Crocuta crocuta (spotted hyena): 144230199
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Entry
144230199 CDS
T11532
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
ccru Crocuta crocuta (spotted hyena)
Pathway
ccru01521
EGFR tyrosine kinase inhibitor resistance
ccru01522
Endocrine resistance
ccru04010
MAPK signaling pathway
ccru04014
Ras signaling pathway
ccru04015
Rap1 signaling pathway
ccru04066
HIF-1 signaling pathway
ccru04068
FoxO signaling pathway
ccru04081
Hormone signaling
ccru04114
Oocyte meiosis
ccru04140
Autophagy - animal
ccru04144
Endocytosis
ccru04150
mTOR signaling pathway
ccru04151
PI3K-Akt signaling pathway
ccru04152
AMPK signaling pathway
ccru04211
Longevity regulating pathway
ccru04213
Longevity regulating pathway - multiple species
ccru04510
Focal adhesion
ccru04518
Integrin signaling
ccru04519
Cadherin signaling
ccru04520
Adherens junction
ccru04550
Signaling pathways regulating pluripotency of stem cells
ccru04730
Long-term depression
ccru04913
Ovarian steroidogenesis
ccru04914
Progesterone-mediated oocyte maturation
ccru05200
Pathways in cancer
ccru05202
Transcriptional misregulation in cancer
ccru05205
Proteoglycans in cancer
ccru05214
Glioma
ccru05215
Prostate cancer
ccru05218
Melanoma
ccru05224
Breast cancer
ccru05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
ccru00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
144230199 (IGF1R)
04014 Ras signaling pathway
144230199 (IGF1R)
04015 Rap1 signaling pathway
144230199 (IGF1R)
04066 HIF-1 signaling pathway
144230199 (IGF1R)
04068 FoxO signaling pathway
144230199 (IGF1R)
04151 PI3K-Akt signaling pathway
144230199 (IGF1R)
04152 AMPK signaling pathway
144230199 (IGF1R)
04150 mTOR signaling pathway
144230199 (IGF1R)
09133 Signaling molecules and interaction
04081 Hormone signaling
144230199 (IGF1R)
04518 Integrin signaling
144230199 (IGF1R)
04519 Cadherin signaling
144230199 (IGF1R)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
144230199 (IGF1R)
04140 Autophagy - animal
144230199 (IGF1R)
09143 Cell growth and death
04114 Oocyte meiosis
144230199 (IGF1R)
09144 Cellular community - eukaryotes
04510 Focal adhesion
144230199 (IGF1R)
04520 Adherens junction
144230199 (IGF1R)
04550 Signaling pathways regulating pluripotency of stem cells
144230199 (IGF1R)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
144230199 (IGF1R)
04914 Progesterone-mediated oocyte maturation
144230199 (IGF1R)
09156 Nervous system
04730 Long-term depression
144230199 (IGF1R)
09149 Aging
04211 Longevity regulating pathway
144230199 (IGF1R)
04213 Longevity regulating pathway - multiple species
144230199 (IGF1R)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
144230199 (IGF1R)
05202 Transcriptional misregulation in cancer
144230199 (IGF1R)
05205 Proteoglycans in cancer
144230199 (IGF1R)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
144230199 (IGF1R)
05214 Glioma
144230199 (IGF1R)
05218 Melanoma
144230199 (IGF1R)
05215 Prostate cancer
144230199 (IGF1R)
05224 Breast cancer
144230199 (IGF1R)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
144230199 (IGF1R)
01522 Endocrine resistance
144230199 (IGF1R)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ccru01001
]
144230199 (IGF1R)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
ccru04090
]
144230199 (IGF1R)
Enzymes [BR:
ccru01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
144230199 (IGF1R)
Protein kinases [BR:
ccru01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
144230199 (IGF1R)
CD molecules [BR:
ccru04090
]
Proteins
144230199 (IGF1R)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Furin-like
Pkinase
fn3
Kinase-like
Motif
Other DBs
NCBI-GeneID:
144230199
NCBI-ProteinID:
XP_077618540
LinkDB
All DBs
Position
Unknown
AA seq
1351 aa
AA seq
DB search
MAVLAPATLSPVRAPFCGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFP
KLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNI
TRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPLCEKTT
INNEYNYRCWTTNRCQKMCPSACGKRACTDSNECCHPECLGSCSAPDNDTACVACRHYYY
AGVCVPTCPPNTYRFEGWRCVDRDFCANIPSAESSDSEGFVIHDGECMQECPSGFIRNGS
QSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELEN
FMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSFYVLDNQNLQQLWDWGH
RNLTIKSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFT
STTTGKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDL
PPNKDAEPGILLQGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLD
VLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRHNYCSKDKIPIRKYADG
TIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPE
RKRRDVTQVTNTTMSSRNRNATVADTYNVTDPEELETEYPFFESRVDNKERTVISNLRPF
TLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWESRPENSIFLKWPEPE
NPNGLILMYEIKYGSQIEDQRECVSRQEYRKYGGARLNRLNPGNYTARIQATSLSGNGSW
TDPVFFYVPAKITYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASV
NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN
EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP
EIENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGM
TRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGL
SNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKDEMEPGFRE
VSFYYSEENKPPEPEELDLEPEDMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVL
RASFDERQPYAHMNGGRKNERALPLPQSSTC
NT seq
4056 nt
NT seq
+upstream
nt +downstream
nt
atggcagttctggcgcctgcaaccttgagtcctgtgcgtgcccccttctgcgggccgggc
atcgatatccgtaacgactatcagcagctgaagcgcctggagaactgcacggtgatcgag
ggctacctccacatcctgcttatctccaaggcagaggactaccgcagctaccgcttcccc
aagctcacggtcatcaccgagtacttgctgctgttccgcgtggccggccttgagagcctc
ggggacctcttcccgaacctcacggtcatccgtggctggaaactcttttacaactacgcc
ctggtcatctttgagatgaccaacctcaaggatattgggctttacaatctgaggaacatt
acccggggggccatcaggattgagaaaaatgccgacctctgttacctctccacggtggac
tggtccctgatcctggatgcagtgtccaacaactacatcgtggggaacaagcccccaaaa
gagtgcggggacctgtgtccggggacaatggaggagaagccgttgtgcgagaagactacc
atcaacaatgagtacaactaccgctgctggaccacaaaccgctgccagaaaatgtgcccg
agcgcgtgtgggaagcgggcctgcacggacagcaacgagtgctgtcaccccgagtgcctg
ggcagctgcagcgcgcccgacaacgacacggcctgcgtggcctgcaggcattactactac
gccggcgtctgcgtgcccacctgcccgcccaacacctaccgcttcgagggctggcgctgc
gtggaccgcgacttctgcgccaacatccccagcgccgagagcagcgactccgaggggttc
gtgatccacgatggcgagtgcatgcaggagtgcccctcggggttcatccggaacgggagt
cagagcatgtactgcatcccttgtgaaggtccttgccccaaggtctgtgaggaggagaag
aaaacaaagaccattgattctgttacctctgcgcaaatgctccaaggatgcaccatcttc
aagggcaacttgctcattaatatccgccgaggcaataacattgcctcggagctggagaac
ttcatggggctcatcgaggtggtgacaggctacgtgaagatccgccattcccacgccttg
gtctccttgtccttcctaaaaaaccttcgccagatcttaggagaggagcagctggagggg
aactactctttctatgtcctcgacaaccagaacctgcagcagctctgggactggggccac
cgcaacctgaccatcaaatctgggaagatgtacttcgctttcaatcccaagttgtgcgtc
tccgaaatttaccgcatggaggaagtgactgggacgaaggggcgccagagcaaaggggac
atcaataccaggaacaacggagagcgagcctcctgtgaaagtgatgtcctgcacttcacc
tctacgaccacggggaagaaccgcatcatcataacctggcaccggtaccggcccccggac
taccgggacctcatcagcttcaccgtctactacaaggaggcaccttttaaaaacgtcaca
gagtatgatggccaggatgcctgtggctccaacagctggaacatggtggacgtggacctc
cctcccaacaaggacgccgagcctggcattctgctgcagggtctgaagccctggacgcag
tatgctgtctacgtcaaggcagtgaccctcaccatggtagagaatgaccacatccgcggg
gccaagagtgaaatcttgtacattcgcaccaatgcttcagttccttccattcccctggat
gttctttcggcatcgaactcttcttctcagctcatcgtgaagtggaacccgccgtcgctg
cccaatggcaacctaagttactacatcgtgaggtggcagcggcagcctcaggacagctac
ctttaccggcacaactactgctccaaagacaaaatccccatcaggaagtatgccgatggc
accattgacatcgaggaggtgaccgagaaccccaagactgaagtgtgcggcggagagaag
gggccttgctgcgcctgccccaaaaccgaggccgagaagcaggccgagaaggaggaggct
gagtaccgcaaagtcttcgagaacttcctgcacaactccatctttgtgcccagacctgaa
aggaagcggagagatgtcacgcaggtcaccaacaccaccatgtccagccggaacaggaac
gccacggtggccgacacctataatgtcacagacccggaggagcttgagacagaataccct
ttctttgagagcagagtggacaacaaggagagaaccgtgatctctaacctccggcctttc
accttgtaccgcattgacatccacagctgtaaccacgaggctgaaaagctgggctgcagc
gcctccaacttcgtctttgcaagaaccatgcctgcagaaggagcagatgacattcctggg
ccggtgacctgggagtcaaggcctgaaaactccatctttttaaagtggccagaacctgag
aatcccaatggactgattctcatgtatgagataaaatacggatcacaaattgaggaccag
cgggaatgtgtgtccagacaggagtaccggaagtacggcggcgccaggctgaaccggctc
aacccagggaactacacggcccggatccaggccacctctctctctgggaacgggtcgtgg
acggatcccgtgttcttctacgtccccgccaagataacatatgaaaatttcatccacctg
atcatcgccctgcccgtcgccgtcctgttgatagtggggggactggtcatcatgttgtac
gtcttccacagaaaaagaaataacagcaggctggggaatggagtgctgtacgcatccgtg
aacccagagtacttcagcgccgcagatgtgtacgtacctgatgagtgggaggttgctcgg
gagaagatcaccatgagccgagagctggggcagggctcgttcgggatggtctacgaggga
gttgccaaaggcgtggttaaagacgagcccgaaaccagggtggccatcaagacagtgaat
gaggccgcgagcatgcgtgaacggattgagtttctcaatgaggcttcagtgatgaaggag
ttcaattgtcaccatgtggtacgcttgctgggcgtggtgtcccagggccagccgacgctg
gtcatcatggagctgatgacacggggtgatctcaaaagttatctcaggtctctaaggcca
gaaatagagaataatccagtcctagcacctccgagcctgagcaagatgatccagatggcg
ggagagattgcagacggcatggcatacctcaacgccaacaagtttgtccacagggacctt
gctgcccggaactgcatggtggctgaagatttcacggtcaaaattggagatttcggtatg
acgagagatatctacgagacagactattaccggaaaggaggcaaggggctgctgcctgtg
cgctggatgtcgcccgagtccctcaaggatggggtcttcaccactcactctgacgtctgg
tccttcggggtcgttctctgggagatcgccacgctggccgagcagccgtaccagggcttg
tccaacgagcaagtcctgcgcttcgtcatggagggcggccttctggacaagccggacaac
tgccccgacatgctgtttgaactgatgcgcatgtgctggcagtacaaccccaagatgagg
ccttccttcctggagatcatcagcagcatcaaggacgagatggagcccggcttccgggag
gtgtccttctactacagcgaggagaacaagccgcccgagccggaggagctggacctggag
ccggaggacatggagagcgtccccctggacccctccgcctcctcgtcctccctgccgctg
cccgacagacactcaggacacaaggccgagaacggcccgggccccggcgtgctggtgctc
cgcgccagcttcgacgagagacagccttacgcgcacatgaacgggggacgcaagaacgag
agggccttgcctctgccccagtcttcgacctgctga
DBGET
integrated database retrieval system
