KEGG   Castor canadensis (American beaver): 109690073
Entry
109690073         CDS       T04791                                 
Symbol
Atp1a4
Name
(RefSeq) sodium/potassium-transporting ATPase subunit alpha-4 isoform X1
  KO
K01539  sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan04022  cGMP-PKG signaling pathway
ccan04024  cAMP signaling pathway
ccan04260  Cardiac muscle contraction
ccan04261  Adrenergic signaling in cardiomyocytes
ccan04820  Cytoskeleton in muscle cells
ccan04911  Insulin secretion
ccan04918  Thyroid hormone synthesis
ccan04919  Thyroid hormone signaling pathway
ccan04925  Aldosterone synthesis and secretion
ccan04960  Aldosterone-regulated sodium reabsorption
ccan04961  Endocrine and other factor-regulated calcium reabsorption
ccan04964  Proximal tubule bicarbonate reclamation
ccan04970  Salivary secretion
ccan04971  Gastric acid secretion
ccan04972  Pancreatic secretion
ccan04973  Carbohydrate digestion and absorption
ccan04974  Protein digestion and absorption
ccan04976  Bile secretion
ccan04978  Mineral absorption
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    109690073 (Atp1a4)
   04022 cGMP-PKG signaling pathway
    109690073 (Atp1a4)
 09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    109690073 (Atp1a4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    109690073 (Atp1a4)
   04918 Thyroid hormone synthesis
    109690073 (Atp1a4)
   04919 Thyroid hormone signaling pathway
    109690073 (Atp1a4)
   04925 Aldosterone synthesis and secretion
    109690073 (Atp1a4)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    109690073 (Atp1a4)
   04261 Adrenergic signaling in cardiomyocytes
    109690073 (Atp1a4)
  09154 Digestive system
   04970 Salivary secretion
    109690073 (Atp1a4)
   04971 Gastric acid secretion
    109690073 (Atp1a4)
   04972 Pancreatic secretion
    109690073 (Atp1a4)
   04976 Bile secretion
    109690073 (Atp1a4)
   04973 Carbohydrate digestion and absorption
    109690073 (Atp1a4)
   04974 Protein digestion and absorption
    109690073 (Atp1a4)
   04978 Mineral absorption
    109690073 (Atp1a4)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109690073 (Atp1a4)
   04961 Endocrine and other factor-regulated calcium reabsorption
    109690073 (Atp1a4)
   04964 Proximal tubule bicarbonate reclamation
    109690073 (Atp1a4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ccan04147]
    109690073 (Atp1a4)
Enzymes [BR:ccan01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.13  Na+/K+-exchanging ATPase
     109690073 (Atp1a4)
Exosome [BR:ccan04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   109690073 (Atp1a4)
  Exosomal proteins of other body fluids (saliva and urine)
   109690073 (Atp1a4)
  Exosomal proteins of colorectal cancer cells
   109690073 (Atp1a4)
  Exosomal proteins of bladder cancer cells
   109690073 (Atp1a4)
SSDB
Motif
Pfam: E1-E2_ATPase Cation_ATPase_C Cation_ATPase Hydrolase Cation_ATPase_N Hydrolase_3 HAD
Other DBs
NCBI-GeneID: 109690073
NCBI-ProteinID: XP_020024800
UniProt: A0A8B7V272
LinkDB
Position
Unknown
AA seq 1049 aa
MELEGKKETMAPHTQNPSLTPESSKKKTVKKKKDMEELKKEVLMEDHKLTLEELSAKYSV
NLTMGHNPEKAKEILIRDGPNILTPPHTTPEWAKFCKQLFGGFSLLLWIGSILCFLAYGI
QQHFDDEPTKDNLYLGAVLAVVVIVTGCFSYYQEAKSSKIMESFKNLVPQQALVIRGGKR
MQINVKEVVLGDLVEVKGGDRIPADLRLIYAQRCKVDNSSLTGESEPQSRSTDFTHENPL
ESRNLCFFSTNCVEGTAKGVVIATGDCTVMGRIASLASGLETGKTPIAIEIEHFIHLITT
VAIFLGVTFFGLSLFLGYPWLEAIVFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNHMTVAHLWFDRKVYAAGTSEIKLVTSGIEKIFA
EGSATWLILARIAGLCNRADFKPHQETLPITKRATTGDASESALLKFIEQSYSSVKEMRE
KNPKVAEIPFNSTNKYQMSIHLQEDDSQAHVLLMKGAPERILEFCSTILLNGQEYPLDDK
MKNAFQSAYLELGGLGERVLGFCFLNLPSSFPKGFQFNTDELNFPMQNLCFVGLISMIDP
PRTAVPDAVNKCRSAGIKVIMITGDHPITAKAIAKSVGIISEGNETVEDIAARLRIPISQ
VDTSNIKAIVVHGSELKGMNSQQLDQILENHKEIVFARTSPQQKLVIVEGCQRLGAIVAV
TGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK
SIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYESAESDIMKR
RPRDPKIDKLVNSRLIAMSYGQIGMIQALAGFFTYFVILAENGFKPYDLLGIRLNWENKF
LNDLEDSYGQQWTYEQRKMVEFTCHTAFFVSIVMVQWTDLLICKTRRNSIFQQGMKNKIL
IFGILEETFLAAVLSYTPGTNVALRMYPLKINWWFCAIPYSLLIFIYDEIRKLIIRKRPG
GEAALGPPLTEWSLVPNDLSHRACFLQTH
NT seq 3150 nt   +upstreamnt  +downstreamnt
atggagcttgaagggaagaaagagaccatggctcctcatacacagaatccaagcttaaca
cctgaaagtagtaagaagaaaacagtgaaaaagaagaaagatatggaagaactgaagaag
gaagtactcatggaggatcacaaattgaccttggaagagctgagtgccaagtactctgtg
aacctgaccatgggccataacccagaaaaggcaaaagaaatcctgattcgagatggaccc
aatatactgactcctccccacaccaccccagagtgggccaaattctgcaaacaactgttt
ggtggcttctctctcctgctgtggattggttccattctctgcttcttggcctatggcatc
cagcagcattttgatgatgaacctactaaagataatctatatttgggcgccgtactagct
gtcgtggtcatcgtcactggctgcttctcctattatcaggaggccaagagctccaagatc
atggagtcttttaagaacttggtaccacagcaagctctggtgattcgaggaggaaagagg
atgcaaatcaatgtaaaagaagtggtgctgggagacctggtagaagtgaagggtggagac
cgaattcctgctgaccttcggctgatctatgcacaaagatgtaaggtggacaactcatcc
ttgactggggagtcagagccccaaagtcgctctactgatttcacccatgagaaccctctg
gaaagccgaaacctctgcttcttctctactaactgtgtggaaggaacagccaagggtgtt
gtgattgcaacaggagactgcacagtgatgggccgaattgcctcactggcatcaggccta
gagacgggcaagacccccattgctattgagattgaacacttcatccacttgatcacaaca
gtggccattttccttggtgtcactttttttggtctctcgcttttcctgggctatccctgg
cttgaggctattgtttttctcattggcatcattgtggccaatgtgcctgaggggctactg
gccactgtcacggtgtgcctgaccctgacagccaagcgcatggcacggaagaactgcctg
gtgaagaacctggaggcagtggagacactgggctccacgtccaccatctgctcagacaag
acaggcaccctcacccagaaccatatgacggtggcccacctctggttcgacaggaaggtg
tatgcagctggcaccagtgaaatcaaactggtgactagtggtattgagaaaatatttgct
gagggctctgctacctggctaatcctggcccgaattgctggcctctgcaaccgtgctgac
tttaaacctcatcaggagactctgcccataactaagagggcaacaacaggggatgcttct
gagtcagccctcctcaagttcatcgaacagtcttacagctctgtgaaggaaatgagagag
aaaaaccccaaggtggcagagattccctttaattctaccaataaataccagatgtccatc
caccttcaggaggatgactcccaagcccatgtgctgctgatgaagggtgctcctgagagg
atcttggagttctgctcaactatcctcctgaatggacaggagtacccacttgatgacaaa
atgaagaatgccttccaaagtgcctacttggaactgggaggtctcggggagcgagtgctg
gggttctgcttcttgaatctgcctagcagctttcctaaaggattccagtttaatacagat
gaactaaattttcccatgcaaaatctgtgttttgtgggcctcatatccatgattgaccct
cctcgaactgctgtgcctgatgctgtgaacaagtgccgcagtgcagggattaaggtgatt
atgataacaggggatcatcctattacagccaaggccattgccaagagtgtgggcatcatt
tcagaaggcaatgaaacagtggaagacattgccgcccggcttaggattcccatcagtcag
gtcgataccagtaacattaaagccattgtggtccacggctcagagctgaagggtatgaac
tcacagcagctggaccaaattctcgaaaaccataaagaaatcgtgtttgctcggacttcc
ccacagcagaagctcgtcattgtggaggggtgtcagaggctgggagccattgtggcggta
acaggtgatggggtaaatgactcaccggctctgaagaaggctgacattggcattgctatg
ggcatctctggctctgatgtctctaagcaggcagccgacatgatcctgctggatgacaac
tttgcttccatcgtcacaggcgtggaggagggccgcctgatctttgacaacctgaagaag
tccattgcgtacaccctgaccagcaacatccccgagatcacccccttcctgctgttcatt
attgccaacatccccctccctctgggcactgtgaccatcctctgcattgacctgggtact
gacatggtccctgctatctccttggcctatgagtcagctgaaagtgacatcatgaagagg
cgtccacgggacccaaagattgataagctagtgaacagccgtctcattgccatgtcctat
ggacagattgggatgatccaggctctggctggattctttacctattttgtgatcctggct
gagaatggctttaagccttatgatctgctgggcatccgcctgaactgggaaaacaaattc
ttaaatgacctggaggacagctatggacagcagtggacctacgagcagcgaaagatggtg
gagttcacttgccacacagccttctttgtcagcatcgtgatggtgcaatggaccgacctc
cttatctgcaagacccgccgcaactcgatcttccagcagggcatgaaaaacaagatccta
attttcgggatcctggaggagacattcctggcggctgtactgtcctacactccaggcaca
aacgtggctctgcgaatgtacccactgaagataaactggtggttctgtgccattccctac
agccttcttatcttcatctatgacgaaatcagaaaacttatcatccgtaaacggcctggc
ggtgaggctgccctgggccctcctctgacagagtggtcactagtccctaatgacctttcc
catcgggcctgcttcctccagactcactag

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