KEGG   Crocuta crocuta (spotted hyena): 144222600
Entry
144222600         CDS       T11532                                 
Symbol
NOTCH1
Name
(RefSeq) LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1
  KO
K02599  Notch 1
Organism
ccru  Crocuta crocuta (spotted hyena)
Pathway
ccru01522  Endocrine resistance
ccru04330  Notch signaling pathway
ccru04658  Th1 and Th2 cell differentiation
ccru04919  Thyroid hormone signaling pathway
ccru05020  Prion disease
ccru05165  Human papillomavirus infection
ccru05200  Pathways in cancer
ccru05206  MicroRNAs in cancer
ccru05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:ccru00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    144222600 (NOTCH1)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    144222600 (NOTCH1)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    144222600 (NOTCH1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    144222600 (NOTCH1)
   05206 MicroRNAs in cancer
    144222600 (NOTCH1)
  09162 Cancer: specific types
   05224 Breast cancer
    144222600 (NOTCH1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    144222600 (NOTCH1)
  09164 Neurodegenerative disease
   05020 Prion disease
    144222600 (NOTCH1)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    144222600 (NOTCH1)
SSDB
Motif
Pfam: EGF hEGF EGF_TEN EGF_CA EGF_2 Ank_2 Ank NOD NODP Notch Ank_4 Ank_3 Ank_5 EGF_3 JAG1-like_EGF2 EGF_DL_JAG cEGF
Other DBs
NCBI-GeneID: 144222600
NCBI-ProteinID: XP_077609251
LinkDB
Position
Unknown
AA seq 2434 aa
MLKPPGVQDPSAPGSXNGGKCEVSPNGTEACVCSGAFAGQRCQAPNPCLSAPCKNAGTCH
AVDHGGLVDYACTCRLGFSGPLCLTPRDNACLANPCRNGGTCDLLTLTEYKCRCPPGWSG
KMCQQADPCASNPCANGGQCLPFEASYICGCPPGFHGPTCRQDVNECSQSPGLCRNGGTC
HNXXGPHCELPYVPCSPSPCQNGGTCRPTGDTTHECACLPGFTGQNCEENIDDCPGNSCK
NGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGW
TGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNC
DTNPVNGKAICTCPSGYTGPACSQDVDECXGRANPCEHAGKCINTLGSFECQCLQGYTGP
RCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLQSGRCLD
KINEFLCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCSEGYTGPHCEVDI
DELLPPPGPNCETNLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDECAAHPC
HHGGTCEDGINSFTCRCPEGYHGPTCLSEVNECSSNPCIHGACRDSLNGYKCDCDPGWSG
ANCDVNNNECESNPCANGGACRDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGSCI
DDVAGYTCNCPLPYTGATCEVVLAPCAPGPCRNGGECQESEDFESFSCVCPTGWQGQTCE
VDINECVKSPCRHGASCQNTNGGYRCRCRAGYTGPDCETDIDDCRPNPCHNGGSCTDGIN
AAFCDCLPGFRGAFCEEDINECASNPCRHGANCTDCVDSYTCTCPPGFSGIHCEDNTPDC
TESSCFNGGTCVDGINSFTCVCPPGFTGSYCQHDINECDSRPCLHGGTCQDSYGAYKCTC
PQGYTGLNCQNLVRWCDSSPCKNGGKCWQTNTLYRCECHSGWTGLYCDVPNVSCEVAAQR
QDINVTHLCRNGGLCLDAGNTHHCRCQAGYTGSYCEDQVDECAPSPCQNGATCTDYPGGY
SCECVAGYHGVNCSEEINECLSHPCQNGGTCIDLINTYKCSCPRGTQGVHCEVNVDDCSP
LIDPVSRGPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQR
VNDFYCECRAGHTGRRCESVINGCKGRPCQNGGTCAVASNTARGFICKCPAGFEGATCEN
DARACGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPAGSPCVGGNPCYNQGSCEPVP
ESPFYRCLCPAKFNGLLCHILDYSFGGGLGVDIPPPQIEEACELPECREEAGNKVCSLGC
NNHACGWDGGDCSLNFNDPWQNCSQSLQCWKYFSDGRCDSQCNSAGCMGHVCACARSPLY
DQYCKDHFGDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVLVVLTPPAQLRNNSLHF
LRELSRLLHTNVVFKRDAHGQPMIFPYYGREEELHKHPIKRAVDGWGAPGALLDRVEAAL
LPGSGAGRRRRELDPMDIRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLN
IPYKIEAVQSETVEPPPPPQLHFMYVAVAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGF
KVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDSQHEWGDDDLEAKKFRFEEPVGLPD
LDDQTDHRQWTQQHLDAADLRVSAMAPTPPQGEADADCMDVNVRGPDGFTPLMIASCSGG
GLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASAD
ANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLED
LINSHADVNAVDDLGKSALHWAAAVNNVEAAAALLKSGANKDMQNNKEETPLFLAAREGS
YETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYSLARSPQLHGTALGGAP
TLSPPLCSPGGYLGNLKPTVQGKKARKPSTKGLACGGKEAKDLKARRKKSQDGKGCLLDS
SSVLSPVDSLESPHGYLSDVASPPLLPSPFQQSPAVPLSHLPGMPDTHLGVGHLSVAAKP
EMAALGGGGRLAFEAGPPRLSHLPVASSTSSVLGGSSGGGAMNFTVGGATGLNGQCEWLS
RLQNGLVPNQYNPLRGNVAPGTLSTQAPALQHGMMGPLHAGLSTATLSQMMSYQALPNTR
LAGQPHLVQTPQLQQVQQQQQQNLQMQQPGLQPQXTAXADVQPLGPGSLAVHTILPQDSL
APPTALPATLAPPMTTAQFLTPPSQHSYSSSPADNTPSHQLQVPEHPFLTPSPESPDQWS
SSSPHSHVSDWSEGISSPPTSTQSHMAHIPEALK
NT seq 7299 nt   +upstreamnt  +downstreamnt
atgttgaagccccctggggttcaggaccccagtgccccagggtctganaatggcgggaag
tgtgaagtgtcccccaacggcacggaagcctgtgtctgcagcggggccttcgcgggccag
cgatgccaggcgcccaacccctgcctcagcgccccctgcaagaacgccgggacgtgccac
gcggtggaccacggcggcctggtggactacgcctgcacctgccgcctgggcttctccggg
cccctctgcctgacgccccgggacaacgcctgcctcgccaacccctgccgcaacggcggc
acctgtgacctgctcacgctgaccgagtacaagtgccgctgccccccgggctggtcaggg
aagatgtgccagcaggccgacccatgtgcctccaacccgtgtgccaatggcggccagtgc
ctgcccttcgaggcctcctacatctgcggctgcccacccggcttccacggccccacctgc
aggcaggacgtcaacgagtgcagccagagccccgggctctgccgcaacggcggcacctgt
cacaganccggcccccactgcgagctgccgtacgtgccctgcagcccctcgccctgccag
aacgggggcacctgccgccccacgggggacaccacccacgagtgcgcctgcctgccaggc
ttcaccggccagaactgcgaggagaatatcgacgactgtcccggaaacagctgcaagaac
ggaggtgcctgcgtggacggcgtgaacacttacaactgccgctgcccgcccgagtggaca
ggccagtactgcaccgaggacgtagacgagtgccagctgatgcccaacgcctgccagaat
ggcgggacctgccacaacacccacggcggctacaactgcgtgtgtgtcaacggctggacg
ggggaggattgcagtgagaacatcgacgactgcgccagcgccgcctgtttccacggcgcc
acctgccacgaccgggtggcttccttctactgcgagtgtcctcacggccgcaccggcctg
ctgtgccacctgaatgacgcctgcatcagcaacccttgcaacgaaggctccaactgtgac
accaaccccgtcaacggcaaggccatctgcacctgcccctcggggtacacgggcccggcc
tgcagccaggacgtggacgagtgcncggggcgcgccaacccctgcgagcacgcaggcaag
tgcatcaacacgctgggctccttcgagtgccagtgtctgcaaggctacacgggcccgcgc
tgtgagattgacgtcaatgagtgcatctcgaacccgtgtcagaatgacgccacctgcctg
gaccagatcggagagttccagtgcatctgcatgcctggctacgagggcgtgcactgtgaa
gtgaacacggacgagtgtgccagcagcccctgcctgcagagcggccgctgcctggacaaa
atcaacgagttcctgtgcgagtgccccacaggcttcaccgggcacctgtgtcagtacgac
gtggacgagtgtgcgagcacgccctgcaagaacggcgccaagtgcctggacgggcccaac
acctacacctgcgtgtgctcagaaggctacacggggccgcactgcgaggtggacatcgac
gagttgctgccgccgccaggacccaactgcgagaccaacctggatgactgtgccagcaac
ccctgtgactcgggcacgtgtctggacaagattgacggctacgagtgtgcatgtgagccg
ggctacacagggagcatgtgcaacgtcaacatcgacgagtgtgcggcccacccctgccac
cacggaggcacctgcgaggacggcatcaacagctttacctgccgctgccccgagggctac
cacggccccacgtgcctgtccgaggtcaacgagtgcagcagcaacccctgcatccacggc
gcctgccgcgacagcctcaatgggtacaagtgtgactgtgaccccgggtggagcggggcc
aactgtgacgtcaacaacaacgagtgcgagtccaacccgtgcgccaacgggggcgcctgc
agggacatgaccagcggctacgtgtgcacctgccgcgagggcttcagcggtcccaactgc
caaaccaacatcaatgagtgtgcatctaacccgtgcctgaaccagggctcctgcatcgat
gacgtggccgggtacacgtgcaactgcccgctgccctacacaggagccacgtgtgaggtg
gtgctggccccgtgcgcccccggcccctgcaggaacggaggcgagtgccaggagtctgag
gacttcgagagcttctcgtgcgtctgtcccacaggctggcaaggacagacctgcgaagtc
gacattaacgagtgcgtgaagagtccgtgccgccacggcgcctcctgccagaacacgaac
ggcggctaccgctgccgctgccgcgccggctacacggggcccgactgcgagacggacatc
gacgactgccgaccgaacccgtgccacaacggcggctcctgcacggacggcatcaacgcg
gctttctgcgactgcctgccgggcttccggggggccttctgcgaggaggacatcaacgag
tgcgccagcaacccctgccgccacggggccaactgcaccgactgcgtggacagctacacc
tgcacctgccccccgggcttcagcgggatccactgcgaggacaacacgcccgactgcaca
gagagctcctgtttcaacggcggcacctgcgtggacggcatcaactccttcacctgcgtg
tgcccgcccggcttcacgggcagctactgccagcatgacatcaacgagtgtgactcccgg
ccctgcctgcacggcggcacctgccaggacagctacggggcttacaagtgcacctgcccg
cagggctacacgggcctcaactgccagaacctcgtgcgctggtgtgactcctcgccgtgt
aagaacggtggcaagtgctggcagaccaacacgctgtaccgctgcgagtgccacagcggc
tggaccggcctctactgcgacgtgcccaacgtgtcctgcgaggtggccgcgcagcgacaa
gacatcaacgtcacccacctgtgccggaacggggggctctgtctggatgcgggcaacacg
caccactgccgctgccaagcgggctacacgggcagctactgcgaggaccaggtggacgag
tgtgcacccagcccctgccagaacggggccacctgcaccgactaccctggcggctactcc
tgcgagtgcgtggccgggtaccacggggtgaactgctccgaggagatcaatgagtgtctg
tcccacccgtgccagaacgggggcacctgcatcgacctcatcaacacctacaagtgttct
tgtccccggggcacacagggggtgcactgcgaggtcaacgtggacgactgcagtcccctc
atcgacccagtctcccggggccccaagtgctttaacaacggcacctgcgtggaccaggtg
ggcggctacagctgcacctgcccacccggcttcgtcggcgagcgctgtgagggggacgtg
aacgagtgcctgtccaatccctgcgacgcccgtggcacccagaactgcgtgcagcgcgtc
aacgacttctactgcgagtgccgtgcaggccacactggacgccgctgtgagtcggtcatc
aacggctgcaagggcaggccctgccagaacgggggcacctgcgccgtggcctccaacact
gcccgcgggttcatctgcaagtgcccggcgggcttcgagggcgccacgtgcgagaacgac
gcgcgagcctgcgggagcctgcgctgcctcaacggcggcacgtgcatctcgggcccgcgc
agccccacctgcctgtgcctgggccccttcaccgggcccgagtgccagttcccggcgggc
agcccctgcgtgggcggcaacccctgctacaaccagggcagctgcgagccggtgcccgag
agccccttctaccgctgcctgtgccccgccaagttcaacgggctcttgtgccacatcctg
gactacagcttcgggggcggcctgggcgtcgacatccccccgccgcagatcgaggaggcg
tgcgagctgcccgagtgccgcgaggaggcgggcaacaaggtgtgcagcctgggctgcaac
aaccacgcgtgcggctgggacggcggcgactgctccctcaacttcaacgacccctggcag
aactgctcgcagtcgctgcagtgctggaagtacttcagcgacggccgctgcgacagccag
tgcaactccgcaggatgcatggggcacgtctgcgcctgcgcccgcagtcccctgtacgac
cagtactgcaaggaccacttcggggacgggcactgcgaccagggctgcaacagcgccgag
tgcgagtgggacgggctggactgcgccgagcacgtacccgagcggctggcggccggcacg
ctggtgctggtggtgctgacgccgcccgcgcagctgcgcaacaactccctgcacttcctg
cgggagctcagccgcctgctgcacaccaacgtggtcttcaagcgcgacgcgcacggccag
cccatgatcttcccgtactacggccgcgaggaggagctgcacaagcaccccatcaagcgc
gccgtggacggctggggcgcgccgggggccctgctcgaccgcgtggaggctgccctgctc
ccgggcagtggggctggccgccggcgccgggagctggaccccatggacatccgcggatcc
attgtctacctggagattgacaatcggcagtgtgtccagtcgtcctcacaatgcttccag
agcgccacggacgtggccgcctttctgggcgcactcgcctcactgggcagcctcaacatc
ccctacaagatcgaggccgtgcagagtgagaccgtggagccgcccccacccccgcagctg
cacttcatgtacgtggccgtggccgccttcgtgctcctcttctttgtgggctgcggggtg
ctgctatctcgcaagcgccggcggcagcatggacagctgtggttccccgagggcttcaag
gtgtcagaagccagcaagaagaagcggcgggagcccctcggcgaggactccgtgggcctc
aagcccctgaagaacgcctcggacggtgcgctcatggacgacagccagcatgagtggggt
gacgacgacctggaggccaagaagttccggttcgaggagccggtgggtcttccagacctg
gatgaccagacagaccaccggcagtggacccagcagcacctggatgccgccgacctgcgc
gtgtctgccatggcccccacgccaccccagggcgaggctgacgccgactgcatggacgtg
aacgtccgagggccagatggcttcacgcccctcatgatcgcctcctgcagcggaggcggc
ctggagacgggcaacagcgaggaggaggaggacgcgcctgccgtcatctcggacttcatc
taccagggcgccagcctgcacaaccagacggaccgcactggcgagaccgcgctgcacctg
gctgcccgctactcgcgctccgacgcggccaagcgcctgctggaagccagcgccgatgcc
aacatccaggacaacatggggcgcaccccgctgcacgcggccgtgtctgccgacgcgcag
ggcgtcttccagatcctgatccggaaccgagccacagacctagatgcccgcatgcacgac
ggcacgacgccgctgatcctggccgcccgcctggcggtggagggcatgctggaagacctc
atcaactcgcacgccgacgtcaacgccgtggacgacctgggcaagtccgccctgcactgg
gccgccgccgtgaataacgtggaggccgctgcggcgctgctgaagagcggggccaacaag
gacatgcagaacaacaaggaggagacacccctgttcctggccgctcgggagggcagctat
gagactgccaaggtgttgctggaccacttcgccaaccgggacatcacggaccacatggac
cgcctgccgcgtgacatcgcgcaggagcgcatgcaccacgacatcgtgcggctgctggat
gagtacagcctggcacgcagcccccagctgcacggcacagccctgggtggcgcgcccacc
ctgtcgccgccgctctgctcgcccggcggctacctgggcaacctcaagcccactgtgcag
ggcaagaaggcccgcaagcccagcaccaagggcctggcctgtggcggcaaggaggccaag
gacctgaaggcgcgcaggaagaaatcccaggacggcaagggctgcctgctggacagctcg
agcgtgctgtcgcccgtggactccctcgagtcgccgcacggctacctgtcggacgtggcc
tccccgcccctcctgccttctccgttccagcagtccccggctgtgcccctcagccacctg
cccggcatgcctgacacccacctgggcgtaggccacctgagcgtggctgccaagcccgag
atggcagcgctgggtgggggtggccggctggcctttgaggcgggaccaccacggctctcc
cacctgcccgtggcctccagcaccagctcggtcctgggcggcagcagcggcggcggcgcc
atgaatttcaccgtgggcggggccacaggcttgaacggccagtgtgagtggctgtcccgg
ctgcagaatggcctggtgcccaaccagtacaacccgctgcgagggaatgtggcgccgggc
accctgagcacacaggccccggccctccagcacggcatgatgggcccgctgcatgccggc
ctgtccacggccaccctgtcccagatgatgagctaccaggccctgcccaacacgcgcctg
gccggccagccgcacctggtgcagaccccgcagctccagcaggtgcagcagcagcagcag
cagaacttacagatgcagcagccgggcctgcagccgcacacagccnaggccgacgtgcag
ccgctgggccccggcagcctggccgtgcacaccatcctgccgcaggacagcctggccccc
cccacggcgctgcccgccacgctggccccgcccatgaccacggcgcagttcctgaccccg
ccctcccagcacagctactcctcctcgcccgcggacaacacccccagccaccagctgcag
gtgcctgagcaccccttcctcaccccgtcccccgagtccccggaccagtggtccagctcg
tcaccgcactcccacgtctctgactggtccgagggcatctccagcccgcccaccagcacg
cagtcccacatggcccacattccggaggcgctcaagtaa

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