Coregonus clupeaformis (lake whitefish): 121544942 Help Entry 121544942         CDS       T08357                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism cclu  Coregonus clupeaformis (lake whitefish) Pathway cclu04020   Calcium signaling pathway cclu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cclu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121544942    04020 Calcium signaling pathway     121544942  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cclu04040]     121544942 Ion channels [BR:cclu04040]  Voltage-gated cation channels   Ryanodine receptor    121544942 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 Motif Other DBs NCBI-GeneID:  121544942 NCBI-ProteinID:  XP_045065072 LinkDB All DBs Position 29:complement(26066210..26284131) Genome browser AA seq 4896 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIHKENRKFCLTAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKTGQNSEGAAQGGGHRTLLYGHAILLRHSFSAMYLTC LKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSISNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVLRLFHGHDEVLTIPGSDQS DEQQRLVNYETGNAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYLALMEERG VVLQDREKSDTSSTAFCFRASKEKLESSPKRDMEGMGTADIKYGDSICFVMHAATGLWLS YLAPDVKSSRLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSHFIRDL DCLGGKNRASVALPIEEVLQTLNDLITYFQVPDAELEHEEKQIMLRSLKNRQNLFKQEGM LTLVSCCIDRLNVYNSAAHFGECAGADAGASWKDILNLLYELLAALIRGNRNNCTQFSNN LDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIYLGVSEGSAQYKKWY YELMIDQVDHFLTSDPSHLRVGWATNKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLNLWS GRISRAVASINQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGLFFPVVSF SAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKMKVEPVKEYKRDMEGVRDLLGTT PFMSQASFIPTPVETSQIVMPPYLEKVRDRLAENIHELWGMNKIELGWSYGKIREDNKRQ HPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVQVNANAEEDLKKIKLPKNYMMSN GYKPTPLELSDVKLTPGQELLVEKLAENAHNVWAKDRIKQGWTYGIQQDVKSKRNPRLVP YALLDERTKKSNRDSLREAIRILIGYGYNIEPPDQEGGHVVDRLSIDKIRFFRVERTYAV MTGKWYFEFDLVTGGDMRVGWARPGCRPDVELGTDELAFVFDGYKGHRLNMGSRFFGRCW HAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQVGRMN LGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKNHNHIMVTRIDGT IDSPPCLKVSHRTFGTQNSNGDMVYCRLSMPVEFHSFFKTSPVIDMNGVHEEHESLKLKH RHPLKSMRHSHDGIRGTDYSNISTYYYSVRVFAGQDPSCVWVGWVTPDYHYYSNHFNLSK NRTVTVTLGDQRGRVHESVRRSNCYMVWGGDVTSSGHSSSRSNVDLEIGCLIDLATGLVN FTVNGKELATSYQVEPNTKLFPAVFVRPTSPNLFQFELSKIKNAMPLSAAIFKSEHKNPV PQCPPRLDVQTINSVLWSRMPNTFLKVETARVSERHGWVVQCLEPLQMLAVHIPEENRCV DIMELSEQEDLRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLR EGFYNILISIHLETAKEARLMMNNEFIIPITAETRSICLFSDASKHHSPPGVGLSTSLKP RLNFYPPCFISTKREQHLYSPQIPLDALKEKAITMLTEAVQGGGQHIRDPVGGSVEYQFV PILRLIGTLLTMGVLGSQDVHKILLLIDPNVFVEHSEEAVTVVMEATEKEGLTATEKKAV EAGEEEAAKEAKLPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSK LQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSTGEDCPCPEDIQEEL YDFHNELRLHCGIPMEEEEDEQDTSIKGRLLALVYKIKGQPLKTEEEPTEQEQQAPSNLK ELISQTMVSWAQECHIQDPELVRVMFSLLRRQYDSIGELLRAMRKSYTISAASIQDTINL LASLGQIRSLLSVRMGKEEEKLMIDGLGSDIMNNKIFYQHPNLMRVLGMHETVMEVMVNV LGGGKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGST PLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLDKGYPDIGWNPIEGERY LSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISENPA LDLPSSGQGVSYDVSAEDDEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEAL RIRAILRSLVPTEDLVGIISIALKMPVIHKDGTVTEPDMAASFCPDHKAPMVLFLDRVYG IEDQSFLLHLLEVGFLPDLRASASLDTEVLSTTETALAMNRYIGSAMLPLLTRCAPHFAG TEHYAALIDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCRYLRPSMLQQLLRRLVFDVP LLTEYCKMPLRLLTNHYEQSWKYYCLPSGWGSYGMASDEELLLTKKIFWGVLDSLSQRKY DADLFKMAMPCLSAISGALPPDYIDSTISTTLEKPVSVDAQGNFDPKPISTANISLPEKL EHVANKYAEHSHDKWSAEKVMLGWKYGDCIDEKAKTHPQLRTYKGLTEKEKEIYRLPGRE TLKSMLAMGWNIDRTKDGETMSLRESEKMRKISQSSSQGNGFNPTPIDTSDVVLSRELQG MVEVVAENYHNIWAKKKKNDLGIRGGATHPLLVPYDTLTAKEKARDKEKAQDLFRFLQIN GYAITRGLKDMEQDSSSMEKRFAYKFLKKLLKYVNSAQEFIAHLEAIATSGKTDKSPHEQ EIKFFAKVLLPLIDQYFKNHCLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHR ISLFGSDSTTMVSCLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKTLENLKLG KFTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLY ALGTGKNIYVERQLPALGECLATLAGAMPVAFLEPLLNKHNPCSVFNTKTARERAILSMP EAVEEMCPEMPRLDVLMTDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWEKGPENQA SPYSGGRFGGSVFSTTVTSEHLSLILGNILKILNSNLGIDEASWMKRIAVYAQPIISKAR AVLLKSHFLPTLEKLKKKTVKVVMEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYP MLIHYVDNNRSRWLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFL TGDSKTKMSKSGGQDQERKHKRKRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISL AKTRYLLKDTDDEVKEHVRQNLHLQEKSEDPAVRWQLNLYKDVMVKNEGPPDPERTVFRV QSISAAVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLG YQRIWIETETYSFEEKLVQDLAKTQLKVEEEEEEEAEMQPDPLHQLILHFSHNALTERSS LEDDPLYIAYADMMAKSCAEDEEEEDEEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMV LQMISASKGSLGPMVTFTLKLGISILNGGNILVQQKMLDYLKEKGDAGFFKSLSGLMQSC SVLDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDF QNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIMDEAGQRNFSKALAVAK QIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDL QKDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKE YDPESKGVISKKEFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEEFVERFHEPAKDI GFNVAVLLTNLSEHMPHDARLATFLDLAESVINYFEPYLGRIEIMGGAKRIERVYFEISE SSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDAVER PEDDDEDSQSVTELPEEEEEDSMMETHSAFTNSCVSMRKNLSSFRQLLTFKSMRRQYRRF RKMSVREMVQGFFSFFWMIFTGLFRFLYNLVWGFFHILWSSMFGGGLVEGAKNMKVTDIL GNMPDPTQFGIHGDVLEEEKMEASEASSVAEMGHMGQGDKAEADLMAELLNIQTKSQGGK HAAEPGLGDMGEVVGVDAPSLASAVKQKKAKEAATKEPANGDHKVEPEKADPEDGEKKDK DKAKEETPPEPPPEEKKAPKKRPGLKKEPPEAFMASFFSGLDIYQTKMLNYLARNFYNLR FLALFVAFAINFILLFYKVTGDDGDDNDPDPWHGGEATDEEDDESGMEYFVLQESTGYMA PTLRFLAILHTVISFLCVVGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQ WDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEETVVKE ASLVSWLSSIDTKYQCWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFK TLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDNQPDMKCDDMMT CYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFG ELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDET EHTGQESYVWKMYQERLWDFFPAGDCFRKQYEDQLG NT seq 14691 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggtgaaggggaggatgaaattcagttcttgagaactgatgatgaagtg gtgctccagtgtgtcgcctgcatccacaaggagaatcgcaagttctgcttgacagcagag gggctcggcaatcgactgtgctaccttgaacccacatcagaggcaaagtatgtccctcca gacctgtgcatctgcaactttgtgctggagcagtctctctctgtgcgggccttgcaggag atgctggctaagactggccagaacagtgagggggcggctcagggcggtggacacaggaca cttctgtatggacacgctatcctcctgaggcactcctttagcgctatgtatctgacctgt ttgaagacttcaaggtcacagacagataagctgtcctttgatgtggggctgcaggaggac tcaacaggtgaagcctgttggtggaccatccatcctgcttccaaacagaggtcagagggc gagaaggtacgcatcggagatgacctcatccttgtcagcgtgtcatcagaacgatacctt cacctgtccatctccaatggcaacatccaggtggacgcgtccttcatgcagactctgtgg aacgtccaccccacctgctccggcagcaacgtggaggagggttacctgctgggtggccat gtgttgcgtctgttccatggtcatgatgaggttttgaccatcccagggtccgaccagagt gatgagcaacagaggttagtgaactatgagacgggaaatgcaggagccaaggccaggtct ctgtggaggctggagcctctcagaatcagctggagtgggagtcacattcgctggggtcag cccttccgtctccgccacctcaccacggggcactacctggcgctgatggaggagaggggg gtggtgcttcaggaccgggagaagtctgacacatcctccaccgccttctgcttcagagcc tccaaggaaaagctggagtcgagcccaaagcgggacatggagggcatggggacggcggac attaagtatggggactcaatctgcttcgtcatgcatgcggccacgggactctggctgtcc tacctggcgcctgacgtaaaatcatctcgcctgggccctctcaagagacgggcctgcctc cactctgagggtcatatggatgatgggctgaccttgcagcggtgtcagcacgaagagtcc cgtgctgctcgcataatccgtaacaccacccgcctcttcagccacttcatcagagacctg gactgtctggggggaaagaaccgtgcatcagtagccctgcccatcgaggaggtcctccag accctcaatgacctcatcacctacttccaggtgcctgacgctgagctggagcacgaggag aaacagataatgctgcgctctctcaagaaccgacagaacctcttcaaacaggaaggcatg ctgacgctggtgtcctgctgcattgaccgtctcaacgtgtacaacagtgcagcccacttc ggggagtgtgccggggcagatgctggggcttcctggaaggacatccttaacctgctctat gagctgctggctgcgctgatccgaggcaacaggaacaactgcacccagttttccaacaac ctggactggctggtcagcaagctggagagactggagtcctcctcaggcatactggaggtt ctccactgcattctaattgagagcccggaggctctaaatatcatccagagaggacacatc aagtccatcatctccctgctctacaaacatggacgcaaccacaagattttggatgtgctc tgttccctctgtgtgtgtaacggggtggcagtacgagccaatcagaacctcatctgcgat cacctgctccccaaaagagatctgcttctccagacccgattggtcaatgacgtccaaagc atgaggcccaacatctacctgggagtgagtgagggctcggcccagtataagaagtggtac tatgagctgatgattgatcaggtggatcacttcttgaccagcgacccctctcacctgcgc gtgggctgggccaccaacaagggttacgccccttacccaggtggaggggagggttggggg ggcaatggggtgggggacgacctctactcttacggctttgacggacttaatctctggtca ggtcgtatctcccgggcggtggcttctattaaccaacacatcctgacctctgaggatgtg gtgagctgttgtctggacctgggagctcccagcatctccttcaggatcaatggacagccc gtacagggcatgttcgagaacttcaacatcgatggactcttcttccctgttgtcagcttt tccgctggggtcaaggtgcgtttcttgttgggtggtcgtcatggtgacttcaagttcctg cctccgtcaggctacgctccgtgttacgaggccctgctccctaaggagaagatgaaggtg gagccagtgaaggagtacaagagggacatggagggggtccgagacctgctggggaccaca cctttcatgtcccaggcctccttcatacccacccctgtggagaccagccagatcgtcatg ccgccatacctggagaaggtccgggacagactggctgagaatatccacgagctgtggggc atgaacaagatagaactgggctggtcttatgggaagataagggaggacaataagcggcag cacccctgccttgtggatttttccaagctgcctgaaacggaaaagaattataacctgcag atgtcaacggagaccttgaagaccctgctggcattaggctgccatgttgtccaggtcaat gccaacgctgaagaggacctgaagaagatcaaactcccaaagaactacatgatgtcgaat ggttacaagcccacgccactggagctgtctgacgtgaaactgaccccaggccaggaactt ctggtggaaaaactggcggaaaacgcccacaacgtgtgggccaaggacaggatcaaacaa ggatggacctatggcattcagcaggatgtgaagagcaagcggaaccctcgcctggtgcca tatgctttattagacgagcgcactaagaagtccaaccgggacagcctccgtgaggccatc cgcattctgattggatacggatacaatatcgaacctccagatcaggagggcggccatgtg gtggacagactgagcatcgacaagatccgtttcttccgtgtggagaggacgtacgcggtg atgacggggaagtggtactttgagtttgacttggtgacggggggagacatgcgtgttggc tgggccagacctggatgtaggcctgatgtagagctgggcactgacgagctggcctttgtc ttcgacggatacaagggtcatcgtctgaacatgggcagccgtttctttgggcggtgttgg cacgcgggggacgtggtgggctgtatgatcaacatggaggacaagtctatgatcttcacc ctcaacggagagatcctcatcaccaacaagggctctgagctctgcttcgctgacttcgag acggaggacggttttatcccagtgtgtagtctgggcctgtcccaggtgggtcgtatgaac ctggggaaggacgccagtacctttaagtactacaccatgtgtggtctccaggagggcttt gaacccttcgccgtcaacatgaaccgtgaggtcaccatgtggttcagcaaacgcctcccc acctttgtcaatgtgccaaagaaccacaaccacataatggtgactagaatagatggcacc atcgacagccctccctgtctgaaggtgagccacaggacgtttgggacccagaacagtaat ggtgacatggtgtactgtcgtctgagcatgcccgtggagttccactccttcttcaagacc agccctgtcatcgacatgaacggagtgcacgaagagcacgagtccctcaaactgaaacac agacatccattgaagtctatgagacacagtcatgatggaataagaggaacagattacagc aacatcagcacgtactactactctgtcagggttttcgctggtcaggatccatcctgtgtg tgggtgggctgggtcacccctgactaccattactatagcaaccacttcaacctcagtaag aaccggacggtgacggttaccctgggagaccagcgtgggcgggtccatgagagtgtgagg aggagtaactgctacatggtgtggggtggggacgtcaccagctcaggccactcgtccagt cgcagtaatgtggacctggagataggctgtctcattgacctggccactggcctggtgaac ttcactgtcaatgggaaggagctggccacctcctaccaggtggaacccaacacaaagctg tttcctgctgtgtttgtgcgaccaaccagccccaacctcttccagtttgagctgtccaag ataaagaatgccatgcccctttcagctgccatctttaagagtgagcataagaacccagtg ccccagtgccctccgaggctggatgtccagaccatcaactcagtgctgtggagccgtatg ccaaacaccttcctgaaggtggagacagccagggtcagtgagagacacggctgggtggtg cagtgtctggagcccctgcagatgctggctgtacacatacctgaggagaacaggtgtgtt gacatcatggagctgtctgagcaggaggacctgaggaagttccactaccacaccctgaag ctctactgtgccctgtgtgccctgggaaacacccgcgtggcacacgccctctgcagccac ctggaccaatcccagctgctctacaccatcgacaaccagtacctgtcgggcatgctgcgc gagggcttctacaacatcctgatcagcattcacctggagacggccaaggaggcccgcctc atgatgaacaacgagtttattatccccatcaccgccgagacgcgcagcatctgcttgttc tccgatgcctccaagcaccactctcctcccggggtgggcctcagcacctcgctgaagccc cggctcaacttctaccccccctgcttcatcagcaccaagagggagcagcacctgtacagc ccccagatccccctggatgccctgaaggagaaggccatcaccatgctgactgaggcagtg cagggcggtgggcaacacatcagggaccctgtagggggcagcgtggagtaccagtttgtg cccatcctgaggctgattggcacactgctcaccatgggcgtgctgggcagtcaggacgtt cataaaatcctgctcctcatcgaccccaacgtgtttgtggagcacagcgaggaggccgtc accgtggtgatggaggccacagagaaggaggggctgacggccaccgagaagaaggcggtg gaggccggggaggaggaggcggccaaagaggccaagctgccaatgaaaggtctgctggag aagaggctgcctgagccagtcaaacgacagatgtgtgagctgctgcactacttctgtgac tgtgagctgaagcatcgcatcgaggccatcgtgtccttctcagacagctttgtctccaag ctgcagtacaaccagaagttcagatacaacgagctgatgctggccctcaacatgtctgct gctgtcaccgccaagaagaccaaggagttccgctcccctccccaagaacagattaacatg ctgttgaacttcagtacgggggaggactgcccgtgtccagaggacattcaggaggagctc tatgacttccacaatgagctgcggctgcactgtggaatccctatggaggaagaggaagat gagcaggacacgtctattaaaggtcgtctcctggccctggtctacaagatcaaaggtcaa cctctgaagactgaagaggagcccacggagcaggaacaacaagccccctccaaccttaaa gagctgattagccagacaatggtgagctgggctcaggagtgccacatccaggacccggag ctggtcagagtgatgttcagccttctgaggagacagtacgacagcataggagagctgctc cgggccatgaggaagagctacactatcagtgctgcctctatacaggacaccatcaaccta ctggcctctctgggtcagatcagatcactgctgtccgtacgcatgggcaaggaggaggag aaactcatgatcgatggtctgggtagtgacatcatgaacaacaagatattctaccagcac cccaacctgatgcgtgtgctgggcatgcatgagacggtgatggaggtgatggtcaacgtg ctgggaggaggcaagtcccaggagatagcgttccccaagatggtggcaagctgctgtcgc ttcctgtgttacttctgcaggatcagtcgtcagaaccagaaggccatgtttgaccacctc agctacctcctggagaacagcagcgtgggcctggcatccccagccatgaggggctccact cctctagacgtggctgcctcctctgtgatggacaacaacggcctggccttggccctggag gagcccgacctggataaggtggtgacgtacctagcaggctgtgggctccagagttgtccc atgctgctggacaaaggttaccctgacatcggttggaaccccatcgagggcgagcgctac ctctccttcctgcgcttcgctgtctttgtcaatggtgagagtgtggaggagaactccagt gtggtggtgaagctactgatcagacgtccggagtgttttggcccggccctgagaggagag gggggtaacgggctgctagcagccatgaaggaggccatcaagatctctgagaaccctgct ctggacctaccctcctctggccagggggtcagctatgacgtgtctgctgaggatgatgag gaggaagaggtggttcacatgggaaatgccatcatgtccttctactctgctctcatcgac ttattgggacgctgtgccccagagatgcacttgattaacaaggggaaaggggaggccctg cgtatccgtgccatcctgcgctccctagtgcccactgaagacctggtgggcatcatcagc atagccctcaaaatgcccgtcatccacaaagacggcactgtgacagagcctgatatggcg gccagtttctgcccggaccacaaggcccccatggtgctgttcctggaccgggtctatggt atcgaggaccaaagcttcctactacacctgctggaagtgggcttcctgccagacctgcga gcctctgcttctctggacacggaggtacttagcaccacagagacggctctggccatgaac aggtacatcggctctgccatgcttcccctgctcacccgctgtgccccccacttcgctggc acagagcactacgccgcgctcatcgactccacgctgcacaccatctacaggctgtccaag ggccgctcgctcaccaaggcccagagagacgctatcgaggagtgtctgctggctgtctgc aggtacctgcgtccctccatgctgcagcagctcctgcgacgcctcgtctttgacgtgccc ttgctgacggagtactgcaagatgcctctcaggctcctgaccaaccactatgagcagagc tggaagtactactgtctgccgtcaggctggggcagctacggcatggcctcagatgaggag ctgctcctcacaaagaagatattctggggtgtcttggattcgctctcacagaggaagtac gatgcagatctctttaagatggccatgccctgtctgagtgccatatctggggccttaccg cctgactacatagactccaccatcagcaccaccctggagaagcctgtgtctgtggacgct cagggcaactttgaccccaaacccatcagcacagctaacatatctcttccagagaaactg gaacatgttgccaacaaatatgctgagcattcccatgacaaatggtcagcagagaaggtg atgttgggatggaaatacggggactgtatagatgagaaggccaagactcaccctcagctc aggacctacaaaggcctcacagagaaggagaaggagatctacaggttgccgggaagggag actctgaagagcatgctggctatgggctggaacattgacaggaccaaggatggagagacc atgtccctacgggaaagtgagaagatgcgcaagatctcccagtcctcctctcagggtaac ggtttcaacccgaccccaatagacaccagcgatgtggttctgtctagagagttacagggc atggtggaggttgtggctgagaattatcacaacatctgggctaagaagaaaaagaacgac cttggaattagaggtggggcaactcaccctctgctggtgccctatgacaccctgactgcc aaagagaaggccagggacaaagagaaggcccaggacctgttccgcttcctacagatcaac ggctatgctatcaccagaggtctgaaggacatggagcaggactcttcctccatggagaag aggtttgcctacaagttcctcaagaagctcctcaagtatgtgaactcagcccaggagttc atcgcccaccttgaggccatagctaccagtggtaagacagacaagtcacctcatgaacaa gaaataaagtttttcgccaaagtcctcctccctctgatagaccagtacttcaagaaccac tgtctctacttcctgtcttctcccagtaagaacctgagcagcagcggctatgcatctaat aaggagaaggagatggtcaccagcctgttctgtaaactggcagctcttgtcagacacagg atttccctatttgggagtgactccaccaccatggtgagctgtctccacatcctggcccac acactggacaccaggacggtgatgaagtctggctcagagctggtgaaggcggggttaagg acgttctttgagaacgcagcagaggacctggagaagacccttgagaacctgaagctgggg aagttcacccactcccgctcacagatgaagggcgtgtcccagaacattaactacaccacg gtggccctgctacccatcctcactgccctgtttgaacatatcacccagcaccactttgga gtggacctgctcttggatgatgtccaagtgtcctgctatcgtatcctgaccagcctctat gcgctcgggactggaaaaaacatctatgttgaaaggcagctgccggccctgggggagtgt ctggccaccctggcaggtgccatgcctgttgccttcctggagccactgctcaacaaacac aacccctgctctgtgttcaacaccaagaccgcccgcgaacgcgccatcctaagcatgcca gaggcggtggaggagatgtgtccggagatgcctcgtctagacgtcctgatgacggacatc aacgacatgtctgagtctggggcgcgctacacagagatgccccacgtcatcgaggtggtg ctgcccatgctgtgtaactacctgtcctactggtgggagaagggcccagagaaccaggcg tctccatacagcgggggcagatttgggggcagtgtgttctccaccaccgtcacctcagaa cacctcagcctcatcctaggaaacatcctgaagatcctcaacagcaacctgggcatcgac gaggcctcctggatgaagaggatcgcagtgtacgcccagcccatcatcagtaaggccagg gctgttctgttgaagagtcatttcctgcctacgctggagaagctgaagaagaagacagtg aaggtggtgatggaggaggagctactgaaggctgacagtaagggagacacccaggaggct gagctcctcatcctggatgagtttgccgtgctctgcagagacctctacgccttctacccg atgctcatccattacgtagacaacaacaggtccaggtggctgaaagaaccagacgctgac tccaatgaactcttcagaatggtggctgagatcttcatcctctggtgcaaatcacataac ttcaaaagggaagagcagaactttgtggttcagaatgaaatcaacaacctgtctttcctg actggtgatagcaagacgaagatgtcaaagtcagggggtcaggaccaggagaggaagcat aagaggaagcgaggagagttctactccatccagacctccctgatcgtggctgccctgaag aagatgctgcccatcggactcaacatgtgcacccccggggaccaggagctaatctccctg gccaagacacgctacctcctgaaagacacagatgatgaagtgaaggaacatgtgcggcaa aatttgcaccttcaagagaagtcagaggaccctgcagtgaggtggcagctgaacctgtat aaggatgtgatggtgaagaacgaggggcctccagaccctgagaggacagtgttcagagtc cagagcatctcagctgcagtcttccacctggagcaggtggagcagccattgaggtctaag aagtgtgtttggcagaagctgctgtccaagcagagaaagcgtgcggtggtggcctgcttc cgcatggctcctctctacaaccttcccaggcatcgctctattaacctcttcctcctgggc tatcagagaatatggatagaaacagagacgtactcttttgaagagaagctagtgcaggac ctggcaaagacccaactgaaggtggaggaggaggaagaggaggaggcagagatgcagcca gaccctcttcatcagctcatattgcattttagtcacaatgcgctcactgagcggagttct ttggaagacgatcctttgtatattgcatatgcagacatgatggcaaagagttgtgcagaa gatgaagaagaggaagatgaagaaggaaaagagaaaacatttgaggaaaaagagatggag aaacagaagactctgtaccagcaggccaggctgcatgacagaggagctgctgagatggtg ttacagatgatcagcgccagcaaaggttcacttgggcccatggtgacctttaccttgaaa ctgggcatctctatactcaacggaggcaacatactggttcagcagaaaatgcttgactat ctgaaggaaaaaggagatgctggctttttcaagagtttgtcaggactcatgcagtcttgc agtgtcctggatttgaatgcattcgaaaggcaaaacaaagcagaaggtcttgggatggtg actgaggaaggatcaatcaacgtgagtgagcggggttccaaagtactgcagaacgatgag ttcactaaggatctctttaggtttctgcaactgctctgtgagggacacaacaacgacttc caaaacttcctgcggactcaaacagggaacacgaccaccgtaaatatcatcatcagcact gtggactacctgctccgtctgcaggaatccatcagtgatttctactggtactactctggg aaagatatcatggatgaggctggtcagcggaacttctccaaagccctggctgtggccaag cagatcttcaactctctcactgagtacatacagggcccgtgtattgggaaccagcagagt ctggcacacagcaggctatgggatgcagtggtgggattcctgcatgtgtttgccaatatg cagatgaagctctcacaggactcaagtcagattgagttattgaaggagctgctggacctg cagaaggacatgatcgtgatgatgctctcccttctggaaggtaacgttgtcaacggaacc atcggcaaacagatggtggacaccctggtggagtcctccagcaatgtggagatgatcctc aagttcttcgacatgtttctcaaactcaaagaccttaccacctcggacaacttcaaggag tacgacccggagagcaagggagtgatctccaagaaggagttccagaagtccatggagaac caaaagcagtactcccagtcggagatcgagttcctgctctcctgcgccgaggctgacgag aacgacatgttcaactacgaggagtttgtggagcgctttcatgagccggccaaggacatt ggctttaacgtggcggtcctgctcaccaacctatcagaacacatgcctcacgacgcccgt ctggccaccttcctggacctggccgagagtgtgatcaactacttcgagccgtacctgggc cgcatagagatcatgggcggggccaagcgcatcgaaagggtctactttgagatcagcgag tctagtcgtacacagtgggagaagccccaggtcaaagagtccaagagacagtttatcttt gacgtggtgaacgagggtggagagagcgagaagatggagctgtttgtcaacttctgtgag gacaccatttttgagatgcagctggcctcacagatatctgagcctgatgcagtggagcgt cccgaggacgacgacgaggacagccagagtgtgacggagttgccagaggaggaagaggag gacagcatgatggagactcactccgccttcaccaactcctgtgtttccatgaggaagaac ctgtccagcttccgccagctgctcaccttcaaaagcatgaggcggcagtacaggaggttc aggaagatgagtgtgagggagatggtccaaggcttcttttctttcttctggatgattttc acgggcctcttccgcttcctctacaacctggtgtggggcttcttccacatcctgtggtcc tccatgtttggcgggggcctggtggagggggccaagaacatgaaggtcacagacatcctg gggaacatgcccgaccccacacagtttggtatccatggtgatgtgctggaggaagagaag atggaggcgagtgaggcgtcatctgtggcagagatgggccacatgggccagggggacaag gcagaggcagacctgatggctgagctgcttaacatccaaaccaagagccaggggggaaag catgcggccgagccaggtctgggggacatgggtgaggtggtgggggttgacgccccctct ttagccagtgccgtcaagcagaagaaggccaaggaggctgcgactaaggagcctgccaac ggagaccacaaagtcgagccagagaaagcagacccagaggatggggagaagaaggacaag gacaaagccaaagaggagactcccccagaacccccaccggaggagaagaaggcccccaag aagagacctggactgaagaaagagcccccagaggccttcatggccagcttcttctctggc ctggacatctaccagaccaagatgctgaactatctggccagaaacttctacaacctgcgt ttcttggcattgttcgttgcatttgccataaactttattctgctcttctacaaagtgact ggtgatgacggggatgacaatgatccagatccctggcatggaggtgaagctactgatgaa gaggatgatgaaagtgggatggagtattttgtcctccaggagagcacaggctacatggca cccacactgcgcttcctggccatactacacacagtcatctctttcctgtgtgtggtggga tactactacctaaaggtgcctctggtggtgttcaagagagagaaggagatcgccaggaag ctggagtttgacggcctctacatcacagagcagccgtcagatgatgacatcaaaggacag tgggaccgcctcgtcatcaataccccttccttccctaataactactgggacaagtttgtg aaacgcaaggtgatcaataagtatggagatctgtatggagcagagaggatagcagagctt ctggggctggataagagtgctctggacttcaaccccacagaggagacggtggtgaaggag gcatcgctggtgtcctggttgagctctattgacaccaagtaccagtgctggaaaatgggt gtggtgtttacagacaattcattcctgtacctggtgtggtacaccaccatgtccatcctg ggtcactacaacaacttcttcttcgctgcccatctgctggacatcgccatgggcttcaag accctccggaccattctgtcctcggtcacccacaatggcaaacagctggttctgactgta ggtctcctggcggtggtggtctatctgtacactgtggtggccttcaacttcttccgcaag ttctacaacaagagtgaggatgacaaccagcccgacatgaagtgtgacgacatgatgact tgctacctgttccacatgtacgttggtgtgagggcagggggtggcatcggcgatgagatc gaggaccctgcgggcgacccgtacgagctctaccgcatcctcttcgacatcaccttcttc ttcttcgtcatcgtcatcctgctggccatcatccagggtctgatcattgatgcttttgga gagctgagagaccaacaggaacaagtgaaagaggatatggagaccaaatgtttcatctgt ggcatcggtaatgactactttgacacgacgcctcacggctttgagacacacaccttacaa gagcacaacttggccaactacctgtttttcctgatgtaccttatcaacaaagatgagaca gaacacactggtcaggagtcatacgtgtggaagatgtaccaggagaggctctgggacttt ttccctgctggagactgtttcagaaagcagtatgaggatcagcttggatag

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