| Entry |
|
| Symbol |
Plcb2
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
|
| KO |
|
| Organism |
ccan Castor canadensis (American beaver)
|
| Pathway |
| ccan04070 | Phosphatidylinositol signaling system |
| ccan04261 | Adrenergic signaling in cardiomyocytes |
| ccan04613 | Neutrophil extracellular trap formation |
| ccan04621 | NOD-like receptor signaling pathway |
| ccan04723 | Retrograde endocannabinoid signaling |
| ccan04750 | Inflammatory mediator regulation of TRP channels |
| ccan04925 | Aldosterone synthesis and secretion |
| ccan04928 | Parathyroid hormone synthesis, secretion and action |
| ccan04933 | AGE-RAGE signaling pathway in diabetic complications |
| ccan04935 | Growth hormone synthesis, secretion and action |
| ccan04961 | Endocrine and other factor-regulated calcium reabsorption |
| ccan04973 | Carbohydrate digestion and absorption |
| ccan05022 | Pathways of neurodegeneration - multiple diseases |
|
| Module |
| ccan_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:ccan00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
109701244 (Plcb2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
109701244 (Plcb2)
04310 Wnt signaling pathway
109701244 (Plcb2)
04371 Apelin signaling pathway
109701244 (Plcb2)
04020 Calcium signaling pathway
109701244 (Plcb2)
04070 Phosphatidylinositol signaling system
109701244 (Plcb2)
04072 Phospholipase D signaling pathway
109701244 (Plcb2)
04071 Sphingolipid signaling pathway
109701244 (Plcb2)
04022 cGMP-PKG signaling pathway
109701244 (Plcb2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
109701244 (Plcb2)
04081 Hormone signaling
109701244 (Plcb2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
109701244 (Plcb2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
109701244 (Plcb2)
04613 Neutrophil extracellular trap formation
109701244 (Plcb2)
04621 NOD-like receptor signaling pathway
109701244 (Plcb2)
04062 Chemokine signaling pathway
109701244 (Plcb2)
09152 Endocrine system
04911 Insulin secretion
109701244 (Plcb2)
04922 Glucagon signaling pathway
109701244 (Plcb2)
04929 GnRH secretion
109701244 (Plcb2)
04912 GnRH signaling pathway
109701244 (Plcb2)
04915 Estrogen signaling pathway
109701244 (Plcb2)
04921 Oxytocin signaling pathway
109701244 (Plcb2)
04926 Relaxin signaling pathway
109701244 (Plcb2)
04935 Growth hormone synthesis, secretion and action
109701244 (Plcb2)
04918 Thyroid hormone synthesis
109701244 (Plcb2)
04919 Thyroid hormone signaling pathway
109701244 (Plcb2)
04928 Parathyroid hormone synthesis, secretion and action
109701244 (Plcb2)
04916 Melanogenesis
109701244 (Plcb2)
04924 Renin secretion
109701244 (Plcb2)
04925 Aldosterone synthesis and secretion
109701244 (Plcb2)
04927 Cortisol synthesis and secretion
109701244 (Plcb2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
109701244 (Plcb2)
04270 Vascular smooth muscle contraction
109701244 (Plcb2)
09154 Digestive system
04970 Salivary secretion
109701244 (Plcb2)
04971 Gastric acid secretion
109701244 (Plcb2)
04972 Pancreatic secretion
109701244 (Plcb2)
04973 Carbohydrate digestion and absorption
109701244 (Plcb2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
109701244 (Plcb2)
09156 Nervous system
04724 Glutamatergic synapse
109701244 (Plcb2)
04725 Cholinergic synapse
109701244 (Plcb2)
04728 Dopaminergic synapse
109701244 (Plcb2)
04726 Serotonergic synapse
109701244 (Plcb2)
04720 Long-term potentiation
109701244 (Plcb2)
04730 Long-term depression
109701244 (Plcb2)
04723 Retrograde endocannabinoid signaling
109701244 (Plcb2)
09157 Sensory system
04742 Taste transduction
109701244 (Plcb2)
04750 Inflammatory mediator regulation of TRP channels
109701244 (Plcb2)
09159 Environmental adaptation
04713 Circadian entrainment
109701244 (Plcb2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
109701244 (Plcb2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
109701244 (Plcb2)
09174 Infectious disease: parasitic
05146 Amoebiasis
109701244 (Plcb2)
05142 Chagas disease
109701244 (Plcb2)
05143 African trypanosomiasis
109701244 (Plcb2)
09164 Neurodegenerative disease
05010 Alzheimer disease
109701244 (Plcb2)
05016 Huntington disease
109701244 (Plcb2)
05017 Spinocerebellar ataxia
109701244 (Plcb2)
05022 Pathways of neurodegeneration - multiple diseases
109701244 (Plcb2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
109701244 (Plcb2)
05415 Diabetic cardiomyopathy
109701244 (Plcb2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
109701244 (Plcb2)
04934 Cushing syndrome
109701244 (Plcb2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:ccan04131]
109701244 (Plcb2)
Enzymes [BR:ccan01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
109701244 (Plcb2)
Membrane trafficking [BR:ccan04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
109701244 (Plcb2)
Endocytosis
Macropinocytosis
Phospholipase C
109701244 (Plcb2)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
Unknown
|
| AA seq |
1175 aa
MSLLNPVLLPPQVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQRMEFLDIT
SIRDTRFGKFAKIPKSQKLRDVFNMDFPDNHFLLKTLTVVSGPDMVDLTFHNFVSYKENV
GKDWAEDVLALAKHPATTNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVE
AALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSHHAKAKPYMTKEHLT
KFINKKQRDSRLNSLLFPPARPDQVQGLIEKYEPSGINVQRGQLSPEGMVWFLCGPENSV
LAQDKLLLHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWK
GKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSSRQQAKMAE
YCRTMFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGSTVPSKEPDGEAE
DSCPPSAPSGEDTVWAAEEGAELEEMEEEEEESGNLDEEEMKKMQSDEGTASLEVTAYEE
MSSLVNYIQPTKFVSFELSAQKNRSYIISSFTELKAYDLLSKASVQFVDYNKRQMSRIYP
KGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRPD
KQFNPFSVDSIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPN
TNSINPVWKEEPFVFEKILMPELASLRVAVMEESNRFLGHRIIPINALNSGYHHLCLHSE
SNIPLTMPALFVFLELKDYVPDTWADLTVALTNPIKYFSAHDKKSVKLKEATGSLPEKLF
PSGSPVSRQVNGSSVPASNGSAAAGVKEQAPKEAVEPQTASPEELRELKGVVKLQRRHEK
ELRELERRGVRRWEELLQRGVAQLAELGPPAGICKLRPGKGSRKKRIVPSSEEPAGAAPS
ESIEGADPRVQELKDRLEQELQLQGEEQHRCILKRKEQHVAEQIAKMIELAKEKQASELK
TFKETSEIDTKDMKKKLEAKRLERIQAMTKVTTDKMAQERLKREINNSHIKEVVQAVQQM
KETMEQHQQKLEEKQAACLEQIREMEKKFQQEALAEYEARMEGLEAEVKESVRACLKGCF
PSETEDKPERALEASKEPCEQDPLTDKADTQESRL |
| NT seq |
3528 nt +upstreamnt +downstreamnt
atgtctctgcttaaccccgtcctgctgcctccccaggtgaaggcctatctgagccaaggg
gagcgcttcatcaagtgggatgatgaaaccacaatagcctccccggttatcctccgcgtg
gatcccaagggctattatttatactggacatatcagagaatggagtttcttgatatcact
agcatccgggacacccgttttgggaagtttgccaagatacccaagagccagaagctccgg
gatgtcttcaacatggactttccagacaaccacttcctgctgaagaccctcacggtggtg
tcgggccctgacatggtggatctcacctttcacaacttcgtctcctacaaggagaatgtg
ggcaaggactgggctgaggatgtactggccttggctaagcacccagcgacaaccaatgcc
ccccgcagcactttcctggataagatcctggtgaagctcaagatgcagttgaaccctgaa
gggaagattccagtgaagaattttttccagatgtttcctgctgaccgaaagcgagtggaa
gctgctctcagtgcctgccaccttgcaaaaggcaagaatgatgctatcaatcctgaggac
ttcccagagtccgtgtacaagagcttcctcatgagcctctgtcctcggccagaaatcgat
gagatcttcacttcccaccatgctaaagctaaaccttacatgaccaaggaacacctgacc
aaattcatcaacaagaaacagcgggactctcggctcaactccttgctgttcccaccagca
cggcctgaccaggtgcagggtctcattgagaagtatgagcccagcggtatcaacgtgcag
aggggccagctgtcacccgagggcatggtctggtttctctgtggaccagagaacagtgta
ctggcccaagacaaactgctgctccaccaagatatgacacagccactcaatcactacttc
atcaactcttcacacaacacctatctgacagctggccagttctcaggcctttcctcggct
gagatgtaccgccaggtgctgctgtcgggctgccgttgtgtggagctggactgctggaag
ggaaagccccctgacgaggagcccattatcacacacggctttaccatgaccactgacatc
ttgtttaaggaagcaattgaagcaattgcagaaagtgcctttaagacctccccctatcct
gtcatcctgtcatttgaaaaccacgtggactcatcccgccaacaagctaaaatggccgaa
tactgccggaccatgtttggggatatgctgctcacagagcccctggaaaagttcccactg
aaaccaggtgtccctctgcccagccctgaggacctccggggcaaaatcctcatcaagaat
aagaagaaccagttttctggttcaacggttcccagcaaggagcctgatggggaggctgag
gacagctgccctcccagtgccccctcgggggaggacacagtgtgggctgctgaggaaggg
gctgagctggaggagatggaagaggaggaggaggagtcagggaacctggatgaagaagag
atgaagaagatgcagtcggatgagggcacagcgagcctggaggtgacagcttatgaggag
atgtccagcctcgtcaattacatccagcccaccaagtttgtctcctttgagctctctgcc
cagaagaaccgaagttacatcatctcttccttcacggagctcaaggcctatgacctgctc
tctaaggcctcggtgcagtttgtggactacaacaagcgccagatgagccgcatttacccc
aagggcacccgcatggactcttccaattacatgccccagatgttctggaacgctggctgc
cagatggtagccctcaacttccagaccatggacctgcccatgcagcagaacatggcgttg
ttcgagtttaatgggcagagtggctacctcctcaagcatgagttcatgcgccgaccggac
aagcagttcaatcccttctccgtggacagcatcgatgtggtggtagccaccaccctttcc
attacggtgatctctgggcagttcttgtcagaacgcagtgtgcgcacctatgtggaagtg
gagctgtttggccttccaggggaccccaagaggcgctatcgcaccaagctgtcacccaat
accaactccatcaatcctgtctggaaggaggaaccctttgtctttgagaagatcctgatg
cctgagctggcttccctcagggtggctgtgatggaagaaagcaacagatttcttggacac
cgcatcatccccatcaatgcccttaattctggatatcaccatctgtgcctgcacagtgag
agcaacatacccctcaccatgcctgcactcttcgtcttcctggagctgaaggactacgtc
cctgacacctgggcagatctcactgtggccctcaccaaccccatcaagtacttcagtgcc
cacgataagaagtctgtcaagctcaaggaagccacgggaagtctgcctgagaagctcttc
ccatctgggagtccagtttcccgccaggtcaatgggtcgtcagtcccagcaagcaatgga
tcagcagcagctggagtcaaggagcaggcgccgaaagaggctgtggagccgcagacagcc
agccccgaggagctgcgcgagctgaagggcgtcgtgaagctgcagcggcggcacgagaag
gagctgcgggagctggagcggcgtggcgtgcggcgctgggaggagctgctgcagcgcggt
gtggctcagctggccgagctggggccgccggccgggatctgcaagctccgccctggcaag
ggctcccgcaagaagaggatcgtgccctccagcgaggagcccgcgggggctgcgcccagc
gagagcatcgagggtgcagacccacgcgtgcaggagctgaaggacaggctggagcaggag
ctgcagctgcagggtgaggagcagcaccggtgcatcctgaagcgcaaggagcaacacgtg
gctgagcaaatcgccaagatgatagagctggccaaagagaaacaggcctctgagctgaag
accttcaaggagacctcagaaattgacaccaaagacatgaagaaaaagctggaggccaag
aggctggagcgaatacaggccatgaccaaagtcaccacagacaagatggctcaggagagg
ctaaagagagagattaacaactcccacatcaaggaagtggtgcaggctgtccagcagatg
aaggagaccatggagcagcaccagcagaagctagaggagaagcaggcagcctgcctggaa
cagatccgggagatggaaaagaagttccagcaggaggccctggcagagtatgaggccagg
atggagggcctggaggccgaagtcaaggagtcagtaagagcctgcctcaagggctgcttc
ccctccgagactgaggacaagcctgagagagcccttgaggcctccaaggagccctgtgaa
caggatcctctcacagacaaggcagacacccaggagagccgcctctga |