KEGG   Castor canadensis (American beaver): 109684223
Entry
109684223         CDS       T04791                                 
Symbol
Plcb1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan00562  Inositol phosphate metabolism
ccan01100  Metabolic pathways
ccan04015  Rap1 signaling pathway
ccan04020  Calcium signaling pathway
ccan04022  cGMP-PKG signaling pathway
ccan04062  Chemokine signaling pathway
ccan04070  Phosphatidylinositol signaling system
ccan04071  Sphingolipid signaling pathway
ccan04072  Phospholipase D signaling pathway
ccan04081  Hormone signaling
ccan04082  Neuroactive ligand signaling
ccan04261  Adrenergic signaling in cardiomyocytes
ccan04270  Vascular smooth muscle contraction
ccan04310  Wnt signaling pathway
ccan04371  Apelin signaling pathway
ccan04540  Gap junction
ccan04611  Platelet activation
ccan04613  Neutrophil extracellular trap formation
ccan04621  NOD-like receptor signaling pathway
ccan04713  Circadian entrainment
ccan04720  Long-term potentiation
ccan04723  Retrograde endocannabinoid signaling
ccan04724  Glutamatergic synapse
ccan04725  Cholinergic synapse
ccan04726  Serotonergic synapse
ccan04728  Dopaminergic synapse
ccan04730  Long-term depression
ccan04742  Taste transduction
ccan04750  Inflammatory mediator regulation of TRP channels
ccan04911  Insulin secretion
ccan04912  GnRH signaling pathway
ccan04915  Estrogen signaling pathway
ccan04916  Melanogenesis
ccan04918  Thyroid hormone synthesis
ccan04919  Thyroid hormone signaling pathway
ccan04921  Oxytocin signaling pathway
ccan04922  Glucagon signaling pathway
ccan04924  Renin secretion
ccan04925  Aldosterone synthesis and secretion
ccan04926  Relaxin signaling pathway
ccan04927  Cortisol synthesis and secretion
ccan04928  Parathyroid hormone synthesis, secretion and action
ccan04929  GnRH secretion
ccan04933  AGE-RAGE signaling pathway in diabetic complications
ccan04934  Cushing syndrome
ccan04935  Growth hormone synthesis, secretion and action
ccan04961  Endocrine and other factor-regulated calcium reabsorption
ccan04970  Salivary secretion
ccan04971  Gastric acid secretion
ccan04972  Pancreatic secretion
ccan04973  Carbohydrate digestion and absorption
ccan05010  Alzheimer disease
ccan05016  Huntington disease
ccan05017  Spinocerebellar ataxia
ccan05022  Pathways of neurodegeneration - multiple diseases
ccan05142  Chagas disease
ccan05143  African trypanosomiasis
ccan05146  Amoebiasis
ccan05163  Human cytomegalovirus infection
ccan05200  Pathways in cancer
ccan05415  Diabetic cardiomyopathy
ccan05417  Lipid and atherosclerosis
Module
ccan_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109684223 (Plcb1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    109684223 (Plcb1)
   04310 Wnt signaling pathway
    109684223 (Plcb1)
   04371 Apelin signaling pathway
    109684223 (Plcb1)
   04020 Calcium signaling pathway
    109684223 (Plcb1)
   04070 Phosphatidylinositol signaling system
    109684223 (Plcb1)
   04072 Phospholipase D signaling pathway
    109684223 (Plcb1)
   04071 Sphingolipid signaling pathway
    109684223 (Plcb1)
   04022 cGMP-PKG signaling pathway
    109684223 (Plcb1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    109684223 (Plcb1)
   04081 Hormone signaling
    109684223 (Plcb1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109684223 (Plcb1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109684223 (Plcb1)
   04613 Neutrophil extracellular trap formation
    109684223 (Plcb1)
   04621 NOD-like receptor signaling pathway
    109684223 (Plcb1)
   04062 Chemokine signaling pathway
    109684223 (Plcb1)
  09152 Endocrine system
   04911 Insulin secretion
    109684223 (Plcb1)
   04922 Glucagon signaling pathway
    109684223 (Plcb1)
   04929 GnRH secretion
    109684223 (Plcb1)
   04912 GnRH signaling pathway
    109684223 (Plcb1)
   04915 Estrogen signaling pathway
    109684223 (Plcb1)
   04921 Oxytocin signaling pathway
    109684223 (Plcb1)
   04926 Relaxin signaling pathway
    109684223 (Plcb1)
   04935 Growth hormone synthesis, secretion and action
    109684223 (Plcb1)
   04918 Thyroid hormone synthesis
    109684223 (Plcb1)
   04919 Thyroid hormone signaling pathway
    109684223 (Plcb1)
   04928 Parathyroid hormone synthesis, secretion and action
    109684223 (Plcb1)
   04916 Melanogenesis
    109684223 (Plcb1)
   04924 Renin secretion
    109684223 (Plcb1)
   04925 Aldosterone synthesis and secretion
    109684223 (Plcb1)
   04927 Cortisol synthesis and secretion
    109684223 (Plcb1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109684223 (Plcb1)
   04270 Vascular smooth muscle contraction
    109684223 (Plcb1)
  09154 Digestive system
   04970 Salivary secretion
    109684223 (Plcb1)
   04971 Gastric acid secretion
    109684223 (Plcb1)
   04972 Pancreatic secretion
    109684223 (Plcb1)
   04973 Carbohydrate digestion and absorption
    109684223 (Plcb1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    109684223 (Plcb1)
  09156 Nervous system
   04724 Glutamatergic synapse
    109684223 (Plcb1)
   04725 Cholinergic synapse
    109684223 (Plcb1)
   04728 Dopaminergic synapse
    109684223 (Plcb1)
   04726 Serotonergic synapse
    109684223 (Plcb1)
   04720 Long-term potentiation
    109684223 (Plcb1)
   04730 Long-term depression
    109684223 (Plcb1)
   04723 Retrograde endocannabinoid signaling
    109684223 (Plcb1)
  09157 Sensory system
   04742 Taste transduction
    109684223 (Plcb1)
   04750 Inflammatory mediator regulation of TRP channels
    109684223 (Plcb1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    109684223 (Plcb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109684223 (Plcb1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    109684223 (Plcb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109684223 (Plcb1)
   05142 Chagas disease
    109684223 (Plcb1)
   05143 African trypanosomiasis
    109684223 (Plcb1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109684223 (Plcb1)
   05016 Huntington disease
    109684223 (Plcb1)
   05017 Spinocerebellar ataxia
    109684223 (Plcb1)
   05022 Pathways of neurodegeneration - multiple diseases
    109684223 (Plcb1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109684223 (Plcb1)
   05415 Diabetic cardiomyopathy
    109684223 (Plcb1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    109684223 (Plcb1)
   04934 Cushing syndrome
    109684223 (Plcb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccan04131]
    109684223 (Plcb1)
Enzymes [BR:ccan01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     109684223 (Plcb1)
Membrane trafficking [BR:ccan04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    109684223 (Plcb1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    109684223 (Plcb1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y PLCB1-4-like_EFh EF-hand_like PH_14
Other DBs
NCBI-GeneID: 109684223
NCBI-ProteinID: XP_020016083
UniProt: A0A8B7U8N5
LinkDB
Position
Unknown
AA seq 1072 aa
MITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKL
QVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCP
RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN
NSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA
GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK
TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK
ILVKNKKKSHKSSDGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCK
KSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK
SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYE
YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM
FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRI
LPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME
QRAKQLAALTLEDEEEVKKEVDLGETPSEAPSETRTTPTENGVNHTTSLAPKPPSQALHS
QPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKT
TDLIKEHTTKYNEIQNDYLRRRATLEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEM
TQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEIC
EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ
EKLVEKHKEIRQQILDEKPKGEGSSSFLSETCHEDPSVPPNLTPPNPQALKW
NT seq 3219 nt   +upstreamnt  +downstreamnt
atgataacagtggtgtatgggcctgacctggtgaacatttcccatttgaatcttgtggct
ttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggccacaaacctg
ctggcccaaaacatgtccagggatgcatttctggaaaaagcttatactaaacttaagctg
caagtcactccagaaggacgtattcctctcaaaaacatatatcgcttgttttcagcagac
cggaagcgagttgaaactgcattagaggcttgtagtcttccatcttcaaggaatgactca
atacctcaagaggatttcactccagatgtgtacagagttttcctgaacaacctttgcccc
cgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccataccttact
gttgatcagatgatggattttatcaaccttaagcagcgagatccccggctaaatgaaata
ctttacccacctctgaaacaagagcaagtccaagtattgattgagaagtatgaacccaac
aacagcctcgccaaaaaaggacagatatcagtagacggatttatgcgttatctgagcgga
gaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcagccc
ctgtctcactatttcattaattcctcacacaacacctacctcacagctggccagctggct
ggaaactcctctgttgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtggaa
ctggactgctggaagggaaggactgcagaagaagaacctgtcatcacccatggattcacc
atgacaaccgaaatatccttcaaggaagtgatagaagcaatcgcggagtgtgcatttaag
acttcaccttttccaattctcctttcatttgagaaccacgtggattccccaaagcaacaa
gccaagatggcggaatattgccgactgatctttggggatgcccttctcatggagccactg
gaaaaatacccactggaatctggagtccctcttccaagccctatggatttaatgtacaaa
attttggtgaaaaacaagaagaaatcacacaagtcatcggacggaagtggcaaaaagaag
ctctcagagcaagcctccaacacatacagtgactcctccagcgtgtttgagccctcctct
ccaggagctggggaagctgatacggagagtgacgacgacgacgacgacgatgactgtaaa
aaatcttcaatggatgaggggactgctgggagtgaagccatggccacagaggagatgtct
aacctggtgaactatattcagccagtcaagtttgagtcatttgaaatttctaaaaaaaga
aataaaagttttgaaatgtcttccttcgttgaaaccaaaggacttgaacaacttaccaaa
tctccagtggaatttgtagaatacaacaaaatgcaactcagcaggatctatccaaaagga
acacgtgtggattcatccaactacatgcctcagctcttctggaacgcgggctgtcagatg
gtggctcttaatttccagacagtggatctggctatgcaaataaacatggggatgtatgag
tacaatgggaagagtggctataggttaaaaccagaattcatgaggaggccagacaagcat
tttgatccatttactgaaggcatcgtggatggaatagtggctaacactctgtcagtcaag
attatttcaggtcagtttctttctgataagaaagttggaacttacgtggaagtggatatg
tttggtttgcctgtggatacaaggaggaaggcatttaagaccaagacatcccaaggaaat
gctgtaaatcctgtatgggaagaagaacctattgtgttcaaaaaggtggttcttccttct
ctggcctgtttaaggatagcagtttatgaagaaggaggtaaatttattggccaccggatc
ttgcctgtgcaagccattcggccaggctatcactacatctgcctgaggaatgagaggaac
cagccgttgatgctaccagctgtcttcgtctacatagaggtgaaagactatgtgccagat
acatatgcagatgtgattgaagccttgtcaaacccaatccgatatgtaaatctgatggag
cagagagctaagcaactggctgctttgacactggaagatgaagaagaagtgaagaaggag
gttgatcttggtgaaacaccctcagaggctccaagtgaaaccaggacaaccccaacagaa
aatggggtgaatcacactacgtccctggcacccaagccaccctctcaggctctgcacagc
caaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcaaagtgtc
ttaacagaagtggaagcacagactattgaagagcttaaacaacagaaatcatttgtgaaa
cttcaaaagaagcactacaaagaaatgaaagacctggttaagagacaccacaagaaaacc
acggacctgatcaaagaacacactacaaagtataatgaaattcagaacgactacttgaga
aggcgggcaactttggaaaagactgccaaaaaggacagcaagaaaaaatcagagcccagc
agtcctgaccatggctcgtctaccattgagcaagaccttgctgccctggatgctgaaatg
acccaaaagctgatagacttgaaggacaagcaacagcagcagctgcttaatcttcggcaa
gaacagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaaaag
ttgacagatgttgctgaagaatgtcagaacaatcaattaaagaagctcaaagaaatctgt
gagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagataaca
gaagctaaatctaaagacaaaagccagatggaagaggagaagacagagatgatccggtca
tacatccaggaggtggtgcagtatatcaagaggttagaagaagcacaaagtaaacggcaa
gaaaaacttgtagaaaaacacaaggaaattcgccagcagatcctggatgaaaagcccaag
ggggaaggttcctcctcattcttgtcggaaacttgccatgaggatccctctgttcccccc
aacttaactccccccaaccctcaagctctcaagtggtga

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