Crocuta crocuta (spotted hyena): 144219770
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Entry
144219770 CDS
T11532
Symbol
NF1
Name
(RefSeq) LOW QUALITY PROTEIN: neurofibromin
KO
K08052
neurofibromin 1
Organism
ccru Crocuta crocuta (spotted hyena)
Pathway
ccru01521
EGFR tyrosine kinase inhibitor resistance
ccru04010
MAPK signaling pathway
ccru04014
Ras signaling pathway
Brite
KEGG Orthology (KO) [BR:
ccru00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
144219770 (NF1)
04014 Ras signaling pathway
144219770 (NF1)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
144219770 (NF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PH_NF1
RasGAP
CRAL_TRIO_2
CRAL_TRIO
MIF4G_like_2
Motif
Other DBs
NCBI-GeneID:
144219770
NCBI-ProteinID:
XP_077605984
LinkDB
All DBs
Position
Unknown
AA seq
2836 aa
AA seq
DB search
MMPYRRRWLPPSQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNN
MRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREG
NQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDC
AKLKRLLKETAFKFKSLKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAE
KLFDLVDGFAESTKRKAAVWPLQIILLVLCPEIIQDISKDVVDENNMNKKLFLDSLRKAL
AGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRG
SQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWP
KIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDVETR
SYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAME
ALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICR
NKFLLKNKQADRSSCHFLFLYGVGCDVPSSGATSQMSMDHEELMRTCTPGASLRKGKGNS
SMESAAGCGSAPPICRQAHTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDE
VSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWE
QATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLC
ALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCN
HEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTI
AIMKNLLDNHTEGSSEHLGQASIETMMLNLVRXVFLLKHLQXVHAIQIKTKLCQLVEVMM
ARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGL
PLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRH
CTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLAD
RFERLVELVTMMGDQGELPIAMALASVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSK
EVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSEWQHVSFEVDP
TRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATAK
EKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMS
KILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDTVNHSLSFISDGN
VLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLN
LTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLL
IYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCN
SWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNA
LKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTI
ANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLG
SSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLT
LEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTI
NEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNV
KLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYL
FHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYL
LFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTC
KWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPD
TYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVSLYSAGSALLEQNLH
TLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSP
AIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLL
TDISMENVPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAATYPTVGQTSPRARKSMS
LDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQR
ISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYL
AEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYL
QSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYP
PAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPASGHCSSGRTRHGSASQVQK
QRSAGSFKRNSIKKIV
NT seq
8511 nt
NT seq
+upstream
nt +downstream
nt
atgatgccgtataggaggagatggctgccaccttcacagcttccaataaaaacaggacag
cagaacacgcataccaaagtcagtactgaacacaacaaggaatgtcttattaatatttcc
aaatacaagttttctttggttatcagcggcctcaccactatcttaaagaatgttaacaat
atgagaatatttggagaagccgccgaaaaaaatttgtatctctctcagttgattatattg
gatacactggaaaaatgtcttgctgggcaaccaaaggacacaatgagattagatgaaacg
atgctggtcaaacagttgctgccagaaatctgccattttcttcacacctgtcgtgaagga
aaccagcatgcagctgaacttcggaattctgcgtctggggttttgttttctctcagttgc
aacaacttcaatgcggtgtttagtcgcatttctaccaggttacaagaattgactgtttgt
tcagaagacaatgttgacgttcatgatatagaattgttacagtatatcaatgtggattgc
gcaaaattaaaacgactcctaaaggaaacagcatttaaatttaaatccctaaagaaggtt
gcacagttagcagttataaatagcctggaaaaagcattttggaactgggtagaaaattat
ccagatgagtttacgaagctgtaccagattccacagacagatatggctgagtgtgcagag
aaactgtttgacctggtggatggttttgccgaaagcaccaaacgtaaagcagcagtttgg
ccgctgcaaatcattctccttgtcttgtgcccagagataatccaggatatatcgaaggat
gtggttgatgaaaacaacatgaataagaagttgtttctggacagcctacggaaagcactc
gctggccacggaggaagcaggcagctgaccgagagtgctgcgatcgcctgtgtgaaactg
tgtaaggccagtacttacatcaactgggaggacaactctgtcatcttcctactagtccag
tccatggtggtggatcttaagaacctgctttttaatccaagtaagccattctcaagaggc
agtcagcccgcagatgtggatctcatgattgactgccttgtttcttgctttcgtataagt
cctcacaacaaccaacactttaagatctgcctggctcagaattccccttctacatttcac
tacgtgctggtaaattcactccatcgaatcatcaccaattctgcgttggattggtggcct
aagattgatgctgtgtactgtcactcagtcgagcttcgaaacatgtttggtgaaacgctt
cataaagcggtgcagggctgtggagcccacccggcaatacgaatggccccgagtcttacg
tttaaagaaaaagtaacaagccttaaatttaaagaaaaacctacagacgtggagacaaga
agctataagtatcttctcctgtccatggtgaaactcattcatgcggatccaaagctcttg
ctttgtaaccccaggaagcaggggcctgagacccagggcagcacagcggagttaattaca
gggcttgtgcagctggtccctcagtcacacatgcccgagatcgctcaggaggcaatggag
gccctgctcgttcttcatcagttagatagcattgatttgtggaatcctgatgctcctgtg
gaaacgttttgggaaattagctctcaaatgcttttttacatctgcaagaaattaactagc
catcaaatgcttagtagcacagaaattctcaaatggttgcgggaaattttgatctgcagg
aataaatttcttcttaaaaataagcaggcagatagaagttcctgtcactttctcttcctt
tatggggtaggatgtgacgttccttcaagtggagctaccagtcagatgtccatggatcat
gaagaattaatgcgcacctgcactcccggagcctctcttcggaagggaaaaggaaactcg
tccatggagagcgcggcagggtgcggcagcgccccacccatatgccggcaggcgcacacc
aaactggaagtggccctgtacatgtttctgtggagccctgacaccgaagccgtcctggtg
gccatgtcctgtttccgccacctctgtgaggaagcagacatccgctgtggggtggatgaa
gtgtcggtgcacaacttcctgcccaactataacacgttcatggagtttgcctctgtcagc
aatatgatgtcaacaggaagagcagcgcttcagaagagagtgatggcacttctcaggcgc
atcgagcaccccactgcagggaacacggaggcttgggaagatacacatgcaaagtgggaa
caagccacgaaactaatcctcaactatccaaaagcgaaaatggaagatggccaggcagca
gaaagccttcacaagaccattgttaagaggcgaatgtctcacgtgagtggaggaggatcc
atagatttgtctgacacggactccctgcaggagtggatcaacatgaccggcttcctgtgt
gcccttgggggagtgtgcctgcagcagagaagcaactctggcttggcaacctacagcccg
cccatgggcccagtcagcgaacgcaagggctccatgatttccgtgatgtcctcggaggga
aatgcagatacacctgtcagcaaattcatggaccggctcttatccttaatggtgtgtaac
catgagaaagtgggacttcagatacggaccaacgttaaggatctggtgggcctagaattg
agtcctgctctttatccaatgctgtttaacaaactgaagaacactatcagcaagttcttt
gactcccagggacaggttttattgactgacaccaacactcagtttgtggagcaaaccata
gctatcatgaagaacttactagataatcatactgaaggcagctctgaacatctggggcaa
gctagcattgaaacaatgatgttaaatctagtcaggtaagtatttctattaaaacatttg
caaaangtccatgcaattcaaatcaaaacaaaactgtgtcagttggtcgaggtgatgatg
gcaaggagagatgacctctcgttttgtcaagagatgaaatttaggaataagatggtagaa
tacctgacagactgggtcatgggaacatcaaaccaggcagcagatgatgatgtaaagtgt
cttacaagagacttggaccaggcgagtatggaagcagtcgtgtcactcctggccggcctt
ccgctgcagcccgaggaaggagacggcgtggaattgatggaagccaaatcacagttattt
cttaagtatttcacgttgtttatgaaccttttgaacgactgtagtgaagttgaagatgaa
aatgcacaaacaggcggcaggaaacgtggcatgtctcggaggctggcatcactgaggcac
tgtaccgtacttgcaatgtccaacctactcaatgcgaatgtggacagtggcctcatgcac
tccataggtttaggttatcacaaagatcttcagacaagagccacatttatggaagttctg
accaaaatcctccagcagggcacagaatttgacacacttgcagaaacggtgctggccgac
cggtttgagaggctggtagagctggtgacgatgatgggggaccaaggggagctgccgata
gccatggctctggccagcgtggtcccgtgttctcagtgggatgaactagctcgagttcta
gtcactctgtttgattctcgccatttgctctaccaactgctctggaacatgttttctaag
gaggtagaattggcagactccatgcagactcttttccggggaaacagcttagccagtaaa
atcatgaccttctgtttcaaggtatatggtgctacctacctacagaaactcctggatccg
ttattacgaatcgtaatcacatcctctgagtggcagcacgttagctttgaagtggatccc
accaggttagaacagtcagagagccttgaggaaaaccagcggaaccttcttcagatgact
gaaaagttcttccatgccatcattagttcctcctcagaattcccccctcagcttcgaagt
gtatgccactgtttataccaggcaacttgccactccctactgaataaagctacagcaaaa
gaaaaaaaggaaaacaaaaaatccgttgttagccagcgtttccctcagaacagcatcggt
gcggtgggaagtgccatgttcctcagatttatcaatcctgccattgtctcaccgtatgaa
gcagggattttagataaaaagccgccacctagaattgaaaggggcttgaagttaatgtca
aagatacttcagagcattgccaatcatgttctcttcacaaaagaagagcatatgcggcct
tttaatgattttgtgaaaagcaactttgatgcagcacggaggtttttccttgatatagca
tcggactgtcctacaagtgacacagtgaaccatagcctctccttcatcagcgatggcaat
gtgctcgctttacatcgtctcctctggaacaatcaagagaaaattggccagtatctttct
agcaacagggatcacaaagctgttggaagacgaccttttgataagatggcaacacttctt
gcctacctgggtcctccggagcacaaacccgtggccgacacacactggtccagccttaac
cttaccagttcaaagtttgaggaatttatgactaggcatcaagtacatgaaaaagaagag
ttcaaggctttgaaaacattaagtattttctaccaagctgggacttccaaagctgggaat
cctatattttattatgtggcacggaggtttaaaactggtcagatcaatggtgatttgctg
atttaccacgtcttgctgaccttaaagccatattatgcaaagccatatgaaatcgtagtg
gaccttactcacaccgggcctagcaatcgctttaaaacggacttcctctccaagtggttt
gttgtttttcctggctttgcttacgacaacgtctctgcagtctacatctataactgtaac
tcctgggtcagggagtacaccaagtaccacgagcggctgctcacgggcctcaaaggcagc
aagaggctcattttcatagactgtcctgggaagctggctgagcacatagagcacgagcaa
cagaagctccccgctgccacactggccttagaagaggacctgaaggtgttccacaatgct
ctcaagctggcgcacaaagacaccaaggtctctattaaagttggttctactgctgttcaa
gtaacctcagcagagcgaacaaaggtcctggggcagtcggtctttctgaatgacatctat
tacgcttcagaaattgaggagatctgcctggtggacgagaaccagtttaccttaaccatt
gcaaaccagggcaccccgctcaccttcatgcaccaggagtgcgaagccatcgtccagtcc
atcattcacatccggacgcgctgggagctgtcgcagcccgactccatcccccagcacacc
aagattcggcccaaagatgtccctgggacactgcttaatattgcattacttaatttaggc
agctcggaccctagtttacggtcagctgcctataatcttctctgtgccttaacttgtacc
tttaatttgaaaatcgagggccagttactagagacgtcaggtttatgcatccctgccaac
aacaccctctttattgtctctattagtaagaccctggcagccaacgagccacatctcacc
ttagaatttttggaagagtgtatttctggatttagcaaatctagtattgaactgaaacat
ctctgtttggaatacatgactccctggctgtccaacctcgtccgtttttgtaagcacaat
gatgatgccaaacgacaaagagttaccgccattctcgataagctcataacaatgactata
aatgagaaacagatgtacccatctattcaagccaaaatctgggggagccttgggcagatt
acagatctccttgacgtcgttctagacagtttcatcaaaaccagtgcaacaggtggcttg
ggatcaataaaagccgaggtgatggcagatactgctgtagctttggcttctggaaatgtg
aaattggtttcgagcaaggttattggaaggatgtgcaaaataattgacaagacgtgcttg
tctccaactcccaccttagaacaacatctcatgtgggacgatatcgccatcctagcacgc
tacatgctgatgctgtccttcaacaattcccttgatgtggccgctcatctcccctacctc
ttccacgtcgtcactttcttagtagccacggggccgctctccctcagagcttccacgcac
ggactggtcattaatatcattcactccctgtgtacttgctcacagctgcattttagtgaa
gagaccaagcaagttttgagactcagcttgacggagttctccttacccaagttttacttg
ctgtttggcattagcaaagtcaagtcggctgccgtcatcgccttccgctcgagttaccgg
gacaggtcgttctctcccggctcctatgagagggagacatttgctttgacctccttggaa
acagtcacagaagctttgttggagatcatggaggcatgcatgagagatattccaacttgc
aagtggctggaccagtggacagaactagctcagagattcgcattccaatataatccgtcc
ctgcaaccgcgagctcttgttgtctttggctgtattagcaagcgtgtgtctcacgggcag
ataaagcagattatccgtattcttagcaaggcacttgagagttgcttaaaaggacctgat
acttacaacagtcaagttctgatagaagccacagtaatagcgctaaccaaattacagccg
ctcctcaataaggactcccctctgcacaaagccctcttctgggtggcggtggccgtgctc
cagctcgacgaggtgagcttgtactcagcaggctccgcgctcctggagcagaacctgcac
accttagacagtctgcgcatattcaatgacaagagtccggaggaagtatttatggccatc
cggaatcctctggaatggcactgcaagcagatggaccattttgttggactcaacttcaac
tctaactttaacttcgcgctggttggacacctcttaaaaggctacaggcatccttcgcct
gccatcgttgcaagaacggtcagaattctgcacacactactgactctggttaacaaacac
agaaactgtgacaagtttgaggtgaacacacagagcgtggcttacttagcagccttactc
acagtgtctgaggaggttcgaagtcgctgcagcctaaaacatagaaagtctcttcttctt
actgatatttcaatggaaaatgttcctatggatacatatcccatccaccatggcgacccc
agctataggacactaaaggagaaccagccgtggtcgtctcccaaaggttctgaaggctac
cttgccgccacctatcctaccgtgggccagaccagtccccgggccaggaaatccatgagt
ttggacatggggcagccttctcaggccaatacgaagaagttgctgggaacaaggaaaagt
tttgatcacttgatatcagacacaaaggctcctaaaaggcaagaaatggaatcagggatc
acaacaccccccaaaatgaggagagtagcagaaactgattatgaaatggagactcagagg
atttcctcgtcgcagcaacacccgcatttacgtaaagtctcggtgtctgaatcaaatgtt
ctcttggatgaagaagtacttactgatccgaagatccaagcgctccttcttaccgttctg
gctacgctggtaaaatataccacagatgaatttgatcagcgaattctttatgaatactta
gcggaagccagtgtggttttccccaaagtttttcctgtcgtacacaatttgttggactct
aagatcaacacgctgttgtcattgtgccaagatccaaatctgttaaatccaattcatgga
attgtgcagagtgtggtgtaccatgaagagtccccaccacagtaccagacctcttacctg
caaagttttggttttaatggcttgtggcggtttgcaggacccttttcaaagcaaacccaa
atcccagactatgctgagcttattgttaagtttcttgatgccttgattgacacgtatttg
cctggaattgatgaagaaaccagtgaggagtccctcctgacacccacttctccttatcct
cctgcagtgcagagccagctcagtatcactgctaaccttaacctttctaattccatgacc
tcactcgccacttcccagcattccccagggatcgacaaggagaatgtcgaactctccccc
gcctctggccactgtagcagtggacgcactcgccacgggtccgcgagccaggtgcagaag
caaagaagcgctggcagtttcaaacggaatagcatcaagaagatcgtgtga
DBGET
integrated database retrieval system
