Crocuta crocuta (spotted hyena): 144236771 Help Entry 144236771         CDS       T11532                                  Symbol ADCY4 Name (RefSeq) adenylate cyclase type 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism ccru  Crocuta crocuta (spotted hyena) Pathway ccru00230   Purine metabolism ccru01100   Metabolic pathways ccru01522   Endocrine resistance ccru04015   Rap1 signaling pathway ccru04020   Calcium signaling pathway ccru04022   cGMP-PKG signaling pathway ccru04024   cAMP signaling pathway ccru04062   Chemokine signaling pathway ccru04072   Phospholipase D signaling pathway ccru04081   Hormone signaling ccru04082   Neuroactive ligand signaling ccru04114   Oocyte meiosis ccru04211   Longevity regulating pathway ccru04213   Longevity regulating pathway - multiple species ccru04261   Adrenergic signaling in cardiomyocytes ccru04270   Vascular smooth muscle contraction ccru04371   Apelin signaling pathway ccru04540   Gap junction ccru04611   Platelet activation ccru04713   Circadian entrainment ccru04714   Thermogenesis ccru04723   Retrograde endocannabinoid signaling ccru04724   Glutamatergic synapse ccru04725   Cholinergic synapse ccru04727   GABAergic synapse ccru04742   Taste transduction ccru04750   Inflammatory mediator regulation of TRP channels ccru04911   Insulin secretion ccru04912   GnRH signaling pathway ccru04913   Ovarian steroidogenesis ccru04914   Progesterone-mediated oocyte maturation ccru04915   Estrogen signaling pathway ccru04916   Melanogenesis ccru04918   Thyroid hormone synthesis ccru04921   Oxytocin signaling pathway ccru04923   Regulation of lipolysis in adipocytes ccru04925   Aldosterone synthesis and secretion ccru04926   Relaxin signaling pathway ccru04927   Cortisol synthesis and secretion ccru04928   Parathyroid hormone synthesis, secretion and action ccru04934   Cushing syndrome ccru04935   Growth hormone synthesis, secretion and action ccru04970   Salivary secretion ccru04971   Gastric acid secretion ccru04972   Pancreatic secretion ccru04976   Bile secretion ccru05032   Morphine addiction ccru05163   Human cytomegalovirus infection ccru05166   Human T-cell leukemia virus 1 infection ccru05200   Pathways in cancer ccru05207   Chemical carcinogenesis - receptor activation ccru05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:ccru00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     144236771 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     144236771 (ADCY4)    04371 Apelin signaling pathway     144236771 (ADCY4)    04020 Calcium signaling pathway     144236771 (ADCY4)    04072 Phospholipase D signaling pathway     144236771 (ADCY4)    04024 cAMP signaling pathway     144236771 (ADCY4)    04022 cGMP-PKG signaling pathway     144236771 (ADCY4)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     144236771 (ADCY4)    04081 Hormone signaling     144236771 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     144236771 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     144236771 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     144236771 (ADCY4)    04062 Chemokine signaling pathway     144236771 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     144236771 (ADCY4)    04923 Regulation of lipolysis in adipocytes     144236771 (ADCY4)    04912 GnRH signaling pathway     144236771 (ADCY4)    04913 Ovarian steroidogenesis     144236771 (ADCY4)    04915 Estrogen signaling pathway     144236771 (ADCY4)    04914 Progesterone-mediated oocyte maturation     144236771 (ADCY4)    04921 Oxytocin signaling pathway     144236771 (ADCY4)    04926 Relaxin signaling pathway     144236771 (ADCY4)    04935 Growth hormone synthesis, secretion and action     144236771 (ADCY4)    04918 Thyroid hormone synthesis     144236771 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     144236771 (ADCY4)    04916 Melanogenesis     144236771 (ADCY4)    04925 Aldosterone synthesis and secretion     144236771 (ADCY4)    04927 Cortisol synthesis and secretion     144236771 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     144236771 (ADCY4)    04270 Vascular smooth muscle contraction     144236771 (ADCY4)   09154 Digestive system    04970 Salivary secretion     144236771 (ADCY4)    04971 Gastric acid secretion     144236771 (ADCY4)    04972 Pancreatic secretion     144236771 (ADCY4)    04976 Bile secretion     144236771 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     144236771 (ADCY4)    04727 GABAergic synapse     144236771 (ADCY4)    04725 Cholinergic synapse     144236771 (ADCY4)    04723 Retrograde endocannabinoid signaling     144236771 (ADCY4)   09157 Sensory system    04742 Taste transduction     144236771 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     144236771 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     144236771 (ADCY4)    04213 Longevity regulating pathway - multiple species     144236771 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     144236771 (ADCY4)    04714 Thermogenesis     144236771 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     144236771 (ADCY4)    05207 Chemical carcinogenesis - receptor activation     144236771 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     144236771 (ADCY4)    05163 Human cytomegalovirus infection     144236771 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     144236771 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     144236771 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     144236771 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     144236771 (ADCY4) Enzymes [BR:ccru01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      144236771 (ADCY4) SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N Motif Other DBs NCBI-GeneID:  144236771 NCBI-ProteinID:  XP_077626601 LinkDB All DBs Position Unknown AA seq 1077 aa AA seqDB search MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALLALLAVASASGRELASDPG FLTTVLCALGGFSLLLGLASHEQRLQRWTRPLSGLVWAALLGLGHGFLFTGGLVSAWDQV SFFLFIIFTVYAMLPLGMRDAAAAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL FLCGNVAGAYHKALMERALRATFREALRSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRRATG VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG AYAVEDAAMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPKMRPSLLMTR YLESWGAAKPFAHLSHLESPVSTSTPLPEKALASFSPQWSLDRSRTSRGLDDDLDTGDAK FFQVIEQLNSQKQWRQSKDFNPLTLYFRRKELEKEYRLSALPAFKYYAACTFLVFLSNFV IQMLVTNRPPALAITYSITFLLFLLLLFVCFSEHLTRCVLKGPKMLHWLPALSGLVATRP GLRVALGTTTILLVFVMAIPSLFFLPAASNCPFWASNVSSMAFNNSWELPGSLPLISIPY SMHCCVLGFLSCSLFLHMSFELKLLLLLLWLGASCSLFLHSHAWLSDCLIARLYPDPLDS RPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEQEETETMENLTRL LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMV EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST GVLGKIQVTEETARVLQSLGYTCYSRGVIKVKGKGQLCTYFLNTDSIRTGPPSATLG NT seq 3234 nt NT seq  +upstreamnt  +downstreamnt atggcccgcctcttcagtccccggccaccccccagcgaagacctcttctacgaaacctac tacagcctgagccagcagtacccgctgctgctgctgctgctggtgatcgtgctctgcgcg ctcctggcgctgctggctgtcgcctccgccagcggccgggagctagcttcagacccgggc ttcctgaccactgtgctgtgcgcgctgggcggcttctcgctgctcctgggcctggcctcc catgagcaacgactgcagcgctggacacgtcccctatcgggcctcgtatgggcagcgctt ctcgggctaggccatggcttcctgttcactgggggcctggtgagcgcctgggaccaggtg tcctttttcctcttcatcatcttcaccgtgtatgccatgttgcccttgggcatgcgggat gccgccgctgcgggccttgcctcgtcgctctcccacctgctggtccttgggctatacctt gggcctcagccagactcgcggccggccctgctaccgcagctggcagcaaacgcggtgttg ttcctgtgcggaaacgtggcaggggcgtaccacaaggcgctgatggagcgtgcgctgcgc gccaccttccgcgaagcacttcgttcgctgcactcacgtcggcggctggacaccgagaag aaacaccaggaacaccttctcttgtccatccttcctgcctacttggcccgggagatgaag gcagagatcatggcacggctgcaggctggacaggggtcacggccagagagcaccaacaac ttccacagcctctatgtcaagaggcaccagggagtcagtgtgctgtatgctgacatcgtg ggcttcacccggctggccagtgagtgctcccctaaggagttggtgctcatgctcaacgag ctctttggcaagttcgaccagatcgccaaggagcatgaatgcatgcggatcaagatcctg ggagactgttactactgtgtctctgggctaccgctctccctgccagaccacgccatcaac tgcgtgcgcatggggctggacatgtgccgggccatcaggaaactccggagagccactggt gtggacatcaacatgcgtgtgggcgtgcattcaggcagtgtgctctgcggagtcattggg ctgcagaagtggcagtatgatgtctggtcccatgacgtcacactggccaaccacatggag gcgggtggcgtaccaggacgagtacatattacaggggctaccctggccctgctggcaggg gcttatgctgtggaagatgcagccatggaacaccgggacccataccttcgggagctaggg gagcctacctacctagtcatcgacccccgggctgaggaggaggatgagaagggcactgcg ggagggttgctgtcctctctcgagggccccaagatgcgtccgtccctgctgatgacccgc tacctggagtcctggggcgccgccaagccttttgcccatctgagccacctagagagccct gtgtctacctccacccctctcccggagaaggctctggcctccttcagcccccagtggagc ctggaccggagccgtacctcccggggcctagatgacgacctggacactggggatgccaag ttcttccaggtcatcgaacagctcaactctcagaaacagtggaggcagtcaaaggacttc aaccccctgacactgtacttcagaaggaaggaactggagaaagagtaccgactctctgca ctccccgccttcaaatactatgcagcctgcaccttcctggtttttctttccaatttcgtc atccagatgctggtgacaaacaggcccccagctctggccatcacctatagcatcaccttc ctcctcttcctcctcctcctcttcgtctgcttctcagagcacctgacgaggtgtgtcttg aaaggccccaagatgctgcactggctgccagccctgtctggcttggtggccacacggcct ggactgcgagttgccctgggcacgactaccatcctactggttttcgtgatggccattccc agcctgttcttcttaccggcagcatcaaactgccctttctgggcttccaatgtgtcctcc atggctttcaacaactcctgggagctccctgggtccctgcctctcatcagcatcccgtac tctatgcactgctgcgtgctggggttcctgtcctgctccctctttctgcacatgagcttc gagctgaagttgctgctgctcctgctgtggctgggggcctcctgctccctcttcctgcac tcccacgcctggctgtccgactgcctcatcgcccgcctctatccggatcccctggactcc aggccaggggtgctgaaggagcccaaactgatgggagctatctccttcttcatcttcttc ttcaccctccttgtcctggctcggcagaatgagtattactgccgcctggacttcctgtgg aagaagaagctgcggcaggagcaggaggagacagagaccatggagaacctgacaaggctg ctgttggagaatgtgctccctgcacacgtggccccccagttcattggccagaaccggcgc aatgaggacctctaccaccagtcctacgagtgtgtctgtgtcctgttcgcctcagttcca gactttaaggagttttactccgagtccaacatcaaccacgagggtctagagtgtctgcgg ctgctcaatgagataattgctgactttgatgagctgctctcaaagcccaagtttagtggg gtggagaagatcaaaaccattggcagcacctacatggcagctacaggcttaaatgccacc tccggacaggacgcacaacaggatgctgagcgaagctgcagccaccttggcaccatggtg gagtttgcagtggcccttggatcaaagctggacgtcatcaataagcactcattcaacaac ttccgcctgcgtgtggggttgaaccatggacctgtagtggctggagtgatcggggcccag aaacctcaatatgacatctggggcaacacagtgaatgtggccagccgcatggagagtaca ggagttctgggcaagatccaggtgactgaagagacagcccgggtgctgcagtccttaggc tatacctgctacagccggggtgtcatcaaggttaaaggcaaagggcagctctgcacctac tttctgaacacagattcgatacgaactggacctccctcggccactctgggctga

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