KEGG   Canis lupus familiaris (dog): 100856190
Entry
100856190         CDS       T01007                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04062  Chemokine signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04081  Hormone signaling
cfa04082  Neuroactive ligand signaling
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04270  Vascular smooth muscle contraction
cfa04310  Wnt signaling pathway
cfa04371  Apelin signaling pathway
cfa04540  Gap junction
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04621  NOD-like receptor signaling pathway
cfa04713  Circadian entrainment
cfa04720  Long-term potentiation
cfa04723  Retrograde endocannabinoid signaling
cfa04724  Glutamatergic synapse
cfa04725  Cholinergic synapse
cfa04726  Serotonergic synapse
cfa04728  Dopaminergic synapse
cfa04730  Long-term depression
cfa04742  Taste transduction
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04911  Insulin secretion
cfa04912  GnRH signaling pathway
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04918  Thyroid hormone synthesis
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04922  Glucagon signaling pathway
cfa04924  Renin secretion
cfa04925  Aldosterone synthesis and secretion
cfa04926  Relaxin signaling pathway
cfa04927  Cortisol synthesis and secretion
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04929  GnRH secretion
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa04961  Endocrine and other factor-regulated calcium reabsorption
cfa04970  Salivary secretion
cfa04971  Gastric acid secretion
cfa04972  Pancreatic secretion
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05016  Huntington disease
cfa05017  Spinocerebellar ataxia
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05142  Chagas disease
cfa05143  African trypanosomiasis
cfa05146  Amoebiasis
cfa05163  Human cytomegalovirus infection
cfa05200  Pathways in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
Module
cfa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100856190 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100856190 (PLCB2)
   04310 Wnt signaling pathway
    100856190 (PLCB2)
   04371 Apelin signaling pathway
    100856190 (PLCB2)
   04020 Calcium signaling pathway
    100856190 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100856190 (PLCB2)
   04072 Phospholipase D signaling pathway
    100856190 (PLCB2)
   04071 Sphingolipid signaling pathway
    100856190 (PLCB2)
   04022 cGMP-PKG signaling pathway
    100856190 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100856190 (PLCB2)
   04081 Hormone signaling
    100856190 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100856190 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100856190 (PLCB2)
   04613 Neutrophil extracellular trap formation
    100856190 (PLCB2)
   04621 NOD-like receptor signaling pathway
    100856190 (PLCB2)
   04062 Chemokine signaling pathway
    100856190 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    100856190 (PLCB2)
   04922 Glucagon signaling pathway
    100856190 (PLCB2)
   04929 GnRH secretion
    100856190 (PLCB2)
   04912 GnRH signaling pathway
    100856190 (PLCB2)
   04915 Estrogen signaling pathway
    100856190 (PLCB2)
   04921 Oxytocin signaling pathway
    100856190 (PLCB2)
   04926 Relaxin signaling pathway
    100856190 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    100856190 (PLCB2)
   04918 Thyroid hormone synthesis
    100856190 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100856190 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    100856190 (PLCB2)
   04916 Melanogenesis
    100856190 (PLCB2)
   04924 Renin secretion
    100856190 (PLCB2)
   04925 Aldosterone synthesis and secretion
    100856190 (PLCB2)
   04927 Cortisol synthesis and secretion
    100856190 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100856190 (PLCB2)
   04270 Vascular smooth muscle contraction
    100856190 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    100856190 (PLCB2)
   04971 Gastric acid secretion
    100856190 (PLCB2)
   04972 Pancreatic secretion
    100856190 (PLCB2)
   04973 Carbohydrate digestion and absorption
    100856190 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100856190 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    100856190 (PLCB2)
   04725 Cholinergic synapse
    100856190 (PLCB2)
   04728 Dopaminergic synapse
    100856190 (PLCB2)
   04726 Serotonergic synapse
    100856190 (PLCB2)
   04720 Long-term potentiation
    100856190 (PLCB2)
   04730 Long-term depression
    100856190 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100856190 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    100856190 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    100856190 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100856190 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100856190 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100856190 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100856190 (PLCB2)
   05142 Chagas disease
    100856190 (PLCB2)
   05143 African trypanosomiasis
    100856190 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100856190 (PLCB2)
   05016 Huntington disease
    100856190 (PLCB2)
   05017 Spinocerebellar ataxia
    100856190 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    100856190 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100856190 (PLCB2)
   05415 Diabetic cardiomyopathy
    100856190 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100856190 (PLCB2)
   04934 Cushing syndrome
    100856190 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    100856190 (PLCB2)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100856190 (PLCB2)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100856190 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100856190 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh C2 EF-hand_like Gp58 COG6_C
Other DBs
NCBI-GeneID: 100856190
NCBI-ProteinID: XP_022268404
Ensembl: ENSCAFG00000009036
VGNC: 44645
UniProt: A0A8C0TUN2
LinkDB
Position
30:complement(7526161..7547075)
AA seq 1228 aa
MSLLSPVLLPPKVEAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKETEFLD
ITSIRDTRFGKFAKIPKSQKLREVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKNWAEDVLALAKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMNLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPDQVRGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLSQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRMMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPAAPSKESGGD
AEGNCPPNASVGEGTVWPGEEGEELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFELSAQKNRSYVISSFTELKAYDLLSKASVKFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
RLSPSANSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKSVKLKEAMGAL
PEKPFPTGSPVAGQVNGPLAPVSNGSAAARARAGEEAAKEAAEPQTASPEELQELKGVVK
LQRRHEKELRDLERRGARRREELLQRGAAQLAGLGPPGAGGCGGRRLGPGKGSRKKRTSP
CDEAAGAAPQEDREGPEGADARARELKDRLELELLQQGEEQYECILKRKEQHVAEQIAKM
MELAREKQAAELKTLKETLETDTKEMKKKLEAKRLERIQAMVKVTSDKMAQERLKREINN
SHIQEVVQVIKQMTESLEKHQEKLEEKQAACLEQIREMEKQFQQEALAEYEARMKGLEAE
VKESVRACLRGCFPSEAKDMPERPCEAFRELCEQDPLAAKFPNTEPGTLSKLPGDGCFQD
PRTRLLPWPPACGGWEPDLEKLPQLSDH
NT seq 3687 nt   +upstreamnt  +downstreamnt
atgtctctgctcagccctgtcctgctgccccccaaggtggaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacgatagcttctccggttatccttcgtgtg
gatcccaagggctactacttatattggacatatcagagtaaggagacggagtttctagat
atcaccagcatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgagaggtcttcaacatggactttcctgacaacaacttcctgctaaagacactcacc
gtggtatctggccctgacatggtggacctcaccttccacaactttgtctcctacaaggag
aatgtgggcaagaactgggctgaagacgtgctggctctggccaagcacccactgacggcc
aatgcttcccgcagcaccttcttggacaaaatcctggtgaaactcaagatgcagctcaac
cccgaagggaagattcctgtgaaaaattttttccagatgtttcctgctgaccgcaagcgg
gtagaagctgccctcagtgcctgccacctcccaaaaggcaagaatgatgccatcaatcct
gaggacttcccagaatctgtctacaagagtttcctcatgaacctctgtcctcggccagaa
atagacgagatcttcacttcttaccatgccaaggccaaaccctacatgaccaaggagcat
ctgaccaaattcatcaaccagaaacagagggacccccgtctcaactccttgctgtttcca
cctgcgcggcctgaccaggtgcggggcctcatcgacaagtatgaacccagtggcatcaac
gtgcagaggggccagctatcacctgagggcatggtgtggtttctgtgtggcccagagaac
agcgtcctgtcccaggacaagctgctactccaccacgacatgacgcagccactcaaccat
tacttcatcaactcctcacacaacacctacctgacagccggccagttctctggcctctcc
tcggcagagatgtaccgccaggtgctgctggctggctgccgctgtgtggagctggactgc
tggaagggcaagccccctgacgaggagcccatcatcacccatggcttcaccatgaccaca
gacatctatttcaaggaagccattgaagccattgcagaaagtgcctttaagacctccccc
tatcctgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatg
gctgagtactgccggatgatgtttggggatatgctgctcacagagcccttggaaaagttc
ccactgaaaccaggcatccctctgcctagccctgaggatctccgaggcaagatcctcatc
aagaacaaaaagaaccagttttctggcccagcagcccccagcaaggaatccggtggggac
gctgagggcaactgcccacctaatgcctctgtgggtgagggcacagtgtggcctggtgag
gaaggggaagagctggaggaggaagaggtggaggaagaggaggaggaggagtcgggaaac
ctggatgaggaagagatcaagaagatgcagtcggatgagggcacggcgggcctggaggtg
acagcctacgaggagatgtccagcctcgtgaattacatccaacccaccaaattcatctcc
ttcgagctctctgcccagaagaaccgaagttatgtcatctcgtccttcacagagctcaag
gcttatgacctgctctccaaggcctcagtgaagtttgtggactacaacaagcgccagatg
agccgcatttaccctaagggcacccgcatggactcctccaactacatgccccagatgttc
tggaatgctggttgccagatggttgccctcaacttccagactatggacctgcccatgcag
cagaacatggcgctgttcgagttcaatgggcagagtggttacctcctcaagcatgagttc
atgcgccgcccagacaagcagttcaaccccttctcggtggatcgcattgacgtggtggta
gccaccaccctgtccattacggtgatctctgggcagttcctgtctgaacgcagtgtgcgc
acctatgtggaagtagaactctttggccttcctggggaccccaagaggcgctatcgcacc
aggctgtcacccagtgccaactccatcaatcctgtctggaaggaagagccttttgtcttt
gagaagatcttgatgcctgagctggcctctctcagggtggctgtaatggaggaaggcaac
aaatttcttggacaccgcatcatccccattaatgccctgaattctggctaccaccatctg
tgcctgcacagcgagagcaacatgccccttaccatgcctgcgctttttgtcttcttggag
atgaaggactatgtacctgacacctgggcagatctcaccgtggctcttgccaatcccatc
aagttcttcagtgcccacgataagaagtctgtgaagctcaaggaagccatgggagctctg
cctgagaaacccttccccactgggagtccagttgccggccaggtcaatgggccattggcc
ccagtgagcaacggatctgcagcagcccgggccagggccggggaggaggccgccaaagaa
gctgcggagccgcagaccgccagcccggaggagctgcaggagctgaagggcgtcgtgaag
ctgcagcggcggcacgagaaggagctccgggacctggagcggcgcggcgcgcggcgccgg
gaggagctgctgcagaggggcgcggcgcagctggccgggctggggccgccgggcgcgggg
ggctgcgggggccgcaggctcggccccgggaagggctcccgcaagaagaggacttcgccc
tgcgacgaggccgccggggccgcgccccaggaggaccgcgagggccccgagggcgcggac
gcgcgtgcgcgcgagctgaaggaccggctggagctggagttgctgcagcagggcgaggag
cagtacgagtgcatcctgaagcgcaaggagcagcacgtggctgagcaaatcgccaagatg
atggagctggccagagagaagcaggctgcagagctgaagaccctcaaggagaccttggag
actgacactaaagagatgaagaaaaagctggaagccaagaggctggagcggattcaggcc
atggtcaaagtcacctcagacaagatggctcaggaaaggctgaagagagagattaacaac
tcccacatccaggaggtggtgcaagtcattaagcagatgacagagagcctggagaagcac
caggagaagctggaggagaagcaggcagcctgcttggaacagatccgggagatggaaaag
cagttccagcaggaggctctggcagagtacgaggccaggatgaagggcttggaggccgag
gtgaaggagtccgtgagggcctgccttaggggctgcttcccctctgaggccaaggacatg
cctgagaggccctgtgaggccttccgggagctgtgtgagcaggacccactcgcagcaaag
ttccctaatacagaacccggcactctgtccaagcttcctggggacggctgcttccaggat
cccaggacgaggttgcttccctggcctcctgcctgtgggggatgggagcctgacctggaa
aagctgcctcagctgtctgaccactga

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