Castor canadensis (American beaver): 109694442
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Entry
109694442 CDS
T04791
Symbol
Nos3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
ccan
Castor canadensis (American beaver)
Pathway
ccan00220
Arginine biosynthesis
ccan00330
Arginine and proline metabolism
ccan01100
Metabolic pathways
ccan04020
Calcium signaling pathway
ccan04022
cGMP-PKG signaling pathway
ccan04066
HIF-1 signaling pathway
ccan04071
Sphingolipid signaling pathway
ccan04151
PI3K-Akt signaling pathway
ccan04370
VEGF signaling pathway
ccan04371
Apelin signaling pathway
ccan04611
Platelet activation
ccan04915
Estrogen signaling pathway
ccan04921
Oxytocin signaling pathway
ccan04926
Relaxin signaling pathway
ccan04931
Insulin resistance
ccan04933
AGE-RAGE signaling pathway in diabetic complications
ccan05415
Diabetic cardiomyopathy
ccan05417
Lipid and atherosclerosis
ccan05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ccan00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
109694442 (Nos3)
00330 Arginine and proline metabolism
109694442 (Nos3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
109694442 (Nos3)
04371 Apelin signaling pathway
109694442 (Nos3)
04066 HIF-1 signaling pathway
109694442 (Nos3)
04020 Calcium signaling pathway
109694442 (Nos3)
04071 Sphingolipid signaling pathway
109694442 (Nos3)
04022 cGMP-PKG signaling pathway
109694442 (Nos3)
04151 PI3K-Akt signaling pathway
109694442 (Nos3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
109694442 (Nos3)
09152 Endocrine system
04915 Estrogen signaling pathway
109694442 (Nos3)
04921 Oxytocin signaling pathway
109694442 (Nos3)
04926 Relaxin signaling pathway
109694442 (Nos3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
109694442 (Nos3)
05418 Fluid shear stress and atherosclerosis
109694442 (Nos3)
05415 Diabetic cardiomyopathy
109694442 (Nos3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
109694442 (Nos3)
04933 AGE-RAGE signaling pathway in diabetic complications
109694442 (Nos3)
Enzymes [BR:
ccan01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
109694442 (Nos3)
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Ortholog
Paralog
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
109694442
NCBI-ProteinID:
XP_020031961
UniProt:
A0A8B7VIY5
LinkDB
All DBs
Position
Unknown
AA seq
1243 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCSKQTPASPTSEPSRAPASPPPTSPAPDNSPPLTR
PPEGPRFPRVKNWEVGSIAYDTLCAQAQQDGPCTPRRCLGSLVFPRKLQSRPTQGSPPPE
QLLGQARDFINQYYSSIKRSGSQAHEQRLQEVEEEVASTGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCQGRGDF
RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWVPGNGRFDVLPLLLQAPDEPPE
LFTLPSELVLEVPLEHPTLEWFVALGLRWYALPAVSSMLLEIGGLEFPAAPFSGWYMSSE
IGMRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGAGITRKKTFKEVANAVKITASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSAQAEGLQLLPGTVLTSPPSAGSLGFPGSKDSLIQAPLPGSGSV
SFAPSSSLGLIHVHRRKMFQASILSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIG
VCPPNRPGLVEALLSRVEDPPPPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALT
FFLDITSPPSPRLLRLLSTLAEESSEQEELEALSQDPRRYEEWKWFRCPTLLEVLEQFPS
VALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWL
SQLKAGDLVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPA
PMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGHVLTAFSREPNSPKTYVQDVLRTELAAEV
HRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIF
GLTLRTQEVTSRIRTQSFSLQERQLRGAVPWALDPTGPDTPGS
NT seq
3732 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggaacctgggccaccctgtggcctggggctggga
ctgggccttggactgtgcagcaagcagaccccggcctctccaacatcagagcccagccgg
gcaccagcatccccacccccgacctcaccagcgccagacaacagccccccactaacccgg
cctccagaggggcccaggttccctcgagtgaagaactgggaagtgggcagcattgcctat
gacaccctgtgtgcccaagctcagcaggatgggccctgcaccccaagacgctgcctggga
tcccttgtgtttccaaggaaactacagagcaggcctacccagggctcaccaccccctgaa
cagctgctgggtcaggccagggacttcatcaaccagtactacagctccatcaagaggagt
ggctctcaggcccatgagcagcgacttcaagaggtagaggaagaggtagcatctacaggc
acctaccagctccgggagagtgagctggtgttcggggccaagcaagcctggcgcaatgct
ccccgctgtgtgggccggatccagtggggaaagctacaggtatttgatgcccgagactgc
aggactgcccaggaaatgttcacctacatctgcaatcacatcaagtatgccaccaaccga
ggcaaccttcgctccgccatcacagtgttcccccagcgctgccaaggccgcggagacttc
cggatctggaacagccagttggtgcgttatgctggctacaggcagcaggatggctctgtg
cgaggggaccctgccaacgtggagatcactgagctctgcatccagcatggctgggtccca
ggaaatggccgttttgacgtactgcccctgctgctccaggcccctgatgagcctccagaa
ctcttcactctgccctctgagctggtcctcgaggtgcccctggagcaccccacgctggag
tggttcgtggcactgggcctgcgctggtacgccctcccggcagtatccagcatgcttctg
gaaattgggggcttggagttccctgcggcccctttcagcggctggtacatgagctctgag
atcggaatgaggaacctgtgtgaccctcaccgctacaacatcctggaggatgtagctgtc
tgcatggacctggacacccggacaacctcgtccctgtggaaagacaaggcagcagtggaa
attaacgtggctgtactgcacagttaccagctggccaaagtgaccattgtggaccaccat
gctgccacagcctcgtttatgaaacacctggagaatgagcagaaggccaggggtggctgc
cctgctgactgggcctggatcgtaccccccatctcgggcagcctcactcctgtcttccat
caagagatggtcaactatttcctgtcccctgctttccgctaccagccagacccctggaag
gggagcgcagccaagggtgccggcatcaccaggaagaagacctttaaggaagtggccaat
gcagtgaagatcactgcctcgctcatgggcacagtgatggcaaagcgcgtgaaggcaacc
atcctgtatggctcagagactggccgggcccagagctacgcacagcagctggggaggctc
ttccggaaggcgttcgatccccgggtcctgtgtatggatgagtatgacgtggtgtccctt
gagcatgagacactggtgttggtggtgaccagcacatttgggaatggagatcccccagag
aatggagagagttttgcagcagcgctaatggagatgtcgggaccctacaacagctcccct
cgaccagagcagcacaagagttacaaaatccgcttcaacagtgtctcctgctcagaccca
ctggtgtcttcttggcggcggaaaaggaaggagtccagcaacacagacagtgcaggggca
ctaggcacactcaggttctgtgtgttcgggctgggctcccgggcgtacccccacttctgt
gcctttgcccgggcggtggacacaaggctggaggagctgggtggagagcgactacttcag
ctgggccagggcgatgagctgtgtggccaagaggaggccttccgtggctgggcccaggct
gccttccaggcctcctgtgagaccttctgtgtgggagaagacgccaaggctgctgcccgg
gacatattcagccccaaacgcagctggaagcgccagaggtatcggctgagtgcccaggcc
gagggcctgcagctgctgccaggtacagtcctgacctcacccccatccgcaggctctctg
gggttcccagggtccaaggactcacttattcaggccccgctccctggctcaggctcagtc
tcctttgcaccctcctcatccttaggcctgatccatgtgcacaggcggaagatgttccaa
gcttcaatcctctccgtggaaaatctacaaagcagcaaatccacccgggccacgatcctg
gtgcgcctggacactggaggccaggaggggctgcagtaccagcccggggaccacataggt
gtctgcccgcccaaccgtcctggcctcgtggaggcactgctgagccgtgtagaggaccca
ccgccacccacagagcctgtggcagtagagcagctggagaagggcagccctggtggccct
ccccccggttgggtacgagaccctcggctacccccgtgcacacttcgccaggctctcact
ttcttcctggacatcacatccccacccagcccacgccttctccgactgctgagcaccctg
gctgaagagtccagtgagcaggaggagctggaggccctcagccaggaccctcggcgctat
gaggagtggaagtggttccgctgccccacgcttttggaggtgctggagcagttcccatca
gtggcactgcctgctcccctgctcctcactcagctgcccctactccagcctcggtactac
tcagtcagctcagcacccagtgcacacccaggagagatccacctcaccgttgctgtgctg
gcatacaggacacaggatggactgggccccctgcactatggagtctgctccacatggcta
agccaactcaaggccggagaccttgtgccctgcttcatcaggggggctccctccttccgg
ctgccacctgatcccagtttaccctgcatcctggtgggcccaggcactggcattgccccc
ttccggggattctggcaagaaagactgcatgacattgaaagcaaagggctgcagcccgcc
cctatgactttggtgttcggctgccgttgctcccaactcgaccacctctaccgcgacgag
gtgcaggacgcccagcagcgcggggtgttcggtcacgtcctcaccgccttctccagggaa
ccaaacagccccaagacctacgtgcaggacgtcctgaggactgagctggctgctgaggtg
catcgcgtgctgtgcctggaacgaggccacatgtttgtctgcggcgatgtcaccatggca
accagcgtcctacagacagtgcagcggatcctggcgacagagggcgacatggagctggat
gaggcgggtgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacatcttc
gggctcacactgcgcacccaggaggtgacaagccgcatacgcacccagagcttttcattg
caggagcgacagctgcggggggcagtgccctgggcattggacccgactggcccagacacg
ccaggctcctga
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