Crocuta crocuta (spotted hyena): 144229239 Help Entry 144229239         CDS       T11532                                  Symbol SOS2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism ccru  Crocuta crocuta (spotted hyena) Pathway ccru01521   EGFR tyrosine kinase inhibitor resistance ccru01522   Endocrine resistance ccru04010   MAPK signaling pathway ccru04012   ErbB signaling pathway ccru04014   Ras signaling pathway ccru04062   Chemokine signaling pathway ccru04068   FoxO signaling pathway ccru04072   Phospholipase D signaling pathway ccru04150   mTOR signaling pathway ccru04151   PI3K-Akt signaling pathway ccru04510   Focal adhesion ccru04540   Gap junction ccru04630   JAK-STAT signaling pathway ccru04650   Natural killer cell mediated cytotoxicity ccru04660   T cell receptor signaling pathway ccru04662   B cell receptor signaling pathway ccru04664   Fc epsilon RI signaling pathway ccru04714   Thermogenesis ccru04722   Neurotrophin signaling pathway ccru04810   Regulation of actin cytoskeleton ccru04910   Insulin signaling pathway ccru04912   GnRH signaling pathway ccru04915   Estrogen signaling pathway ccru04917   Prolactin signaling pathway ccru04926   Relaxin signaling pathway ccru04935   Growth hormone synthesis, secretion and action ccru05034   Alcoholism ccru05160   Hepatitis C ccru05161   Hepatitis B ccru05163   Human cytomegalovirus infection ccru05165   Human papillomavirus infection ccru05200   Pathways in cancer ccru05205   Proteoglycans in cancer ccru05206   MicroRNAs in cancer ccru05207   Chemical carcinogenesis - receptor activation ccru05208   Chemical carcinogenesis - reactive oxygen species ccru05210   Colorectal cancer ccru05211   Renal cell carcinoma ccru05213   Endometrial cancer ccru05214   Glioma ccru05215   Prostate cancer ccru05220   Chronic myeloid leukemia ccru05221   Acute myeloid leukemia ccru05223   Non-small cell lung cancer ccru05224   Breast cancer ccru05225   Hepatocellular carcinoma ccru05226   Gastric cancer ccru05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:ccru00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     144229239 (SOS2)    04012 ErbB signaling pathway     144229239 (SOS2)    04014 Ras signaling pathway     144229239 (SOS2)    04630 JAK-STAT signaling pathway     144229239 (SOS2)    04068 FoxO signaling pathway     144229239 (SOS2)    04072 Phospholipase D signaling pathway     144229239 (SOS2)    04151 PI3K-Akt signaling pathway     144229239 (SOS2)    04150 mTOR signaling pathway     144229239 (SOS2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     144229239 (SOS2)    04540 Gap junction     144229239 (SOS2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     144229239 (SOS2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     144229239 (SOS2)    04660 T cell receptor signaling pathway     144229239 (SOS2)    04662 B cell receptor signaling pathway     144229239 (SOS2)    04664 Fc epsilon RI signaling pathway     144229239 (SOS2)    04062 Chemokine signaling pathway     144229239 (SOS2)   09152 Endocrine system    04910 Insulin signaling pathway     144229239 (SOS2)    04912 GnRH signaling pathway     144229239 (SOS2)    04915 Estrogen signaling pathway     144229239 (SOS2)    04917 Prolactin signaling pathway     144229239 (SOS2)    04926 Relaxin signaling pathway     144229239 (SOS2)    04935 Growth hormone synthesis, secretion and action     144229239 (SOS2)   09156 Nervous system    04722 Neurotrophin signaling pathway     144229239 (SOS2)   09159 Environmental adaptation    04714 Thermogenesis     144229239 (SOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     144229239 (SOS2)    05206 MicroRNAs in cancer     144229239 (SOS2)    05205 Proteoglycans in cancer     144229239 (SOS2)    05207 Chemical carcinogenesis - receptor activation     144229239 (SOS2)    05208 Chemical carcinogenesis - reactive oxygen species     144229239 (SOS2)    05231 Choline metabolism in cancer     144229239 (SOS2)   09162 Cancer: specific types    05210 Colorectal cancer     144229239 (SOS2)    05225 Hepatocellular carcinoma     144229239 (SOS2)    05226 Gastric cancer     144229239 (SOS2)    05214 Glioma     144229239 (SOS2)    05221 Acute myeloid leukemia     144229239 (SOS2)    05220 Chronic myeloid leukemia     144229239 (SOS2)    05211 Renal cell carcinoma     144229239 (SOS2)    05215 Prostate cancer     144229239 (SOS2)    05213 Endometrial cancer     144229239 (SOS2)    05224 Breast cancer     144229239 (SOS2)    05223 Non-small cell lung cancer     144229239 (SOS2)   09172 Infectious disease: viral    05161 Hepatitis B     144229239 (SOS2)    05160 Hepatitis C     144229239 (SOS2)    05163 Human cytomegalovirus infection     144229239 (SOS2)    05165 Human papillomavirus infection     144229239 (SOS2)   09165 Substance dependence    05034 Alcoholism     144229239 (SOS2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     144229239 (SOS2)    01522 Endocrine resistance     144229239 (SOS2) SSDB OrthologParalogGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH RHG20_PH PH_19 PH_10 DUF5055 IQ_SEC7_PH Motif Other DBs NCBI-GeneID:  144229239 NCBI-ProteinID:  XP_077617354 LinkDB All DBs Position Unknown AA seq 1321 aa AA seqDB search MDLSVNSCTQPECECSYQVQEQVHPNLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVE ERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIV AVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEP SSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIERIFSNISDIH ELTMKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFNEHFSK LMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECL NQAITALMNLQGSMDRIYKQYSPRRRPGDLVCPFYNRHLRSKHLAIKKMNEIQKNIDGWE GKDIGQCCNEFIMEGPLTRVGAKHERHIFLFDGLMISCKPNHSQSRLPGYSSAEYRLKEK FVMRKIQICDKEDTCECKHAFEIVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRM LDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERL TYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADRLAVEKGEQPISAD LKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESI AKIIRRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLES DLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLS RIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKKRILDEAVELSQDHFK KYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQ YQNQPYCLRIEPEMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTF SLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETDLESTVSAPTSPNTPST PPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPP RKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPAPTGAFDGPLHSPPPPPPRDP LPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDPEWFRDVSTCPNSPNTPPSTPSPRVP RRCYALSSSHNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPSYRLPLLENAETP Q NT seq 3966 nt NT seq  +upstreamnt  +downstreamnt atggacttgtctgtgaacagttgcactcagccagagtgtgagtgcagttatcaggttcag gagcaagtacatcccaatctctcagctaatgaagagtctctctattatattgaagagctg atttttcagctgctcaataaattatgcatggctcaaccaaggactgttcaagatgtggag gaacgcgttcagaagacctttcctcatccaattgacaaatgggctattgctgatgcacaa tctgccatagagaaacgaaaacgaagaaatcctctcttactgcctgtggacaaaatccat ccttcattgaaggaagttttagggtacaaagtggactatcatgtatccctgtatattgtg gctgtactagagtatatctcagctgatattttgaagttggctggtaattatgtttttaat atccgacattatgaaatatctcagcaggacattaaagtgtcaatgtgtgcagataaggtt ttgatggacatgtttgatcaggatgacataggtttggtttctctctgtgaagatgaacct agttcttcaggtgaattaaactactatgaccttgtcagaactgaaattgcagaagaaagg caatatctacgggaattaaatatgattataaaagtgtttcgagaagcctttctttctgac agaaagctgtttaaaccttctgatattgaaaggattttcagtaacatttcagatatacat gaattgactatgaaacttctaggtctgattgaagacacagttgaaatgactgatgaaagt agccctcatccattagctggcagctgttttgaagatttggcagaagagcaagcatttgat ccttatgaaacattatcacaggacattctgtctccagaatttaatgaacatttcagtaag ttgatggccagacctgcagtggctctacactttcagtccattgctgatggttttaaagag gcagttcgttacgtccttccacgccttatgctggtgcctgtgtatcattgttggcactat tttgaattattaaagcaattgaaagcatgtagtgaagagcaggaagacagagaatgtttg aaccaagctattactgctcttatgaatctacaaggtagtatggaccgaatttacaagcag tattcacctagacgccgacctggggatcttgtttgccctttttataatcgtcacttaaga agcaagcatctggctattaaaaaaatgaatgaaattcagaaaaacatagatggatgggaa ggcaaagatattggacagtgttgtaatgaattcattatggaaggtccattgacacgagtt ggtgctaaacatgagcggcatatttttctctttgatggcttaatgattagctgtaagccc aatcatagccagtcacgccttccaggttacagtagcgcagaatacagattaaaagaaaaa tttgtcatgaggaaaatacaaatatgtgataaagaagatacctgtgagtgtaaacatgct tttgaaatcgtatccaaagatgaaaacagcataatatttgctgcaaagtctgctgaagag aaaaataattggatggctgcacttatttctcttcactatcgtagtacactagatcgaatg ctagattcagtgttattgaaagaagaaaatgagcagccattgagattaccaagtcctgaa gtatatcgttttgtggtaaaagactctgaggaaaacattgtttttgaagacaacttgcaa agtagaagtggaattcccattattaaaggaggaactgtggtgaaattaattgaaaggtta acatatcatatgtatgcagatcccaattttgtccgtacttttcttactacataccgttca ttttgtaaaccacaggaattgcttagcttactgattgaacgatttgaaattccagagcca gaacctactgaagcagatagattggcagtagagaaaggcgaacagccaatcagtgcagac cttaaaaggtttcgcaaggaatatgtccaaccagtacaacttaggatcttaaatgtgttt cggcactgggttgaacatcatttttatgactttgaaagagatttggagttgcttgagaga ctagaatccttcatttcaagtgtaagagggaaagctatgaagaagtgggtagagtcaatt gctaagatcatcaggaggaagaaacaagctcaggcaaatggaataagccataatattacc tttgaaagtccgcctccaccgattgaatggcatattagcagaccaggacagtttgaaaca tttgatcttatgacacttcatccaatagaaattgcacgtcagctgacacttctggaatct gatctttacaggaaagtccagccttctgaacttgtagggagtgtgtggaccaaagaagat aaagaaataaattctccaaatttgttaaaaatgattcgccataccacgaatctcaccctc tggtttgaaaagtgcattgtggaagcagaaaattttgaggaacgggtggcagtactaagt agaattatagaaattctacaagtttttcaagatttgaataatttcaatggtgtattagag atagtcagtgcagtaaattcagtgtcagtgtacagactagaccatacttttgaggcattg caggaaagaaaaaagagaattttggatgaagctgtggaattaagtcaagatcactttaaa aaatacctagtaaaacttaagtcaatcaatccaccttgtgtgcctttttttggaatatat ttaacaaatattctgaaaactgaagaagggaataatgattttttaaaaaagaaagggaaa gatttaatcaatttcagtaagaggaggaaagtagctgaaattactggagaaattcagcag tatcaaaatcaaccttactgtttacggatagaaccagaaatgaggagattctttgaaaac cttaatcccatgggaagtgcttctgaaaaggagtttacagactatttgttcaataagtca ctagaaattgaaccccgaaactgcaaacagccacctcgatttcctaggaaatcaactttc tctttaaaatctcccggaataaggcctaatacaggccgacatggctctacctcaggcact ttacgaggtcatccaacaccattagaaagagaaccatgtaagataagctttagtaggatt gctgaaactgatcttgaatcaactgtgtcagcaccaacatctccaaatacaccatctact ccaccagtatctgcttcttcagaccttagtgtgtttttagatgtggatctcaacagttcc tgtggcagcaatagcatctttgctccagtcctcctgccacattcaaagtctttcttcagt tcatgtggtagtttacataaactaagtgaagagccactgattcctcctcctcttcctcct cgaaaaaagtttgatcacgatgcttcaaattccaagggaaatatgaaatctgatgatgac ccccctgctattccaccaagacaacctcctcctccaaaggtaaaacccagagttcctgct cctactggtgcatttgacgggcctctgcatagtccacctccaccaccgccgagagatcct cttcctgatacccctccaccagttccccttcggcctccagaacactttataaactgtcca tttaatcttcagccaccaccgctaggacatcttcacagagatccagagtggttcagagac gttagtacctgtccaaattcgccaaatactcctcctagcacaccctctccaagagtaccg cgtcgatgctatgcgctcagttccagtcacaataaccttgctcatcctcaagctccccct gttccaccaaggcagaattcaagccctcacctaccaaaactgccaccaaagacttataaa cgggagctttcgcaccccccatcgtacagactgcctttgctagaaaatgcagaaactcct caatga

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