Canis lupus familiaris (dog): 100686627 Help Entry 100686627         CDS       T01007                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism cfa  Canis lupus familiaris (dog) Pathway cfa04020   Calcium signaling pathway cfa04371   Apelin signaling pathway cfa04713   Circadian entrainment cfa04921   Oxytocin signaling pathway cfa04970   Salivary secretion cfa05010   Alzheimer disease cfa05012   Parkinson disease cfa05020   Prion disease cfa05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100686627 (RYR3)    04020 Calcium signaling pathway     100686627 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100686627 (RYR3)   09154 Digestive system    04970 Salivary secretion     100686627 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     100686627 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100686627 (RYR3)    05012 Parkinson disease     100686627 (RYR3)    05020 Prion disease     100686627 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     100686627 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cfa04040]     100686627 (RYR3) Ion channels [BR:cfa04040]  Voltage-gated cation channels   Ryanodine receptor    100686627 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  100686627 NCBI-ProteinID:  XP_038317032 Ensembl:  ENSCAFG00000008056 VGNC:  45823 UniProt:  A0A8C0P7N9 LinkDB All DBs Position 30:complement(1223971..1742310) Genome browser AA seq 4869 aa AA seqDB search MAEGAEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLHGHAVLLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSICFVQHMAS GLWVTYKAQDAKNPRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPIALPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGTAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHINPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFIGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRVD GTVDSPPCLKVTHRTFGAQSGGASMVYCRLSMPVECHSSFSHGPCPDGDAVHKRKQMQEI LSPTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLHSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWCGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMYFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLAHAKE RKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRTCLRPGFRFSTPCFVVTGEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDSSVFGEHGAETEDGTEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWTGKLRALVYKIKGPPKPEKKQPIEEEERYPTTLKELISQTMIRWAQEDQIQDAELVR MMFTLLQRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDSEDEEIVHMG NAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSL NKDGSISEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTV SLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKAQ RDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLMNHYEQCWKYYCLPS GWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRI SAMLEKQISVDADGNFDPKPINTTNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYGI SLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALAQQRENE KLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGS HPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGILVSRGMKDMELDASSMEKRFAYKFLK KILKYVDSAQEFIAHLEAIISSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSP LKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVM KSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILT SIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAI PVAFLEPTLNRYNPLSVFNTRTPRERSILGMPDTVEEMCPDLPQLEGLMKEISDLAESGA RYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTRVTSEHLSVILGNILKIINN NLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTKG DTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPNADSDQLFRMVAEVFILW CKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERRKTKRRGDLYSI QTSLIVAALKKMLPIGLNMCTPGDQELISLAKARYGARDTDEEVKEHLRNNLHLQEKSDD PAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQ RKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKEEEEE EEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEK TFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAG VQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERG EKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESIS DFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG FLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVES STNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFL LSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVL NYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKM ELFVNFCEDTIFEMQLASQISESDSADRPEEEEEEDEDSSYMLEIEGEEEDSKSLESASA FAMACASVKRNVANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFFWMLFLELFRLFFA ILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMDSERAEVTEPGIT PELIHFVKAEKGDTDIMSDLFGFHPKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVQK KRKAQAAEMKAAHDAEGKVEPEKMDLEDGEKEDMAKEEEQAEAPWAEVTKKKKPRRGQKV EKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEE TEDIANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVP LVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEENKAEAASLVSWLSSIDMKYHIWKLGVVFTDNS FLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggggcagaaggaggcgaggacgagatccagttcctgcggactgaagatgag gtggttctccagtgcatcgcaaacgtccacaaggagcaacggaagttctgcctggcggcc gagggacttgggaaccgcctgtgcttcttggaacccacgtcagaagccaagtacgttcct ccagatctctgtgtctgcaattttgtgctggaacagtccctctctgtgagagccctgcag gagatgcttgccaacacaggtgaaaatggtggtgaaggggcggcccaaggcgggggccac cggacgctgctgcacggccacgcggtcctcctgcggcactccttcagcggcatgtatcta acttgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgctacaggagaagcctgttggtggaccatacatcccgcttccaaacagagatcc gagggagagaaagttcgaattggtgatgacctcatccttgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatgggaacatacaagtggacgcctcttttatgcaaaca ctctggaatgtacaccctacgtgctcaggaagtagcattgaagaaggatacctacttggt gggcacgtggtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgattcccagcacaggaggatattctatgaagctgggggagctgggacgcgagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgactccggcatctcacgacaggccactacctggccttgacagaggac caaggccttatactgcaggaccgggcaaagtcggacaccaagtccacagccttctctttc cgggcttccaaggaaatcaaggagaaattggattccagtcacaaacgagatatagaaggc atgggtgttccagaaatcaagtatggagattccatctgctttgtccagcatatggccagt ggtctgtgggtgacctacaaagcacaagatgccaagaacccccgccttggacctctgaag agaaaggtcattctccatcaggaaggccacatggatgatgggttaacactgcagagatgc caacgtgaggagtcccaggctgctcggatcatccggaacacgaccgccttattcagccag tttgtaagtggaaacaatcgcacagctgcccccatcgctctgcccatagaagaggtcctg cagaccttacaggacttgattgcctactttcagcccccagaggaggagatgcagcatgaa gacaagcagaacaagctccgctcactcaagaacagacagaacctttttaaggaagaagga atgttggcccttgtgttaaactgcatcgatcgcttgaatatctataacagcgtagcacac tttgcggggattgcaagggaggagagtggcacggcttggaaagagatcctgaaccttctg tacaaactgctggctgctctcattcgtggaaacagaaacaactgcgcccagttctctaat aaccttgattggctcatcagcaaattggacagactagaatcttcctcaggtattttggaa gttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgcagtcagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacacggctgattaatgatgtgaca agcattcggcccaacatcttcctgggagttgctgagggctctgcacagtacaagaagtgg tacttcgagctaatcatcgaccaggtggaccctttcctaacagctgagcccacacacctg cgggtgggctgggcctcttcctcaggctatgctccgtaccctggcggaggagaagggtgg ggaggcaatggtgttggcgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtagcctccatcaaccagcacctcctgagatcagacgac gtggtgagctgttgccttgacctcggagtgcccagcatctctttccgcatcaacgggcaa cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctctgcaggtgtcaaagtgcgtttcctgatgggtggacgtcatggcgaatttaagttc ctgcctccatctggctacgcaccttgctatgaagccttacttccgaaagaaaagatgaga ctggagcctgtcaaagaatataaacgtgacgctgaaggagtcagagatctgctgggtacc acccagtccctctctcaagcctctttcatcccgtgtcccatagacaccagtcaggtggtt ttgccacctcacctagaaaagatccgagacagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaaccctcctggcccttgggtgccacatcgctcatatt aatccagctgctgaggaggacctcaagaaggtcaaattgcccaaaaactatatgatgtcc aacggctataaaccagcccctttggacttgtctgatgtgaagctgttaccgcctcaagaa attttagtagataagcttgcagaaaacgcacataacgtttgggccaaagacagaataaag caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtg ccatatgcattactggatgagcgtaccaagaagtccaacagggacagccttcgtgaagct gttcgcacgtttattggttatggctataacattgagccatctgaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagattcgatttttccgggtagagcggtcttat gcagtaagatctggaaagtggtattttgagtttgaggtggtgacaggaggagacatgcgc gtcggctgggccaggccaggctgtcggcctgacattgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgt acatggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgat tatgagattgagaatggctttgtgcccatctgctccctgggactgtctcagatcggccgc atgaatctcgggatggatgccagcaccttcaagttttataccatgtgtggccttcaagag ggctttgagccttttgctgtcaacatgaaccgcgatgttgcaatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggatcatccacatatagaggtggtgagggtggac ggcaccgtggacagccccccctgcctcaaggtgacccacaggacgttcggcgcgcagagc ggcggcgccagcatggtctactgccgcctgagcatgcccgtcgagtgccactcctcgttc agccacggcccctgtccggacggcgacgcggtccacaagaggaaacagatgcaagaaata ctctctcctacaacaacgcagtgctactatgcaatccgcatctttgctggacaggacccc tcctgcgtctgggtcggttgggtcactccagactatcacttacacagtgagaagtttgac ctgaataagaactgtacagtgactgtgactctaggggatgagcgaggccgagtccatgaa agtgtaaagcgcagcaactgctacatggtctggtgtggggatattgtggccacttcccaa agatcaagtcggagcaacgtggacctggagatcggctgccttgtggatctggcgatgggc atgttgtctttctccgccaatgggagggaacttggcacctgctaccaggtggagcccaat accaaagtgtttccagcagtcttcctgcagcccacgagcacctccttgtttcagtttgaa cttgggaagctgaagaacgcgatgcccctgtcggcggccatatttaagagtgaagagaag aacccagttccacagtgtccccctcggctggacgtccaaaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatcccagaggagaac aggtgtgtggatgttctagagctctgcgagcaggaggacctgatgtacttccattaccac acgctgcgcctctacagtgccgtgtgcgccctgggaaacagccgagtggcctacgccctg tgtggccacgtggacctgtcccagctcttctatgccatagacaacaagtacctccctggc ctcctccgctccggtttctatgacctgctcatcagcatccacctggcccatgctaaggag aggaagctaatgatgaagaatgagtacatcattcccatcactagcaccactaggaaaatc cgcctgtacccagatgagtccaagaggcacgggctacccggagtgggcctcagaacatgc ctcaggccaggattcaggttctccaccccttgctttgttgtgactggcgaggagcaccag aagcagagccctgagatccccttggagattctcaagacaaaggcactgagcatgctgacg gaggcagtgcagcacagcggggctcatatccgggaccccgtcggcgggtctgtagagttc caatttgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgat gatgacgtccggcagatcctcctcctgattgattcctctgtgtttggggagcatggtgca gagacagaggatggcacagagaaggaagaggtgacccaggtggaggagaaggcagtggag gctggggaaaaggccagcaaggaggctccggtcaagggcttgttgcagacccgactgcca gagtccgtcaagcttcagatgtgcgagctcctcagctacctctgcgactgtgagctacag catcgagtggaagccattgtggcgttcggcgacatttacgtctccaaactccaggcaaat cagaagttccgctacaatgagctcatgcaggccttgaacatgtctgcagccctgactgcc cggaagaccagggagttccgctcacctccacaggagcagatcaacatgcttcttaacttt caactgggagagaattgcccctgcccagaggagatccgggaggagctatatgacttccat gaggaccttctcattcactgtggagttccactggaggaggaggaagaagaggaggaggac acctcctggactgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gagaagaaacagccgatagaagaggaggagagataccctacaaccttgaaggagctcatc tcacagaccatgatccgctgggcccaagaggaccagatccaggatgcggagttggtccgg atgatgttcaccctcctgcagaggcagtacgacagcattggggagctgctgcaagccctg cggaagacctataccatcagtcaggcctccgtgagcgataccatcaatctgctggctgcc ctgggccagatccgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatg atcaatgggctgggagacattatgaacaataaggtgttttaccagcaccccaacctcatg agagtccttggcatgcacgagacggtgatggaggtgatggtgaacgtgttgggtgcagag aagtcccagattgcttttccaaaaatggttgctagctgctgccgcttcctttgctatttc tgtcgaatcagccggcaaaatcagaaggccatgtttgagcatctaagttacctgctggag aatagcagtgttggcttagcatccccttcaatgagaggatctaccccactggatgtggca gcttcctctgtgatggacaacaacgagttagcgctgggcttggaggaaccagatcttgag aaggtggtaacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa ggataccctgatgtcggctggaaccccattgaaggggaacgttacctgtccttcttgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctg ctcatcagacgcccagagtgcttcgggccagccctgcgaggtgaaggaggaaacggccta ttggcagctatgcagggcgccattaagatctctgagaacccggctctcgacctcccctct cagggatacaagagagaagtcatggaggacagtgaggatgaagagatcgtgcacatgggc aacgcaattatgtccttttattcagctcttatagatctcctgggtcgttgtgctcctgaa atgcatcttatccagacgggaaagggggaagccatccggatcaggtcaatcctgcgctcc ctggtccccaccgaggacctggttgggatcatcagcatccccttaaagctgccctctctg aacaaagatgggtccatcagcgagccagatatggcagccaacttctgccctgaccacaag gctcccatggtgctgttcttggatcgtgtttatggcattaaggatcagacttttctgctc cacttgctagaggttggatttttacccgacttaagagcttctgcctctctagatacagtt tccctaagcaccacggaggctgcgcttgcactcaataggtatttgtgttctgctgtgctc ccgctcctcacaagatgcgccccgctctttgccggaacagaacactacacttctttgatc gattctacactacagacaatatataggctttccaagggacggtccctcaccaaagctcag agggacaccatagaagaatgtttgcttgctatttgcaatcacttgaggccttccatgtta cagcaactcttgcgacgtctggtttttgatgtgccgcagctcaacgaatactgcaaaatg cctcttaagcttctgatgaatcactatgaacagtgctggaagtactactgcctgccttca ggatgggggagctatggtctagctgtggaagaagaactgcacctgaccgagaagctcttc tgggggatttttgactctctctcccataagaagtatgacccagaccttttccgaatggcc cttccttgtctcagtgctatcgctggggccctgccaccggattacttagataccagaatc tcggccatgttggagaaacagatctcagtggatgcagatggcaactttgaccccaaaccc atcaacaccacgaatttctccttgcctgaaaaatgggaatacatcgtcaccaagtatgct gagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaagtacggaatt tccctggatgaaaacgtgaagacccatccactcataaggccttttaagacattaacagaa aaggagaaggagatttaccgctggcctgccagagagtctctgaaaaccatgctggctgtg ggctggtctgtggagaggaccaaagagggagaggccctggctcaacagcgggaaaatgag aaacttcggagcgtgtcccaggctagccagggcaacagctacagccctgcccccctggat ctctccaacgtggtgctttccagagagctccaggggatggtggaagtcgtggctgaaaac tatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggcggcagt caccctctgttggtgccatatgacaccttgacagccaaggagaagttcagggaccgggag aaggcacaggacctgtttaaattcctccaagtgaacggcatcttggtttctagaggtatg aaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaag aagatcctgaaatatgttgattctgcccaagagtttattgcccatttggaagccattatc agcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaagtt ctcctaccgctcgttgaccagtacttcaccaatcaccgcctctacttcctgtcatcccct ctgaagccccttagcagcagcggctatgcctctcataaggagaaagaaatggtggccagc ctcttctgcaaactcgctgctcttgttcgacacaggatttccctctttgggagcgattct acaacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatg aagtcaggctcagagctggtgaaggctgggttacgagcattctttgaaaatgctgcagaa gacttagagaagacttcagaaaatctgaagctcgggaagtttacccattccagaacacag attaaaggcgtgtctcaaaatattaactataccacggtggctctgctccccatcctgaca tccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggtgatgtg caaatttcatgctaccacatactgtgcagcctctactcccttgggactggaaagaatatc tatgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgccata ccagtagcattcctggaacccacccttaaccgctacaatccactctcagtcttcaacacc agaacccccagggagaggtctattctggggatgccggacacagtggaagagatgtgcccc gacctccctcagctggaaggcctgatgaaggaaatcagcgacctggccgagtcaggggcc cgatacacggagatgccccacgtcatcgaggtgatcttacccatgctctgcaactacctg tcctactggtgggagcgggggcctgagcacctgccccccagcacaggcccctggtgcacc agggtcacctctgaacacctcagtgtcatcctgggaaacattctaaaaatcatcaacaac aatctgggcatcgatgaggcatcctggatgaagcgcattgcagtgtacgcccagccaatc atcagcaaagcacggccagacctgctgaagagccacttcatcccaactctggagaagctg aagaaaaaggctgtcaagactgtgcaggaggaggagcagctgaaagccgacaccaaagga gacacccaagaggcggagctcctcatcttggacgagtttgcagtcctctgcagagacctc tatgccttctaccccatgctgattcgctacgtggacaacaacagatctaactggctcaaa agtcccaatgctgattctgaccagctcttccgcatggtggctgaggtcttcatcctgtgg tgcaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaattaat aatttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaagtaaag tctggaggccaggaccaggaacggaggaagaccaagcggaggggagacttgtattccatc cagacctctctcatcgtggccgcgctcaagaagatgctgcccattggtttgaatatgtgc acgccgggcgatcaggagctgatctcccttgccaaggcccgctacggcgctagggacacg gatgaagaggtgaaggaacatctgcggaacaacttgcacctgcaggaaaagtctgatgac ccagcagtaaagtggcagctgaacctctacaaagatgttttaaagagtgaagaaccgttc aatccagaaaagactgtagaacgtgtacagagaatttcagcagctgtcttccacctggag caggtggaacagcctttgagatccaagaaggcggtctggcacaaactgttgtcaaagcag cggaaacgggcagtggtggcctgtttcaggatggcccctctctataacctgcccaggcac cgctccattaacctcttcctccatggctatcagagattttggatagaaacagaggagtat tcctttgaagagaaactagtacaggatttggctaaatcccccaaggaggaagaggaggag gaggaggagacagaaaagcaaccagacccacttcatcagattattctccattttagccgc aatgctctcacggagaggagcaaattggaagacgaccccttgtacacatcctattccagc atgatggccaagagttgtcagagcggggaggatgaagaagaggaggaagacaaggaaaaa acatttgaagagaaagaaatggaaaagcagaaaactctctatcaacaagcacggctgcat gagcgtggagctgcagagatggtccttcagatgataagtgccagcaaaggtgagatgagc cccatggtggttgagactctgaagctggggatcgccattctgaatggtggcaacgctggt gtacaacagaaaatgctagattacctaaaggagaaaaaggatgctggattctttcaaagc ctgtctggtcttatgcagtcttgcagtgtccttgatttgaatgcctttgagaggcagaat aaagctgaaggcctggggatggttactgaggaaggaacactcattgttcgagagcgtggt gaaaaagtactccagaatgatgagtttacacgagacctctttagattcctgcagttactt tgtgaaggacataacagtgactttcagaacttcctacggactcagatgggcaataccacc actgtaaacgtcatcatcagtaccgtggactacctcctacgtctacaggagtcaatcagt gatttctactggtattattcagggaaggacatcattgatgaatctggacagcacaatttt tccaaagctctggcagtcacgaagcagattttcaattctcttacagaatacatccagggc ccttgcattgggaaccaacaaagcctggctcacagcaggctgtgggacgcggtggtcggc ttcctccatgtatttgctaacatgcagatgaaactctctcaggattccagtcagatcgag ctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctg gaagggaatgtggtaaatggaactattggcaagcagatggttgacacactggtagaatca tctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacctc accagctcagacaccttcaaagaatatgacccagatggtaaagggattatctccaaaaaa gagttccagaaggccatggaagggcaaaaacagtacacacagtcagagattgactttctc ctttcatgtgcagaagctgatgagaatgatatgtttaattacattgattttgtagaccgg ttccatgagccggccaaggacatagggtttaatgtggcagtgttactgacgaatctctcc gaacatatgccaaatgattctcgcctgaagtgtctgttggacccagcagaaagtgtacta aattactttgaaccctacctgggacgtattgagatcatgggaggggccaagaaaattgag cgcgtttattttgaaatcagtgaatccagtcgaactcaatgggagaagccccaagtgaag gaatctaagcggcagttcatctttgatgtggtcaatgaaggtggagagcaagaaaagatg gaactgtttgtgaacttctgtgaggataccatttttgaaatgcagttagcatctcagatc tctgaatctgactcagctgacagacccgaagaagaggaggaagaagatgaagattcatct tatatgttagaaattgagggtgaggaggaggacagcaagtctctcgagtctgcctctgca tttgccatggcctgtgcctcagtgaagagaaatgttgccaactttctgaagaaggcaacc ctgaagaacctcaggaagcagtacaggaaggtgaaaaagatgactgtgaaggagctggtg aaggtgtttttctctttcttctggatgttgtttctggagctgttccggttgttcttcgcc atattgggaggaatctttcagatcctctggaacacagtgtttggagggggcctagtggaa ggggcaaagaacatcagagtgaccaagatcctgggtgatatgcctgacccaacccaattt ggtatccatgatgatgccatggattctgagagggcagaggtgactgagccaggtattaca cctgaattgattcacttcgtgaaggctgaaaagggagacacagatatcatgtcagatctc tttggattccacccaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggt gacctctctgagattattggcaaggatgagccacctacactagagagtactgtacagaag aaaagaaaagcacaggcagcagagatgaaagcagcacatgatgcagaaggaaaagtggaa cccgagaaaatggacctagaagatggggagaaggaggatatggccaaagaggaagaacag gccgaggccccgtgggcagaagtgacaaagaagaagaagccacggcggggccagaaagtc gagaagcctgaagccttcatggctaatttcttcaaagggctggaaatctatcagaccaag ttactgcattacctggccaggaatttctacaacctgaggttcctcgctctgtttgtcgcc ttcgctatcaacttcattctgctcttttacaaggttactgaagaacctctagaagaagag acagaggacattgcaaatctgtggaattcctttaatgatgaagaagaagaagaagcgatg gtgttctttgttctgcaggagagcactgggtatatggcaccgacgttgcgggctttggcc attatccacaccatcatctctttggtctgtgtggtgggctattactgcctgaaggtccct ctggtggtattcaaaagggaaaaagaaattgccaggaagctggagttcgatggcctgtac atcactgaacagccatctgaagatgacatcaaggggcagtgggaccgcctggtaatcaac acaccatctttccctaataactactgggacaagtttgtcaagagaaaggtgatcaacaag tatggagatctctacggagcagaacgcattgcggaactcctaggtttggacaaaaatgcc cttgatttcagcccagtcgaagagaacaaagcagaggcggcctctcttgtgtcatggctg agctccattgacatgaagtaccatatctggaaactgggagttgttttcaccgacaactcg tttctctaccttgcctggtacacaaccatgtcagtcctgggccactacaacaacttcttt tttgctgctcatctgctggacatcgcaatgggcttcaagacgctgaggactattctgtca tctgtaactcacaatggcaaacagctggtcctgaccgtgggtctcctggctgtggtggtc tacctctacaccgtggtggccttcaacttctttcgcaagttctacaacaagagtgaagat gatgatgagccggacatgaagtgtgacgacatgatgacgtgttacctgttccacatgtac gtgggagtgcgagccgggggcggcatcggtgacgaaattgaagaccccgccggtgacccc tacgaaatgtaccgcattgtcttcgacatcacgttcttcttctttgtcatcgtcatcctg ctggccatcattcaaggtctcatcatcgacgcctttggagagctgagagaccagcaggaa caagtgcgcgaggacatggagactaagtgcttcatctgcgggattggcaacgactacttt gacacgactcctcatggcttcgagacacacaccttacaggagcacaacttggccaactat ctgttcttcctgatgtatctgattaataaagatgaaacggaacacacgggtcaggaatct tatgtctggaagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgcttt cggaaacagtatgaagatcagcttggataa

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