Crocuta crocuta (spotted hyena): 144234982 Help Entry 144234982         CDS       T11532                                  Symbol SETX Name (RefSeq) putative helicase senataxin   KO K10706   ATP-dependent RNA/DNA helicase, senataxin [EC:5.6.2.5 5.6.2.3] Organism ccru  Crocuta crocuta (spotted hyena) Pathway ccru05014   Amyotrophic lateral sclerosis Brite KEGG Orthology (KO) [BR:ccru00001]  09160 Human Diseases   09164 Neurodegenerative disease    05014 Amyotrophic lateral sclerosis     144234982 (SETX)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:ccru03021]     144234982 (SETX) Enzymes [BR:ccru01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.3  DNA 5'-3' helicase      144234982 (SETX)     5.6.2.5  RNA 5'-3' helicase      144234982 (SETX) Transcription machinery [BR:ccru03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Transcription termination factor      144234982 (SETX) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AAA_11 AAA_12 AAA_19 UvrD-helicase AAA_30 AAA_22 ResIII nSTAND3 SLFN-g3_helicase NAT10_TcmA_helicase Adeno_E1A AAA_16 TniB UvrD_C_2 Motif Other DBs NCBI-GeneID:  144234982 NCBI-ProteinID:  XP_077624542 LinkDB All DBs Position Unknown AA seq 2663 aa AA seqDB search MSTCCWCTPGGISTVDFLKRYASRTRASECQTADEDLCYCLECVAEYHKARDELPFLHQV LWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEAQLFDFPGQDFENKLRVPLLEILKY PYLLLHERVNELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGK VDRDDYYDLQEVLTCLFKVIELGLLEDPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLG ICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMERQADDNSVDPFWPALHCFMVILDRL GSKVWGQRIDPIEAFQTIINNMSYNKEIQNIRNSSVRTKSDSESRSVNTVSCSQMVYNYN PEKTKKDSGWRSAICPDYCPNMYEEMETLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMD LKDLGVAYIVEVIHHLHSEVKDVLNQTDAVCDKVTEFFLLILVSVIELHRNKKCLHLLWV SSQQWVEAVVKCAKLPTTAFARSSEKSSGNCSKGTAMISSLSLHSMPSNSVQLACVQLIR SLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTTQETHELQTCLKQIIRNIKLKVP PCSTFVDLAPVCKTPPASYNKEESEQIGKKSKKDLLCLESSSPTFSKEPMKAEAYQMQEN ISIKASNTIGEDNEQNYVKDLKLEDHLSAESCIKQGSKSLFTDRAQDPVKTSKGKHKSVK ENRTSRNGPERGGDRVVIVSAHSLTDSGIDSLAKASTSTEDFSFKDDIFGKTLRAKTKPQ KAEICAKLSHVMKQHRKSTSVNDAVSLEENLTVATIDSFFSKKDSGGQKGEGLINHLSLD PNDIPDDKNGERKSQNSLLLKKKQLKSEEFDIFSSRENSRQIQERQADDKDLVSLTEMTD PCVKKTLPFKNPMTVLESRGKEVSKSTTSQVSSHLRDQPPSLSPQSEALTDSQVDRDLHD LSLIAQASVIKFPSDSTQNSSQLQRKVKGKRCFTVNPNNAGEACQGQVIIISDSDDDDGD EGVLGFEKHIKRDKRSIKKEYPEECVSVAGANVERNLIKEEETKSLWEFEESDSQFFEFE SPHDVFSVWHDLEPDKNLVQEDEKNSHLTHIKDVTNDWGYDTDYVSEEVIKKVAEGIEKH TEAQSSSSVGEFCKTEVKKPKRKRYEKPVAEDPLRPSPSERNEDQSDILNERGLTENDLK STELRSSPSSNIQRDSPVSRKKSPKLRTYSKPIRRVPHSKPSKKTHSETKKGQNKSSNYI SCRTTPAIVPPKVLRQYPEPTSAVEKLGLKKAPRRAFQLSQRSQGYVAQLRDHGKTVGVV DTRKKTKLISPQTLSVKNNKKLLTSQDLQSRRQVKHKSKQNRQGSLGSESTGTRRAGRRS AQNPDTLVPESDSSDRSSKGGAEVCASNTGKRSVKRVSSEPEPVKTKCVSQVADDPCLLT QSASVVLNGRIPTDEVIASTSADPLGGGDLAAHHVELTTLKERKRESNSDSEDENLFLTQ RDPEDMDLCSQMANSSEKLIEIGQGKDTAPKEESWSGTKCKYKDCVETPQNQGEYCSKHC EAKAADEDVFRKPGLPLSASKRPSTTKVFSSRSTSRIANLSKSLESTSALPPSLKRKSNG VTSASKAPQPTSPLSPKPVGELKSLSNVLRPQTPNNSNRQGYKFLFGESKSFSASSAVNI VLSSQSISDTFVKEVLKWKYEMFVNFDQCGPPTSLCQSISRPVPVRFQDCGDYFNVFFPL VVLNTFETVAQEWMSSPNKDKFYQLHLRKFPADYKKYWEFVVHLEECELTKQLHPKENDL VFLVLENGEDTEGNRMPDFNEYYCGYVHKFRRTSVMRNGKSECSLSIQTQDNLMLNLNEL VKCTVISSLVTTQRKLKAMSLLSGRNQLARVVLNPNPMDFCTKDLLTTTSERIIAYLKDF NEDQKKAIETAYAMVKHSPSVAKVCLIHGPPGTGKSKTIVGLLYRLLTESQRRGHSDENS NAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPMGNCGDINLVRLGPEKSINN EVLRFSLDSQVNHRMKKDLPSHVQEMHRRKEFLDHQLDELSRQRALCRGGKETQRQELDE KIAKVSKERQELASKIKEVQGRPQKTQSIIILESHVICCTLSTSGGLLLESAFRGQGGVP FSCVIVDEAGQSCEVETLTPLIHRCNKLVLVGDPKQLPPTVISMKAQEYGYDQSMMARFY KLLEDNVEQNVIGRLPVLQLTVQYRMHPDICLFPSNYVYNKRLLFRRLTETNRCSSDWPF QPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKDKRRDVTFRNIGIITHYKAQKTM IQKDLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVRANAMQGSIGFLASLQRLNVTITR AKYSLFILGHLRTLMENQHWNQLIQDAQKRGAIIKTCDKNYRHDAAKILKLKPVLQRSLT QPPTGAPEMAWPQGGLPGSKPDGEFARTSSPSSLYHVPSDSKESAGTVTAKDPERPPIQD RLRDPRLLRRLGLDPEAKGTCPWDPQPLSPQHSGATPPLGEPGFPSSHQDLGGAQPPAAR GAALGTHKPPVQREPPAAGTEASASKRTYDWEGGVSHRRETRAFSEGDQEPQSPERRHVR RHSGWDHRRLEGDDGGSKKRRFL NT seq 7992 nt NT seq  +upstreamnt  +downstreamnt atgagcacatgctgttggtgtacgccaggtggtatttccaccgttgacttcctgaagcgc tatgcgtccaggacccgcgccagtgaatgtcagacagctgacgaagacctctgttactgc ctagagtgtgtggccgagtaccacaaagcccgggacgagctgccattcttgcatcaggtt ttgtgggaattagaaactttacgtctcataaatcattttgaaaaatccatgaaggcagaa attggagatgatgatgaattgtacatagtagacaacaatggagaggcacaactatttgac ttccccggccaagactttgaaaataagcttcgagttcctcttcttgaaatcctgaagtat ccatatctgcttttacatgaacgtgtcaacgaattatgtgtcgaagcactttgtcggatg gaacaagctaattgctcctttcaggttttcgacaaacatccaggcatttatttgtttctg gtccatcccaacgaaatggttcgacgttgggctatcctgaccgcaaggaatttgggaaaa gtggacagagatgactattatgacttgcaggaagttttaacttgcctttttaaagtcatc gagctgggacttttggaagatccggacatttatacttcctctgtcctcgagaagggtaaa ctgatccttctgcctgcccacatgtacgataccaccaactacaagaactactggttgggt atttgcatgttgctgaccattcttgaagagcaggccatggactccctgttgctgggctca gacaaacagaatgatttcatgcagtccatacttcacaccatggagaggcaagcagacgat aatagcgtggatcctttctggccagcattacactgttttatggtgattctggatcgcctt ggatcaaaggtctggggtcaacgcattgatcctattgaggcatttcagaccataatcaac aatatgagctacaataaagagatccagaatatacggaacagctctgtaaggaccaagtca gactcggagtcacgttcggttaatacggtgtcctgcagccagatggtatacaattataat cctgaaaagaccaaaaaggattctgggtggagatcagccatttgcccagattactgtcct aacatgtatgaggagatggaaacattagccagcgtgcttcagtcagatattggtcaagac atgcgtgttcacaacagcacgtttctgtggttcatcccttttgttcagtccctcatggat cttaaggatttgggtgtggcttatatagtagaggttattcaccatctgcactctgaagtc aaagatgtcctcaaccaaacagatgctgtgtgcgacaaagttactgagttttttcttctg attttggtgtccgtgattgagctgcacagaaataaaaaatgtttgcacttgctgtgggtt agctcccagcagtgggtggaggctgttgtaaaatgcgccaagcttcctaccactgcattt gcacggagttccgagaagtcgtctggaaattgttccaaaggaacagcaatgatatcatct ctgtcgttacattcgatgccatctaactctgtccagctggcttgtgtgcagctcattaga agtctccttaaagaaggttatcagcttgggcagcaaactctgtgcaagcgattctgggat aagctcaacttatttctgcgtggaaatttgtctctaggttggcaattgactactcaggaa acccatgagttacaaacttgtttaaagcaaattattaggaacataaaattaaaagtacct ccatgtagcacttttgtggatctggcccctgtttgtaaaacccctcctgcgtcttataat aaagaagaaagtgaacagatagggaagaagtctaaaaaagacctgctctgtctggaaagc tccagcccaacattttctaaagaaccaatgaaagcagaggcatatcaaatgcaagagaat atatcgatcaaagcaagtaacactataggagaggataatgagcaaaattatgtaaaagat ttgaaattggaagaccatctctcagctgagtcatgcataaagcagggtagtaaaagcctt ttcactgacagagctcaagacccagttaaaacaagtaaagggaagcataagtctgtgaaa gagaatcgtacttccagaaatggtcccgaaaggggaggtgacagagtggtgatagtgtca gcacactcgttgactgattctggcattgactctctggcaaaggcgtccacatcaactgag gatttctctttcaaggatgatatttttggcaaaaccttgagagcaaaaactaagccacag aaagccgaaatctgcgctaagttatcacatgtgatgaagcaacacaggaaaagtacttcg gtcaatgatgctgtcagtttagaggaaaacctgactgtggctaccattgacagtttcttt tcaaagaaagattcaggaggtcagaaaggggagggcctcataaaccatctctctctagac cctaatgacattcccgatgataaaaatggggagcgaaaatctcaaaacagtttattgctg aaaaagaaacaattaaagagtgaagagtttgatatcttctcttcccgtgaaaacagccgt caaatacaggaacgtcaggccgacgataaagatttggtctcattgacggaaatgactgat ccttgtgtgaagaaaaccttgcccttcaaaaatcccatgactgttcttgaatcaagaggt aaggaagttagcaagagtaccaccagtcaggtgtcttctcacttgagagaccagcctccc agcctaagtccacagtccgaagccttgacggactcccaggtcgaccgcgacctccacgac ttatctttaatagctcaagccagtgttattaagtttccatcagattcaacccaaaactcg tcccagctacaaaggaaagtaaaaggtaaaagatgtttcacagttaacccaaataatgct ggcgaagcctgccagggccaggtgattattatttcagattccgatgatgatgatggcgat gaaggagttttgggttttgagaaacacatcaaacgagacaaaagaagcatcaagaaggag tacccggaggagtgtgtttcagtagctggtgcaaatgtggaaaggaatctaataaaggaa gaagagacaaagtccctgtgggagtttgaggaatcagattctcagttttttgagtttgaa agtccacatgatgtgttttcagtttggcacgatctggaaccagacaagaatttagttcaa gaggatgaaaaaaattcacatttgactcacataaaagatgtcacaaatgactggggttat gatacagattatgtatctgaagaggttattaagaaagtagcagagggcattgaaaaacac acagaagcacagagtagtagttctgttggggaattttgcaaaactgaagtaaaaaaacct aagagaaaacgatatgaaaaacctgtagctgaagatcctctgaggccttcaccttctgag agaaatgaggaccagtctgatattcttaatgagagaggtctgactgaaaatgatcttaaa agtacagagctaaggtctagtcccagttcgaatattcagagagactctccggtttcacga aagaaatctccaaagcttcgtacttactccaaacccatcaggagagtcccgcattctaaa ccttctaagaaaacacattcagaaaccaaaaaagggcagaataaaagttccaattacata agttgtaggacaactcctgctatagtcccaccaaaggtacttcgccagtaccctgaacca acttcagctgttgagaaactgggtctgaaaaaggctcctcgtagggcgtttcagttatct cagcgatctcaagggtatgtagctcagttacgcgaccatggcaaaactgttggagtggtt gatactagaaaaaagactaaattaatttctcctcagactctctccgtcaaaaataataag aagctgttgacaagccaagatcttcagtcacgaaggcaggtgaaacacaaatcgaaacag aacaggcaaggatctctgggttctgaaagtacaggtaccagaagagcaggtcggcgttcg gcacagaatcctgacacgcttgtcccagaatctgatagctcagatcgtagttctaaagga ggcgctgaggtgtgtgccagcaatactgggaaacgatcagtaaagcgtgtgtcttccgaa ccagaacccgtgaaaaccaaatgtgtttctcaggtggctgatgatccttgccttttgacc cagagtgcttctgttgtgttaaacggaagaataccaacagatgaagtcattgcctctacg tcagctgaccctttaggcggaggtgacctagcagcacatcatgtagagttgaccactttg aaagagagaaagcgtgaatccaacagtgactcggaggatgagaatctatttctaacacag cgtgaccctgaagatatggatttatgttcacaaatggcgaacagtagtgagaagcttatt gagataggtcaggggaaagatacagctccgaaggaagaatcttggagtggcacaaagtgt aagtacaaggattgtgtcgaaaccccacaaaaccagggtgaatactgctcgaaacactgt gaagctaaagcagcggatgaagatgtgtttcgtaaaccgggcttgcccctctccgcgtct aagagaccttccactactaaggtgtttagctcaagaagtacttcacgaattgctaatctt tccaagtctttggaaagtacctctgcactgccgccgtccctaaaacgtaagtccaacggg gtgacgtctgcttcgaaagctccacagccaacctctccgttgtctccaaagccagtgggt gaactgaagagtttgtccaatgttcttcgtcctcagactccgaataattccaacaggcaa ggttacaaatttctgtttggcgaaagcaaatctttttcggcttcctctgcagtaaacatt gtcctgtcctcgcagtccatctctgacacctttgttaaagaggtcttaaagtggaagtac gaaatgtttgtgaacttcgatcagtgcgggccccccacaagcctttgtcagtccatctca agaccggtgcctgtcagatttcaagactgtggagattattttaatgtttttttccctttg gtggtattgaatacttttgaaacggtggcgcaggagtggatgagctctccgaacaaagac aagttctatcagctgcacttacgaaaatttcctgctgattataaaaaatactgggagttt gtggttcatcttgaggaatgtgaactaactaaacagctgcatccaaaggaaaatgatttg gtgtttttggttcttgaaaatggagaggacacagagggaaatcgcatgccggatttcaac gaatattactgcggttatgttcataaatttcgccgcacttcagtcatgcgtaatgggaaa tctgagtgttccctttccatccagactcaagataatttgatgctcaatttaaacgaactt gtgaaatgcactgtcatcagttctctggtaactacacaaaggaagttgaaagccatgtct ttgctgagtggacggaaccaactggccagagttgttctgaatccaaaccccatggacttc tgtacaaaagatttactaactacaacgtccgagagaatcattgcctacctgaaagatttc aatgaagaccagaagaaagcgatagaaactgcatatgccatggtcaaacactccccatca gttgccaaggtctgtttgattcatggaccacctggaacaggaaaatcaaaaactatcgtt ggccttctgtaccgcctgctgacagagagccagaggagggggcactcagatgagaactcc aacgccaaaatcaaacagaaccgtgtcctcgtgtgtgcgccttccaacgcggctgttgac gaacttatgaaaaaaatcatccttgaatttaaagagaagtgtaaagacaagaagaaccct atgggaaactgtggagatataaatttagtacgtctgggtccagaaaagtctattaataat gaggttctaagatttagtttggacagccaagttaaccacagaatgaaaaaagacttacct tctcatgttcaggagatgcatagaagaaaggaatttctagatcatcaactagatgaactt tcccgccagcgtgctttatgccgaggtggaaaggaaacacagaggcaagaattagatgaa aaaattgcaaaagtttcaaaagagaggcaggaactagcttctaaaattaaagaggttcaa ggacgcccacagaaaacacagagcatcatcatcttagagtcccatgtcatctgctgcacg ctgagcacgagcggtggtttattgctcgagtctgcttttcgtgggcaagggggtgtcccc ttcagttgtgtcattgtcgatgaggctgggcagtcctgtgaggttgagacccttactcca ctcatccatcgttgcaacaagctcgtcctggtcggagaccctaaacagcttcctcccacg gtcatttccatgaaggcacaggaatatggctacgaccagtcaatgatggctcgtttctac aagctgctggaagacaacgttgagcaaaacgtgattggcaggctgcctgtcttacagctc actgtgcagtacaggatgcacccagacatatgtctcttcccctctaattatgtttataac aaaaggctgctttttcgtagactgactgaaaccaatcggtgttcatcagactggccgttt caaccttacctcgtgtttgatgtcggagatggctcagagagacgggataatgactcatat ataaatgttcaagaaataaaactggtaatggaaataattaaacttattaaagacaaaaga agggatgttactttccggaacattggcataataacccattacaaggcccagaagacgatg attcagaaggatttggacaaagagtttgatagaaaagggccagcagaagtagataccgtg gacgcattccagggccgccagaaagattgtgttattgtcacgtgtgtcagagcgaatgcc atgcaaggctcaattggatttctggcaagtttgcaaagattgaatgtcaccatcacacga gccaagtacagcctcttcatcctgggacatttaaggaccttgatggaaaaccagcactgg aaccagctgattcaggacgcgcagaagcggggcgccattatcaagacgtgcgacaaaaac tacaggcatgacgcagccaagattctgaagctcaagcccgtgctgcagaggagcctgacg cagcctcccaccggggccccggagatggcctggccccagggcggcctgcccggcagcaag ccagacggtgagtttgccaggacgtcgtccccttcttccctgtatcacgtgccctctgac agcaaggagtccgccggcaccgttaccgcaaaggacccggaaagacctcctattcaggac cggcttcgggacccacgactgctcaggaggctgggcctagaccctgaagccaaagggaca tgcccgtgggatccacagcccctgagcccccagcactccggagccacccctcccctggga gagccaggcttcccctcgagtcaccaggacctgggcggggcccagccacccgctgccaga ggggccgcgctgggcacccacaaacctcccgtgcagcgggagcctccggctgccggcacg gaagcgtctgcgagtaaaaggacctatgactgggaaggaggcgtcagccacaggagggag accagggctttcagtgaaggggaccaggagccgcagagccctgagaggcgtcacgtgagg aggcactctggctgggaccacaggagactggagggggacgacggtggttccaagaaaaga aggttcttatag

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