Corynebacterium diphtheriae NCTC11397: ERS451417_00325
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Entry
ERS451417_00325 CDS
T04861
Symbol
hemD
Name
(GenBank) uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
cdip
Corynebacterium diphtheriae NCTC11397
Pathway
cdip00860
Porphyrin metabolism
cdip01100
Metabolic pathways
cdip01110
Biosynthesis of secondary metabolites
cdip01120
Microbial metabolism in diverse environments
cdip01240
Biosynthesis of cofactors
Module
cdip_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
cdip00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
ERS451417_00325 (hemD)
Enzymes [BR:
cdip01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
ERS451417_00325 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
ERS451417_00325 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
ECH_1
Motif
Other DBs
NCBI-ProteinID:
CKG66979
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Position
1:313466..315136
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AA seq
556 aa
AA seq
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MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHL
EVPQAKLDAAEAEYERMCAAAKRRKPPRPEAPTAAEIIEVSAAASVDEVMAVLLPLLDEG
DVIRLVQGNPLADSRTLDEITAVTQVGADFQIVPGMSLPAAVPAFAGITLGDSYTKTTVS
EDTNWDQLATAPLPLILQASKDDLLTIATELKDRKLPAGTPVTVTMNGTTRLQRSFDVTL
KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYG
AIAQEVPTISVEPPRNPAQLERAIKGIVEGRYQWVVFTSVNAVKAVREKIVSFGLDSRAF
AGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSVFPNYVEGLDPVGRVLLPRAD
IATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG
IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVAALVDALAEHVEKLRAAGELPP
PRKKRRARRKSKEGAV
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
atgcgattaatcatgaagcccgagcactcaacgcgaggacgtgtcatcttcgtcggcgcc
ggtcccggcaacccagatcttttgacggttcgagcccgcgaggtgctgggctccacagcc
aatgcggtggtggattccactgttggcgtaggtatccgtgcagttattgctgagcatctt
gaggtgccgcaggccaagcttgatgcagctgaagctgagtatgagcgcatgtgtgcggct
gcgaagcgtcgtaagcctccgcgtcccgaggcccccaccgccgcggaaatcattgaggtg
tccgctgcggcgagcgtcgatgaggtgatggcggtgctgttgccgttgctagacgaaggt
gatgtgattcgcttggtgcagggaaatccgttggcggattctcgcacgctcgatgagatc
acggctgttactcaggtgggcgcggatttccagattgtgccaggtatgtcgttgccggct
gcggttcctgctttcgcgggtattacgttgggcgattcttataccaagactacggtgagt
gaagatactaactgggatcagttggcaaccgccccgctgccgttgattttgcaggcgagt
aaagacgacttgctgactatcgctacggagctgaaggatcgcaaacttccggcgggcact
ccggtgacggtgacgatgaatggcacgacgcgtttgcagcgcagctttgacgtgacgctt
aaaactatgaagtcgctggtcaaacaggagctcgatggcacccttgtggtcacagtgggt
gtatcggatcgcagtacattttcttggtgggaaagccgcgcgttgtttggctggcgggtg
ttggttccccgtgcgaaggatcaagctggtccgatgagcagccgaatcgccgcttatggt
gctattgcccaagaggttcccactatttctgtggagccgccgcgtaatccggcgcagttg
gagcgtgcgattaagggcattgtggaggggcgctaccagtgggtggtgtttaccagcgtg
aatgctgttaaggcggtgcgtgagaagatcgtgtcgtttggtttggattctcgcgcgttc
gcgggggtgcatatcgctgcggtgggggctaagactgcggcggcgattcgtgagtttggc
attactcctgagctaattccgccacgtaaggagcataatgctgcgggtatggtgtcggtt
ttccctaattatgtggagggcttggacccggtaggtcgggtgttgctgccgcgggctgat
attgccactgatgtgctggttgatggtttggtcaaccttggctgggaagttgatgatgta
gtggcgtatcgtacggtgcgtgccgcgccgccgagtgcggaagtccgcgacatgattaag
tccggcgattttgatgcggtgtgttttacctctgcgtcgacggtgcgcaatttggtgggt
attgcgggtaagccgcatgcgcgcacgatcattgcatgtattgggccgatgaccgccgcg
gaggcagagaagcaagggctgcgtgtcgacgtcatccccgaggtggctaacgttgcggct
cttgtggatgcgctcgcggagcatgtggagaaactgcgtgctgcgggtgagttgccgccg
ccgcgtaagaagcgtcgggcccgtcgcaaatctaaggaaggtgctgtatga
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