KEGG   Crocuta crocuta (spotted hyena): 144216498
Entry
144216498         CDS       T11532                                 
Symbol
MAPK1
Name
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ccru  Crocuta crocuta (spotted hyena)
Pathway
ccru01521  EGFR tyrosine kinase inhibitor resistance
ccru01522  Endocrine resistance
ccru01524  Platinum drug resistance
ccru04010  MAPK signaling pathway
ccru04012  ErbB signaling pathway
ccru04014  Ras signaling pathway
ccru04015  Rap1 signaling pathway
ccru04022  cGMP-PKG signaling pathway
ccru04024  cAMP signaling pathway
ccru04062  Chemokine signaling pathway
ccru04066  HIF-1 signaling pathway
ccru04068  FoxO signaling pathway
ccru04071  Sphingolipid signaling pathway
ccru04072  Phospholipase D signaling pathway
ccru04114  Oocyte meiosis
ccru04140  Autophagy - animal
ccru04148  Efferocytosis
ccru04150  mTOR signaling pathway
ccru04151  PI3K-Akt signaling pathway
ccru04210  Apoptosis
ccru04218  Cellular senescence
ccru04261  Adrenergic signaling in cardiomyocytes
ccru04270  Vascular smooth muscle contraction
ccru04350  TGF-beta signaling pathway
ccru04360  Axon guidance
ccru04370  VEGF signaling pathway
ccru04371  Apelin signaling pathway
ccru04380  Osteoclast differentiation
ccru04510  Focal adhesion
ccru04517  IgSF CAM signaling
ccru04520  Adherens junction
ccru04540  Gap junction
ccru04550  Signaling pathways regulating pluripotency of stem cells
ccru04611  Platelet activation
ccru04613  Neutrophil extracellular trap formation
ccru04620  Toll-like receptor signaling pathway
ccru04621  NOD-like receptor signaling pathway
ccru04625  C-type lectin receptor signaling pathway
ccru04650  Natural killer cell mediated cytotoxicity
ccru04657  IL-17 signaling pathway
ccru04658  Th1 and Th2 cell differentiation
ccru04659  Th17 cell differentiation
ccru04660  T cell receptor signaling pathway
ccru04662  B cell receptor signaling pathway
ccru04664  Fc epsilon RI signaling pathway
ccru04666  Fc gamma R-mediated phagocytosis
ccru04668  TNF signaling pathway
ccru04713  Circadian entrainment
ccru04720  Long-term potentiation
ccru04722  Neurotrophin signaling pathway
ccru04723  Retrograde endocannabinoid signaling
ccru04724  Glutamatergic synapse
ccru04725  Cholinergic synapse
ccru04726  Serotonergic synapse
ccru04730  Long-term depression
ccru04810  Regulation of actin cytoskeleton
ccru04910  Insulin signaling pathway
ccru04912  GnRH signaling pathway
ccru04914  Progesterone-mediated oocyte maturation
ccru04915  Estrogen signaling pathway
ccru04916  Melanogenesis
ccru04917  Prolactin signaling pathway
ccru04919  Thyroid hormone signaling pathway
ccru04921  Oxytocin signaling pathway
ccru04926  Relaxin signaling pathway
ccru04928  Parathyroid hormone synthesis, secretion and action
ccru04929  GnRH secretion
ccru04930  Type II diabetes mellitus
ccru04933  AGE-RAGE signaling pathway in diabetic complications
ccru04934  Cushing syndrome
ccru04935  Growth hormone synthesis, secretion and action
ccru04960  Aldosterone-regulated sodium reabsorption
ccru05010  Alzheimer disease
ccru05020  Prion disease
ccru05022  Pathways of neurodegeneration - multiple diseases
ccru05034  Alcoholism
ccru05132  Salmonella infection
ccru05133  Pertussis
ccru05135  Yersinia infection
ccru05140  Leishmaniasis
ccru05142  Chagas disease
ccru05145  Toxoplasmosis
ccru05152  Tuberculosis
ccru05160  Hepatitis C
ccru05161  Hepatitis B
ccru05163  Human cytomegalovirus infection
ccru05164  Influenza A
ccru05165  Human papillomavirus infection
ccru05166  Human T-cell leukemia virus 1 infection
ccru05167  Kaposi sarcoma-associated herpesvirus infection
ccru05170  Human immunodeficiency virus 1 infection
ccru05171  Coronavirus disease - COVID-19
ccru05200  Pathways in cancer
ccru05203  Viral carcinogenesis
ccru05205  Proteoglycans in cancer
ccru05206  MicroRNAs in cancer
ccru05207  Chemical carcinogenesis - receptor activation
ccru05208  Chemical carcinogenesis - reactive oxygen species
ccru05210  Colorectal cancer
ccru05211  Renal cell carcinoma
ccru05212  Pancreatic cancer
ccru05213  Endometrial cancer
ccru05214  Glioma
ccru05215  Prostate cancer
ccru05216  Thyroid cancer
ccru05218  Melanoma
ccru05219  Bladder cancer
ccru05220  Chronic myeloid leukemia
ccru05221  Acute myeloid leukemia
ccru05223  Non-small cell lung cancer
ccru05224  Breast cancer
ccru05225  Hepatocellular carcinoma
ccru05226  Gastric cancer
ccru05230  Central carbon metabolism in cancer
ccru05231  Choline metabolism in cancer
ccru05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccru05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccru00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    144216498 (MAPK1)
   04012 ErbB signaling pathway
    144216498 (MAPK1)
   04014 Ras signaling pathway
    144216498 (MAPK1)
   04015 Rap1 signaling pathway
    144216498 (MAPK1)
   04350 TGF-beta signaling pathway
    144216498 (MAPK1)
   04370 VEGF signaling pathway
    144216498 (MAPK1)
   04371 Apelin signaling pathway
    144216498 (MAPK1)
   04668 TNF signaling pathway
    144216498 (MAPK1)
   04066 HIF-1 signaling pathway
    144216498 (MAPK1)
   04068 FoxO signaling pathway
    144216498 (MAPK1)
   04072 Phospholipase D signaling pathway
    144216498 (MAPK1)
   04071 Sphingolipid signaling pathway
    144216498 (MAPK1)
   04024 cAMP signaling pathway
    144216498 (MAPK1)
   04022 cGMP-PKG signaling pathway
    144216498 (MAPK1)
   04151 PI3K-Akt signaling pathway
    144216498 (MAPK1)
   04150 mTOR signaling pathway
    144216498 (MAPK1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    144216498 (MAPK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    144216498 (MAPK1)
   04148 Efferocytosis
    144216498 (MAPK1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    144216498 (MAPK1)
   04210 Apoptosis
    144216498 (MAPK1)
   04218 Cellular senescence
    144216498 (MAPK1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    144216498 (MAPK1)
   04520 Adherens junction
    144216498 (MAPK1)
   04540 Gap junction
    144216498 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    144216498 (MAPK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    144216498 (MAPK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    144216498 (MAPK1)
   04613 Neutrophil extracellular trap formation
    144216498 (MAPK1)
   04620 Toll-like receptor signaling pathway
    144216498 (MAPK1)
   04621 NOD-like receptor signaling pathway
    144216498 (MAPK1)
   04625 C-type lectin receptor signaling pathway
    144216498 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    144216498 (MAPK1)
   04660 T cell receptor signaling pathway
    144216498 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    144216498 (MAPK1)
   04659 Th17 cell differentiation
    144216498 (MAPK1)
   04657 IL-17 signaling pathway
    144216498 (MAPK1)
   04662 B cell receptor signaling pathway
    144216498 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    144216498 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    144216498 (MAPK1)
   04062 Chemokine signaling pathway
    144216498 (MAPK1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    144216498 (MAPK1)
   04929 GnRH secretion
    144216498 (MAPK1)
   04912 GnRH signaling pathway
    144216498 (MAPK1)
   04915 Estrogen signaling pathway
    144216498 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    144216498 (MAPK1)
   04917 Prolactin signaling pathway
    144216498 (MAPK1)
   04921 Oxytocin signaling pathway
    144216498 (MAPK1)
   04926 Relaxin signaling pathway
    144216498 (MAPK1)
   04935 Growth hormone synthesis, secretion and action
    144216498 (MAPK1)
   04919 Thyroid hormone signaling pathway
    144216498 (MAPK1)
   04928 Parathyroid hormone synthesis, secretion and action
    144216498 (MAPK1)
   04916 Melanogenesis
    144216498 (MAPK1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    144216498 (MAPK1)
   04270 Vascular smooth muscle contraction
    144216498 (MAPK1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    144216498 (MAPK1)
  09156 Nervous system
   04724 Glutamatergic synapse
    144216498 (MAPK1)
   04725 Cholinergic synapse
    144216498 (MAPK1)
   04726 Serotonergic synapse
    144216498 (MAPK1)
   04720 Long-term potentiation
    144216498 (MAPK1)
   04730 Long-term depression
    144216498 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    144216498 (MAPK1)
   04722 Neurotrophin signaling pathway
    144216498 (MAPK1)
  09158 Development and regeneration
   04360 Axon guidance
    144216498 (MAPK1)
   04380 Osteoclast differentiation
    144216498 (MAPK1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    144216498 (MAPK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    144216498 (MAPK1)
   05206 MicroRNAs in cancer
    144216498 (MAPK1)
   05205 Proteoglycans in cancer
    144216498 (MAPK1)
   05207 Chemical carcinogenesis - receptor activation
    144216498 (MAPK1)
   05208 Chemical carcinogenesis - reactive oxygen species
    144216498 (MAPK1)
   05203 Viral carcinogenesis
    144216498 (MAPK1)
   05230 Central carbon metabolism in cancer
    144216498 (MAPK1)
   05231 Choline metabolism in cancer
    144216498 (MAPK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    144216498 (MAPK1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    144216498 (MAPK1)
   05212 Pancreatic cancer
    144216498 (MAPK1)
   05225 Hepatocellular carcinoma
    144216498 (MAPK1)
   05226 Gastric cancer
    144216498 (MAPK1)
   05214 Glioma
    144216498 (MAPK1)
   05216 Thyroid cancer
    144216498 (MAPK1)
   05221 Acute myeloid leukemia
    144216498 (MAPK1)
   05220 Chronic myeloid leukemia
    144216498 (MAPK1)
   05218 Melanoma
    144216498 (MAPK1)
   05211 Renal cell carcinoma
    144216498 (MAPK1)
   05219 Bladder cancer
    144216498 (MAPK1)
   05215 Prostate cancer
    144216498 (MAPK1)
   05213 Endometrial cancer
    144216498 (MAPK1)
   05224 Breast cancer
    144216498 (MAPK1)
   05223 Non-small cell lung cancer
    144216498 (MAPK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    144216498 (MAPK1)
   05170 Human immunodeficiency virus 1 infection
    144216498 (MAPK1)
   05161 Hepatitis B
    144216498 (MAPK1)
   05160 Hepatitis C
    144216498 (MAPK1)
   05171 Coronavirus disease - COVID-19
    144216498 (MAPK1)
   05164 Influenza A
    144216498 (MAPK1)
   05163 Human cytomegalovirus infection
    144216498 (MAPK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    144216498 (MAPK1)
   05165 Human papillomavirus infection
    144216498 (MAPK1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    144216498 (MAPK1)
   05135 Yersinia infection
    144216498 (MAPK1)
   05133 Pertussis
    144216498 (MAPK1)
   05152 Tuberculosis
    144216498 (MAPK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    144216498 (MAPK1)
   05140 Leishmaniasis
    144216498 (MAPK1)
   05142 Chagas disease
    144216498 (MAPK1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    144216498 (MAPK1)
   05020 Prion disease
    144216498 (MAPK1)
   05022 Pathways of neurodegeneration - multiple diseases
    144216498 (MAPK1)
  09165 Substance dependence
   05034 Alcoholism
    144216498 (MAPK1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    144216498 (MAPK1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    144216498 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    144216498 (MAPK1)
   04934 Cushing syndrome
    144216498 (MAPK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    144216498 (MAPK1)
   01524 Platinum drug resistance
    144216498 (MAPK1)
   01522 Endocrine resistance
    144216498 (MAPK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccru01001]
    144216498 (MAPK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ccru03036]
    144216498 (MAPK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ccru04147]
    144216498 (MAPK1)
Enzymes [BR:ccru01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     144216498 (MAPK1)
Protein kinases [BR:ccru01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   144216498 (MAPK1)
Chromosome and associated proteins [BR:ccru03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     144216498 (MAPK1)
Exosome [BR:ccru04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   144216498 (MAPK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH RIO1 STATB_N Haspin_kinase FTA2 Kdo Kinase-like
Other DBs
NCBI-GeneID: 144216498
NCBI-ProteinID: XP_077601999
LinkDB
Position
Unknown
AA seq 326 aa
MHHVPSSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT
IEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSN
LLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV
GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVP
WNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPVAEAPFKFDME
LDDLPKEKLKELIFEETARFQPGYRS
NT seq 981 nt   +upstreamnt  +downstreamnt
atgcatcatgtacccagctctgcttatgataatgtcaacaaagttcgagtagctatcaag
aaaatcagtccttttgagcaccagacctactgccagagaaccctgagggagataaaaatc
ttactgcgcttcagacatgagaacattattggaatcaatgatattattcgagcaccaacc
atcgagcaaatgaaagatgtatatatagtacaggacctcatggaaacagatctctacaag
ctcttgaagacacaacacctcagcaacgaccatatctgctattttctttaccagatcctc
agagggttaaaatatatccattcagccaatgtactacaccgtgacctcaaaccttccaac
ctgctgctcaacaccacctgcgatctcaagatctgtgactttggcttggcccgtgttgca
gatccggaccatgatcacacagggttcctgacggagtatgtagccacacgttggtacagg
gctccggaaattatgttgaattccaagggctataccaagtccattgatatttggtctgta
ggctgcattctggcagagatgctgtccaacaggcccatcttcccggggaagcattatctc
gaccagctgaaccacattctgggtattcttggatccccatcacaggaagacctgaactgc
ataataaatttaaaagctagaaactacttgctttctcttccacacaaaaataaggtgcca
tggaacaggctgttcccaaatgctgactccaaagctctggatttactggacaaaatgttg
acattcaaccctcacaagaggattgaagtagaacaggctctggcccatccatacctggag
cagtattatgacccaagtgatgagcccgttgctgaggcaccgttcaagttcgacatggag
ctggacgacctgcccaaggaaaagctcaaagaactcatcttcgaagaaacggccaggttc
cagccgggatacaggtcttaa

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