Crocuta crocuta (spotted hyena): 144241113 Help Entry 144241113         CDS       T11532                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism ccru  Crocuta crocuta (spotted hyena) Pathway ccru05165   Human papillomavirus infection ccru05203   Viral carcinogenesis Brite KEGG Orthology (KO) [BR:ccru00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     144241113 (UBR4)   09172 Infectious disease: viral    05165 Human papillomavirus infection     144241113 (UBR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:ccru04121]     144241113 (UBR4) Enzymes [BR:ccru01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      144241113 (UBR4) Ubiquitin system [BR:ccru04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     144241113 (UBR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR Motif Other DBs NCBI-GeneID:  144241113 NCBI-ProteinID:  XP_077631682 LinkDB All DBs Position Unknown AA seq 5095 aa AA seqDB search MATSGGDEAAAPAPAPGAPAXVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYE PFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLIL LIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQM NFLNQLTSVFNPRTVASPPVGPQTPAEGENDEQSSTDQASAIKTKNVFIAQNVASLQELG GSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALD TLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYE SDAATIVQKCLEIYDMIGQAISNSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALAD KGKEKDPLAALRVRDILARTKEGVGSPKLGPGKGSSLTACVLQRQRKGSMSSDASASTDS NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKVAPPPPPPPPPLESSPRVKSP SKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATL ASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWP LYIHPQSLSVLSRLLLIWQHKAGAQGDPDVPECLKVWDRFLSTMKQSALQGTVPSETEDL NVEHLQLLLLIFHNFTEKGRRAILTLLVQTIQELSANMAAQARSVPLILARLLLVFDYLL HQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSSSRRGTAPLYHGFKEVEENWSKHFSSDA VPQPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYTALTSLLAAGSQLDTVRRK ENKNVTALEACALQYYFLILWRILGILPPSKTYMNQLAMNSPEMSECDILHTLRWSSRLR ISSYVSWIKDNLIKQGMKAEHAGSLLELASTKCSSVKYDVEIVEEYFARQISSFCSIDCT TILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLID TYASFTRAYLLQNFSEEGSTEKPSQEKLHGFAAVLAIGSSRCKANTLGPTLVQNLPSWVQ TVCESWNNINTNEFPSIGSWRNAFANDTIPSESYISAVQAAHLGTLCGQSLPLAASLKHT LLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFL ARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLEGSQSRKAMEEFFSDSGEL VQIMMATANENLSAKFCNRVLRFFTKLFQLTEKNPNPSLLHLCGSLAQLACVEPVRLQAW LTRMTASPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLIPMATEMLA NGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNASVMHG KHVTVLECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDS QAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYA KYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRVSESLVRHTSTSPADKA KVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLSFLMDAIQTNFQQ ASAVGSSSRAQQALRELHTVDKMVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQL ISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASA PVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWL PGSQTELAIVTADFVKIYDLSVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAG YIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQ GKSFAATISRTTLEVLQLFSINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPL VVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVEN TSYWLQPSLQPSSVVSIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDL LQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYI EIFGRTMQLNLSRSRWFDFPFTREEALQADKKLSLFIGASVDPAGVTMIDAVKIYGKTKE QFGWPDEPPEEFPSASVSNICPSSLNQSNGAGDSDSAAPAATSGTVLERLVVSSLEALES CFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALL SKAVQCLSTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPPMETEGADEGR EPQKQVEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYC TCELDCIHTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGD KDDDDDDDADEKMQSSGIPSAGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPS PLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAP SSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPAEHGGSVGSESGGSAVDSVAGE HSVSGRSSAYGDATVEGHPAGPGSVSSSTGAISTATGHQEGDGSEGEGEAEGEGDVHTSN RLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQL IAELGMDKKDVSRKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICEPSSLISSATAAA LLSSGAVDYCLHVLKSLLEYWKSQQSDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGH AADVFEAYTQLLTEMVLRLPYQIKKIADANSRIPPPVFDHSWFYFLSEYLMIQQTPFVRR QVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDT LISLMEHLKACAEIAAQRTVNWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALC GSKVLAALAASAGSSGAAASSAPAAAASGQATTQSKSSTKKSKKEEKEKEKEGESSGSQE DQLCTALVNQLNKFADKETLVQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLL DLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHP NSNIYSTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGS HTISKVTVKIGDLKRTKMVRTVNLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVK IDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCR SINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADR VYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCK NSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTS STKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGSAAMREEVRQL MCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDGCWEL RLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPY SNEIHAQAQLWLKRDPKASYEAWKKCLPIRGIDGNGKSPSKSELRHLYLTEKYVWRWKQF LSRRGKRTPPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTS YLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATL STDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQ DMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTE FFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMEL LVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEED EEEVYKMAGVMAQCGGLECMLNRLAGIKDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKL EMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLT GDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCSFDKYD EDHSGDDKVFLDCFCKIAAGIKNSSNGHQLKDLILQKGITQSALDYMKKHIPSAKNLDAD IWKKFLSRPALPFILRLLRGLAVQHPATQVLIGTDSITNLHKLEQVSSDEGIGTLAENLL EALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQME ELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHY DCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTG QREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIVHTVLYVLNTTRATS REEKNLQGFLEQPKEKWVESAFEVDGPHYFTVLALHILPPEKWRATRVEILRRLLVTSQA RAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIR HNDMPIYEAADKALKTFQEEFMPVETFSEFLDAAGLLSEITDPESFLKDLLNSIP NT seq 15288 nt NT seq  +upstreamnt  +downstreamnt atggcgacgagcggcggcgatgaggcggcggcgccggctccggcgcctggggccccggcg anggtgcggcccctgctgtctgcgtcctattccgccttcgagatgaaggagttgccgcag ctggtggcctcagtcatcgagagtgaatctgaaatcctgcaccacgagaagcagtacgag cccttctactcctcttttgttgcactttccacacactatattacaacagtctgcagcctc attccccggaaccagcttcagtcagtggcagcagcctgtaaagtcctgattgagttttct ctgctacgcctggagaatccagatgaggcttgcgctgtgtcccagaaacacttgattctc ctcatcaagggcctgtgcactggctgtagccgactggataggaccgaaattattacgttc acagcaatgatgaaatccgccaaactgccacagaccgtgaagacactctcagatgtggaa gatcaaaaagagctggcttcaccagtcagcccagagctgaggcagaaggaggtacagatg aattttttgaaccagctgacgtcagttttcaacccgaggactgtagcatcaccacccgta ggtccacagactccggctgaaggagaaaatgatgagcagtcatccacagaccaagcctct gctatcaaaaccaagaatgtgtttatagctcagaacgtggctagtcttcaagagctcggt ggctcagagaagctgctgcgcgtgtgtttgaacctgccgtatttcctgcgctacatcaat cggtttcaagatgcggtgttggccaattctttcttcatcatgcctgcaacggtagcagat gccactgctgttcgcaacggttttcattcactggtgattgatgtaaccatggcgttggac accctctctctacctgtgttggagcctctcaatccttctcgtctgcaagatgtgacagtc ctcagcctcagttgtctgtatgcaggtgtgagtgtagcaacttgcatggccatcctgcat gtgggtagcgcccagcaggtgcggacggggtccacgagctccaaagaagacgactacgag agcgacgcggctacgatcgtccagaaatgtcttgaaatctatgacatgattggacaagcg atcagcaactcccgccgggccggtggagagcactatcagaacttccagctgctgggtgcc tggtgtttgttgaacagtcttttcctcatattgaacctcagccctactgccttggctgat aaagggaaagagaaagacccgctggctgcactccgagtcagagacatccttgctcgcaca aaagagggagtgggctctcctaaactggggcctggaaaagggtcctctttgacagcctgt gtcctgcagcgtcagaggaagggctccatgagcagtgatgccagtgcgtctactgactcc aacacctactacgaggatgatttcagcagcacagaggaggacagcagccaagatgatgac agtgagcctattttggggcaatggtttgaggagaccatctcccccagtaaagagaaagtg gcacctcctcctcctcccccgccccctccgctggagagctcacctcgagttaaaagcccc agtaaacaggcccctggtgagaagggcaacattttggctagtcgcaaagatcctgagttg ttcttaggtctggcttccaacattttgaacttcattacctcttccatgctgaactcgcgg aacaattttatccgaaactacctgagcgtgtctctttcagaacaccacatggccaccctg gccagtatcattaaagaggtggacaaagatggactcaagggttcatcagatgaagagttt gctgctgctctctatcacttcaaccattctctggtaacttctgaccttcagtcgcccaac ctgcagaacacactgttgcagcagctgggagtagctcctttctctgagggcccctggccc ttgtacattcaccctcaaagcctatctgtgctttcacgccttttgctcatctggcaacat aaagctggtgctcaaggtgatccggatgtccctgaatgccttaaagtttgggacaggttc ttgtcgaccatgaagcagagtgccctgcaggggacggtgcccagtgagacggaagatctg aatgtagaacacctgcagctgctcctcctcatcttccacaacttcaccgagaaaggccgg cgggccatcctgaccctcttagtgcagaccatccaggagctgagtgccaacatggctgcc caggcacgctccgtgcccctcatcctggcccgcctccttctggtcttcgattatctgctt catcagtactccaaagcccctgtgtatctgtttgagcaggtgcagcataacttgttgagt cctccttttgggtgggcaagtggatcccaggacagcagcagccgccgggggaccgcccct ctctatcacgggttcaaagaagtagaagaaaactggtctaagcatttttcatcagatgct gtcccacaacccagattctactgtgtcctgtccccagaggcctcagaggatgatttgaac cgactcgattctgtggcatgtgatgttcttttctccaagcttgtcaaatatgatgagctt tacacggcactgacatctctgctcgcggctggctctcagctggatacagtcaggagaaag gaaaacaagaacgtaacggccctggaggcctgtgcccttcagtattatttcctgatactg tggaggatcctagggattttgccaccatcaaagacctacatgaaccagctggccatgaac tcccctgagatgagtgaatgtgacatcttacataccctgcggtggtcttcccgcctccgc atcagctcctacgtcagctggataaaggataaccttatcaaacagggcatgaaggctgaa catgccggttctctcttagaactggcctccaccaagtgcagctcagtgaagtatgacgtt gaaattgtagaggagtactttgctcggcagatctcatcattctgtagcatcgactgtacc accatcttgcagctccatgaaatcccaagtctgcagtccatctacaccctcgatgccgcc atctcgaaggtccaggtctctctggatgagcatttttctaagatggccgctgagaccgac ccccataagtcgtctgagatcaccaagaacctgcttccagccacactgcaactcatcgac acctatgcatcgttcactagagcctatttactacagaactttagtgaagaaggatccact gaaaaaccttcccaggagaaattgcatggctttgctgctgttttggctattggctctagt aggtgcaaggccaacactttgggtcccacactcgtgcagaatttaccatcctgggtgcag actgtgtgtgaatcctggaacaacatcaacaccaatgagtttcccagcattggttcctgg cgcaatgcctttgctaatgacaccatcccttctgagagttatatcagtgctgtgcaggct gctcacctggggacgctttgtggccaaagcctgcccctggctgcttccctgaagcacacc ctcctctcactggtcaggctgaccggagatctcattgtttggtccgatgagatgaacccg ccacaggtaattcggaccctgctgccccttctcttggagtcgagcaccgagagcgtcgcc gagatcagtagcaattccctagagcgcatcctgggccctgcggagtctgatgagttcttg gctcgagtgtacgagaagctgatcaccggctgttacaacattctggccaaccatgcagat cccaacagtggactggatgaatccatcttggaggaatgtctccagtatttggaaaagcag ctggaaggcagccagtcccgtaaggctatggaggagtttttttctgacagcggggaactg gtgcagatcatgatggcaacagccaatgagaacctgtctgctaaattctgtaaccgagtc ctcagattcttcaccaaactcttccagctgaccgagaagaaccctaaccccagccttctg cacctctgtggctctctggcacagctggcctgtgtggagcctgtgcgtctccaggcctgg ctcacccgcatgactgcgtcaccccccaaagattccgatcagctggatgtgattcaggag aaccggcagctgctacagttactgactacgtatatcgttcgggaaaacagccaagttggg gaaggtgtgtgtgctgtgcttctgggtaccctgatccccatggcgacagagatgttggcc aatggtgatgggactggttttcctgaactcatggtcgtgatggccaccctggccagtgca ggtcaaggtgccggccaccttcagctccataatgctgctgtggactggctgagtagatgc aagaaatacctatcacagaagaatgtggttgagaaactgaatgccagtgtcatgcatggg aagcatgtgacagtcctggagtgcacctgccacattatgtcttacttggctgatgtcacc aatgccctgagccagagtaacggtcaaggcccaagtcacctctcggtggatggggaggag cgagccattgaggtggattcagactgggtggaggagttggcagtggaagaggaggactcc caggctgaggattcagatgaagattctctttgcaacaaactctgcactttcacgatcact cagaaagaattcatgaaccagcactggtaccactgtcatacctgcaaaatggtagacggg gtgggtgtgtgcacagtgtgtgccaaggtgtgccacaaggatcacgagatctcctacgcc aagtatgggtccttcttctgtgactgtggggccaaagaagatggcagctgtttggcgctg gtgaagcggacccccagcagcggcatgagctccaccatgaaggagtcggcatttcagagc gagcccagggtttcagagagcctggtgcgccacaccagcacctccccggctgacaaggcc aaagtcaccatcagcgacgggaaggttgccgacgaggagaagcccaagaagagcagcctg tgccgaacggtggagggctgtcgggaggagctgcagaaccaggccaatttctccttcgct cctctcgtgttagacatgctcagtttcctcatggatgccattcagaccaactttcagcag gcttcagcggtggggagcagcagccgggctcagcaagccctccgcgagctgcacacagtg gacaagatggttgagatgacagaccagctgatggttcccaccttaggctcccaggaaggt gcctttgagaacgttcggatgaattacagcggagaccagggccagactattcgacagctc atcagcgcccatgtgctccggcgggtggctatgtgcgtgctctcctccccacacgggcgc cgccagcatttggccgtcagccacgagaaaggcaagatcaccgttctgcagctctctgca ctcctgaagcaagcagattccagcaagaggaagctgactctgacccgcctggcttccgcc cccgtcccctttactgtgttgagcctcacgggcaatccctgcaaggaggactaccttgcc gtttgtgggctcaaggactgccacgtgctgacgttcagtagctcaggctctgtttcagac cacttggtgctacaccctcaattggcaacgggcaacttcatcattaaagctgtgtggtta cctggttcacagaccgagttagcgatcgtcactgcggactttgtcaagatttatgacctg tctgttgatgccttgagccccaccttctactttctcctgccgagctccaagataagagat gttaccttcctcttcaacgaggagggaaagaacatcatcgttataatgtcttcagctggt tacatctatacccagctcatggaagaggccagtagtgcccagcagggacccttctacgtc accaatgtgctggaaatcaaccacgaggacctgaaggacagtaacagccaggtggcaggc ggcggtgtgtccgtctactactcccatgtgctgcagatgttgttcttcagctattgtcaa ggcaagtccttcgcagccaccatcagcaggacgactctggaggtgttgcagctcttctcc atcaacatcaaaagttccaatggtggcagtaagacgtcccctgccctctgccagtggtcc gaggtgatgaaccaccctggcttggtgtgttgtgtccagcaaaccactggtgtgcccctg gtggtgatggtgaagccagacactttccttatccaagagatcaagactcttcctgctaaa gcaaagatccaagacatggttgccattcggcacacggcctgcaacgagcagcagcggacc acgatgatcctgttgtgtgaggatggcagcctgcgcatttacatggccaacgtggagaac acctcctactggctccagccgtccctgcagcccagcagtgtcgtcagcatcatgaaacct gtgcgaaagcgcaagactgctaccatcacaacccgcacgtccagccaggtgaccttccct atcgacttctttgaacacaaccagcagctgacagatgtggagtttggtggtaatgacctc ctgcaggtctacaatgcgcagcagataaaacaccggctgaattccaccggcatgtatgtg gccaacaccaagcccggtggcttcaccatcgagatcagcaataacaacagcactatggtg atgacaggcatgcggatccagatcgggacccaggccatcgaacgggccccatcgtacatt gagatttttggcagaaccatgcagctcaacctgagtcgctcgcgctggtttgacttccct ttcaccagggaagaagccctgcaggccgacaagaagctgagcctcttcattggggcctcg gtggatccagcaggcgtcaccatgatcgacgctgtaaaaatttacggcaagacgaaggag cagttcggctggcctgacgagcccccagaagagttcccctctgcctctgtcagcaacatc tgcccttccagcctgaaccagagcaatggcgctggagacagcgactccgcggcgcctgcc gccaccagtggaactgtcctggagaggctggttgtgagttctttagaagccctggaaagc tgctttgctgttggcccaatcatcgagaaggagagaaacaagaatgcagcccaggagctg gccactttgctgctgtccctgccggcccctgccagtgtgcagcagcagtccaagagcctc ctggccagcctgcataccagccgctcggcctatcacagccacaaggatcaggccttgctg agcaaagctgtgcagtgtctcagcacatccagcaaagaaggcaaggacttggaccctgag gtcttccagaggctggtgatcacagctcgctccattgccatcatgcgccctaacaacctt gtccactttacggagtccaagctgcccccgatggaaacagaaggagcggacgaggggaga gaaccccagaagcaggtggaaggagactgctgcagtttcatcacccagctggtgaaccac ttctggaaactccatgcatccaaacccaagaatgccttcttggcacctgcctgcctgcca ggcctgactcacatcgaagctaccgtcaacgcgctggtagacattatccatggctactgc acgtgtgagctggactgcattcacacagcatccaagatctacatgcagatgctgctgtgt cccgatcctgccgtgagcttttcttgtaaacaggctctaattcgagtcctaaggcccagg aacaagcggagacatgtgacacttccatcttcccctcgaagcaatactccaatgggagac aaggatgacgatgatgatgatgacgcagatgagaaaatgcagtcatcagggattccgagt gccggtcacatccgtcaggagagccaggaacagagtgaggtggaccatggagattttgag atggtgtccgagtcgatggtcctggagacagctgaaaatgtcaacaacggcaacccctct cccctggaggccctgctggcaggcgcagagggcttcccccccatgctggacatcccgcct gatgcagatgacgagaccatggttgaactagccattgccctgagcctgcagcaggaccaa caaggcagcagcagcagtgccctgggcctgcagagcctggggctgtccggccaggcaccc agctcttcctctctggacgcaggaaccctctctgacaccacagcatcagctccagcctcg gacgatgagggcagcacggcagcgactgacggctccacccttcgcacctcccctgctgag catggcgggagcgtgggctcagagagcggggggagcgccgtggactcggtggctggcgag cacagtgtatctggtcggagcagcgcttacggtgacgccacagtggaggggcacccagct gggcccggaagcgtcagctcaagcactggcgccatcagcaccgccaccggccaccaggaa ggagatggctccgagggagaaggagaagcggaaggagaaggagatgtccatactagcaac aggctgcacatggtccgtctgatgctgttggagagactcctgcagaccttgccccagtta cgaaatgttggaggcgtccgggccatcccatacatgcaggtcattctgatgctcactaca gatctggatggagaagatgagaaagacaagggagctctggacaacctgctctcccagcta attgccgaactgggcatggacaaaaaggacgtctccaggaagaatgagcgcagcgccctg aacgaagtccatctagtcgtgatgaggctcctgagtgtcttcatgtcccggaccaagtcc gggtccaagtcttccatatgtgagccctcgtccctcatctccagcgccacggcagcggcc ctgctgagctccggcgccgtggactactgcctgcacgtgctcaagtccctgctggagtac tggaagagccagcagagcgacgaggagcccgtggccaccagccagctgctgaagccacac accacgtcatcgccgcctgacatgagccccttcttcctccgccagtacgtgaagggccat gctgctgatgtgtttgaggcctacactcagcttctaacggagatggtcctgcggcttcct taccaaatcaagaagatcgccgacgccaactctcgaatcccccctcctgtctttgatcat tcatggttttactttctctcagagtacctgatgatccagcaaactccttttgtgcgtcgt caagtccgcaagcttctgctcttcatctgtggatcgaaagagaagtaccgccagctccgg gatctgcacaccctggactcccatgtgcgtgggatcaagaagctgctggaggaacagggc atcttcctccgggcaagcgtggttacagccagctcgggctctgcgctgcagtacgacaca ctcatcagcctgatggagcacctgaaagcttgtgcagagattgctgcccagcggaccgtc aactggcagaagttctgcatcaaagacgactccgtcctctacttcctcctccaagtcagc ttcctggtggacgagggggtgtccccggtgctgctgcagctgctgtcctgcgccctgtgc ggcagcaaagtcctcgccgctctggcggcctccgcaggctcctctggcgccgccgcctcc tcagcccctgcagctgctgcttctggacaagccacgacgcagtccaagtcatccacgaag aagagcaagaaagaagaaaaggagaaggagaaagagggtgagagctcaggcagccaggag gaccagctgtgcacggctctggtgaaccagctgaacaaattcgcagataaggagaccttg gtccagttcctgcgctgcttcctgttggagtccaattcctcctcggtgcgctggcaggcg cactgtctgacgctgcacatctacagaaactcgagcaaatctcagcaggagctcctgctg gatctgatgtggtccatatggccagaactcccagcctatggccggaaggctgcccagttc gtggacctgctagggtatttctccttgaaaactccacagacggagaagaagttgaaggaa tattcacagaaggctgtggagattctgcggactcaaaaccatattcttaccaaccacccc aactccaacatctacagcaccttgtctggcttagtggagtttgatggctattacctggag agcgatccctgcctggtgtgtaataatccagaggtgccgttctgttatatcaagctgtct tccattaaagtggacacgcggtacaccaccacccagcaggtcgtgaagctcatcggcagc cacaccatcagcaaggtgacggtgaaaatcggagatctgaaacggacaaagatggtgcgg actgtcaacctctattacaacaaccggaccgtgcaggcgatcgtggagttgaaaaacaag ccggctcgttggcacaaagccaagaaggttcaactgacccccgggcagacagaggtgaag atcgacctgcccttgcccatcgtggcctccaacctgatgatcgagtttgcagacttctat gaaaactaccaggcttccacagagaccctgcagtgcccacgctgcagcgcctccgtgcct gccaaccccggggtctgcggcaactgtggagagaatgtataccagtgtcacaagtgcagg tccatcaactatgacgagaaggaccccttcctctgcaatgcctgtggtttctgcaaatac gcgcgcttcgattttatgctctatgccaagccctgctgtgcggtggaccccattgagaat gaggaagaccggaagaaggccgtttccaacatcaacacgcttctggacaaagctgaccgc gtctaccaccagctgatgggacaccggccacagctggagaacctgctgtgcaaagtgaac gaggcagcccccgagaagccgcaggatgactcagggacagccgggggcatcagctctacc tccgccagtgtcaatcggtacatcctgcagctggcccaggagtactgtggtgactgcaag aactctttcgacgagctctccaaaatcatccagaaagtctttgcttcacgcaaagagttg ttggaatatgacctgcagcagagggaagcagccaccaagtcgtcccgaacctccgtgcag cccacattcactgccagccagtaccgcgccttgtccgtcctgggctgtggccacacgtcc tccaccaagtgctacggctgcgcctcggccgtcacggaacattgtatcacgctgctccgg gccctggccaccaatccggccctgaggcacatcctcgtgtcccagggcctcatccgtgag ctcttcgattacaatcttcgccgaggctccgcggccatgcgggaggaggtccgccagctc atgtgcctgctgactcgagacaatcccgaagccacccagcaaatgaatgacttgatcatt ggcaaagtgtccactgccctgaagggccactgggccaatcccgatctggcaagcagcctg cagtatgagatgctgttgctgacagactccatctcgaaggaggacggctgctgggagctg cggctgcgctgtgctctcagcctcttcctcatggcggtgaacatcaagacccccgtagtg gtggagaacatcaccctcatgtgcctgcggatcctgcagaagctgatcaaaccgcctgct cccaccagcaagaagaacaaggacgtccctgtcgaggccctcaccacagttaagccatac tccaacgagatccatgcccaggctcagctgtggctcaagagagaccccaaagcatcctat gaagcctggaagaagtgtcttcctattagagggatagatggcaacgggaagtcccccagc aagtcggagctccgccacctctatttgaccgagaagtacgtgtggaggtggaagcagttc ctcagtaggcgggggaagaggaccccgcccttggatctcaaactgggccataacaactgg ctgcgacaagtgctcttcactccggccacgcaggccgcgcggcaggcagcctgcaccatt gtggaagctctggccaccatccccagccgcaagcagcaggtcctggacctcctcaccagc tacttggacgagctgagcatagcaggcgagtgcgccgccgagtacttggctctctatcag aagctcatcacttcagcccactggaaagtgtacctggccgcgcggggcgtgctcccctac gtgggcaacctcatcaccaaggaaatcgcccgcctgttggccctggaggaggccaccctg agcaccgacctgcagcagggctacgccctcaaaagtctcacaggcctcctttcctccttt gtcgaggtggagtccatcaaaagacacttcaaaagtcgcttggtgggcaccgtgctgaat ggctacctgtgcttgcggaagctggtggtgcagaggaccaagctgatcgatgagacccag gacatgctgctggagatgctggaggacatgaccacaggtacagaatcagaaaccaaggcc ttcatggctgtgtgcattgagacagccaagcgctacaacctggatgactaccggaccccc gtcttcatcttcgagaggctctgcagcatcatttatcccgaggagaatgaagtcactgaa ttctttgtgaccctggagaaggacccccaacaagaagacttcttgcaaggcaggatgccc gggaacccgtatagcagcaacgagccaggcattgggccacttatgagggacataaagaac aagatttgccaggactgtgacttggtggctcttctggaggacgacagtgggatggagctt ctagtgaacaacaagatcatcagtttggatctccctgtggccgaggtttacaagaaggtc tggtgcaccacgaatgagggagagcccatgaggattgtttaccgcatgcgggggctgttg ggtgatgccaccgaggagtttatcgagtccttggactccaccacagatgaagaagaggat gaagaagaagtgtataagatggctggggtcatggcacagtgtgggggcctggagtgcatg ctgaacagactggcagggatcaaagacttcaagcagggacgccaccttctaactgtgctc ctgaaattgttcagttactgtgtgaaggtgaaagtcaaccgacagcagctggtcaagctg gaaatgaacaccctgaatgtcatgctggggaccctaaacctggccctggtagctgagcaa gaaagcaaggacagtggcggtgcagctgtggccgagcaagtgcttagtatcatggagatc attctggatgaatccaacgccgagcccctgagtgaggacaagggcaacctcctcctgacg ggcgacaaggatcagcttgtgatgctcctggaccagatcaacagcacgtttgttcgctcc aacccgagcgtgctccagggtctgcttcgcatcatcccgtacctttcctttggtgaggtg gagaagatgcagatcttggtggagcgcttcaagccgtactgcagctttgacaagtatgac gaagaccacagcggcgacgataaggtcttcctggactgcttctgtaagatcgcggccggc atcaagaacagcagcaacgggcatcagctgaaggacctgatcctccagaagggaatcacg cagagcgcgctggactacatgaagaagcacattcccagtgccaagaatctggatgctgac atctggaaaaagttcttatctcgcccagccctgccgtttatcttgaggcttctccggggg ctggctgtccagcaccctgccacgcaggttctgattggaacggactccatcacgaaccta cataaactagagcaggtgtccagcgatgagggcattgggaccctggcagagaacctgcta gaggcattgcgggaacaccctgatgtcaacaagaagatcgatgccgcccgcagggagacc cgcgcggagaagaagcgcatggccatggcaatgaggcagaaggctctgggtaccctgggc atgacgacaaacgagaagggccaggtcgtgaccaagacagcactcctgaagcagatggag gagctaattgaggagccgggtctcacgtgctgcatctgcagggaggggtacaagttccag cccacgaaagtcctgggcatttataccttcaccaagcgggtagccttggaagagatggag aataagccccggaagcagcagggctacagcaccgtgtcccacttcaacatcgtgcactac gactgccacctggctgccgtcaggctggctcgtggccgggaagagtgggaaagcgcagcc cttcagaatgccaacaccaagtgcaatgggctccttccggtctgggggccccacgtcccc gaatcagcttttgccacctgcttggcaaggcacaacacttacctccaggaatgcacgggc cagcgggagcccacctaccagctcaacatccacgatatcaagctgctcttcctgcgcttt gccatggagcagtcgttcagcgcggacaccggcgggggcggccgggagagcaacatccac ctgatcccgtacattgtccacactgtgctttacgtcctgaacacaacccgagcaacttcc cgagaggaaaagaacctccagggcttcctggaacagcccaaggagaagtgggtggagagt gcctttgaagtggacgggccccactatttcacagtcctggccctccacatcctgcccccc gagaagtggagagccacgcgcgtagaaatcctgcggaggctgctggtgacctctcaggcc cgggcagtggctccagggggagccaccaggctgaccgacaaggcggtgaaggactattct gcttatcgctcttcccttctcttttgggccctcgtcgatctcatttacaacatgtttaag aaggtgcctaccagcaacacggagggaggctggtcctgctctctagcggaatacatccgc cacaacgacatgcccatctacgaggctgctgacaaagccctgaagaccttccaggaggag ttcatgccagtggagaccttctcggagttcctcgatgcggctggtctgttatcggagatc actgatcctgagagcttcctaaaggacttgttgaactccatcccctga

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