Camelus dromedarius (Arabian camel): 105088820 Help Entry 105088820         CDS       T04642                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism cdk  Camelus dromedarius (Arabian camel) Pathway cdk04020   Calcium signaling pathway cdk04024   cAMP signaling pathway cdk04260   Cardiac muscle contraction cdk04261   Adrenergic signaling in cardiomyocytes cdk04371   Apelin signaling pathway cdk04713   Circadian entrainment cdk04911   Insulin secretion cdk04921   Oxytocin signaling pathway cdk04972   Pancreatic secretion cdk05020   Prion disease cdk05022   Pathways of neurodegeneration - multiple diseases cdk05410   Hypertrophic cardiomyopathy cdk05412   Arrhythmogenic right ventricular cardiomyopathy cdk05414   Dilated cardiomyopathy cdk05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:cdk00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105088820    04020 Calcium signaling pathway     105088820    04024 cAMP signaling pathway     105088820  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     105088820    04921 Oxytocin signaling pathway     105088820   09153 Circulatory system    04260 Cardiac muscle contraction     105088820    04261 Adrenergic signaling in cardiomyocytes     105088820   09154 Digestive system    04972 Pancreatic secretion     105088820   09159 Environmental adaptation    04713 Circadian entrainment     105088820  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     105088820    05022 Pathways of neurodegeneration - multiple diseases     105088820   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     105088820    05412 Arrhythmogenic right ventricular cardiomyopathy     105088820    05414 Dilated cardiomyopathy     105088820    05415 Diabetic cardiomyopathy     105088820  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cdk04040]     105088820    04990 Domain-containing proteins not elsewhere classified [BR:cdk04990]     105088820 Ion channels [BR:cdk04040]  Voltage-gated cation channels   Ryanodine receptor    105088820 Domain-containing proteins not elsewhere classified [BR:cdk04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    105088820 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RR_TM4-6 RYDR_ITPR SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  105088820 NCBI-ProteinID:  XP_031316658 LinkDB All DBs Position 11:complement(1551006..1861782) Genome browser AA seq 4067 aa AA seqDB search MNKIELGWQYGPVRDDNKRQHPCLVEFSRLPEQERNYNLQMSLETLKTLLALGCHVGISD EHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQ GWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYSLEAPDQDHAAR AEVCSGTGERFRIFRAEKTYAVRAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDEHA FAFDGFKAQRWHQGSEHYGRPWQAGDVVGCMADVTERTMVFTLNGEVLLDDSGSELAFKD FDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNREVTMWLSKR LPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPVECAEVF SKTAAGGIPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEAAKPECNNHK DYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFP GQDPTNVWVGWITSDFHQYDTAFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESM SPGQGRNSNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPHVFQ FELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISER QGWLVQCVEPLQFMSLHIPEENRSVDILELTEQEDLLKFHYHTLRLYSAVCALGNHRVAH ALCSHVDEPQLLYAIESKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETK SITLFPDENKKHGLPGIGLSTSLRPRMQVSSPSFVSISHESYQYSPEFPLDILKAKTIQM LTEAVREGSLHARDPVGGTTEFLLVPLIKLFYTLLIMGVFHSRDLKHVLQLIEPSVFKEA AAPDEESEVLEGEPCAEDPKPDGATEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLC DCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQIN MLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVE KVTYLKKKQAEKPVESAAKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDG IGGLVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKV FYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAM FDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGL QSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPA LRGEGGDGLLAAMEEAIKIAGDPSRDGPSPTSGSGKTLDPEEEEDTIHTGNAVMTFYSAL IDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTVAKDGNVVEPD MSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALA LNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLS ICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASE EELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSM DSEGNFNPQPVDTSNITIPEKLEYFISKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQP LMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSV DAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYD TLTAKEKAKDREKAQDILKFLQISGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDE AHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGH ASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLETVKS ALRAFLDSAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQH QFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHL DKHNVYSIYNTKSSRERAALSLPANVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVM EVILPMLCSYMSRWWEHGPENHPGRADTCCTALSSEHMNTLLGNILKIIYNNLGVDEGAW MKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEARGDMSEAELLI LDEFTTLARDLYAFYPLLIRFVDYNRAKWLQEPNAEAEDLFRMVAEVFIYWSKSHNFKRE EQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRRGDRYSMQTSLIVAALKRLLP IGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLP NRTEDTSDPERTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSNRGSGGRWPASGWPP CTTPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLI LLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEEDDGEEEVKSFEVTGSQRSKEKEME KQKLLYQQARLHDRGAAEMVLQTLSASKGETGPMVAATLRLGIAVLNGGNSTVQQKMLDY LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF LKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTPSETEFLLSCAETDENETLDY EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQTFLELAESVLSYFQPFLGRIEVMG SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM QLAAQISESDLNERSASKEESEKERPEEPGPRMGFFSVGTVRAALLALRYNVLALMRMLS LKSLRKQVKRVKKMTVKDMVTAVFTSYWAVFLSLLHFVASVFRGFSRILCSLLLGGSLVE GAKKIRVAELLANMPDPTQDEVRGDGEDAERKATEAALPSEDLTDLKELTEESDLLSDIF GLDLKREGGQYKLIPHNPNAGLSDLMSSPVPIPEVQEKFQEQVPKEEEKEEKEESKSEPE KAEGEDGEKEDKAKEDKGKQRPRQPHTHRYGEPEAPESAFWKKIIASQQKLLNYFARNFY NMRMLALFVAFAINFILLFYKVSTSSVVEGREPPPRSSGENTRGGSLDGGSPRVIAVHYV LEESSGYMEPTLRILAVLHTVIAFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS DAREKKKPKKDSSLSAVLSSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 12204 nt NT seq  +upstreamnt  +downstreamnt atgaataagattgaactcggttggcagtatggcccggttagagatgacaataagagacag cacccgtgtctggtggagttctccaggctgcctgaacaggaacgcaattacaatttacag atgtcacttgagaccctgaagaccttgttggcattaggatgtcacgtgggcatatcggat gaacatgctgaagaaaaggtgaaaaaaatgaagctgcccaagaattaccagctgacgagt gggtacaagcctgccccgatggacctgagctttatcaaactcaccccatctcaggaagcg atggtggacaagttggcggaaaatgctcataacgtgtgggcccgggatcgaatccgccag ggctggacctacggcatccagcaggacgtaaagaacagaagaaacccgcgcctcgttccc tacgcccttctggatgaccgaaccaagaaatcaaacaaggacagcctccgcgaggcagtg cgcacgctgctggggtacggctacagcctggaggcgcccgatcaagaccacgccgccagg gcagaggtgtgcagtggcaccggggagcggttccggatcttccgggccgagaaaacttat gccgtgagggccggaaggtggtatttcgagttcgaggctgtcactgctggagacatgcga gtgggctggagccggccaggctgccagcccgatcaggagctgggctcggatgaacatgcc tttgctttcgatggcttcaaggcccagcgctggcaccagggcagcgagcactacgggcgg ccctggcaggcgggcgacgtggtgggctgcatggccgacgtgaccgagcgcaccatggtg ttcacgctcaacggcgaggtcctgctcgacgactcgggctccgagctggccttcaaggac ttcgacgtcggcgacgggttcataccagtgtgtagcctcggagtggctcaggtgggcagg atgaacttcggaaaggatgtcagcaccttgaaatacttcaccatctgcggcttacaggag ggctatgagccatttgccgttaatacaaacagggaggttaccatgtggctgagcaagagg ctccctcagtttctccaggttccatcgaaccacgaacacattgaggtgaccaggatagac ggcaccatagacagctccccgtgtttaaaggtcactcagaagtcatttggctcccagaac agcagcacggacatcatgttctaccgcctgagcatgcccgtcgagtgcgcggaggtcttc tccaagactgcggcgggcggcatcccgggcgccggcctctttgggcccaagaacgatttg gaggattatgatgcagattcggacttcgaggttctcatgaagacagctcatggccatctg gtgccagatcgagtggacaaagacaaagaagctgcaaaaccggagtgtaacaaccacaag gattacgctcaggaaaagccctctcgtctgaaacaaagatttctgctcaggaggacaaag ccagattacagcacaagccattccgcaagactcactgaggacgtccttgccgatgacagg gatgactacgactacttgatgcagacgtccacgtactattactcagtgagaatctttcct ggacaagaccccactaatgtctgggtgggctggattacatcagatttccatcagtacgat accgcctttgacctggacagagttcgcacagtgaccgtgactctaggagatgaaaaagga aaggtgcacgaaagcatcaaacgcagcaactgctacatggtgtgtgcgggcgagagcatg agcccggggcaggggcgcaacagtaatggcctggagatcggctgtgtggtggacgcggcc agcgggctgctcaccttcaccgccaacggcaaggagctgagcacctactaccaggtggag ccaagtacaaagttatttcctgccgtttttgcacaagctacaagtcctcatgtctttcag tttgagttgggaagaataaagaacgtgatgcctctctcagcgggactgttcaagagtgag cacaaaaacccggtgccgcagtgccccccacgcctccatgtgcagttcctgtcccacgtc ctctggagcaggatgcccaaccagttcttaaaggtcgacgtctctcgaatcagcgagcgc cagggctggctggtgcagtgtgtggaacccttgcagttcatgtctcttcacatcccggag gagaacaggtctgtggacatcctggagttgaccgagcaggaggacctgctgaagttccac taccacacgctccggctgtactcggcggtgtgtgcgctggggaaccaccgcgtggcccat gccctgtgcagccacgtggatgagccgcagctgctctacgccatcgagagcaagtatatg cccggcctgctgcgcgccggctactacgacctgctgattgacatccacctcagctcctac gccaccgccaggctcatgatgaacagcgagttcatcgtccccatgacggaggagaccaag agcatcacgctgttcccggacgagaacaagaagcacggcctcccgggcattggcctcagc acctcgctcaggccgcggatgcaggtgtcctcccccagcttcgtgagcatcagtcacgag agctaccagtacagccctgagttcccgctggacatcctcaaggccaagaccatccagatg ctgacagaggcagtgcgagagggcagcctgcacgcccgggaccccgtggggggcaccact gagttcctcctcgtgcccctcatcaagctcttctacaccctgctcatcatgggtgtcttc cacagccgggacctcaagcacgtcctgcagctcatcgagcccagcgtgttcaaggaagct gctgcccctgacgaggagagcgaggtgctggagggggagccctgcgccgaagaccccaag cccgacggagccacggaggaagaagccaaagggggtaagaggcccaaggaaggtctgctc caaatgaaactgcccgagccagttaaattgcagatgtgcctcctacttcagtacctctgt gactgccaggtccggcaccggatagaagccattgtggccttttctgatgactttgtagcc aagctccaggacaaccagcggttccgctacaacgaggtcatgcaagccttaaacatgtcg gctgccctcacagccagaaagacaaaggagtttcgatcaccacctcaagaacagatcaat atgcttctcaattttaaggatgacaaaagcgaatgtccatgtcctgaagaaatccgagac cagctcttggattttcatgaagatttgatgacgcattgtggaattgagctggatgaagac gggtctctggatggaaacagtgatttaacgattagaggacgcctgctgtccttggtggaa aaggtgacatacctgaagaagaagcaagccgaaaagccagttgagagtgccgccaagaag tcgtccactctgcagcagctgatatccgagaccatggtccgctgggcccaagagtctgtc atcgaagaccctgagctggtgagggccatgtttgtgctgctccaccgacagtatgacggc attgggggtctggttcgtgctctgcccaagacctacactatcaacagcgtttccgtcgag gacaccatcaacctgctggcatctcttggtcagattcgctctctgctgagcgtgagaatg ggaaaagaagaagagaagctcatgatccgcggattgggggatatcatgaataataaagta ttctaccagcaccctaatctcatgagggcgcttgggatgcacgagacagtgatggaggtc atggtgaacgtccttggaggcggagagtccaaggaaatcacttttcccaagatggtggcc aactgctgccgttttctctgttacttctgtcgtataagcaggcagaatcagaaagccatg tttgatcatctcagttacttactggagaacagcagtgttggtctcgcctcaccagctatg agagggtcaacgccgctggatgtggccgcagcctcggtgatggataataatgagctcgcc ctggctctgcgggagccagatctggaaaaggtggtccgctatctggctggctgtggactg cagagctgccagatgttggtgtcgaagggctatccagacatcggctggaatcctgttgaa ggagagagatacctcgactttctcagatttgctgtgttctgtaatggggagagtgtggag gagaacgccaacgtcgtggtcagactgctcatccggaggcctgagtgcttcggtcccgcc ctgcggggggaaggtggggacggtctgctcgcagccatggaagaggccatcaagatagcc ggagacccttctcgtgacggtccctccccaaccagcggctccggcaaaacccttgaccca gaggaggaggaggacacaatccacacggggaatgccgtcatgaccttctactcggctctg atcgacctgctggggcgttgtgccccggagatgcacctgatccacgctgcgaagggagag gccatcaggatcaggtctattttgagatccctgattccactgggagacttggtgggcgtg atcagcatcgctttccagatgccgaccgtagccaaagatgggaatgtggtggagcctgac atgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtc tatggaattgaggttcaagacttcctcctccaccttcttgaggttggctttctgccagat ctccgggctgctgcttctttagacacggctgccctgagcgccacagacatggccctggcc ctcaatcggtacctctgcacagctgtgctgcccttgttgacccggtgcgctcctctgttt gcgggcaccgagcaccacgcttcgctcatcgactccttacttcacacggtgtacagactc tctaagggctgttcacttaccaaagctcagcgggactccattgaagtgtgtctgctctcc atttgtggccaactgagaccttctatgatgcagcacttactcagaagattagtgtttgat gttccactattaaatgaacatgcaaagatgcctcttaagctgctgacaaatcattatgaa agatgctggaaatattactgcctgcctggagggtggggaaactttggagctgcctcagaa gaagaacttcatttatcaagaaagttgttctggggcatttttgatgcactgtctcaaaag aaatatgaacaagaacttttcaaactggcactgccttgcctgagcgcagttgcaggagct ttgcccccagactacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatg gattctgaagggaactttaacccacaacctgttgatacctcaaatatcacaattcctgag aagttggagtacttcattagcaaatatgcagagcattcccatgacaaatggtcgatggac aagttggcaaatggatggatttatggagaaatatattcagactcatctaaagttcagcca ttaatgaagccatataagctgttatctgaaaaggaaaaagaaatttatcgctggccaatc aaagaatctttaaaaactatgctggcttgggggtggaggattgaaaggacacgggaggga gacagcatggccctttacaaccggactcgtcgcatttctcagacaagccaggtttctgtg gatgccgcccatgggtacagcccccgagccattgacatgagcaatgttacactatctcga gatctacatgcgatggcagaaatgatggctgaaaactaccataatatatgggcaaagaaa aagaagctggagctggaggccaaaggaggtggaaatcatccactgctggttccctatgac acactgacagccaaagagaaagccaaggacagggagaaagcacaggacatcctcaagttc ctgcagatcagcgggtatgctgtgtccagaggcttcaaggacctggaattggacacacct tctattgagaaacgatttgcctatagtttccttcagcagctcattcgctatgtggatgag gcccatcagtatatcctggagttcgatggtggcagcagaagcaaaggagaacatttccct tatgagcaagaaatcaagttctttgctaaagtcgttcttcctttaattgatcagtatttc aaaaaccatcgtttatacttcttatctgcagcaagcagacctctctgttctggaggacat gcttcaaacaaagagaaagaaatggtgactagcctattctgcaaacttggagttcttgtc aggcataggatttcactgtttggaaatgatgcaacatcaattgtcaactgtcttcatatt ttgggtcagactttggatgcaaggaccgtgatgaagactggcctggagactgtcaagagc gcgctgcgggctttcctggacagcgccgccgaggatctggagaagacgatggagaacctc aagcagggccagttcacccacacccgaaaccagcccaaaggcgttactcagattatcaat tataccacggtggcgctgctgccaatgctgtcgtccttatttgagcatattggccagcat cagttcggagaagatctgatattggaagatgtgcaggtgtcatgctatagaattctgact agcttgtatgctttgggaactagcaagagtatttatgtggaaaggcaacgttctgcatta ggagaatgcctggctgcctttgctggtgcgtttcctgtagcctttttggaaactcatctg gacaaacacaacgtttactcaatctacaatacgaagtcttcacgagagagagcagctctc agtttgccagctaatgtggaagacgtttgtccaaatataccatctctggagaagctcatg gaagaaatcgtggaactggctgagtccgggatccgctacactcagatgccacatgtgatg gaggtcatcttgcccatgctctgcagctacatgtcccgctggtgggagcacggccccgag aaccacccggggagggcagacacgtgctgcacggcactgagctcggagcacatgaacacg ctgctgggcaacatcctgaagatcatatacaacaacctgggggtggacgagggcgcctgg atgaagaggctggcagtgttttcccagcccattataaacaaagtgaaacctcagctcttg aaaactcatttcctgccattaatggagaaactcaagaaaaaggcggcgatggtggtatcg gaggaggaccacctgaagtccgaggccaggggggacatgtccgaggcggagctgctcatc ctggacgagttcaccacgctggccagggacctctacgccttctacccgctcctgattcga tttgtggactacaacagggcaaagtggctccaggagcctaacgcagaagcagaggacctt ttccgcatggtggccgaggtgtttatctactggtcaaagtcccacaacttcaaaagggaa gagcagaacttcgtggtgcagaatgaaatcaacaacatgtcttttctcatcacagacacc aagtcaaagatgtcgaaggcagccgtgtctgaccaggagaggaagaagatgaagcgcaga ggggaccggtactccatgcagacgtcgctcatcgtggcggcgctgaagcggctgctgccc atcggcctgaacatctgcgcgcccggggaccaggagctcatcgctctggccaaaaatcgg tttagtctgaaagacactgaggatgaagtacgagatataatccgcagtaatattcacctt caaggcaagttggaggatcctgccattcggtggcagatggccctttacaaagacctacca aacaggactgaagacacttccgaccccgagaggacagttgaaagggtactggacatagca aacgtgctcttccaccttgagcaggtggagcacccgcagagatccaagaaggccgtgtgg cacaagctgctctccaacagaggaagcggcgggcggtggcctgcttccggatggccccct tgtacaaccccgaggcatcgggctgtcaatctctttcttcagggatatgaaaagtcttgg attgaaacagaagagcattactttgaagataaactgatagaagacttggcgaaacctgga gcagagcctccggaggaagatgaaggcactaagagggtcgatcctctgcaccagctgatc cttctgttcagccgaacggctctgacggagaaatgcaaactggaagaagattttttatat atggcttatgcagatattatggcaaagagctgtcatgacgaggaggaggatgacggcgaa gaggaggtgaagagctttgaagtcacaggatcgcagcgcagcaaggaaaaggaaatggag aagcagaagcttctgtaccagcaagccaggctgcatgaccgcggcgctgccgagatggtg ctgcagaccctcagcgccagcaaaggtgagactggacccatggtggctgctactctgaga ctcgggattgctgtcttaaatggcgggaactccacagtgcagcagaaaatgctcgactac ctcaaggagaaaaaggacgtgggcttctttcagagcctggcgggcctgatgcagtcgtgc agcgtcctcgacctcaatgcatttgagcgacagaacaaagccgagggactcgggatggtg acggaagaaggatcaggagagaaggttctgcaggatgacgagttcacctgtgacctcttc cgcttcttgcagctgctctgtgagggacacaactcagattttcaaaattatctgagaacc cagacgggcaacaatacgactgtcaacatcatcatctccacggtggactacctgctgcga gtccaggaatcaatcagtgatttctattggtattactctgggaaagacgtcatcgatgag caaggacaaaggaatttctccaaagcaattcaagtagcaaagcaagtcttcaacactctt acagagtatattcagggcccttgcacggggaaccagcagagcctggcccacagccggctg tgggacgcggtggtgggcttcctccacgtgttcgcccacatgcagatgaagctgtcccag gactccagccagatcgagctcctgaaagagctgatggacctccagaaggacatggtggtc atgctgctgtccatgctggaaggtaatgttgtgaacggcaccatcggcaaacagatggtg gacatgctcgtggagtcttccaacaacgtggagatgattctcaaatttttcgacatgttc ctgaaactgaaggacttgacgtcttccgacgccttcaaagagtatgaccccgacggcaag ggcgtcatctccaagagagacttccacaaggcgatggagagccacaagcactacacgccg tccgagaccgagttcctcctgtcctgcgccgagacggacgagaacgaaaccctggactac gaggagttcgtcaagcggttccacgagcccgccaaggacatcggcttcaacgtggcggtg ctgctgacaaacctgtccgagcacatgcccaacgacagccggctgcagaccttcctggag ctggccgagagcgtgctcagctacttccagcccttcctgggccgcatcgaggtcatgggc agcgccaagcgcatcgagagggtctactttgagatcagcgagtccagccggacccagtgg gagaagccacaggtcaaggagtccaagaggcagttcatattcgacgtggtcaacgagggg ggtgagaaggagaagatggagctgttcgtgaacttctgtgaggacaccatcttcgagatg cagctggcggctcagatctcagagtcggacctgaacgagaggtcggcgagcaaggaggag agcgagaaggagcggccggaggagccgggcccgaggatgggcttcttctccgtggggacg gtgcgcgcggccctgctcgccctgcgctacaacgtcctggccctcatgcggatgctcagc ctcaagagcctgaggaagcaggtgaagcgcgtgaagaagatgacggtcaaggacatggtc acggccgtcttcacatcctactgggccgtcttcctgagcctcctgcacttcgtggccagc gtgttcaggggcttctcccgcatcctctgcagcctcctgctggggggcagcttggtggaa ggtgccaagaagatccgagtggccgagctcttggccaacatgccggaccccacgcaggac gaggtcaggggggacggggaggatgcagagaggaaggccacggaagctgccctgccctcc gaggacctcacagacctgaaggaactgacggaggagagcgacctgctctccgacatcttc ggcttggacctgaagcgagaaggaggacagtacaagctcatcccgcataatcccaacgcc ggcctgagcgacctcatgagcagcccggtccccatccccgaggtgcaggagaagttccag gaacaggtgcccaaagaagaggagaaggaagaaaaagaagagagcaaatcagaacccgag aaagccgagggagaagatggagaaaaagaagacaaagccaaagaagacaagggcaagcag aggccgaggcagccgcacacacacagatacggggagcccgaggctcccgagtcggctttc tggaagaagatcatagcctctcagcagaagctgctcaactatttcgctcgcaacttttac aacatgaggatgttagccttgtttgtcgcgtttgcgatcaatttcatcttgctcttttac aaggtctccacttcttctgtggttgaaggaagggagccgccccctcgcagctcaggcgaa aatacccgaggcggcagcctggacggcggctcgccgcgagtcatcgccgtgcactacgtg ctggaggagagcagcggctacatggagcccacgctgcgcatcctggccgtgctgcacacg gtcatcgccttcttctgcatcatcgggtactactgcctgaaggtcccactggttattttt aagcgagaaaaggaagtagctcgaaaattggaattcgatgggctttatattacagaacag ccttcggaagatgatattaaaggccagtgggatagactcgtaatcaacacacagtcattt cccaataactactgggacaaatttgttaaaagaaaggttatggataaatacggggaattc tatggccgagacagaatcagcgagctgcttggcatggacaaagccgccctggacttcagc gacgcccgggaaaagaagaagccgaagaaagacagctccctgtcggccgtactgagctcc atcgatgtgaagtatcagatgtggaagctgggagtcgttttcactgacaactccttcctc tacctggcctggtacatgaccatgtccgtccttgggcactacaacaacttcttcttcgct gctcatcttctggacattgccatgggattcaagaccctaagaaccatcctgtcgtcagtc acacacaatggcaagcagcttgtgctgaccgtcggcttactggccgtcgtcgtgtacctg tacactgtggtggcattcaacttcttccgaaaattctacaacaaaagtgaagacggtgac acaccagacatgaagtgtgacgacatgctgacgtgctacatgttccacatgtatgtcggg gtgcgtgctggcgggggcatcggcgacgagatcgaggaccccgcgggcgatgagtacgag atctaccgcatcatcttcgacatcaccttcttcttcttcgtgatcgtcatcctcttggcc atcatccaaggtttgatcattgatgccttcggggaactgagagaccagcaggagcaggtc aaggaagacatggagaccaagtgcttcatctgtgggataggcaacgattacttcgacacc gtgccgcacggcttcgagacccacaccctgcaggagcacaacctggccaattacctgttt ttcctgatgtatctcataaacaaagacgaaacagagcacacaggacaggaatcttacgtc tggaagatgtaccaggaaaggtgctgggagttcttcccagccggggattgtttccggaaa cagtacgaagaccagctgaactga

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