KEGG   Castor canadensis (American beaver): 109694940
Entry
109694940         CDS       T04791                                 
Symbol
Raf1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan01521  EGFR tyrosine kinase inhibitor resistance
ccan01522  Endocrine resistance
ccan04010  MAPK signaling pathway
ccan04012  ErbB signaling pathway
ccan04014  Ras signaling pathway
ccan04015  Rap1 signaling pathway
ccan04022  cGMP-PKG signaling pathway
ccan04024  cAMP signaling pathway
ccan04062  Chemokine signaling pathway
ccan04068  FoxO signaling pathway
ccan04071  Sphingolipid signaling pathway
ccan04072  Phospholipase D signaling pathway
ccan04140  Autophagy - animal
ccan04150  mTOR signaling pathway
ccan04151  PI3K-Akt signaling pathway
ccan04210  Apoptosis
ccan04218  Cellular senescence
ccan04270  Vascular smooth muscle contraction
ccan04360  Axon guidance
ccan04370  VEGF signaling pathway
ccan04371  Apelin signaling pathway
ccan04510  Focal adhesion
ccan04540  Gap junction
ccan04550  Signaling pathways regulating pluripotency of stem cells
ccan04613  Neutrophil extracellular trap formation
ccan04625  C-type lectin receptor signaling pathway
ccan04630  JAK-STAT signaling pathway
ccan04650  Natural killer cell mediated cytotoxicity
ccan04660  T cell receptor signaling pathway
ccan04662  B cell receptor signaling pathway
ccan04664  Fc epsilon RI signaling pathway
ccan04666  Fc gamma R-mediated phagocytosis
ccan04720  Long-term potentiation
ccan04722  Neurotrophin signaling pathway
ccan04726  Serotonergic synapse
ccan04730  Long-term depression
ccan04810  Regulation of actin cytoskeleton
ccan04910  Insulin signaling pathway
ccan04912  GnRH signaling pathway
ccan04914  Progesterone-mediated oocyte maturation
ccan04915  Estrogen signaling pathway
ccan04916  Melanogenesis
ccan04917  Prolactin signaling pathway
ccan04919  Thyroid hormone signaling pathway
ccan04921  Oxytocin signaling pathway
ccan04926  Relaxin signaling pathway
ccan04928  Parathyroid hormone synthesis, secretion and action
ccan04929  GnRH secretion
ccan04935  Growth hormone synthesis, secretion and action
ccan05010  Alzheimer disease
ccan05022  Pathways of neurodegeneration - multiple diseases
ccan05034  Alcoholism
ccan05132  Salmonella infection
ccan05152  Tuberculosis
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05163  Human cytomegalovirus infection
ccan05164  Influenza A
ccan05165  Human papillomavirus infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05170  Human immunodeficiency virus 1 infection
ccan05200  Pathways in cancer
ccan05205  Proteoglycans in cancer
ccan05206  MicroRNAs in cancer
ccan05207  Chemical carcinogenesis - receptor activation
ccan05208  Chemical carcinogenesis - reactive oxygen species
ccan05210  Colorectal cancer
ccan05211  Renal cell carcinoma
ccan05212  Pancreatic cancer
ccan05213  Endometrial cancer
ccan05214  Glioma
ccan05215  Prostate cancer
ccan05218  Melanoma
ccan05219  Bladder cancer
ccan05220  Chronic myeloid leukemia
ccan05221  Acute myeloid leukemia
ccan05223  Non-small cell lung cancer
ccan05224  Breast cancer
ccan05225  Hepatocellular carcinoma
ccan05226  Gastric cancer
ccan05230  Central carbon metabolism in cancer
ccan05231  Choline metabolism in cancer
ccan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109694940 (Raf1)
   04012 ErbB signaling pathway
    109694940 (Raf1)
   04014 Ras signaling pathway
    109694940 (Raf1)
   04015 Rap1 signaling pathway
    109694940 (Raf1)
   04370 VEGF signaling pathway
    109694940 (Raf1)
   04371 Apelin signaling pathway
    109694940 (Raf1)
   04630 JAK-STAT signaling pathway
    109694940 (Raf1)
   04068 FoxO signaling pathway
    109694940 (Raf1)
   04072 Phospholipase D signaling pathway
    109694940 (Raf1)
   04071 Sphingolipid signaling pathway
    109694940 (Raf1)
   04024 cAMP signaling pathway
    109694940 (Raf1)
   04022 cGMP-PKG signaling pathway
    109694940 (Raf1)
   04151 PI3K-Akt signaling pathway
    109694940 (Raf1)
   04150 mTOR signaling pathway
    109694940 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109694940 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    109694940 (Raf1)
   04218 Cellular senescence
    109694940 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109694940 (Raf1)
   04540 Gap junction
    109694940 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    109694940 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109694940 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    109694940 (Raf1)
   04625 C-type lectin receptor signaling pathway
    109694940 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    109694940 (Raf1)
   04660 T cell receptor signaling pathway
    109694940 (Raf1)
   04662 B cell receptor signaling pathway
    109694940 (Raf1)
   04664 Fc epsilon RI signaling pathway
    109694940 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    109694940 (Raf1)
   04062 Chemokine signaling pathway
    109694940 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109694940 (Raf1)
   04929 GnRH secretion
    109694940 (Raf1)
   04912 GnRH signaling pathway
    109694940 (Raf1)
   04915 Estrogen signaling pathway
    109694940 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    109694940 (Raf1)
   04917 Prolactin signaling pathway
    109694940 (Raf1)
   04921 Oxytocin signaling pathway
    109694940 (Raf1)
   04926 Relaxin signaling pathway
    109694940 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    109694940 (Raf1)
   04919 Thyroid hormone signaling pathway
    109694940 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    109694940 (Raf1)
   04916 Melanogenesis
    109694940 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    109694940 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    109694940 (Raf1)
   04720 Long-term potentiation
    109694940 (Raf1)
   04730 Long-term depression
    109694940 (Raf1)
   04722 Neurotrophin signaling pathway
    109694940 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    109694940 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109694940 (Raf1)
   05206 MicroRNAs in cancer
    109694940 (Raf1)
   05205 Proteoglycans in cancer
    109694940 (Raf1)
   05207 Chemical carcinogenesis - receptor activation
    109694940 (Raf1)
   05208 Chemical carcinogenesis - reactive oxygen species
    109694940 (Raf1)
   05230 Central carbon metabolism in cancer
    109694940 (Raf1)
   05231 Choline metabolism in cancer
    109694940 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109694940 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109694940 (Raf1)
   05212 Pancreatic cancer
    109694940 (Raf1)
   05225 Hepatocellular carcinoma
    109694940 (Raf1)
   05226 Gastric cancer
    109694940 (Raf1)
   05214 Glioma
    109694940 (Raf1)
   05221 Acute myeloid leukemia
    109694940 (Raf1)
   05220 Chronic myeloid leukemia
    109694940 (Raf1)
   05218 Melanoma
    109694940 (Raf1)
   05211 Renal cell carcinoma
    109694940 (Raf1)
   05219 Bladder cancer
    109694940 (Raf1)
   05215 Prostate cancer
    109694940 (Raf1)
   05213 Endometrial cancer
    109694940 (Raf1)
   05224 Breast cancer
    109694940 (Raf1)
   05223 Non-small cell lung cancer
    109694940 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    109694940 (Raf1)
   05161 Hepatitis B
    109694940 (Raf1)
   05160 Hepatitis C
    109694940 (Raf1)
   05164 Influenza A
    109694940 (Raf1)
   05163 Human cytomegalovirus infection
    109694940 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109694940 (Raf1)
   05165 Human papillomavirus infection
    109694940 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109694940 (Raf1)
   05152 Tuberculosis
    109694940 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109694940 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    109694940 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    109694940 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109694940 (Raf1)
   01522 Endocrine resistance
    109694940 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccan01001]
    109694940 (Raf1)
Enzymes [BR:ccan01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     109694940 (Raf1)
Protein kinases [BR:ccan01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   109694940 (Raf1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 109694940
NCBI-ProteinID: XP_020032744
UniProt: A0A8B7VQR3
LinkDB
Position
Unknown
AA seq 668 aa
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTMGESGAPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNILNASPRAWSRRFCVRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGTGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatccagggagcctggaagacgatcagcaatggttttgggctcaaagatgcg
gtgtttgatggctccagctgcatctcccctacaatagtccagcagtttggctatcagcgc
cgggcctcagatgatggcaaacttacagattcttctaagacaagcaacactatccgcgtt
ttcttgccgaataagcaaagaacagtggtcaatgtgcggaatggaatgagcttgcatgat
tgccttatgaaagctctgaaggtgagggggctccagccggagtgctgcgcggtgttcaga
cttctccaggaacacaagggtaaaaaagcacgtttagactggaatactgatgccgcctct
ttgattggagaagaacttcaagtggatttcctggaccatgttccccttaccacacacaac
tttgctcggaagacgttcctgaagcttgcattttgtgacatctgccagaagttcctgcta
aatggatttcgatgtcagacttgcggctacaaatttcacgagcactgtagtaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttgctgtttccaaactccaca
atgggtgagagtggggccccagcactgccctccttgacgatgcgtcggatgcgagagtct
gtttcccggatgcctgtcagttcccagcacagatactccacaccccacgccttcactttc
aacacctccagcccctcctctgaaggctccctctcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcagaatgattgagaataac
atcctgaatgcttctcccagggcgtggtccagacgattttgtgtgaggggaagagacgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagcagtcccaacaacctg
agtccaacaggctggtcacagcccaaaacccctgtgccagcacaaagggagcgggcacca
ggaactgggacccaggagaaaaataaaatcaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaggtgatgctctccactcggatcgggtctggctctttt
ggaactgtttacaagggcaagtggcatggagacgttgctgtgaagatcctaaaggttgtt
gacccaactccagagcagttccaggccttcaggaatgaggttgctgtcctgcgcaaaaca
cggcatgtgaacatcctgctcttcatgggatacatgacgaaggacaacctggcaattgtg
acccagtggtgcgaggggagcagtctctacaaacacctgcatgtccaggagaccaaattc
cagatgttccagttaattgacattgcccggcagacagctcagggaatggactatttgcat
gcaaagaatatcatccacagagacatgaaatccaacaatatctttctccacgaaggcctc
acggtgaaaattggagactttggtttggcgacagtgaagtcgcgctggagtggttctcag
caggttgaacagcccacaggctctgtgctgtggatggccccagaggtgatccgaatgcag
gacaacaacccattcagcttccagtcggacgtgtactcctatggcatcgtgctgtatgag
ctgatgacgggggagcttccctactcccacatcaacaaccgggatcagatcatcttcatg
gtgggccgtgggtatgcctcgccggatctcagcaggctgtacaagaactgtcctaaggcg
atgaagaggctggtggcggactgcgtgaagaaagtaaaggaagagaggcctctctttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaaaatcaaccggagtgct
tctgagccatccctccaccgggcggcccacactgaggacattaatgcttgcacgctaacc
acatccccaaggctgcctgtcttctag

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