Castor canadensis (American beaver): 109685215 Help Entry 109685215         CDS       T04791                                  Symbol Nf1 Name (RefSeq) neurofibromin   KO K08052   neurofibromin 1 Organism ccan  Castor canadensis (American beaver) Pathway ccan01521   EGFR tyrosine kinase inhibitor resistance ccan04010   MAPK signaling pathway ccan04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:ccan00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     109685215 (Nf1)    04014 Ras signaling pathway     109685215 (Nf1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     109685215 (Nf1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  109685215 NCBI-ProteinID:  XP_020017535 UniProt:  A0A250Y8L7 LinkDB All DBs Position Unknown AA seq 2841 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPTIRMAPSLTFKEKVTSLKFKEK PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE IAQEAMEALLVLHQLDSIDLWNPDAPIETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPASGTTTQMSMDHEELLRTYTPGASL RKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEAD IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWE DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI NMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRL LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNT QFVEQTIAIMKNLLDNHTEGSSEHLGQASIEAMMLNLVRYVRVLGNMVHAIQIKTKLCQL VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVS FEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG LKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDLARRFFLDIASDCPTSDAVNHSLSF ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ FTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA HLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC LKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL EQNLHTLDSLRIFNDRSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY RHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR KSLLLTDISVENVPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAATYPSVGQTSPRA RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE METQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP TSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTSGHCNSGRTRHGSA SQVQKQRSAGSFKRNSIKKIM NT seq 8526 nt NT seq  +upstreamnt  +downstreamnt atggccgcgcacaggccggtggaatgggtccaggccgtggtcagtcgcttcgacgagcag cttccaattaaaacaggacaacagaacacacataccaaagtcagcactgaacacaacaag gaatgtctgatcaatatttccaaatacaagttttctttggttataagtggcctcactact atcttaaagaatgttaacaatatgaggatatttggagaagctgcagaaaaaaatttatat ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgagattagatgaaacgatgctggtcaaacagttactgccagaaatctgccatttt cttcacacctgtcgtgaaggaaaccaacacgcagctgaacttcggaattctgcctctggg gttttattttctctcagctgcaacaacttcaatgcagtctttagtcgcatttctaccagg ttacaggaattgactgtttgttcagaagacaatgttgatgtccatgatatagaattgtta cagtatatcaacgtagattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa tttaaagccctaaagaaggttgcacagttagcagttataaatagcctggaaaaggccttt tggaactgggtagaaaattatccagatgagtttacaaagctctatcagattccacagact gatatggctgagtgtgcagagaagctgtttgacttggtggatggttttgctgaaagcacc aaacgtaaagcagcagtttggccactgcaaattattctccttattttgtgtccagaaata atccaggatatatccaaggatgtggttgatgaaaacaatatgaataagaaattatttctg gacagtctacgaaaagcacttgcaggtcatggaggaagcaggcagctgacagaaagtgct gcgattgcttgtgtcaaactgtgtaaagcaagtacttacatcaattgggaagacaactct gtcattttcctgctagttcagtccatggtagttgatcttaagaatctgctttttaatcca agtaaaccattctcaagaggcagtcaacctgcagatgtggatctaatgattgactgcctt gtctcgtgctttcggataagccctcacaataaccagcactttaagatctgcctggctcag aattcaccgtctacatttcactacgtgttggtaaattcactgcatcgcatcatcactaat tctgcattggattggtggcctaagattgatgccgtatattgtcactcagttgaacttcgg aatatgtttggtgaaacgctgcataaagcagtgcagggctgtggagcacacccaacaata cggatggcaccgagtcttacatttaaagaaaaagtaacgagccttaaatttaaagaaaaa cctacagacctggagacaagaagctataagtatcttctcttgtctatggtgaaactaatt catgcagatccaaagctcttgctttgtaatccaagaaaacagggccctgaaactcaaggc agtacagcagaattaattacagggctggtccaactggttcctcagtcccacatgccagag attgctcaggaagcaatggaggctttgttggttcttcatcagttagacagcattgatctg tggaatcctgatgctcctatagaaacattttgggagattagttcacaaatgctgttttac atatgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaagtggtta cgggaaattttgatatgcaggaataaatttcttcttaaaaataagcaggcagatagaagt tcctgtcactttcttttcctttatggagtaggatgtgatgttcctgctagtggaactacc actcagatgtccatggatcatgaagaattactacgtacctatactcctggagcatctctg cggaagggaaaaggaaattcctccatggatagtgcagcggggtgcagtggaacccctcca atatgccgacaagctcagaccaagctggaggtagccttgtacatgtttctgtggagccct gacactgaagctgttctggttgccatgtcctgttttcgccacctctgtgaggaagcagat atccggtgtggggtggatgaagtgtcggtgcacaacttcttgcccaactataacacattc atggagtttgcctctgtcagcaacatgatgtcaacaggaagagcagcacttcagaaaaga gtaatggcactgctaaggcgcattgaacatcccactgcaggaaacacagaggcttgggaa gatacacatgcaaaatgggaacaagcaacaaaactaatcctgaactatccaaaagccaaa atggaagatggccaggctgctgaaagccttcataaaaccattgttaagagacggatgtcc catgtgagtggaggtggatccatagatttgtctgatacagactccctacaggaatggatc aacatgactggcttcctttgtgctcttggtggagtatgcctgcagcagagaagcaactct ggtctggcaacctacagtccacccatgggtcccgtcagtgaacgtaaaggttccatgatt tcagtaatgtcctcagaaggaaatgcagatacacctgtcagcaaatttatggatcggctg ttgtccttaatggtgtgtaaccatgagaaagtgggacttcaaatacggaccaatgttaag gatctggtgggtctagaattgagtcctgctctttatccaatgctatttaacaaattaaag aataccatcagcaagttttttgactcccaaggacaggttttattgactgacaccaatact caatttgtagagcaaaccatagctataatgaagaacttattagataatcatactgaaggc agctctgaacatctgggacaagctagcattgaagcaatgatgttaaatctggtcagatat gtacgtgtacttgggaacatggtccatgcaattcagataaaaacaaaactgtgtcagtta gttgaagtaatgatggcaaggagagatgacctctcattttgtcaagagatgaaatttagg aataagatggtagaatacctgacagactgggttatgggaacatcaaaccaagcagcggat gatgatgtaaaatgtcttacaagagatttggaccaggcaagcatggaagcagtagtttca ctccttgctggtcttccgctacaacctgaggaaggagatggtgtggaactgatggaagcc aaatcacagttatttcttaagtacttcacgctatttatgaaccttttgaatgactgtagt gaagttgaagatgaaaacgcacaaacaggtggcaggaaacgtggcatgtctcggagactg gcatccttgaggcactgtacagtccttgcaatgtcaaacttactcaatgctaatgtggac agtggacttatgcactctataggtttaggttatcacaaggatctccagacaagagctaca tttatggaagttctgacaaaaatccttcaacaaggaacagaatttgacacacttgcagaa acagtgttggcggatcggtttgagagactcgtagagttggtcacaatgatgggggatcag ggagagctccctatagcgatggctctggccaatgtggtcccttgttctcagtgggatgaa ctagctcgagttctggttactctgtttgattctcggcatttactctaccaactgctctgg aacatgttttctaaggaagtagaattggcagactcaatgcagactcttttccgagggaac agcttggccagtaaaataatgacattctgcttcaaggtatatggtgctacctatctacaa aaactcctggatcctttattacgaattgttatcacatcctctgattggcaacatgtgagc tttgaagtggaccctaccaggttagagccatcagagagcctggaggaaaaccagcggaat cttcttcaaatgactgagaagttcttccacgccatcatcagttcctcctcagaattcccc cctcagcttcgaagtgtgtgccactgtttatatcaggcaacttgccactccctactgaat aaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgtttccct cagaacagcatcggtgcagtgggaagtgccatgttcctcagatttatcaaccctgctatc gtctctccgtatgaagcagggattttagataaaaagccacctcctagaattgaaaggggc ttgaaattaatgtcaaagatacttcagagtattgccaatcatgttctcttcacaaaagaa gaacatatgcggccttttaatgattttgtgaaaagcaactttgatttggcacgaaggttt ttccttgatattgcatcagattgtcccacaagtgatgcagtaaatcatagtctttccttc atcagtgatggtaatgtgcttgctttacatcgtctgctttggaacaatcaggaaaaaatt gggcagtatctttccagcaacagggatcataaagctgttgggagacgaccttttgacaag atggcaacacttcttgcatacctgggtcctccagagcacaagcctgtggcagatactcat tggtccagccttaaccttaccagttccaagtttgaggaatttatgactaggcatcaggta catgaaaaagaagagttcaaggctctgaaaacgttaagtatattctaccaagctggcact tccaaagcagggaatcctattttttattatgttgcacggaggttcaaaactggtcaaatc aatggcgatttgttgatatatcatgtattgctgactttaaagccatattatgcaaagcca tatgaaattgttgtggaccttacccacactgggcctagcaatcgctttaaaacagacttt ctctccaagtggtttgttgtttttcccggctttgcctatgacaatgtctctgccgtctat atctataactgtaattcctgggttagggagtacaccaagtatcatgagcggctgcttact ggcctcaaaggcagcaaaaggctcattttcattgactgtcctgggaaactggcagagcac atagagcatgaacaacagaaactacctgctgccaccttggccttggaagaggacctgaag gtattccataatgctctcaaactagctcacaaggacaccaaagtttctattaaggttggt tctactgctgttcaagtaacctcagcagagagaacaaaagtactggggcaatcagttttt ctaaatgatatctattatgcctcggaaattgaagagatctgcctggtggatgaaaaccag ttcaccttaaccattgcaaaccagggcacaccactcaccttcatgcaccaggagtgtgaa gccattgtccagtctatcattcatatccggacccgttgggaactgtcgcagcctgactcc atcccccagcacaccaagattcgaccaaaagatgttcctgggacactgctcaatattgcg ttacttaatttaggcagttcagaccctagtttgaggtcagctgcctataatcttctgtgt gccttaacttgcacctttaatttaaaaatcgagggccagttactagagacatcaggttta tgtatccctgccaacaacaccctctttattgtgtctattagtaagacactggcagccaat gaaccacacctcacgttagaatttttggaagaatgtatttctggatttagcaagtctagt attgaattgaaacacctttgtttggaatatatgactccgtggctgtcaaatctagtccgc ttttgtaagcataacgatgatgccaaacgacagagagtcactgctattcttgataaactg ataacaatgaccataaatgagaaacagatgtacccatctattcaagcaaaaatatggggg agccttgggcagattacagatctgcttgatgttgtcctagacagtttcatcaaaaccagt gcaacaggtggcttgggatcaataaaagctgaggtgatggcagatactgctgttgctttg gcttctggaaatgtgaaattggtttcaagtaaggttattggaagaatgtgtaaaataatt gacaagacatgcttatctccaactccaactttagaacagcatcttatgtgggatgatatt gctattttagcacgctacatgctaatgctgtccttcaacaactcccttgatgtggcagct catctcccctacctcttccatgttgtgactttcttagtagccacaggtcccttgtccctt agagcttccacacatggattggtcataaatatcattcactctctgtgtacctgttcacag ctgcattttagtgaagagaccaagcaagttttgagactcagtctaactgagttctcatta cccaaattttacttgctgtttggcattagcaaagttaagtcagctgctgtcattgccttc cgttccagttaccgggataggtcattctctcctggctcctatgaaagggagacttttgct ctgacatccttggaaacagtcacagaggctttgttagagatcatggaggcatgtatgaga gatattccaacatgcaagtggctggatcagtggacagaactagcacagagatttgcattc cagtataatccatccctgcaaccaagagctcttgtggtctttggctgtattagcaaacga gtgtctcatggacagataaagcagattatccgaattcttagcaaggcacttgagagttgc ttaaaaggacctgatacttacaacagtcaagttctgatagaagctacagtaatagcacta accaaattacagccacttcttaataaggactccccgctgcacaaagccctcttttgggtc gcagtggccgtgctgcagctagatgaggtaaacttgtattcagcaggcaccgcacttctg gaacaaaacctgcacaccttagatagtctgcggatattcaatgacaggagtccagaagaa gtatttatggcaatccggaatcctttggaatggcactgcaagcaaatggatcattttgtt ggactcaatttcaactctaactttaactttgctctggttggacacctcttaaaaggatac agacatccttcacctgccattgttgcaagaacggtcagaattttgcacacactactaact ctggttaataaacatagaaattgtgacaaatttgaagtgaatacccagagcgtggcttac ttagcagctttactcacagtgtctgaagaggttcgaagtcgctgcagcctcaaacataga aagtcccttcttcttactgatatttcagtggaaaatgttccaatggatacatatcccatt catcatggtgaccccagctataggacactgaaggaaaaccagccatggtcctcgcccaaa ggttctgaaggttaccttgcagccacctatccatctgtgggccagactagtccaagagcc aggaaatctatgagcttggacatggggcagccttctcaggccaacactaagaagttgctt ggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaa atggaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaa atggaaactcaaaggatttcctcatcacaacagcacccacatttacgtaaagtttctgtg tctgagtcgaatgttcttttggatgaagaagtacttactgatccgaagatccaagcactt cttctcactgttctagctacactggtaaaatatactacagatgaatttgaccaacgtatt ctttatgaatacttagcagaggccagtgttgtgttccccaaagttttccctgttgtgcac aatttgttggactctaagatcaacaccctactatcattgtgccaagatccaaatttgtta aatccaattcatggaattgtgcagagtgtggtgtaccatgaagaatccccaccacaatac cagacatcttacctgcaaagttttgggtttaatggtttatggcggtttgcaggacccttt tcaaagcaaacacaaatcccagactatgctgagcttattgttaagtttcttgatgccttg attgacacgtacttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc acatctccttaccctcctgcactgcaaagccagcttagtatcactgccaaccttaacctc tctaattccatgacctcacttgcaacttcccagcattccccaggaattgacaaggagaac gtcgaactctctcccacctctggccactgtaacagtggacgaactcgccacggatccgca agccaagtacagaagcaaagaagtgctggcagtttcaaacgcaatagcattaagaagatc atgtga

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