KEGG   Castor canadensis (American beaver): 109689664
Entry
109689664         CDS       T04791                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan00562  Inositol phosphate metabolism
ccan01100  Metabolic pathways
ccan01521  EGFR tyrosine kinase inhibitor resistance
ccan01522  Endocrine resistance
ccan01524  Platinum drug resistance
ccan04012  ErbB signaling pathway
ccan04014  Ras signaling pathway
ccan04015  Rap1 signaling pathway
ccan04024  cAMP signaling pathway
ccan04062  Chemokine signaling pathway
ccan04066  HIF-1 signaling pathway
ccan04068  FoxO signaling pathway
ccan04070  Phosphatidylinositol signaling system
ccan04071  Sphingolipid signaling pathway
ccan04072  Phospholipase D signaling pathway
ccan04081  Hormone signaling
ccan04140  Autophagy - animal
ccan04150  mTOR signaling pathway
ccan04151  PI3K-Akt signaling pathway
ccan04152  AMPK signaling pathway
ccan04210  Apoptosis
ccan04211  Longevity regulating pathway
ccan04213  Longevity regulating pathway - multiple species
ccan04218  Cellular senescence
ccan04360  Axon guidance
ccan04370  VEGF signaling pathway
ccan04380  Osteoclast differentiation
ccan04510  Focal adhesion
ccan04517  IgSF CAM signaling
ccan04518  Integrin signaling
ccan04550  Signaling pathways regulating pluripotency of stem cells
ccan04611  Platelet activation
ccan04613  Neutrophil extracellular trap formation
ccan04620  Toll-like receptor signaling pathway
ccan04625  C-type lectin receptor signaling pathway
ccan04630  JAK-STAT signaling pathway
ccan04650  Natural killer cell mediated cytotoxicity
ccan04660  T cell receptor signaling pathway
ccan04662  B cell receptor signaling pathway
ccan04664  Fc epsilon RI signaling pathway
ccan04666  Fc gamma R-mediated phagocytosis
ccan04668  TNF signaling pathway
ccan04670  Leukocyte transendothelial migration
ccan04722  Neurotrophin signaling pathway
ccan04725  Cholinergic synapse
ccan04750  Inflammatory mediator regulation of TRP channels
ccan04810  Regulation of actin cytoskeleton
ccan04910  Insulin signaling pathway
ccan04914  Progesterone-mediated oocyte maturation
ccan04915  Estrogen signaling pathway
ccan04917  Prolactin signaling pathway
ccan04919  Thyroid hormone signaling pathway
ccan04923  Regulation of lipolysis in adipocytes
ccan04926  Relaxin signaling pathway
ccan04929  GnRH secretion
ccan04930  Type II diabetes mellitus
ccan04931  Insulin resistance
ccan04932  Non-alcoholic fatty liver disease
ccan04933  AGE-RAGE signaling pathway in diabetic complications
ccan04935  Growth hormone synthesis, secretion and action
ccan04960  Aldosterone-regulated sodium reabsorption
ccan04973  Carbohydrate digestion and absorption
ccan05010  Alzheimer disease
ccan05017  Spinocerebellar ataxia
ccan05020  Prion disease
ccan05100  Bacterial invasion of epithelial cells
ccan05132  Salmonella infection
ccan05135  Yersinia infection
ccan05142  Chagas disease
ccan05146  Amoebiasis
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05162  Measles
ccan05163  Human cytomegalovirus infection
ccan05164  Influenza A
ccan05165  Human papillomavirus infection
ccan05166  Human T-cell leukemia virus 1 infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05168  Herpes simplex virus 1 infection
ccan05169  Epstein-Barr virus infection
ccan05170  Human immunodeficiency virus 1 infection
ccan05171  Coronavirus disease - COVID-19
ccan05200  Pathways in cancer
ccan05203  Viral carcinogenesis
ccan05205  Proteoglycans in cancer
ccan05206  MicroRNAs in cancer
ccan05207  Chemical carcinogenesis - receptor activation
ccan05208  Chemical carcinogenesis - reactive oxygen species
ccan05210  Colorectal cancer
ccan05211  Renal cell carcinoma
ccan05212  Pancreatic cancer
ccan05213  Endometrial cancer
ccan05214  Glioma
ccan05215  Prostate cancer
ccan05218  Melanoma
ccan05220  Chronic myeloid leukemia
ccan05221  Acute myeloid leukemia
ccan05222  Small cell lung cancer
ccan05223  Non-small cell lung cancer
ccan05224  Breast cancer
ccan05225  Hepatocellular carcinoma
ccan05226  Gastric cancer
ccan05230  Central carbon metabolism in cancer
ccan05231  Choline metabolism in cancer
ccan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccan05415  Diabetic cardiomyopathy
ccan05417  Lipid and atherosclerosis
ccan05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109689664 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109689664 (Pik3ca)
   04014 Ras signaling pathway
    109689664 (Pik3ca)
   04015 Rap1 signaling pathway
    109689664 (Pik3ca)
   04370 VEGF signaling pathway
    109689664 (Pik3ca)
   04630 JAK-STAT signaling pathway
    109689664 (Pik3ca)
   04668 TNF signaling pathway
    109689664 (Pik3ca)
   04066 HIF-1 signaling pathway
    109689664 (Pik3ca)
   04068 FoxO signaling pathway
    109689664 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    109689664 (Pik3ca)
   04072 Phospholipase D signaling pathway
    109689664 (Pik3ca)
   04071 Sphingolipid signaling pathway
    109689664 (Pik3ca)
   04024 cAMP signaling pathway
    109689664 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    109689664 (Pik3ca)
   04152 AMPK signaling pathway
    109689664 (Pik3ca)
   04150 mTOR signaling pathway
    109689664 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    109689664 (Pik3ca)
   04517 IgSF CAM signaling
    109689664 (Pik3ca)
   04518 Integrin signaling
    109689664 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109689664 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    109689664 (Pik3ca)
   04218 Cellular senescence
    109689664 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109689664 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    109689664 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109689664 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109689664 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    109689664 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    109689664 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    109689664 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    109689664 (Pik3ca)
   04660 T cell receptor signaling pathway
    109689664 (Pik3ca)
   04662 B cell receptor signaling pathway
    109689664 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    109689664 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    109689664 (Pik3ca)
   04670 Leukocyte transendothelial migration
    109689664 (Pik3ca)
   04062 Chemokine signaling pathway
    109689664 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109689664 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    109689664 (Pik3ca)
   04929 GnRH secretion
    109689664 (Pik3ca)
   04915 Estrogen signaling pathway
    109689664 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    109689664 (Pik3ca)
   04917 Prolactin signaling pathway
    109689664 (Pik3ca)
   04926 Relaxin signaling pathway
    109689664 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    109689664 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    109689664 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109689664 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109689664 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    109689664 (Pik3ca)
   04722 Neurotrophin signaling pathway
    109689664 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109689664 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    109689664 (Pik3ca)
   04380 Osteoclast differentiation
    109689664 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    109689664 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    109689664 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109689664 (Pik3ca)
   05206 MicroRNAs in cancer
    109689664 (Pik3ca)
   05205 Proteoglycans in cancer
    109689664 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    109689664 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    109689664 (Pik3ca)
   05203 Viral carcinogenesis
    109689664 (Pik3ca)
   05230 Central carbon metabolism in cancer
    109689664 (Pik3ca)
   05231 Choline metabolism in cancer
    109689664 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109689664 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109689664 (Pik3ca)
   05212 Pancreatic cancer
    109689664 (Pik3ca)
   05225 Hepatocellular carcinoma
    109689664 (Pik3ca)
   05226 Gastric cancer
    109689664 (Pik3ca)
   05214 Glioma
    109689664 (Pik3ca)
   05221 Acute myeloid leukemia
    109689664 (Pik3ca)
   05220 Chronic myeloid leukemia
    109689664 (Pik3ca)
   05218 Melanoma
    109689664 (Pik3ca)
   05211 Renal cell carcinoma
    109689664 (Pik3ca)
   05215 Prostate cancer
    109689664 (Pik3ca)
   05213 Endometrial cancer
    109689664 (Pik3ca)
   05224 Breast cancer
    109689664 (Pik3ca)
   05222 Small cell lung cancer
    109689664 (Pik3ca)
   05223 Non-small cell lung cancer
    109689664 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109689664 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    109689664 (Pik3ca)
   05161 Hepatitis B
    109689664 (Pik3ca)
   05160 Hepatitis C
    109689664 (Pik3ca)
   05171 Coronavirus disease - COVID-19
    109689664 (Pik3ca)
   05164 Influenza A
    109689664 (Pik3ca)
   05162 Measles
    109689664 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    109689664 (Pik3ca)
   05163 Human cytomegalovirus infection
    109689664 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109689664 (Pik3ca)
   05169 Epstein-Barr virus infection
    109689664 (Pik3ca)
   05165 Human papillomavirus infection
    109689664 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109689664 (Pik3ca)
   05135 Yersinia infection
    109689664 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    109689664 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109689664 (Pik3ca)
   05142 Chagas disease
    109689664 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109689664 (Pik3ca)
   05017 Spinocerebellar ataxia
    109689664 (Pik3ca)
   05020 Prion disease
    109689664 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109689664 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    109689664 (Pik3ca)
   05415 Diabetic cardiomyopathy
    109689664 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109689664 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    109689664 (Pik3ca)
   04931 Insulin resistance
    109689664 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109689664 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109689664 (Pik3ca)
   01524 Platinum drug resistance
    109689664 (Pik3ca)
   01522 Endocrine resistance
    109689664 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccan04131]
    109689664 (Pik3ca)
Enzymes [BR:ccan01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     109689664 (Pik3ca)
Membrane trafficking [BR:ccan04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109689664 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1
Other DBs
NCBI-GeneID: 109689664
NCBI-ProteinID: XP_020024197
UniProt: A0A250Y6R8
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDFNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactgtttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagcgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
atcggcatgccagtgtgtgaatttgacatggttaaagatccagaagttcaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggatttcaattcacctcat
agtagagcaatgtatgtgtatcctccaaatgtagagtcatcaccagaactgccaaagcac
atatataataaattagacaaaggacaaataatagtggtgatttgggtaatagtttctcca
aataatgataagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
atagctgaagcaatcaggaaaaaaactcgaagtatgttgctctcctctgaacaactaaaa
ctctgtgttttagagtatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctaatggctaaagaaagcctttactctcaactgccaatggac
tgtttcacaatgccatcttattccagacgtatctccacagctacaccgtacatgaacgga
gaaacagctacaaaatccctttgggttataaatagtgcactcagaatcaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatatatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
ccaaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggagcactgt
ccattggcctggggaaatataaacttgtttgattacacagacaccctagtatctggaaaa
atggctttgaatctttggccagtgcctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaacccaaataaagaaactccatgcttagaattggagtttgattggttc
agcagtgtggtgaagtttccagatatgtcagtgatagaagagcatgccaattggtctgtg
tctcgagaagcaggatttagctactcccatgcaggactgagtaacaggctagctagagac
aatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacgggatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacattattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagaacaggctatggag
cttctggactgtaattaccctgatcctatggttcgaggctttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttcacagtacctaattcagctggtacaggtcctaaaa
tacgaacaatatttggataacctgcttgtgaggtttttactcaagaaagcattgacaaat
caaaggattgggcactttttcttttggcatttaaaatctgaaatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgtcgtgcctgtgggatgtatttgaag
cacctgaataggcaagtggaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgagg
caaccagatttcatggatgctctacagggttttctgtctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactctgg
ttgaattgggaaaatccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggcgatgatttacgacaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgcgtgggacttattgaggtggtgagaaattctcacacaatcatgcagatt
cagtgcaaaggtggcctgaaaggtgcactacagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggggaaatatatgatgcggccattgacctgtttacacgttca
tgtgctggatattgtgtcgctaccttcattttgggaattggagaccgtcacaatagtaac
atcatggtgaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaagtttggttataaacgagaacgagtgccatttgtcttgacacaagatttc
ttaattgtgattagtaaaggagcccaagagtgcacaaagacaagagaatttgaaaggttt
caggaaatgtgttacaaggcttatctagctattcggcaacatgccaatctcttcataaat
cttttctccatgatgcttggctctggaatgccagaactacagtcttttgatgatattgca
tatattcgaaagacgctagccttagataaaactgaacaagaggctttggaatattttatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

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