Crocuta crocuta (spotted hyena): 144230301 Help Entry 144230301         CDS       T11532                                  Symbol ADCY9 Name (RefSeq) adenylate cyclase type 9   KO K08049   adenylate cyclase 9 [EC:4.6.1.1] Organism ccru  Crocuta crocuta (spotted hyena) Pathway ccru00230   Purine metabolism ccru01100   Metabolic pathways ccru01522   Endocrine resistance ccru04015   Rap1 signaling pathway ccru04020   Calcium signaling pathway ccru04022   cGMP-PKG signaling pathway ccru04024   cAMP signaling pathway ccru04062   Chemokine signaling pathway ccru04072   Phospholipase D signaling pathway ccru04081   Hormone signaling ccru04082   Neuroactive ligand signaling ccru04114   Oocyte meiosis ccru04211   Longevity regulating pathway ccru04213   Longevity regulating pathway - multiple species ccru04261   Adrenergic signaling in cardiomyocytes ccru04270   Vascular smooth muscle contraction ccru04371   Apelin signaling pathway ccru04540   Gap junction ccru04611   Platelet activation ccru04713   Circadian entrainment ccru04714   Thermogenesis ccru04723   Retrograde endocannabinoid signaling ccru04724   Glutamatergic synapse ccru04725   Cholinergic synapse ccru04727   GABAergic synapse ccru04750   Inflammatory mediator regulation of TRP channels ccru04911   Insulin secretion ccru04912   GnRH signaling pathway ccru04913   Ovarian steroidogenesis ccru04914   Progesterone-mediated oocyte maturation ccru04915   Estrogen signaling pathway ccru04916   Melanogenesis ccru04918   Thyroid hormone synthesis ccru04921   Oxytocin signaling pathway ccru04923   Regulation of lipolysis in adipocytes ccru04925   Aldosterone synthesis and secretion ccru04926   Relaxin signaling pathway ccru04927   Cortisol synthesis and secretion ccru04928   Parathyroid hormone synthesis, secretion and action ccru04934   Cushing syndrome ccru04935   Growth hormone synthesis, secretion and action ccru04961   Endocrine and other factor-regulated calcium reabsorption ccru04962   Vasopressin-regulated water reabsorption ccru04970   Salivary secretion ccru04971   Gastric acid secretion ccru04972   Pancreatic secretion ccru04976   Bile secretion ccru05032   Morphine addiction ccru05163   Human cytomegalovirus infection ccru05166   Human T-cell leukemia virus 1 infection ccru05200   Pathways in cancer ccru05207   Chemical carcinogenesis - receptor activation ccru05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:ccru00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     144230301 (ADCY9)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     144230301 (ADCY9)    04371 Apelin signaling pathway     144230301 (ADCY9)    04020 Calcium signaling pathway     144230301 (ADCY9)    04072 Phospholipase D signaling pathway     144230301 (ADCY9)    04024 cAMP signaling pathway     144230301 (ADCY9)    04022 cGMP-PKG signaling pathway     144230301 (ADCY9)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     144230301 (ADCY9)    04081 Hormone signaling     144230301 (ADCY9)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     144230301 (ADCY9)   09144 Cellular community - eukaryotes    04540 Gap junction     144230301 (ADCY9)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     144230301 (ADCY9)    04062 Chemokine signaling pathway     144230301 (ADCY9)   09152 Endocrine system    04911 Insulin secretion     144230301 (ADCY9)    04923 Regulation of lipolysis in adipocytes     144230301 (ADCY9)    04912 GnRH signaling pathway     144230301 (ADCY9)    04913 Ovarian steroidogenesis     144230301 (ADCY9)    04915 Estrogen signaling pathway     144230301 (ADCY9)    04914 Progesterone-mediated oocyte maturation     144230301 (ADCY9)    04921 Oxytocin signaling pathway     144230301 (ADCY9)    04926 Relaxin signaling pathway     144230301 (ADCY9)    04935 Growth hormone synthesis, secretion and action     144230301 (ADCY9)    04918 Thyroid hormone synthesis     144230301 (ADCY9)    04928 Parathyroid hormone synthesis, secretion and action     144230301 (ADCY9)    04916 Melanogenesis     144230301 (ADCY9)    04925 Aldosterone synthesis and secretion     144230301 (ADCY9)    04927 Cortisol synthesis and secretion     144230301 (ADCY9)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     144230301 (ADCY9)    04270 Vascular smooth muscle contraction     144230301 (ADCY9)   09154 Digestive system    04970 Salivary secretion     144230301 (ADCY9)    04971 Gastric acid secretion     144230301 (ADCY9)    04972 Pancreatic secretion     144230301 (ADCY9)    04976 Bile secretion     144230301 (ADCY9)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     144230301 (ADCY9)    04961 Endocrine and other factor-regulated calcium reabsorption     144230301 (ADCY9)   09156 Nervous system    04724 Glutamatergic synapse     144230301 (ADCY9)    04727 GABAergic synapse     144230301 (ADCY9)    04725 Cholinergic synapse     144230301 (ADCY9)    04723 Retrograde endocannabinoid signaling     144230301 (ADCY9)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     144230301 (ADCY9)   09149 Aging    04211 Longevity regulating pathway     144230301 (ADCY9)    04213 Longevity regulating pathway - multiple species     144230301 (ADCY9)   09159 Environmental adaptation    04713 Circadian entrainment     144230301 (ADCY9)    04714 Thermogenesis     144230301 (ADCY9)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     144230301 (ADCY9)    05207 Chemical carcinogenesis - receptor activation     144230301 (ADCY9)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     144230301 (ADCY9)    05163 Human cytomegalovirus infection     144230301 (ADCY9)   09165 Substance dependence    05032 Morphine addiction     144230301 (ADCY9)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     144230301 (ADCY9)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     144230301 (ADCY9)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     144230301 (ADCY9) Enzymes [BR:ccru01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      144230301 (ADCY9) SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom Motif Other DBs NCBI-GeneID:  144230301 NCBI-ProteinID:  XP_077618657 LinkDB All DBs Position Unknown AA seq 1352 aa AA seqDB search MASPPHQQLLQHHSTEVSCDSSGDSNSVRVKINPKQLSSNSQPKHCKYSISSSCSSSGDS GGVPRRVGAGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACMERCFPQTQRRFRYAL FYIGFACLLWSIYFGVHMRSRLIVMVAPALCFLVVCVGFFLFTFTKVYTRHYVWTSLVLT LLVFALTLAAQFQVLTPLSGRVDSSNHTLAAKPTDACLSQVGSFSMCIEVLFLLYTVMHL PLYLSLCLGVAYSVLFETFGYHFRDKDCFPPPGAGAPHWELLSRALLHVCVHAIGIHLFI MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR HATSSPKNRKKKSSIQKAPIAFRPFKMQQIDEVSILFADIVGFTKMSANKSAHALVGLLN DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIRAIEQFCQEK KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD DRYEMEDGRVTERLGQSVVADQLKGLKTYLIAGQRAKESHCSCSEALLSGFEVIDGSRVS SGPRGQGTASPGSVIDLAQTVKTFDNLKTCPSCGIMFAPKSEAGAEGGAIQNGCQEEHKN NTKAPAAPNSKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF ASATFSSLLDVFLSTTVFLILSITCFLKYGAATAPPPPAALAVFGAALLLEVLSLVVSVR MVFFLEDVMACTKRLLERIAGWLPRHFIGAILVSLPALAVYSHVTSEFDTDIHFTVFTGS AVLTAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVVISHLDVGQNFSSEA NLCNTSLPRDGRAASPIGQEVILVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKI QSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKEC YRVLNELIGDFDELLSRPGYGSIEKIKTIGATYMAASGLNGAQCREGSHPQEHLQVLFEF AKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTG VECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDSGAVPQHQLSISPD IRVQVDGSIGRSPTDEIANLVPSVQSVDKTPPGSENNVQAKDAHLSSKRPWKEPVKAEER CQFGKAIEKSDCEDAGTEEASELTRLNISESV NT seq 4059 nt NT seq  +upstreamnt  +downstreamnt atggcttccccgccccaccagcagctgctgcagcaccacagcacggaggtgagctgtgac tccagcggagacagcaacagcgtgagggtcaaaatcaaccccaagcagctgtcctccaac agccagcccaagcactgcaagtacagcatctcctccagctgtagcagctccggggactcg gggggcgtccctcggagagtgggcgccggaggccgcctgcgcaggcagaagaagctgccc cagctgttcgagagggcctccagccggtggtgggaccccaagttcgactcggtgaacctg gaggaggcttgcatggagcgttgcttcccgcagacccagcgccgcttccggtatgcgctc ttctacatcggcttcgcctgccttctgtggagcatctattttggggtccacatgcggtcc agactgatcgtcatggtagcccctgctctgtgcttcctcgtcgtgtgcgtgggctttttt ctgtttaccttcaccaaggtgtatacccggcattacgtatggacctctctggttctcacc ctcctggtgttcgccctgacgctggctgcccagtttcaggttttgacgcctctctcagga cgtgttgacagctccaatcacaccctcgccgccaagcccacggacgcttgcttatctcaa gtggggagcttttccatgtgcatcgaagtgctctttttgctctacaccgtcatgcactta cctttgtacttgagcttgtgtttgggagtggcctattctgttctctttgagacctttggc tatcacttccgagacaaagactgctttcccccacctggagcaggggccccacactgggag ctgctgagccgagccctgctccatgtctgcgttcacgccattgggatccacctgttcatc atgtcgcaggtgagatccaggagcacctttctcaaggtgggacagtcaattatgcacggg aaggatctggaagtggaaaaagctctgaaagagaggatgattcattctgtgatgccaaga atcatagctgatgacttgatgaaacagggcgatgaggagagcgagaattctgtcaaaagg cacgccacctccagccccaagaacaggaagaaaaagtcttccatacagaaggcccctata gcattccgcccttttaaaatgcagcagatcgatgaagtcagtattttatttgcagatatc gtgggcttcaccaagatgagtgccaataagtctgctcacgctctggtgggtctcctcaat gatctgtttggtcgctttgaccggttgtgtgaagagaccaagtgtgagaaaatcagcacc ctgggagactgctactattgtgtggcagggtgtccagagccccgggccgaccatgcctac tgctgcattgagatgggcttgggcatgatcagagccatcgagcagttctgccaggagaag aaagagatggtgaacatgcgtgtcggggttcacacagggaccgtcttgtgtggcattttg ggtatgaggaggttcaaattcgatgtgtggtccaatgatgtgaacttagccaatctcatg gagcagctgggagtggccggcaaggttcacatttctgaggccaccgcaaaatacctagat gatcggtacgaaatggaagatgggagggtgactgaacgcctcggccagagcgttgttgct gatcagttgaaaggtttgaagacatacctgatagcgggtcagagagcgaaggagtctcat tgcagctgttcagaggccttgctttctggctttgaggtcattgacggctcacgggtgtcc tcaggccctaggggacaggggacagcatcgccagggagtgtcattgacttggcgcagact gtcaaaacctttgataaccttaagacctgcccttcatgcggaatcatgtttgcccccaaa tcagaagctggtgcagaaggaggagccatccaaaacggctgtcaagaggagcataaaaac aacaccaaggctcccgcagctcctaattccaaaactcaaaacggacttctgagccctccc caagaagagaagctcaccaacagtcagacctccctgtgtgagatcttacaggaaaaggga aggtgggcaggggtgagcttggaccagtcagctctccttccgctgagattcaagaacatc cgggagaaaacagatgcccattttgtggatgtcatcaaagaagacagcctgatgaaggat tattttttcaaaccacccatcaatcagttcagcttgaacttcctggatcaggagctagag cgatcctacaggactagctatcaagaagaggtcataaagaattctcctgtgaagactttt gccagtgccaccttcagctccctcctggacgtgtttctgtcgacaacagtgtttctgatt ttgtccatcacctgcttcctgaagtatggggctgccactgcgcctcccccacctgccgcc ctggcagtgttcggtgccgcgctgctgctggaggtgctgtccctcgtggtctccgtcagg atggtgtttttcctggaggatgtgatggcttgtaccaagcgcctgctggagcgcatagcc ggctggctcccacgccatttcatcggggccatcctggtgtcactccctgccctcgccgtg tattcacacgtcacctccgaatttgacaccgacatacacttcaccgtgttcacgggctcc gccgtcctgaccgccgtcgtgcactactgtaacttctgccagctcagctcctggatgaga tcctccttagccaccgtcgtcggggctgggccgctgctcctgctctacgtctccctgtgc ccagacagttccgtagtaatttcacacctggatgtgggacagaatttcagttccgaggca aacctgtgcaatacttccttgccgcgtgatggcagggcagccagcccgattggccaggag gtgattcttgtcttctttctcctgctgttgttggtctggttcctgaatcgagagttcgag gtcagctaccgcttgcactaccacggggacgtggaggcagaccttcaccgcaccaagatc cagagcatgcgggaccaggccgactggctgctgagaaacatcatcccctaccacgtggcc gagcagctgaaggtctcccagacctactccaagaaccacgacagtgggggcgtcatcttc gccagcatcgtcaacttcagcgagttctacgaggaaaactatgaagggggcaaggagtgc taccgcgtcctcaacgagctcatcggagacttcgacgagctcctgagcaggccgggctat ggcagcattgagaagatcaagaccatcggtgccacgtacatggctgcgtcagggctgaac ggcgcacagtgccgggagggcagccacccgcaggagcacctgcaggtcctgttcgagttc gccaaggagatgatgcgcgtggtggacgacttcaacagcaacatgctgtggttcaacttc aagctcagggtgggcttcaaccatgggccgctcacggcaggggtcatcggcacaaccaag ctgctctatgacatctggggtgacaccgtcaacattgccagcaggatggacagcacgggg gtggagtgccggatccaggtgagtgaggagagctaccgcgtcctaagcaagatgggctac gacttcgactaccgagggacggtaaatgtaaagggcaagggccagatgaagacctacctg tacccaaagtgcacggacagtggggccgtgccacagcaccagctgtccatctcccccgac atccgagtccaggtggacggcagcatcggccgctctcccacggacgagatcgccaacctg gtgccttctgtccagagcgtggacaagacgcctccgggttccgaaaacaacgtgcaggcc aaggatgctcacctctcctctaagaggccctggaaagagccagtcaaagctgaggaaaga tgtcaatttggcaaagccatagagaaaagcgactgtgaagacgcgggcactgaagaagcc agcgagctcaccaggctcaacatttctgagagcgtgtga

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