KEGG   Crocuta crocuta (spotted hyena): 144229726
Entry
144229726         CDS       T11532                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ccru  Crocuta crocuta (spotted hyena)
Pathway
ccru01521  EGFR tyrosine kinase inhibitor resistance
ccru01522  Endocrine resistance
ccru01524  Platinum drug resistance
ccru04010  MAPK signaling pathway
ccru04012  ErbB signaling pathway
ccru04014  Ras signaling pathway
ccru04015  Rap1 signaling pathway
ccru04022  cGMP-PKG signaling pathway
ccru04024  cAMP signaling pathway
ccru04062  Chemokine signaling pathway
ccru04066  HIF-1 signaling pathway
ccru04068  FoxO signaling pathway
ccru04071  Sphingolipid signaling pathway
ccru04072  Phospholipase D signaling pathway
ccru04140  Autophagy - animal
ccru04150  mTOR signaling pathway
ccru04151  PI3K-Akt signaling pathway
ccru04152  AMPK signaling pathway
ccru04210  Apoptosis
ccru04211  Longevity regulating pathway
ccru04213  Longevity regulating pathway - multiple species
ccru04218  Cellular senescence
ccru04261  Adrenergic signaling in cardiomyocytes
ccru04370  VEGF signaling pathway
ccru04371  Apelin signaling pathway
ccru04380  Osteoclast differentiation
ccru04510  Focal adhesion
ccru04517  IgSF CAM signaling
ccru04518  Integrin signaling
ccru04550  Signaling pathways regulating pluripotency of stem cells
ccru04611  Platelet activation
ccru04613  Neutrophil extracellular trap formation
ccru04620  Toll-like receptor signaling pathway
ccru04625  C-type lectin receptor signaling pathway
ccru04630  JAK-STAT signaling pathway
ccru04660  T cell receptor signaling pathway
ccru04662  B cell receptor signaling pathway
ccru04664  Fc epsilon RI signaling pathway
ccru04666  Fc gamma R-mediated phagocytosis
ccru04668  TNF signaling pathway
ccru04722  Neurotrophin signaling pathway
ccru04725  Cholinergic synapse
ccru04728  Dopaminergic synapse
ccru04810  Regulation of actin cytoskeleton
ccru04910  Insulin signaling pathway
ccru04914  Progesterone-mediated oocyte maturation
ccru04915  Estrogen signaling pathway
ccru04917  Prolactin signaling pathway
ccru04919  Thyroid hormone signaling pathway
ccru04920  Adipocytokine signaling pathway
ccru04922  Glucagon signaling pathway
ccru04923  Regulation of lipolysis in adipocytes
ccru04926  Relaxin signaling pathway
ccru04929  GnRH secretion
ccru04931  Insulin resistance
ccru04932  Non-alcoholic fatty liver disease
ccru04933  AGE-RAGE signaling pathway in diabetic complications
ccru04935  Growth hormone synthesis, secretion and action
ccru04936  Alcoholic liver disease
ccru04973  Carbohydrate digestion and absorption
ccru05010  Alzheimer disease
ccru05017  Spinocerebellar ataxia
ccru05132  Salmonella infection
ccru05135  Yersinia infection
ccru05142  Chagas disease
ccru05145  Toxoplasmosis
ccru05152  Tuberculosis
ccru05160  Hepatitis C
ccru05161  Hepatitis B
ccru05162  Measles
ccru05163  Human cytomegalovirus infection
ccru05164  Influenza A
ccru05165  Human papillomavirus infection
ccru05166  Human T-cell leukemia virus 1 infection
ccru05167  Kaposi sarcoma-associated herpesvirus infection
ccru05168  Herpes simplex virus 1 infection
ccru05169  Epstein-Barr virus infection
ccru05170  Human immunodeficiency virus 1 infection
ccru05200  Pathways in cancer
ccru05205  Proteoglycans in cancer
ccru05207  Chemical carcinogenesis - receptor activation
ccru05208  Chemical carcinogenesis - reactive oxygen species
ccru05210  Colorectal cancer
ccru05211  Renal cell carcinoma
ccru05212  Pancreatic cancer
ccru05213  Endometrial cancer
ccru05214  Glioma
ccru05215  Prostate cancer
ccru05218  Melanoma
ccru05220  Chronic myeloid leukemia
ccru05221  Acute myeloid leukemia
ccru05222  Small cell lung cancer
ccru05223  Non-small cell lung cancer
ccru05224  Breast cancer
ccru05225  Hepatocellular carcinoma
ccru05226  Gastric cancer
ccru05230  Central carbon metabolism in cancer
ccru05231  Choline metabolism in cancer
ccru05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccru05415  Diabetic cardiomyopathy
ccru05417  Lipid and atherosclerosis
ccru05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccru00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    144229726 (AKT3)
   04012 ErbB signaling pathway
    144229726 (AKT3)
   04014 Ras signaling pathway
    144229726 (AKT3)
   04015 Rap1 signaling pathway
    144229726 (AKT3)
   04370 VEGF signaling pathway
    144229726 (AKT3)
   04371 Apelin signaling pathway
    144229726 (AKT3)
   04630 JAK-STAT signaling pathway
    144229726 (AKT3)
   04668 TNF signaling pathway
    144229726 (AKT3)
   04066 HIF-1 signaling pathway
    144229726 (AKT3)
   04068 FoxO signaling pathway
    144229726 (AKT3)
   04072 Phospholipase D signaling pathway
    144229726 (AKT3)
   04071 Sphingolipid signaling pathway
    144229726 (AKT3)
   04024 cAMP signaling pathway
    144229726 (AKT3)
   04022 cGMP-PKG signaling pathway
    144229726 (AKT3)
   04151 PI3K-Akt signaling pathway
    144229726 (AKT3)
   04152 AMPK signaling pathway
    144229726 (AKT3)
   04150 mTOR signaling pathway
    144229726 (AKT3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    144229726 (AKT3)
   04518 Integrin signaling
    144229726 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    144229726 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    144229726 (AKT3)
   04218 Cellular senescence
    144229726 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    144229726 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    144229726 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    144229726 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    144229726 (AKT3)
   04613 Neutrophil extracellular trap formation
    144229726 (AKT3)
   04620 Toll-like receptor signaling pathway
    144229726 (AKT3)
   04625 C-type lectin receptor signaling pathway
    144229726 (AKT3)
   04660 T cell receptor signaling pathway
    144229726 (AKT3)
   04662 B cell receptor signaling pathway
    144229726 (AKT3)
   04664 Fc epsilon RI signaling pathway
    144229726 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    144229726 (AKT3)
   04062 Chemokine signaling pathway
    144229726 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    144229726 (AKT3)
   04922 Glucagon signaling pathway
    144229726 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    144229726 (AKT3)
   04920 Adipocytokine signaling pathway
    144229726 (AKT3)
   04929 GnRH secretion
    144229726 (AKT3)
   04915 Estrogen signaling pathway
    144229726 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    144229726 (AKT3)
   04917 Prolactin signaling pathway
    144229726 (AKT3)
   04926 Relaxin signaling pathway
    144229726 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    144229726 (AKT3)
   04919 Thyroid hormone signaling pathway
    144229726 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    144229726 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    144229726 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    144229726 (AKT3)
   04728 Dopaminergic synapse
    144229726 (AKT3)
   04722 Neurotrophin signaling pathway
    144229726 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    144229726 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    144229726 (AKT3)
   04213 Longevity regulating pathway - multiple species
    144229726 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    144229726 (AKT3)
   05205 Proteoglycans in cancer
    144229726 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    144229726 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    144229726 (AKT3)
   05230 Central carbon metabolism in cancer
    144229726 (AKT3)
   05231 Choline metabolism in cancer
    144229726 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    144229726 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    144229726 (AKT3)
   05212 Pancreatic cancer
    144229726 (AKT3)
   05225 Hepatocellular carcinoma
    144229726 (AKT3)
   05226 Gastric cancer
    144229726 (AKT3)
   05214 Glioma
    144229726 (AKT3)
   05221 Acute myeloid leukemia
    144229726 (AKT3)
   05220 Chronic myeloid leukemia
    144229726 (AKT3)
   05218 Melanoma
    144229726 (AKT3)
   05211 Renal cell carcinoma
    144229726 (AKT3)
   05215 Prostate cancer
    144229726 (AKT3)
   05213 Endometrial cancer
    144229726 (AKT3)
   05224 Breast cancer
    144229726 (AKT3)
   05222 Small cell lung cancer
    144229726 (AKT3)
   05223 Non-small cell lung cancer
    144229726 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    144229726 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    144229726 (AKT3)
   05161 Hepatitis B
    144229726 (AKT3)
   05160 Hepatitis C
    144229726 (AKT3)
   05164 Influenza A
    144229726 (AKT3)
   05162 Measles
    144229726 (AKT3)
   05168 Herpes simplex virus 1 infection
    144229726 (AKT3)
   05163 Human cytomegalovirus infection
    144229726 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    144229726 (AKT3)
   05169 Epstein-Barr virus infection
    144229726 (AKT3)
   05165 Human papillomavirus infection
    144229726 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    144229726 (AKT3)
   05135 Yersinia infection
    144229726 (AKT3)
   05152 Tuberculosis
    144229726 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    144229726 (AKT3)
   05142 Chagas disease
    144229726 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    144229726 (AKT3)
   05017 Spinocerebellar ataxia
    144229726 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    144229726 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    144229726 (AKT3)
   05415 Diabetic cardiomyopathy
    144229726 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    144229726 (AKT3)
   04932 Non-alcoholic fatty liver disease
    144229726 (AKT3)
   04931 Insulin resistance
    144229726 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    144229726 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    144229726 (AKT3)
   01524 Platinum drug resistance
    144229726 (AKT3)
   01522 Endocrine resistance
    144229726 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccru01001]
    144229726 (AKT3)
Enzymes [BR:ccru01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     144229726 (AKT3)
Protein kinases [BR:ccru01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   144229726 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 ABC1
Other DBs
NCBI-GeneID: 144229726
NCBI-ProteinID: XP_077617949
LinkDB
Position
Unknown
AA seq 479 aa
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDGMDSERRPHFPQFSYSASGRE
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgagcgatgtcaccatcgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccgagatacttccttttgaagacagatggctcattcataggatataaagag
aagcctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtcttcagtggacc
actgttatagaaagaacgtttcatgtagacactccagaggaaagggaagagtggacagaa
gctattcaggctgtagcagacagacttcagagacaagaagaggagagaatgaactgtagc
ccaacttcacaaattgataatataggggaggaagagatggacgcttccacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttgga
aaagttattttggttcgagagaaggcaagtgggaaatactatgctatgaagattttgaag
aaagaagttattattgcaaaggatgaagtggcacacactctcactgagagcagagtgtta
aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggagtatgttaatgggggagagctgtttttccatttgtcgagagag
cgggtgttctccgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatctgatgctggat
aaagatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgcg
gccaccatgaagacattctgtggtacaccagagtacctggcaccagaggtgttagaagac
aatgactatggccgagccgtggattggtggggactaggggtcgtcatgtatgaaatgatg
tgtgggaggttacctttctacaaccaggatcatgagaaactttttgaactaatactaatg
gaagacattaaatttcctcggacactctcttcagatgcaaaatcattgctttcagggctc
ttgataaaggatccaaataaacgccttggcggaggaccagatgatgcaaaagaaattatg
agacacagtttcttttctggagttaactggcaagatgtatatgataaaaagcttgtacct
ccttttaagcctcaagtaacatctgagacagataccagatattttgatgaagaatttaca
gctcagactattacaataacaccacctgaaaaatatgacgaagacggcatggacggcatg
gacagcgagaggcggccacacttccctcagttctcctactctgccagcggccgggaataa

DBGET integrated database retrieval system