KEGG   Camelus dromedarius (Arabian camel): 105107003
Entry
105107003         CDS       T04642                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
cdk  Camelus dromedarius (Arabian camel)
Pathway
cdk00562  Inositol phosphate metabolism
cdk01100  Metabolic pathways
cdk01521  EGFR tyrosine kinase inhibitor resistance
cdk01522  Endocrine resistance
cdk01524  Platinum drug resistance
cdk04012  ErbB signaling pathway
cdk04014  Ras signaling pathway
cdk04015  Rap1 signaling pathway
cdk04024  cAMP signaling pathway
cdk04062  Chemokine signaling pathway
cdk04066  HIF-1 signaling pathway
cdk04068  FoxO signaling pathway
cdk04070  Phosphatidylinositol signaling system
cdk04071  Sphingolipid signaling pathway
cdk04072  Phospholipase D signaling pathway
cdk04081  Hormone signaling
cdk04140  Autophagy - animal
cdk04150  mTOR signaling pathway
cdk04151  PI3K-Akt signaling pathway
cdk04152  AMPK signaling pathway
cdk04210  Apoptosis
cdk04211  Longevity regulating pathway
cdk04213  Longevity regulating pathway - multiple species
cdk04218  Cellular senescence
cdk04360  Axon guidance
cdk04370  VEGF signaling pathway
cdk04380  Osteoclast differentiation
cdk04510  Focal adhesion
cdk04550  Signaling pathways regulating pluripotency of stem cells
cdk04611  Platelet activation
cdk04613  Neutrophil extracellular trap formation
cdk04620  Toll-like receptor signaling pathway
cdk04625  C-type lectin receptor signaling pathway
cdk04630  JAK-STAT signaling pathway
cdk04650  Natural killer cell mediated cytotoxicity
cdk04660  T cell receptor signaling pathway
cdk04662  B cell receptor signaling pathway
cdk04664  Fc epsilon RI signaling pathway
cdk04666  Fc gamma R-mediated phagocytosis
cdk04668  TNF signaling pathway
cdk04670  Leukocyte transendothelial migration
cdk04722  Neurotrophin signaling pathway
cdk04725  Cholinergic synapse
cdk04750  Inflammatory mediator regulation of TRP channels
cdk04810  Regulation of actin cytoskeleton
cdk04910  Insulin signaling pathway
cdk04914  Progesterone-mediated oocyte maturation
cdk04915  Estrogen signaling pathway
cdk04917  Prolactin signaling pathway
cdk04919  Thyroid hormone signaling pathway
cdk04923  Regulation of lipolysis in adipocytes
cdk04926  Relaxin signaling pathway
cdk04929  GnRH secretion
cdk04930  Type II diabetes mellitus
cdk04931  Insulin resistance
cdk04932  Non-alcoholic fatty liver disease
cdk04933  AGE-RAGE signaling pathway in diabetic complications
cdk04935  Growth hormone synthesis, secretion and action
cdk04960  Aldosterone-regulated sodium reabsorption
cdk04973  Carbohydrate digestion and absorption
cdk05010  Alzheimer disease
cdk05017  Spinocerebellar ataxia
cdk05020  Prion disease
cdk05100  Bacterial invasion of epithelial cells
cdk05132  Salmonella infection
cdk05135  Yersinia infection
cdk05142  Chagas disease
cdk05146  Amoebiasis
cdk05160  Hepatitis C
cdk05161  Hepatitis B
cdk05162  Measles
cdk05163  Human cytomegalovirus infection
cdk05164  Influenza A
cdk05165  Human papillomavirus infection
cdk05166  Human T-cell leukemia virus 1 infection
cdk05167  Kaposi sarcoma-associated herpesvirus infection
cdk05168  Herpes simplex virus 1 infection
cdk05169  Epstein-Barr virus infection
cdk05170  Human immunodeficiency virus 1 infection
cdk05171  Coronavirus disease - COVID-19
cdk05200  Pathways in cancer
cdk05203  Viral carcinogenesis
cdk05205  Proteoglycans in cancer
cdk05206  MicroRNAs in cancer
cdk05207  Chemical carcinogenesis - receptor activation
cdk05208  Chemical carcinogenesis - reactive oxygen species
cdk05210  Colorectal cancer
cdk05211  Renal cell carcinoma
cdk05212  Pancreatic cancer
cdk05213  Endometrial cancer
cdk05214  Glioma
cdk05215  Prostate cancer
cdk05218  Melanoma
cdk05220  Chronic myeloid leukemia
cdk05221  Acute myeloid leukemia
cdk05222  Small cell lung cancer
cdk05223  Non-small cell lung cancer
cdk05224  Breast cancer
cdk05225  Hepatocellular carcinoma
cdk05226  Gastric cancer
cdk05230  Central carbon metabolism in cancer
cdk05231  Choline metabolism in cancer
cdk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cdk05415  Diabetic cardiomyopathy
cdk05417  Lipid and atherosclerosis
cdk05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cdk00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105107003 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105107003 (PIK3CD)
   04014 Ras signaling pathway
    105107003 (PIK3CD)
   04015 Rap1 signaling pathway
    105107003 (PIK3CD)
   04370 VEGF signaling pathway
    105107003 (PIK3CD)
   04630 JAK-STAT signaling pathway
    105107003 (PIK3CD)
   04668 TNF signaling pathway
    105107003 (PIK3CD)
   04066 HIF-1 signaling pathway
    105107003 (PIK3CD)
   04068 FoxO signaling pathway
    105107003 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    105107003 (PIK3CD)
   04072 Phospholipase D signaling pathway
    105107003 (PIK3CD)
   04071 Sphingolipid signaling pathway
    105107003 (PIK3CD)
   04024 cAMP signaling pathway
    105107003 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    105107003 (PIK3CD)
   04152 AMPK signaling pathway
    105107003 (PIK3CD)
   04150 mTOR signaling pathway
    105107003 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105107003 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105107003 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    105107003 (PIK3CD)
   04218 Cellular senescence
    105107003 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105107003 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    105107003 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105107003 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105107003 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    105107003 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    105107003 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    105107003 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    105107003 (PIK3CD)
   04660 T cell receptor signaling pathway
    105107003 (PIK3CD)
   04662 B cell receptor signaling pathway
    105107003 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    105107003 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    105107003 (PIK3CD)
   04670 Leukocyte transendothelial migration
    105107003 (PIK3CD)
   04062 Chemokine signaling pathway
    105107003 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105107003 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    105107003 (PIK3CD)
   04929 GnRH secretion
    105107003 (PIK3CD)
   04915 Estrogen signaling pathway
    105107003 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    105107003 (PIK3CD)
   04917 Prolactin signaling pathway
    105107003 (PIK3CD)
   04926 Relaxin signaling pathway
    105107003 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    105107003 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    105107003 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105107003 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105107003 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    105107003 (PIK3CD)
   04722 Neurotrophin signaling pathway
    105107003 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105107003 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    105107003 (PIK3CD)
   04380 Osteoclast differentiation
    105107003 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    105107003 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    105107003 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105107003 (PIK3CD)
   05206 MicroRNAs in cancer
    105107003 (PIK3CD)
   05205 Proteoglycans in cancer
    105107003 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    105107003 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    105107003 (PIK3CD)
   05203 Viral carcinogenesis
    105107003 (PIK3CD)
   05230 Central carbon metabolism in cancer
    105107003 (PIK3CD)
   05231 Choline metabolism in cancer
    105107003 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105107003 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105107003 (PIK3CD)
   05212 Pancreatic cancer
    105107003 (PIK3CD)
   05225 Hepatocellular carcinoma
    105107003 (PIK3CD)
   05226 Gastric cancer
    105107003 (PIK3CD)
   05214 Glioma
    105107003 (PIK3CD)
   05221 Acute myeloid leukemia
    105107003 (PIK3CD)
   05220 Chronic myeloid leukemia
    105107003 (PIK3CD)
   05218 Melanoma
    105107003 (PIK3CD)
   05211 Renal cell carcinoma
    105107003 (PIK3CD)
   05215 Prostate cancer
    105107003 (PIK3CD)
   05213 Endometrial cancer
    105107003 (PIK3CD)
   05224 Breast cancer
    105107003 (PIK3CD)
   05222 Small cell lung cancer
    105107003 (PIK3CD)
   05223 Non-small cell lung cancer
    105107003 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105107003 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    105107003 (PIK3CD)
   05161 Hepatitis B
    105107003 (PIK3CD)
   05160 Hepatitis C
    105107003 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    105107003 (PIK3CD)
   05164 Influenza A
    105107003 (PIK3CD)
   05162 Measles
    105107003 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    105107003 (PIK3CD)
   05163 Human cytomegalovirus infection
    105107003 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105107003 (PIK3CD)
   05169 Epstein-Barr virus infection
    105107003 (PIK3CD)
   05165 Human papillomavirus infection
    105107003 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105107003 (PIK3CD)
   05135 Yersinia infection
    105107003 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    105107003 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105107003 (PIK3CD)
   05142 Chagas disease
    105107003 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105107003 (PIK3CD)
   05017 Spinocerebellar ataxia
    105107003 (PIK3CD)
   05020 Prion disease
    105107003 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105107003 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    105107003 (PIK3CD)
   05415 Diabetic cardiomyopathy
    105107003 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105107003 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    105107003 (PIK3CD)
   04931 Insulin resistance
    105107003 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105107003 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105107003 (PIK3CD)
   01524 Platinum drug resistance
    105107003 (PIK3CD)
   01522 Endocrine resistance
    105107003 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cdk04131]
    105107003 (PIK3CD)
Enzymes [BR:cdk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     105107003 (PIK3CD)
Membrane trafficking [BR:cdk04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105107003 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 105107003
NCBI-ProteinID: XP_031319872
LinkDB
Position
13:6851630..6898558
AA seq 1044 aa
MPPGVDCPMEFWTKEENQDVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLQDPEVNDFRAKMRQFCEEAAVRRQQLSWEAWLQYSFPLQLEPSARSWGP
GTLRVPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LRVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPASQVQKPR
TKPPPIPMKKPSSVSLWSLEQPFCIELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECRLYMWPSVPDEKGELLNPSGTVRSNPNTESAAALVIFLPEVAP
HPVYYPALDKILELGRHGEHGRFTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEIQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTPKPQTKELMHMCMR
QETYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDILWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
VRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYSILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccccggggttgactgccccatggaattctggaccaaagaggagaatcaggacgtg
gcagttgacttcttgctgcccacgggggtctatctgaacttccctgtgtcccgaaatgcc
aacctcagcaccatcaagaaggttttgtggcaccgagcccagtatgagccgctcttccac
atgctcagtgaccccgaggcctatgtgttcacctgcgtcaaccagaccgcagagcagcag
gagctggaggacgagcagcggcggctgtgtgacatccagcccttcctgcccgtcctgcgc
ctggtggcccgcgagggggacagagtgaagaagctcatcaactcccagatcagcctgctc
attggcaaaggcctccacgagtttgactccttgcaagacccggaagtgaatgactttcga
gccaagatgcgccagttctgcgaggaggcagctgtgcggagacagcagctgagctgggag
gcctggctgcagtacagcttcccgctgcagctggagccttcagcacggagctgggggcca
ggcaccctgcgcgtccccaaccgggccctcctggtcaacgtcaagttcgagggtagtgag
gagagcttcaccttccaggtgtccaccaaggatgtgcccctggcactgatggcctgcgcc
ctccggaagaaggccacagtgttccggcagccgctggtggagcagcctgaggactacacg
ctgcgagtgaacgggaggcatgagtacctgtacggcagctaccccctctgccagttccag
tacatctgcagctgcctgcacagcgggctgaccccgcacctgaccatggtgcattcctcc
tccatcctcgccatgcgggacgaacagagcaaccccgcctcccaagtccaaaaaccgcgc
accaagccgccccccattcccatgaagaagccttcctcagtgtctctgtggtccctggag
cagcctttctgcatcgagctgatccagggcagcaaagtgaatgcagatgagcggatgaag
ctggtggtgcaggccgggctcttccatggcaacgagacactgtgcaagacggtgtccagc
tcagaggtgagcgtgtgctcagaacccgtatggaagcagcggctggagttcgacatcaat
gtgtgcgacctgccgcgcatggcccgcctctgctttgcactttatgccgtgattgagaag
gccaagaaggcgcgctctaccaagaagaagtccaagaaggcggactgccccatcgcgtgg
gccaacctcatgttgtttgactacaaggaccagctcaagaccggcgagtgccgcctctac
atgtggccctccgtcccagatgagaaaggggagctgctgaacccctcgggaactgtgcgg
agtaatcccaacactgagagtgcagccgctctggtcatctttctccctgaggtggccccc
caccctgtgtactaccctgccctggacaagatcctggagctggggcggcacggggagcat
gggcgcttcacggaggaggagcagctgcagctgcgggaaatcctggagcggcggggatcc
ggggagctgtatgagcacgagaaggacctggtgtggaagatgcggcacgagatccaggag
cacttccccgaggcgctggcccggctgctgctggtcaccaagtggaacaaacatgaggac
gtggcccagatgctctacctgctgtgctcctggcctgagctgcctgtcctgagtgccctg
gagctgctggacttcagcttccccgaccgccacgtgggctccttcgccatcaagtccctg
cggaaactgacggacgacgagcttttccagtacctgctgcagctggtgcaggtgctcaag
tacgagtcctacctcgactgcgagctgaccaagttcctgctggaccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccgctccgagatgcacgtgccgtctgtg
gccctgcgcttcggcctcatcatggaggcctactgccggggcagcacccaccacatgaag
gtgctgatgaagcagggggaagctctgagcaaactgaaggccctgaacgactttgtcaaa
gtgagctcccagaagacgcccaagccgcagaccaaggagctgatgcacatgtgcatgcgc
caggagacctacctggaggccctctcccacctgcagtccccgctcgaccccagcaccctg
ctggctgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
gtcatgtacagcaacgaggaggccggcagtgacggcagcgtgggcatcatcttcaagaac
ggggatgacctccgccaggacatgctgaccctgcagatgatccagctcatggacattctg
tggaagcaggaggggttggacctgaggatgaccccctatggctgcctctccaccggggac
cgcacaggcctcatcgaggtcgttcttcactcggacaccatcgccaacatccagctgaac
aagagcaacatggcggccacagctgccttcaacaaagatgctctactcaactggctcaag
tccaagaaccctggggaggccctggatcgagccattgaggagttcaccctctcctgtgct
ggctactgcgtggccacgtacgtgctgggcatcggtgatcggcacagcgacaacatcatg
gtccgggagaacggccagcttttccacattgattttggccactttctggggaatttcaag
accaagtttggaatcaaccgtgagcgagtcccattcatcctcacctatgactttgtccac
gtgatccagcaggggaagacgaataatagtgagaaatttgaaaggttccggggctactgt
gagagggcctactccatcctgcggcggcacgggctgctcttcctccacctcttcgccctc
atgcgggcggcaggcctgcctgagctcagctgctccaaagacatccagtatctcaaggat
tctctggccttgggaaaaacagaggaggaggctctgaagcacttccgagtgaagtttaac
gaagccctccgggagagctggaaaaccaaagtgaactggctggcccacaacgtgtccaaa
gataacagacaatag

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