KEGG   Camelus dromedarius (Arabian camel): 105095024
Entry
105095024         CDS       T04642                                 
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase isoform X1
  KO
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Organism
cdk  Camelus dromedarius (Arabian camel)
Pathway
cdk00140  Steroid hormone biosynthesis
cdk01100  Metabolic pathways
cdk04913  Ovarian steroidogenesis
cdk04917  Prolactin signaling pathway
cdk04927  Cortisol synthesis and secretion
cdk04934  Cushing syndrome
Module
cdk_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
cdk_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
cdk_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
cdk_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:cdk00001]
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    105095024
   04917 Prolactin signaling pathway
    105095024
   04927 Cortisol synthesis and secretion
    105095024
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105095024
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:cdk00199]
    105095024
Enzymes [BR:cdk01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     105095024
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     105095024
Cytochrome P450 [BR:cdk00199]
 Cytochrome P450, animal type
  CYP17 family
   105095024
SSDB
Motif
Pfam: p450 DUF4209
Other DBs
NCBI-GeneID: 105095024
NCBI-ProteinID: XP_010985438
LinkDB
Position
11:complement(60865500..60871317)
AA seq 507 aa
MWVFLALLMLTLAYLFRPKNKGPRAKYPKSLPSLPLVGSLPFLPRHGHQHVNFFKLQGKY
GPIYSFRIGSKTTVVIGNYQLAKEVLLKKGKEFSGRPKLLTLDILSENQKGIAFADHGTH
WQLHRKLALSTFALFKDGNLKLEKIINQEVSILCDFLTTKDGQSVDLSRSLSQAVINIIC
FICFNYSFKNGDPAVHALQDFNDRILEVLSKTALADMFPAARILPNKTLEDMKKCVNMRN
ELMRGIFEKCKKNFTGDSITNMMDILIQAKVNADSAGLEQDSKLLSDRHIIATITDIFGA
GVETSTSVIKWIVAFLLHYPSLKKRIQDDIDQNIGFNRTPKVSDRNRLVLLEATIREVLR
LRPVSPTLIPHKAIVDSSIGELAIDKGTDVVVNLWALHHNEKEWHRPDLFMPERFLDPTG
NQLISPTSSYLPFGTGPRSCVGEMLARQEIFLFMAGLLQRFDLEIPDDGQLPSLEGKPSL
VFQIHPFKVKIKVRQSWKEAQAEGNNP
NT seq 1524 nt   +upstreamnt  +downstreamnt
atgtgggtattcttggctctcttgatgctcaccctcgcctatttatttaggcccaagaac
aagggccctcgtgccaagtaccccaagagcctcccatccctgcccctggtgggcagcctg
ccgttcctccccagacatggccaccagcatgtgaacttcttcaagctgcagggaaagtat
ggccccatctattccttccgtatcggttccaagacgacagtggtgatcggcaactaccag
ctggccaaggaggtgcttctcaagaagggcaaggaattctctgggaggcccaaattgttg
actctagacatcctatcagaaaatcaaaagggcattgccttcgccgaccacggtacccac
tggcagcttcatcggaagctggcgctgagcacctttgccctgttcaaggatggcaacctg
aagctggagaagatcattaatcaggaagtcagtatactgtgtgatttcctgaccaccaag
gatgggcagtccgttgatttgtccaggtcactctctcaggcggtgatcaacataatctgc
tttatctgcttcaactactccttcaagaatggggaccctgcagtgcacgcattgcaggat
ttcaatgacaggatcctggaggttctgagcaagacagctttggccgacatgtttccagcg
gctaggattctccccaacaaaaccttggaagatatgaagaagtgtgttaacatgagaaat
gaattgatgagaggaatcttcgaaaagtgtaagaagaacttcaccggtgactctatcact
aacatgatggacatactgattcaagccaaggtgaacgcagacagtgctggcttggaacag
gactcaaagctgctttcagatagacatattatcgccaccataacagacatctttggggcc
ggtgtagagaccagcacctctgtgataaagtggattgtggccttcctgctacactatcct
tcgttgaagaagaggatccaggatgatattgaccagaatataggtttcaaccgcacacca
aaagttagtgaccggaaccgccttgtcctgctggaggccaccatccgagaggtgcttcga
ctccggcctgtgtcccctacgctcatcccccacaaggctatcgttgattccagcatcggc
gagcttgccattgacaagggtacagatgttgtcgtcaatttgtgggcactgcatcacaat
gagaaggagtggcaccggcccgacctgttcatgccagagcgcttcttggaccccactggg
aaccagctcatctcgccgacatcaagctacttgccctttggaacaggaccccgctcctgc
gtaggtgagatgctagcccgccaggagatcttcctcttcatggctgggttgctgcagagg
ttcgacctggagatcccggatgatggacagctaccctctctggagggcaaacccagttta
gtttttcagatccatcctttcaaagtgaaaatcaaggtgcgccagtcctggaaggaagcc
caggcagagggtaacaacccctga

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