Canis lupus familiaris (dog): 100856570
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Entry
100856570 CDS
T01007
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00230
Purine metabolism
cfa00670
One carbon pool by folate
cfa01100
Metabolic pathways
cfa01523
Antifolate resistance
Module
cfa_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
100856570 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
100856570 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100856570 (GART)
Enzymes [BR:
cfa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
100856570 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
100856570 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
100856570 (GART)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
CPSase_L_D2
Dala_Dala_lig_C
ATP-grasp_3
ATP-grasp_4
RimK
Sacchrp_dh_NADP
Motif
Other DBs
NCBI-GeneID:
100856570
NCBI-ProteinID:
XP_003640123
Ensembl:
ENSCAFG00000030829
UniProt:
A0A8C0Z741
A0A8I3PRU8
LinkDB
All DBs
Position
31:complement(28131286..28163328)
Genome browser
AA seq
1011 aa
AA seq
DB search
MAARVLVIGSGGREHTLAWKLAQSSHVKHVLVAPGNAGTACLEKISNTAISISDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIAGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWKAFTKPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACKAVQEIMQDKAF
GAAGETIVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLFLKIKNTILQRTVDGMQQEGMPYTGVLYAGIMLTKEGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLDNRAAITVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKDGKVVTNGGRVLTVTAIQENLLLALEEAKKGLSAIKFEGAFYRKD
IGYRAIAFFQQQPRGLTYKESGVDIAAGNMLVQKIKPLAKATSRPGCDVDLGGFAGLFDL
KAAGFRDPLLACGTDGVGTKLKIAQQCDKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFS
CGKLDLDTTEAVVTGIARACRKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKL
PHLERITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPT
RIYSHSLLPILRSGHVKAFAHITGGGLLENIPRVLPQKFGVDLDAQSWRIPRIFSWLQQE
GHLSEEEMARTFNCGVGAALVVSKDLTEQILKDIKQHKEEAWVIGKVVACPEGSPRVKVR
HLIETMQINGSVLGNGTLKNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSCAHIVV
VISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEYSTDIVCLAGFMRIL
SGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQALEAGVTVTGCTVHFVAEDVDAGQIILQE
SVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGAIRLGENGKIRWVTED
NT seq
3036 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagtacttgtaatcggcagtggaggaagggagcataccctggcctggaaa
cttgcacagtctagtcatgtcaaacatgtgttggttgccccaggaaatgcaggcactgcc
tgcttggaaaagatttcaaataccgccatctccatcagtgaccacactgcccttgctcag
ttctgcaaagatgagaaaattgaattcgtggttgttggaccagaggcacctctggctgct
ggaatcgctgggaacctgacatctgcaggagtgcgatgctttggtcccactgcagaagca
gctcaattagagtccagcaagagatttgccaaagagtttatggaccgacatggaatccca
actgcacggtggaaagctttcaccaaacctgaagaggcctgcagctttataatgagtgca
gacttccctgctttggttgtaaaggccagtggtcttgcagctggaaaaggggtgattgtt
gccaagagcacagaagaggcctgcaaggctgtacaggagattatgcaggataaagctttt
ggagcagctggagaaacaattgtcatcgaagaacttcttgaaggagaagaggtgtcttgt
ctgtgcttcactgatggaaggactgtggcccccatgcctccagcacaagaccataagcga
ttgctggaaggagatcatggccccaacacagggggaatgggggcctattgtccagcacct
caggtttctaaggatttgttcctgaaaataaaaaacaccattcttcagagaacagtggat
ggcatgcagcaggagggcatgccatacacaggtgttctctacgctggtataatgctgacc
aaggagggcccaaaagttctggagtttaattgccgttttggtgatccggagtgccaagtg
atcctcccacttcttaaaagtgatctttatgaagtgattcagtctaccttggatggcctg
ctctgcacatctctgcctgtttggcttgataaccgtgctgccataactgtggtaatggca
agtaaaggctatccaggagattacaccaagggtgtggagataacagggtttcccgaggct
caagctttaggactggaggtattccatgcaggcactgccctgaaagatggcaaagtggtg
actaacgggggtagagtccttacggtaacagcaatccaggaaaatctcctcttggccctt
gaagaagcaaagaaaggactatctgctataaaatttgagggagccttttacaggaaggac
attggctatcgtgccatagccttcttccagcagcagcccaggggcctgacttacaaagaa
tctggggtagacattgcagctggaaatatgctggtccaaaaaattaaacctttagccaaa
gctacttccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttg
aaagcagctggtttcagagatcctcttctggcatgtggaacagatggtgttggaactaaa
ctgaagattgcccagcagtgtgataaacatgatactattggtcaagatttggttgcaatg
tgtgtcaatgacattctagctcaaggggctgagccccttttcttcctcgattacttttcc
tgtggaaaacttgacctcgatacaactgaagcagttgtcactggaattgccagagcttgc
agaaaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcct
ccgggagaatatgacctagctggttttgccgttggtgccatggagcgggatcagaaactt
cctcacctggaaagaatcaccgaaggggatgttgttattggaatagcttcatctggtctt
cacagcaatggatttagccttgtcaggaaaattgtagcaaaatcttccctccagtactcg
tctccagcacccgatggctgtggtgaccagaccttaggggacttacttctaactccaacc
cgaatctacagccattcgctgttacctatcctacgttcaggacatgtgaaggcctttgcc
catattactggtggaggattgctagaaaacatccccagagtccttcctcagaaatttggg
gtggatttagatgcccaaagctggaggatccccaggatcttttcatggctacagcaggaa
ggacacctctctgaagaagagatggcgagaacatttaactgtggagttggggctgccctc
gtggtatcaaaggatctgacggagcagattctgaaggatattaagcagcacaaggaagaa
gcctgggtgattggcaaagtggtggcatgtcctgaaggttctcctcgtgtgaaagtcagg
catctgatagaaactatgcaaataaatgggtcagtattggggaatggcaccctgaaaaat
catttctctgttcaaccaaaaaaggcaagagtggctgtcttaatatctggaacaggatca
aacctgcaagctcttatagacagtactagggagcccagtagctgtgcacacattgttgtt
gttatctccaacaaagctgcagtggctggtttagataaagcagaaagagctggaattccc
accagagtaatcaaccataaattatataaaagtcgtgtagaatttgacactgccattgac
caagtccttgaagagtattccacagacatagtctgtcttgcaggattcatgagaatttta
tctgggccctttgtcagaaaatgggatgggaagatgctcaacatccacccctccttgctc
ccttcttttaagggttcaaatgcccatgagcaagccctggaagctggggtcacagtcact
gggtgtactgtgcactttgtagctgaagatgtagatgctggacaaattattttacaagaa
tctgttccagtgaagagaggtgacactgttgcaactctgtcggaaagagtgaaattagca
gagcataaaatatttcccgcagccctccagctggtagccagtggagctataaggcttgga
gaaaatggcaagatccgttgggtcacagaggattga
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