Crocuta crocuta (spotted hyena): 144221279 Help Entry 144221279         CDS       T11532                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ccru  Crocuta crocuta (spotted hyena) Pathway ccru04020   Calcium signaling pathway ccru04024   cAMP signaling pathway ccru04260   Cardiac muscle contraction ccru04261   Adrenergic signaling in cardiomyocytes ccru04371   Apelin signaling pathway ccru04713   Circadian entrainment ccru04911   Insulin secretion ccru04921   Oxytocin signaling pathway ccru04972   Pancreatic secretion ccru05020   Prion disease ccru05022   Pathways of neurodegeneration - multiple diseases ccru05410   Hypertrophic cardiomyopathy ccru05412   Arrhythmogenic right ventricular cardiomyopathy ccru05414   Dilated cardiomyopathy ccru05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ccru00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     144221279 (RYR2)    04020 Calcium signaling pathway     144221279 (RYR2)    04024 cAMP signaling pathway     144221279 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     144221279 (RYR2)    04921 Oxytocin signaling pathway     144221279 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     144221279 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     144221279 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     144221279 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     144221279 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     144221279 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     144221279 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     144221279 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     144221279 (RYR2)    05414 Dilated cardiomyopathy     144221279 (RYR2)    05415 Diabetic cardiomyopathy     144221279 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ccru04040]     144221279 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ccru04990]     144221279 (RYR2) Ion channels [BR:ccru04040]  Voltage-gated cation channels   Ryanodine receptor    144221279 (RYR2) Domain-containing proteins not elsewhere classified [BR:ccru04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    144221279 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  144221279 NCBI-ProteinID:  XP_077607863 LinkDB All DBs Position Unknown AA seq 5070 aa AA seqDB search MTMKVLAHSLLHGGPMLKVSGTLADWGETLVQKGLLEPRNRQDGAALDGAAWADLEKCAE ERERRPGFLLAGTRALRGALSRALTRVAAVLRTEGGEDDEVVLQCTATIHKEQQKLCLAA EGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWK FMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEETTGEACW WTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISS GSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLET LRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLD VGVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHM DDGLSLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDL IGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAG REGGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVL VESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPG RDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWAS TEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCL DLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGY APCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLE RIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLET LKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKL AENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLG YGYHLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSR PGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNG EILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPF AVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSTADI MFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRV DKDKEAAKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDY LMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDAGFDLDRVRTVTVTLGDEKGKVHES IKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKL FPAAFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRM PNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLR LYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARL MMNSEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNEGYQFS PEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDL KHILQLIEPSVFKEAATPDEETEALEKEPSMEDSKPDGAGEEEVKGAKSPKEGLLQMKLP EPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTA RKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIQDQLLDFHEDLMTHCGIELDEDGSLDG NSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPE LVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEE KLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRF LCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALRE PDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANV VVRLLIRRPECFGPALRGEGGNGLLAVMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEED DTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIA FQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAA ASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGC SLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWK YYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPD YMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLAN GWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMA LYNRSRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKME LESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEK RFAYSFLQQLIRYVDEAHQYILEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHR LYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQT LDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTV ALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECL AAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIV ELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPESNPERAEMCCTALSSEHMNTLLGN ILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDH LKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMV AEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRY SMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKL EDPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYSLGSTV EHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYF EDKLIEDLAKPGADPPEEEESTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMA KSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASK GDTGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAF ERQNKAEGLGMVTEEGSASHFESHRLQTGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNY LRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVF NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKD MVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDP DGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFN VAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSVN KEESEKEKPEEQGPRMGFFSIVTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTMK DMVTAAFSSYWSIFMSLLHFVASVSRGFFRIICSLLLGGSLVEGAKKIRVAELLANMPDP TQDEVRGDGEEGDRKPTEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHN PNAGLSDLMSNPVPIPDVQEKFQEQKVKEEEKEEKEENKSEPEKAEGEDGEKEEKAKEDK GKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFIL LFYKVSTSSVVEGKELPTRSSSGNAKVSSLDSGSPRIIAVHYVLEESSGYMEPTLRILAI LHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINT QSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAV LNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTIL SSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHM YVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQ EQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQE SYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15213 nt NT seq  +upstreamnt  +downstreamnt atgactatgaaggtcttagcacattctcttctccatggaggccccatgctgaaagtttca ggcactctggccgactggggagaaacattagtgcagaagggccttctggaacctcgcaat cgtcaggatggggctgctttagatggtgcggcttgggcggacttggagaagtgtgcggag gaacgggaaagaagacccggcttcctgctggcgggaaccagggctctccgcggggctttg agcagagcgctgactcgtgtggccgctgtgttgagaacagagggtggagaggatgatgag gtggtcctgcagtgcaccgcaaccatccacaaggaacagcagaaactgtgtctggcagca gaagggtttggcaacagactctgtttcctggagtccacttcgaattccaagaatgttccc ccagacctctccatctgcacttttgtgctggaacagtctctctctgtccgggccctacag gagatgctggctaacacagtggagaagtcagaagggcaagttgatgtggaaaaatggaaa ttcatgatgaagactgctcaaggtggtggtcaccgaacactcctgtacggacacgccata ttgctacgccattcctacagtggcatgtatctgtgctgtctgtccacctcccggtcttca actgataaactagcctttgacgtcggcttgcaagaggagacaacaggtgaggcgtgttgg tggactatccatcctgcctctaagcagaggtcagaaggagaaaaggtgcgcgttggagac gacctcatcttagttagtgtgtcctctgagaggtacctgcatttgtcttatggcaatggc agcctacacgtggatgctgctttccagcaaactctctggagcgtggccccaatcagctca ggaagtgaagccgcccaagggtatctaattggtggtgacgtcctcaggttgctgcacgga cacatggatgaatgcctcactgtcccttcaggagaacatggggaagagcagcggagaacc gttcactatgaaggtggtgctgtatctgtccatgcacgttccctgtggagactagagaca ctaagagttgcgtggagtggaagccacataaggtggggccagcctttccgactacgccat gtcacaacaggaaaatacttgagtctcatggaagacaaaaaccttctactcatggacaaa gaaaaggctgatgtaaagtcaacagcatttaccttccgatcttccaaggaaaaattggat gtaggggtgagaaaagaagtcgatggcatgggaacttcagaaataaaatatggagactca gtatgctatattcaacatataaatacaggcctgtggcttacttatcagtctgtggatgtg aaatcggtgagaatgggatccatacagcgtaaggctattatgcatcatgaaggccacatg gatgatggcttaagtttatctagatctcagcatgaagaatcacggaccgcacgagttatc cggagcacagtcttccttttcaatagatttataaggggcctcgatgcgctcagcaaaaaa gtgaaggcttccacagtagacctgcctatagagtctgtgagcctgagtctgcaggacctg attggctacttccatcccccggacgagcatctagaacatgaggacaaacagaacaggtta cgggctctaaagaaccggcagaatctcttccaggaagagggcatgatcaacctcgtgctt gagtgcattgacaggctacatgtgtacagcagtgcggcccacttcgcagatgtggccggg agagaaggaggcgagtcgtggaagtcgattctgaattctctctatgagttgctagcggct ctaattagaggaaatcgtaaaaactgtgctcagttttctggctccctggactggttgatc agccgattggaaagactggaagcttcttctggtatacttgaagttttacactgtgtgtta gtagaaagtccagaagctctaaatattattaaagaaggacatatcaaatctataatctcc cttttagacaagcatggaagaaaccacaaggttctggacgtcctgtgttctctgtgtgtc tgccatggagtcgcagtccgttccaaccagcatcttatctgcgacaatctgctgccggga agagacctcctcctgcagacgcgtcttgtaaaccatgtcagcagcatgaggcccaatatt tttctgggcgtcagtgaagggtccgcccagtataagaagtggtactatgagctgatggtg gaccacacggagccgttcgtcactgctgaagccacccacctgcgggtgggctgggcatcc accgaagggtactctccctaccccggaggcggagaggaatggggtggaaatggagttgga gatgatctcttttcctacggatttgatggccttcacctatggtcaggttgtattgcgcgt actgtaagctcaccaaaccaacatctgttgagaactgacgatgtcatcagttgctgttta gatctgagtgccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgttt gagaatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaag gtacgctttctgcttggggggagacatggagaatttaaattccttcctccacctgggtat gctccttgttatgaagctgtcctgccgaaagagaagttgaaagtggagcacagcagagaa tacaagcaagaaagaacttacacccgagacctgctgggccccacagtttccctgacacag gccgccttcacgccaatccctgtggataccagccagattgtgttaccacctcacctggag agaataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaatcgaa cttggctggcagtatggtccagttagagatgacaataagagacagcatccatgtctggtg gagttctccaagctgcctgagcaggaacgcaattacaatttgcagatgtcgcttgagact ctgaagactttgctggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaa aaggtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgcc ccgatggaccttagctttattaaactcaccccgtctcaggaagcgatggtggacaagttg gcggagaatgctcacaacgtgtgggcccgagatcgaatccggcagggctggacttacggc atccaacaggacgtaaagaacagaagaaaccctcgcctggtcccctatgcccttctagat gaccgcaccaagaaatccaacaaggacagcctccgtgaggccgtgcgcacactgctggga tatggctaccacctggaggcaccagatcaagatcatgctgcccgagctgaagtgtgtagc ggcaccggggagaggttccgaatcttccgtgctgagaaaacctatgcagtcaaggcagga aggtggtattttgaattcgaggctgtcactgctggagacatgagagttggatggagcagg ccaggttgtcaaccggatcaagagctgggctcggacgaacgtgcctttgctttcgatggc ttcaaggcccagcggtggcaccagggcaacgaacactatggacgctcttggcaagcggga gatgttgtaggatgcatggtggacatgactgagcacaccatgatgttcacgctgaatggc gaaatccttcttgatgactcgggctccgaactggccttcaaggatttcgatgttggtgat ggattcattcctgtctgtagcctcggagtggctcaagtgggcaggatgaactttggaaag gatgtcagcaccttgaaatattttaccatctgtggcttacaagaaggctacgaaccattt gctgtgaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctc caggtcccgtcaaaccatgagcatatcgaggtaaccagaatagacggcaccattgacagt tctccgtgtttaaaggtcacccagaagtcctttggctctcagaacagcactgctgacatc atgttctatcgcctaagcatgccgattgagtgcgctgaggttttctccaagacggtggca ggcgggctcccaggcgccggtctctttgggcccaagaatgatctggaagattatgatgca gattctgactttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgtt gacaaagacaaggaagccgcaaaaccagagtttaataaccacaaagattatgctcaggaa aagccctctcgtctgaaacagagatttttgcttagaagaacaaagccagattatagcacg agccattctgcaagactcactgaggacgtccttgcagatgatcgggatgattatgattac ttgatgcaaacgtccacgtactattactcagtgagaatctttcctggccaagaacctgct aacgtctgggtaggctggattacatcagatttccatcagtatgatgcaggctttgacttg gacagagttcgtacagtaaccgttactctaggagatgaaaagggaaaagtgcatgaaagc atcaaacgcagcaactgctatatggtgtgtgcgggtgagagcatgagccccgggcaagga cgcaacaataatggcctggagattgggtgcgtggtggatgccgctagtgggcttctcaca ttcactgccaacggcaaggagctgagcacgtactaccaggtggagccaagtacaaagtta tttcctgcagcttttgcccaagctacaagtcccaatgttttccagtttgagttgggaaga ataaagaatgtgatgcctctctccgcgggattattcaagagcgagcacaaaaaccccgtg ccgcagtgtcccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatg cccaaccagttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtg cagtgtttggatcctctgcagttcatgtctctccatatcccggaggagaacagatctgtg gacatactggaactgacagagcaggaagagctgctgaaattccactaccacactctccgg ctttactctgccgtctgcgctcttggcaaccaccgagtagcacatgcattgtgcagccac gtggatgagccccagctgctctatgccattgagaataagtacatgcctggtttgctgcgt gccggctactacgacctgctgattgacatccacctgagctcctacgctactgccaggctc atgatgaacagtgagttcattgtgcccatgacggaggagaccaagagcatcaccctcttc cctgatgagaataaaaagcatggcctccccggcatcggtctcagcacctccctcaggcct cggatccagttttcctcccctagttttgtgagcatcaataatgaaggttaccaattcagt ccagagttcccgctggacatcctgaaggccaaaaccattcagatgctgacagaagctgtg aaggagggcagcctgcatgcccgggaccctgtggggggcaccactgaatttttgtttgtc ccgctcatcaagcttttctacactctgctcatcatggggatcttccacaatgaggactta aaacacatcctgcagttgatagagcccagtgtgttcaaggaggctgccactcccgatgaa gagacggaggctctggagaaggagccctccatggaagactccaaaccagacggagctgga gaagaagaagtgaaaggggctaagagccccaaggaaggactgcttcagatgaaacttcct gaaccagttaaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccga caccggatagaagccattgtggccttttcagacgactttgtagccaagctccaagacaat cagcgcttccgatacaatgaagttatgcaagctttaaacatgtcagccgcactcaccgcc aggaagacaaaggaatttagatccccacctcaggaacagatcaatatgcttctcaatttt aaggatgacaaaagtgaatgtccatgtcctgaagaaatccaagaccaactcttagatttt cacgaggatttgatgacacattgtggaattgagctggatgaagatgggtctcttgatgga aacagtgacctaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctg aagaagaaacaagccgaaaagccagttgagagtgactccaagaagtcctccactcttcag cagttgatttctgagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaa ctggtgagggccatgtttgtgttgctccatcgacagtatgatggcattgggggtctggtc cgggctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctg ctggcatctcttggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagag aagcttatgattcgtggattaggggacatcatgaataataaggtgttttaccagcaccct aatctcatgagggcacttgggatgcacgagacagtgatggaggtcatggtgaatgtcctt ggaggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgtttt ctttgttacttctgtcgtataagtaggcagaatcaaaaagctatgtttgatcatctcagc tatttattggagaacagcagtgttggtcttgcctcaccagctatgagaggttcaacaccc ctggatgtagcagctgcgtcagtgatggataataatgaactggccttagctctgcgtgag ccagatttggaaaaggtagttcgatatttggctgggtgtggactgcagagttgccagatg ctagtgtctaaaggttacccagacattggctggaatccagttgaaggagagagatacctt gactttctcagatttgctgtattctgtaatggggagagtgtggaagagaatgccaacgtc gtggtgaggttactcatccggaggcccgagtgctttggtcctgccctgagaggagaaggt gggaatggtcttctcgcagtcatggaagaagccataaaaatagccgaggatccctctcga gatggcccctcaccaactagtggatccagtaaaacacttgagacagaagaggaggaagat gacactatccacatggggaatgccatcatgacattttatgcggctttgattgacctcttg ggacgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatc cggtcaattttgagatccctaattccactgggagatttggtgggagtaatcagcattgct tttcagatgccaacaatagctaaagatgggaatgtggtggagcctgacatgtctgcgggg ttttgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgag gttcaagacttcctcctccatcttctcgaggttggctttctgccagatctccgggctgct gcttctttagatacggctgctttgagtgccacagacatggccctggccctcaatcggtac ctttgcacagccgtgttgcctttgctaacaagatgtgcccctctctttgcgggcacagaa caccacgcttctctcattgactcattactgcacactgtgtacagactttctaagggctgc tcacttaccaaagctcagcgggattccatagaagtttgtttactctctatttgtggccaa ttgagaccttctatgatgcagcacttgctccgaagattagtatttgatgtcccattatta aatgaacatgcaaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaa tattactgcctgcctggagggtggggaaactttggagctgcctcagaagaagaacttcat ttatcaagaaagttattttggggcatttttgacgccctgtctcaaaagaaatacgaacaa gaacttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagac tacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaaggg aactttaacccacaacctgttgatacctcaaacattacaatccctgagaagttggaatac ttcattaacaaatatgctgagcattctcatgacaaatggtcaatggacaagttggcaaat ggatggatttatggagaaatatattcagattcatctaaagttcaaccattaatgaagcca tataaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaggaatctttg aaaaccatgctggcgtggggttggcgggttgagcgaacacgggaaggagacagcatggcc ctttacaaccgttctcgtcgtatttcgcagacaagccaggtttctgttgatgctgcgcat ggttatagcccccgagccattgacatgagcaatgtcacactgtccagagacctgcatgct atggcagaaatgatggctgaaaactaccataatatatgggcgaagaaaaagaaaatggag ctggaatccaaaggaggtggaaaccatcccctgctggtaccctatgatacactgacagcc aaagagaaagccaaggatagggaaaaagcacaggacatcctcaagttcttgcagatcaat ggatatgctgtatccaggggattcaaggacctggaattggacacaccttccattgagaaa cgatttgcctatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtat atcctggagttcgatggtggcagcagaagcaaagcagaacatttcccttacgagcaagaa atcaagttctttgctaaagttgttcttcctttaattgatcagtatttcaaaaaccatcgt ttatacttcttatctgcagcaagcagacctctctgctctggaggacatgcatcaaacaaa gagaaagaaatggtgacaagcctattctgcaaacttggagttcttgtcaggcataggatt tcactatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagact ttggatgcaaggactgtcatgaagactggcctggagagtgttaaaagtgcgctcagagct tttctggacaatgctgcagaagacctggagaaaacgatggagaatctcaagcaaggccag ttcacccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtg gctctgttgccgatgctgtcttcattatttgagcatattggccagcatcagttcggagaa gatctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttatacgct ttgggaaccagcaaaagtatttatgtggaaaggcagcgctctgcgttaggagaatgtctt gctgcttttgctggtgcctttcctgttgcattcttggaaactcatctcgacaagcataac atctactctatctacaataccaagtcctcacgagaacgagcagctctcagtttgccaact aatgtggaggatgtttgcccgaacataccatctttggagaaactcatggaagaaatcgtg gaattagccgagtccgggattcgctacacgcagatgccacatgtcatggaagtcatactg cccatgctttgcagctacatgtctcgttggtgggagcacggacctgaaagtaatcccgag agggccgaaatgtgctgtacagccctgagctcagagcacatgaacacactcttggggaat atactgaagatcatatataataacctgggaattgatgagggagcctggatgaagaggctg gcagtattttcgcagcccattataaataaagtgaaacctcagctcctgaaaactcatttc ttgccattaatggagaaactcaagaaaaaggcagcaatggtggtgtcggaggaggaccat ctgaaagctgaggccaggggggatatgtccgaggcagaacttctcattctcgacgagttc accactctggccagagatctctatgccttctacccgctcttgattagatttgtggactat aacagggcaaagtggctgaaagaacctaaccctgaagcagaggaccttttccgcatggtg gctgaagtgtttatttactggtccaaatcccacaatttcaaaagagaggagcagaacttc gtggtacagaatgaaatcaacaatatgtctttccttattaccgacaccaagtcaaagatg tcaaaggccgctgtctctgatcaggaaaggaagaaaatgaagcgtaaaggagatcggtac tccatgcagacctctctcattgtggcagctctgaagcgattactgcccattgggttgaac atctgtgcccctggggaccaggagctcattgctctggccaaaaaccggtttagtatgaaa gacactgaggatgaagtacgagatataatccgcagtaatattcatttacaaggcaagtta gaggatcctgctatcagatggcaaatggctctttacaaagacttaccgaacaggactgaa gatacatcggacccagagaaaaccgtggagagagtattagatatagcaaatgtgcttttc catcttgagcagaaatctacatgtatgcgccggagatattacagtctgggaagtacagtg gaacacccccagaggtcaaagaaagctgtgtggcacaaacttctgtccaagcagaggaag agggctgtggtggcctgcttccgaatggctcctttatataacctgccaaggcaccgggcc gttaacctctttcttcagggatatgaaaagtcttggattgagacagaagaacactacttt gaagataagctgatcgaggatttagcaaaacccggtgcagaccctccagaggaagaggaa agcacgaagagagttgatcccctccatcagctcatccttttgtttagtcgaacagcttta acagagaaatgcaaactggaggaagattttttgtatatggcttatgcagatattatggca aagagttgtcatgacgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtc acaggatcccaacgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccagcaa gccaggctccatgaccgcggggctgctgagatggtgctgcagaccatcagcgccagcaaa ggtgataccggaccaatggtagctgcgactttgaaactcggaattgcgatcttaaatggt gggaactctacagtgcagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggt ttctttcaaagccttgctggcctgatgcagtcatgcagtgtcctcgacctaaatgccttt gagcggcagaacaaagctgaaggacttggaatggtcactgaagaaggatcagcctctcac tttgaaagtcacagactgcagactggggaaaaggttctccaggatgacgagtttacttgt gacctcttccgcttcctgcagctgctctgtgagggacacaactcagattttcaaaattat ctgagaactcagactggcaataacactactgtcaacatcatcatctctactgtagactac ctcctgagagtccaggagtccattagcgatttctattggtattactctgggaaagatgtt attgatgaacaaggacagcggaatttctccaaagcaattcaagtagcaaaacaggtcttt aacacactcacagagtatattcagggtccttgcaccgggaatcagcagagcttggcccac agcaggctgtgggatgcggttgtgggcttccttcacgtgtttgcccacatgcagatgaag ctgtctcaggattccagtcaaattgagctactaaaagaattaatggatcttcagaaggat atggtggtcatgttgctgtccatgctagaaggtaatgttgtcaatggaaccattggcaaa cagatggtcgatatgcttgtggagtcttccaacaacgtggagatgattctcaagtttttt gacatgttcttaaaactgaaggatttgacctcttctgacacatttaaagaatacgaccct gatggtaagggagtcatttccaagagggacttccataaagcgatggagagccataaacac tacacgcagtcagaaaccgagtttcttctgtcctgtgcggagacggatgaaaacgaaacc ctggactatgaagagtttgtcaaaaggtttcatgagcctgcaaaggacattggcttcaat gtggccgttcttctgaccaatctttcagagcacatgcccaatgatacgcgcctgcagact ttcctggagttggcagagagcgtgctgaattacttccagccctttctgggccgcatcgag atcatgggaagtgccaaacgcattgagagggtgtattttgaaatcagtgagtccagccga acccagtgggagaagccacaggtcaaggagtccaaaaggcagttcatatttgacgtggtc aacgaagggggagaaaaggagaaaatggaactttttgtcaacttctgcgaggacaccata tttgaaatgcagctggcggcacagatctccgagtcggatttgaacgagaggtcagtgaat aaagaagaaagtgagaaggagaagccagaagagcaggggcccagaatgggtttcttttcc atcgtgactgtcaggtcggccctgtttgctctcaggtataatatcttgaccctcatgcga atgctcagcctgaaaagcctgaagaaacagatgaaaaaagtgaagaagatgaccatgaag gatatggtcacagctgccttttcgtcctactggagtatcttcatgagcctcttgcacttt gtggccagtgtttccagaggcttcttccgcatcatttgcagcctgctgctgggaggaagc cttgtagaaggagcgaaaaagatccgagtcgcggagctcttggccaacatgccagacccc actcaggatgaggtgagaggggatggagaggagggggacaggaagcccacggaagccgcc ctgccctcggaagacctgacagacctgaaggaactgacggaggaaagcgaccttctctcg gacatatttggcttggatctgaagagagaaggaggacagtacaaacttatccctcataat ccaaatgctggcctcagcgacttaatgagcaacccagtccccatccctgacgttcaggaa aaatttcaggaacagaaggtgaaagaggaagaaaaggaggagaaagaagaaaacaaatct gaacccgaaaaggccgagggagaagatggagaaaaagaagaaaaagccaaagaagacaag ggtaaacagaagttgaggcagctccacacacacagatatggagagccagaagttcccgag tcagcattctggaagaaaatcatcgcctatcaacagaaacttctaaactattttgctcgc aacttttacaacatgagaatgttagccttatttgtcgcgtttgcaatcaatttcatcttg ctcttttataaggtctccacttcttctgtggttgaaggaaaggagctacccactcgcagt tcaagtggaaatgccaaagttagcagcctggacagtggctcacctagaatcatcgcggtt cactacgtcctggaggagagcagcggctacatggagcccacgctgcggatcttagcaatt cttcacaccatcatttctttcttctgcatcatcggctactactgcttgaaagtcccattg gttatttttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctttatatt acagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaacaca cagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaatat ggggagttctatggccgggacagaatcagcgagctccttggtatggacaaagccgccctg gacttcagcgatgcccgggaaaagaagaagccaaagaaggacagctccctgtcagccgta ctgaactctatcgatgtgaagtatcagatgtggaaactaggagtcgtcttcacggacaac tctttcctctacctggcctggtatatgactatgtctgttctgggacattataacaacttt ttttttgctgctcatcttcttgacattgctatgggattcaagacactaagaaccatcttg tcatcggtaactcacaatggcaagcagcttgtattaaccgttggcttgttagctgttgtt gtatacctatatactgttgtggcattcaattttttccgaaaattctacaataaaagtgaa gatggtgacacaccagatatgaaatgtgatgatatgctaacgtgctatatgttccacatg tatgtcggggtacgcgccggagggggaattggcgatgaaattgaagacccagcaggcgac gaatatgagatctatcggatcatctttgatatcaccttcttcttcttcgtgattgtcatt ctcttggccataatacaaggtttaattattgatgcttttggagagctaagagaccaacaa gagcaagtcaaagaagacatggagaccaaatgtttcatctgtgggataggcaacgattac ttcgacacagtgccacatggctttgaaacccacactttacaggaacacaacctggccaat tacctgttttttctgatgtatctcatcaacaaagatgaaacagagcacacaggacaggaa tcttatgtctggaagatgtaccaagaaaggtgctgggagttcttcccagcgggggactgc ttccggaaacagtatgaagaccagctaaattaa

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