagcattccaagttctacaacgaggcggac aattatgcaagtttattagatgccacgttgcacaccgtgtaccgattaagtaagaaccgg atgctgaccaaagggcaacgtgaagcagtgtcggacttcctcgtggcgttgaccagagaa gtccacgagttaaacgtatctcaaatgcaacccagtatgctgttgaaactgcttcgaaaa ttaactgtcgacgtgtccaaattatctgagtacaccacggtcgctttaagattgttaact ttgcattatgaacgctgtgcgaaatattacggttctaccggaggccaaggcgcatacggt gcgtcgagcgatgaagagaaacgcttgacaatggttctcttcagtaacatattcgattcg ttatccaaaatggattacgatccggaattgttcgggaaagctctgccatgtctcacggct atcggttgcgcgttaccacctgattattcgttatcgaaaaattatgacgatgaatggtac ggaagcaaatctgcatctgcacagtcacctgatggaccgtataatcctcagcccatcaac acctccagtgtggtgctcaataacgatctcaaccagatagttcaaaagttctctgagcat tatcacgatgcctgggccagtagaaaattagaaaacggttggactttcggtgaacaatgg tctgacgcgaataaaaatcatccaagattgaaaccttacaacatgttgaacgattacgag agggaacggtacaaagagcctgttagagagagcttgaaagctctattggctataggatgg agcgtcgaacacgcagaagtagatgtaccatccactaatcgtagttccatgaggagatca tcaaaaagtcaaggtgattcagcgaatccgttcaactacaaccctcacccagtggatatg acgaacttgactctgagcagggaaatgcagaacatggcagaacgtcttgcagacaatgcg cacgatatttgggcgaagaagaagaaagaagaactcattacttgtggaggaggtatccac ccccagctggtcccatacgatctcctgactgataaagagaaacgaaaagaccgtgaacgt tctcaggagttcctcaagtatttacagtaccaaggttacaagctccacaagcctaatcgc ggaggagaatctgaagttgcaactgctggagcatcagtagaactacgattcgcttattcg ttgctagagaagttgatagcatatttagataaggccactatcaacatgaaattgttaaaa ccgtctgataccttcagtagacgaaacagttttaaaacatctactagagatatcaaattc tttagcaaagtcgttctaccattgatggagaagtactttagtactcataaaaattatttc atcgccgttgcaacagctacgaataatgttggagctgcgtctttaaaagaaaaggagatg gtagcagctctgttttgcaaattggctagtttattaagatccagactcgccgcctttggt ccagacgtgaggatcaccgttcgttgccttcaagtattagtaaaaggcatagacgcgaag agtttggtgaagaattgtccggaatttattagaacgtccatgttgacgttctttaataat acagcagatgatttgggacatacgatattgaatcttcaagaagggaaatacagtcatctc agaggaacacatttgaagacttctacatccttgtcttatatcaatagtgttgttctacct gtactcacggctatgttcgatcatttagctgcctgcgagtatggaagcgatttattattg gatgaaattcaggtagcatcgtacaaaatgctcgcgtctctctatactctcggcgtggat tcttctctgacacacgatagaaagtacttgaagacagaaattgaacgcaataaaccaaac ctaggttcctgtttaggagcattctccagttgtttccccgtggctttcctagagccgcat ctgaacaaacacaatccattctccctattaaacagaatagcagatcactctttagaagcg caggatatcatggctaaaatggaatcgagcatgccgactcttgaaacaattttgaacgaa gtggaccaattcgtcgagtctgataaaacttacaacgacattccacacgtggtcgacatt atccttcctctactttgctcctacttgccattttggtgggcccaaggaccagacaacgta aatccgaccgaaggaacgtacgtcagcatggtcaccagcgatcatatgaatcaattatta aagaatgtgttaaaattgattaagaagaacattggtaacgagaatgctccttggatgact cgaatcgcggcttacactcaacaaatcatcatcaattcgtccgaggaattattaaaagat ccgttcttgccacttgctgaacgagtcagaaagcgtactgacaatatgttccataaagaa gaatctcttcgcggttttattaaatcatccactgacgacacgtcgcaagtcgaggcgcag attcaagaagattggcagctcctcgtccgagatatctattcgttctatccgcttttaatc aaatacgtcgatttgcaaaggaatcactggttgagaaataatatcccggaggctgaagat ctttacaatcacgttgctgcgattttcaatatctggtccaagtcacaatatttcttacgg gaggaacagaacttcatatcagcgaatgagattgataatatggtactgattatgccaaca gccactagaagacccgctgccatttctgatgggacgacaccttccggtggaggcaagaaa aagaagaaacatcgtgataagaagagggataaagataaagaagtacaggcttcgttaatg gtagcttgtctgaagagactgctacccgttggtctgaacttattcgctggccgtgaacaa gaactggtgcaacattgcaaggacaggttcctgaagaagatgccagagtacgaaatcgca gaattcgctaagacccagttgacgttacctgataagatcgatccagctgacgagatgtcg tggcaacattatctctactctaagttagggcaacagaaagatacgatggaaccggtgaaa gcgcagcaattggaagacgtggttgcgagaattactgacatggctaaagtactttacggt ttacacatgatagatcatccgcaacagcagagcaagggtcagtatcgatccgtggtgtcg atccaacgtaaacgagctgtgatcgcttgtttccgtcaaatttccctacattccctgccc aggcatcgggctataaatatattcgcgcggacgtactacgagctctggttgcaggatgag aatgtcggccaagaagtgatgattgaagatcttacgcaatctttcgaggacgcggaattg aagaaaatggataaagacgaagacgaaagcaaaccagaccctctcacacaattggtaacg acgttctgtcgcggcgcaatgacggaacgatccggtgctcttcaggaagatcctttgtac atgagctatgctcaaattatatcaaaatcttgcggtgaggaggaagaagaaggcgaagac gaaggcggagggggtgaagaagaagccgctgcctccatccataagcgaagtcataagcca cttatgcgaccgatgcacaaactcatggaacaagaaatggaaaagcagaaacttctgttc caccaagcgagacttgcaaatcgtggcgtggcagagatggtgttgcttcacatctcagca tgcaagggtctccccagtgaaatggtgatgaagactctagaattgggaatttcaattcta cgcggtggcaacatagaaattcaacgaggaatgttgaaccacttgaaggagaagaaggac gtaggcttcttcacttcgattgctggcctgatgaactcttgcagtgtattagatttggac gcgttcgagaggaataccaaagctgaaggtcttggggttggttctgagggtgcagctgga gagaagaacatgcacgatgccgagttcacctgcgctttgttcaggttcattcaactgact tgcgagggtcacaatctcggtacgcttcgttattcncaagctggtaacacgacaacagtg aacgtggtcatatgcaccgtcgattatttactacgactgcaagaatctattatggatttc tactggcattactctagcaaagaactgatcgatcctgccggcaaggctaatttcttcaaa gctataggcgtggccagtcaagtgttcaacactctgactgaagtgattcaaggaccctgc gcccagaaccaacaagcattggcccactcccgattgtgggacgctgtcggtggattcctc ttcctgttctcccatatgcaggacaagttgtccaaacactcgagtcaagtggatcttctg aaggagctgttgaacttgcagaaggacatgataactatgatgttgtctatgcttgaaggt aacgtcgtgaatggaaccattggcaaacagatggtggacacgttagtggaatctgccgga aacgtcgagttgattctcaagtacttcgacatgtttttgaaactgaaggatctcgtgtct tcgcctagctttttagaagtggatctcaacagcgatggctgggtttatccgaaggacttc aaagagaagatggaacagcagaagagttacaccgacgaggaaatcgaattcctattggcc tgttgcgaaacgaaccacgatggaaaaatcaattacgtggctttcatggaccgattccac gagccagctaaagaaatcggtttcaatcttgctgtgttgctaactaatctatcggaacac atgccaaacgaaccgagactggccagatttttagaaacagctgggtctgtgttaaattac tttgaaccgtatctgggcaggatagaaattcttggtggtaacaagaaaatagaacgtgtg tatttcgaaatcaaggaatctaatattgaacaatgggaaaaaccgcaaattaaagagtcg aagagaacttatttctacaacaccgtggtggaagctggagaaaaagagaaattggaaaca ttcataaacttctgcgaagatgctatttttgaaatgcaacacgcgagcgcgttaatggcg gtagaagagagtggaggaatcggcaaagccagagaatcctcatatacttatatgactgag gacgatgaagaaaggaacaaagatcccattagaagaagcattcaaacgtgtaaagatagc atttacttcttcttttcgatattttctcctagcaacattaaacataaaatagcagagatg caacagatgacgttcttggaaatattcatttgcttcttcaaaatgatattctacgcgttc tattattctggatttggctgtggttgcgttatcggatactttatgaagctactgttagca ttaatgagaggaccgcatgtagaggaacctgtggttgaggtcaaggaagaggaggagaag ccatcaaggcatttacctgctttacctccaacaccagatgagtcaaatctacaggtgcaa gcgttcggaatggatataacgaaagaagaaggtgggcaaataaagatagcgccgcacgaa tctgcgacttccactccgcagtcaagtattgatcaagaaacgggtgagagcacaccggaa gaaatgactggagaggaaggtgcaagggccgaaggtggcggagatacagaaccacctgtc tccttggtcgacttattgggtggtgagcaggcgagggctcaggcagcagccgcagcggaa gctgcagctgcccaacaagcggccatggcagcggtcgaagctgaagcgaaacaggaaaca acggcagaaccatcaggatcttctatcgatttctctgaatacactcatcgcatcgtctct ttcttagctaggaatttctacaatttaaaatacgtggctctggttctcgcgttctgcatc aatttcatgttgttgttttataaggtttcgtctttgggtgatgatggtgaagaagaaggc agtggtcaaatagttgacatgctggcggagatgtctggtgagggtgaatctggttctggc aacggtagtggtgtggaattaggaagtgggagtggagaggtagaatctgaagaagaggaa gatgcatacgccttggaatacgtagaagtgtcagaggatttctactacatggcacacgtt atcaggctcatggctatgctccatgcaatggtatctctcgctatgctagtcgcctactat cacttaaaggtaccattggctatcttcaaacgggaaaaggaaattgcaagacgagtggag tttgatggtttatacattgcggagacaccggaagaggacgatatcaaagcacattgggac aagatggtgatatcggcaaaaacgttcccagttaattattgggataaatttgttaagaag aaagtcaggcaaaagtacagcgagacttatgatttcgattacatcagcaacttgcttggt atggagaagacttcgtttagccaacaggaagaagaaggatctggtttagttcacttcatt gtaaatatcgattggaggtatcaagtgtggaaagctggagtcaccattacggacaacgcg tttttgtacagtctttggtacttcacgttctcgattctgggaaattataacaactttttc ttcgctgcgcatttgctggacgtagcagttggtttcaagactctgagaacgatcttacaa tcggtaacacacaatggcaagcagctggtgctgacagtgatgctgttgactatcgtcgtc tacatctacacggtcatagccttcaacttcttcaggaaattctatatccaggaagaggac gacgaagtggataagaaatgtcatgacatgctgacatgcttcgtgttccacttgtacaag ggtgtgagagctggtggtggtatcggtgacgagattggcgaaccagatggcgatgattac gaagtctatcgtatcatgttcgacatcactttcttcttcttcgtcatcgtcattttatta gccattattcaaggtttgataatcgacgcgttcggtgagcttcgagatcagcttgagaac gtgaaaacgaacatggagagcaactgtttcatctgcggtttagggaaagagtacttcgat acggtacctcacggtttcgatacgcacgtccaacaggagcataatcttgctaattatatg ttcttcctcatgcacttaattaacaaaccggacacggagtacaccggccaggaaacgtac gtgtggaacatgtaccaacaaagatgttgggacttcttcccagtcggtgactgcttccgc aaacagaacgaagcggtggaggaagaagcgaagaagaaataa

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