Crocuta crocuta (spotted hyena): 144244977
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Entry
144244977 CDS
T11532
Symbol
ERN1
Name
(RefSeq) serine/threonine-protein kinase/endoribonuclease IRE1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
ccru Crocuta crocuta (spotted hyena)
Pathway
ccru04140
Autophagy - animal
ccru04141
Protein processing in endoplasmic reticulum
ccru04210
Apoptosis
ccru04932
Non-alcoholic fatty liver disease
ccru05010
Alzheimer disease
ccru05012
Parkinson disease
ccru05014
Amyotrophic lateral sclerosis
ccru05016
Huntington disease
ccru05017
Spinocerebellar ataxia
ccru05022
Pathways of neurodegeneration - multiple diseases
ccru05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ccru00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
144244977 (ERN1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
144244977 (ERN1)
09143 Cell growth and death
04210 Apoptosis
144244977 (ERN1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
144244977 (ERN1)
05012 Parkinson disease
144244977 (ERN1)
05014 Amyotrophic lateral sclerosis
144244977 (ERN1)
05016 Huntington disease
144244977 (ERN1)
05017 Spinocerebellar ataxia
144244977 (ERN1)
05022 Pathways of neurodegeneration - multiple diseases
144244977 (ERN1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
144244977 (ERN1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
144244977 (ERN1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ccru01001
]
144244977 (ERN1)
Enzymes [BR:
ccru01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
144244977 (ERN1)
Protein kinases [BR:
ccru01001
]
Serine/threonine kinases: Other
IRE family
144244977 (ERN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Other DBs
NCBI-GeneID:
144244977
NCBI-ProteinID:
XP_077636483
LinkDB
All DBs
Position
Unknown
AA seq
963 aa
AA seq
DB search
MNISLQTFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPA
FLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLT
GEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDGD
YKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRY
LTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGST
LPLLEGPQTDGVTIGDKGECVITPSTDLKFEPGLKGKNKLNYLRNYWLLIGHHETPLSAS
TKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVEQTSENAPTAVSQDVEEKFEHAPAK
PEAPVDSVLKDIATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQ
QLPFHPPGDVAPDAELLDSSGLYSESSGTSSPSTSPRASNHSLHSSGSASRAGTSPFLEQ
DDEDEETSMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQ
LLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTS
GLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGT
EGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDC
LHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWGLEKQLQFFQDVSDRIEKESL
DGPIVKQLERGGRAVVKTDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYREL
PAEVRETLGSLPDDFVRYFTSRFPHLLSHTYRAMEPCSHERLFQPYYFHEPPELRPPVTP
DTL
NT seq
2892 nt
NT seq
+upstream
nt +downstream
nt
atgaacatctcattgcagacttttggaagtcccagcacagtgacgcttcccgaaaccttg
ctgtttgtgtcaaccctggatggaagcttgcatgcggtcagcaagaggacaggctccatc
aaatggactttaaaagaagatcctgttctgcaggttccaacgcatgtggaagagcctgcc
ttcctcccagatcccaatgacggcagcctgtacacgcttgggagcaagaataatgaaggc
ctgacgaaacttccctttaccatcccagagctcgtacaggcatccccatgccgaagttca
gatggaattctctacatgggtaaaaagcaggacatttggtatgtaattgacctcctgacc
ggggagaagcagcagactttgtcatcagcctttgcagacagtctctgcccatcgacttct
ctgctgtatctcgggcgaacagagtacaccatcaccatgtacgacaccaaaacccgcgag
ctccggtggaatgccacctacttcgactatgcggcctcgctgccagaggacgacggggac
tacaagatgtcccactttgtgtccaacggcgatgggctggtggtgaccgtggacagtgaa
tctggcgacgtcctgtggatccaaaactatgcttcccctgtggtggccttttatgtctgg
cagcgggagggtctgaggaaggtgatgcacatcaacgtcgcggtggagaccctgcgctac
ctgaccttcatgtctggggaggtgggccgcatcaccaagtggaagtacccgttccccaag
gagacggaggccaagagcaagctgacgcccaccctgtatgtcgggaaatactccaccagc
ctgtacgcctccccctccatggtacacgagggcgtcgccgttgtgccccgaggcagcaca
cttcctttgctggaaggtccccagactgacggggtcaccattggggacaaaggggagtgt
gtgatcacgcccagcacagacctaaagtttgagcctgggctcaaagggaagaacaagctc
aactacttgaggaactactggcttctgataggacaccatgaaacccccctgtctgcgtct
accaagatgctggagagattccccaataatcttcccaaacatcgggaaaacgtgattcct
gctgattcagagaagaagagctttgaggaagttatcaacctggttgagcagacgtcagaa
aacgcgcccaccgccgtttcacaggatgtggaggagaagttcgagcatgcccctgccaag
cccgaggcccccgtggactctgtgctcaaggatatagccaccatcatcctgagcaccttc
ctgctcatcggctgggtggctttcatcattacctaccccttgagcatgcatcagcagcag
cagctccagcaccagcagttccagaaggaactggagaaaatccagctcctgcaacagcag
cagctgcccttccatccccctggagacgtggctccagatgccgagcttctggactcctcc
ggcctgtactcggagagctcgggcaccagcagccccagcacatcccccagagcctccaac
cactcgctccactccagtggctctgcctccagggctggcaccagccccttcctggagcag
gacgatgaggatgaggaaaccagcatggtgatcgttgggaagatctcattctgtcccaag
gacgtgctgggccatggagcggaaggcacgattgtgtaccggggcatgtttgacaaccgc
gacgtggccgtcaagaggatcctccctgagtgttttagtttcgcggaccgtgaggtccag
ctgcttcgagaatcagacgagcaccccaatgtgattcgttacttctgcacggagagggac
cggcagttccagtacattgccatcgagctgtgtgcggccacgctgcaggagtacgtggag
caaaaggactttgcccacctcggcctggagcccatcaccttgctgcagcagaccacctcg
ggcctggcccatctgcactccctcaacatcgttcacagagacctgaagccccacaacatt
ctcctgtccatgcccaacgcacatggcaggatcaaggccatgatctctgactttggcctc
tgcaagaagctggcggtgggcaggcacagtttcagccgccgctcgggggtgcctggcaca
gaaggctggatcgctccagagatgctgagcgaagactgtaaggacaatcccacctacaca
gtggatatcttctctgccggctgtgtcttttactatgtgatatctgagggcagtcaccct
ttcggcaagtccctgcagcggcaagccaacatcctcctgggcgcctacagcctcgactgc
ttacatccggagaagcatgaagacgtcattgcccgggagttaatcgagaagatgattgca
atggaccctcagaaacgcccatctgcgaagcacgtgctgaagcacccgttcttctggggc
ctggaaaagcagctccagttcttccaggacgtgagtgaccggatagaaaaggaatccctg
gacggcccgatagtgaagcagctggagcgaggcgggagagccgtggtgaagacggactgg
agagagaacattaccgtccccctgcagacagatctgcgtaaattcagaacctataaaggt
ggctccgtgcgagaccttcttcgagccatgagaaacaagaagcaccactaccgggagctc
cccgcagaggtgcgggagacgctgggctctctccccgacgactttgtgcgctacttcaca
tcacgcttcccccatctcctctcccacacctaccgggccatggagccctgcagccacgag
aggctcttccagccctactatttccacgagcccccagagctccggcccccagtgactcca
gacaccctttga
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