Canis lupus familiaris (dog): 100855785
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Entry
100855785 CDS
T01007
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X9
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00790
Folate biosynthesis
cfa01100
Metabolic pathways
cfa01240
Biosynthesis of cofactors
cfa01523
Antifolate resistance
cfa04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100855785 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
100855785 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100855785 (FPGS)
Enzymes [BR:
cfa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
100855785 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
bpX5
Motif
Other DBs
NCBI-GeneID:
100855785
NCBI-ProteinID:
XP_003639360
Ensembl:
ENSCAFG00000020111
VGNC:
40973
UniProt:
A0A8C0N3I7
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Position
9:complement(54777453..54806066)
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AA seq
588 aa
AA seq
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MSQARRHLRVALFLAAVSPRGATTGVKARRGLSAWPAPQEPGMEYQDAVRTLNTLQTNAG
YLEQVKRQRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWHLYHRLEETKDSNSCVSMPAYFR
FLTLMAFHIFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGISSLGLDHTSLLGDTVEEI
AWQKGGIFKRGVPAFTVLQPDGPLAVLQDRAQKISCPLYLCPPLEALEEGGPPLALGLEG
EHQRSNAALALQLARCWLQQKNHQGLGELKVSRPSVLWQMPLAPVFQPTSHMRHGLRDTE
WLGRTQVLRRGPLTWYLDGAHTASSVQACVRWFRQALLRGRVPRRGPEVRVLLFNSTGDR
DPVALLKLLQPCQFDYAVFCPNLTEVSSAGNADQQNFMVTLDQVLLRCLAHQQHWSHLNE
EHASPNLWSPTSLEPGEPTSLLLASHQPHTHSTSSLVFSCISHALQWISQGRDPVFQPPS
PPQGLLAHPVAGSGASLLRDAVAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1767 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcacgccgccacctgcgcgtggctctcttcctggcagcagtttccccgcgc
ggtgcaacgaccggggtcaaggcgcggcgagggttgagcgcgtggcccgcgccgcaggag
cccggcatggagtatcaggatgcagtgcgcacactgaataccctgcagaccaatgctggc
tacctggagcaggtaaagcgccagcggggtgatcctcaaacgcagctggaagcaatgaag
ctgtacttggcacggagtggtctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggctccacttgtgccttcacggaacgtattctccgaagc
tacggcctgaagacaggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaatgggcagcccataagccctgagctcttcaccaagcatttctggcacctctac
caccggctggaggagaccaaggacagcaatagctgtgtctccatgccggcctacttccgc
ttcctcacactcatggccttccacatcttcctccaggagaaggtagacctggcagtggtg
gaagtgggcattggtggtgcttatgactgcaccaacatcatcaggaagcctgtggtgtgt
ggtatctcctctcttggccttgaccataccagccttctgggggacacagtggaggagatc
gcatggcagaaagggggcatcttcaagcgtggcgtccctgccttcacggtgctccagcct
gacggtcccctggcagtgctgcaggaccgtgcccagaagatctcatgtcctctctacctg
tgcccaccgctggaagccctggaggaaggggggccgccactggccctgggcctggaggga
gagcaccagcggtccaatgccgccttagccttgcagctggctcgctgctggctgcagcaa
aagaaccaccaaggccttggggagctgaaggtgtctcggcccagtgtcctgtggcagatg
cccctggcacccgtgttccagcccacgtcccacatgcggcatgggcttcgggacaccgag
tggttgggccggacgcaggtgctgcggcgcgggcccctcacctggtacttggatggtgcg
cacaccgccagcagcgtgcaggcctgcgtgcgctggttccgccaggcgctgctccgcggc
cgggtgccgaggcgcggccctgaggtgcgcgtcttgcttttcaactccacgggggaccgg
gatcccgtggccctgctcaagctgctgcagccctgtcagtttgactatgctgttttctgc
ccgaacctgacagaggtgtcgtctgctggcaatgcagaccagcagaacttcatggtgacc
ctggatcaggtgttgctccgctgccttgcacaccaacagcactggagccacctgaatgag
gagcacgccagccccaacctctggagccccaccagcctggagcctggtgagcccacctcc
ttgctgctggcttcccaccaaccccacacccatagcaccagctccctcgtcttcagctgc
atctcccacgccctgcagtggatcagccaaggccgggaccctgtctttcagccacccagt
cccccacagggcctccttgcccaccctgtggcaggcagtggggccagcctgctccgcgac
gctgtagccatccatgtactggtcacaggcagcctgcatctagtgggcggtgtcctcaag
ctgctggagcctgccctgtcccagtag
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