Canis lupus familiaris (dog): 403417 Help Entry 403417            CDS       T01007                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 precursor   KO K10160   toll-like receptor 4 Organism cfa  Canis lupus familiaris (dog) Pathway cfa04064   NF-kappa B signaling pathway cfa04066   HIF-1 signaling pathway cfa04145   Phagosome cfa04151   PI3K-Akt signaling pathway cfa04217   Necroptosis cfa04613   Neutrophil extracellular trap formation cfa04620   Toll-like receptor signaling pathway cfa04621   NOD-like receptor signaling pathway cfa04936   Alcoholic liver disease cfa05132   Salmonella infection cfa05133   Pertussis cfa05134   Legionellosis cfa05135   Yersinia infection cfa05140   Leishmaniasis cfa05142   Chagas disease cfa05144   Malaria cfa05145   Toxoplasmosis cfa05146   Amoebiasis cfa05152   Tuberculosis cfa05161   Hepatitis B cfa05162   Measles cfa05164   Influenza A cfa05170   Human immunodeficiency virus 1 infection cfa05171   Coronavirus disease - COVID-19 cfa05205   Proteoglycans in cancer cfa05235   PD-L1 expression and PD-1 checkpoint pathway in cancer cfa05321   Inflammatory bowel disease cfa05323   Rheumatoid arthritis cfa05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     403417 (TLR4)    04066 HIF-1 signaling pathway     403417 (TLR4)    04151 PI3K-Akt signaling pathway     403417 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     403417 (TLR4)   09143 Cell growth and death    04217 Necroptosis     403417 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     403417 (TLR4)    04620 Toll-like receptor signaling pathway     403417 (TLR4)    04621 NOD-like receptor signaling pathway     403417 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     403417 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     403417 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     403417 (TLR4)    05161 Hepatitis B     403417 (TLR4)    05171 Coronavirus disease - COVID-19     403417 (TLR4)    05164 Influenza A     403417 (TLR4)    05162 Measles     403417 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     403417 (TLR4)    05135 Yersinia infection     403417 (TLR4)    05133 Pertussis     403417 (TLR4)    05134 Legionellosis     403417 (TLR4)    05152 Tuberculosis     403417 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     403417 (TLR4)    05144 Malaria     403417 (TLR4)    05145 Toxoplasmosis     403417 (TLR4)    05140 Leishmaniasis     403417 (TLR4)    05142 Chagas disease     403417 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     403417 (TLR4)    05321 Inflammatory bowel disease     403417 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     403417 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     403417 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:cfa04131]     403417 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:cfa04054]     403417 (TLR4)    04090 CD molecules [BR:cfa04090]     403417 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:cfa00536]     403417 (TLR4) Membrane trafficking [BR:cfa04131]  Endocytosis   Phagocytosis    Toll-like receptors     403417 (TLR4) Pattern recognition receptors [BR:cfa04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    403417 (TLR4) CD molecules [BR:cfa04090]  Proteins   403417 (TLR4) Glycosaminoglycan binding proteins [BR:cfa00536]  Hyaluronan   Cell surface receptors    403417 (TLR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 LRR_4 TIR TIR_2 LRR_9 LRR_EndoS LRR_NXF1-5 LRR_Zer-1 ThsB_TIR LRR_At5g56370 Motif Other DBs NCBI-GeneID:  403417 NCBI-ProteinID:  NP_001002950 Ensembl:  ENSCAFG00000003518 VGNC:  51765 UniProt:  A0A8C0YS26 Q8SQH3 LinkDB All DBs Position 11:69768502..69779281 Genome browser AA seq 833 aa AA seqDB search MMSPTRLVGILIPAMAFLSCLRPESWDPCMQVVANTTYQCMELNLSKIPNNIPTSTEKLD LSFNPLRHLGSHCFSNFPKLQVLDLSRCEIQVIEDDAYQGLNHLSILILTGNPIQRLFPR AFSGLSSLKTLVAKETKLTSLEDFPIGHLKTLKELNVAHNLIHSFKLPAYFSNMPNLENV DLSNNKIQNIYREDLQVLHHMPLLNLSLDLSLNPLYFIQPGSFKEIKLHKLTLRSNFNST DVMKTFIQGLAGLKINQLVLGEFKNERKLESFDNSLLEGLCNLTIEKFRIAYFDSFSKDT TNLFNQLVNISAISLAHLYLDTPKYLPKNLRWQRLEIVNCNLEQFPAWELDSLKEFVLTS NKGMNTFADMKMESLEFLDLSRNRLSFKTCCSHSDFGTTRLKHLDLSFNEIITMSSNFLG LEQLEYLDLQHSSLKQASDFSVFLSLRNLRYLDISYTRTEVAFQGIFDGLVSLEVLKMAD NSFPDNSLPNIFKGLTNLTILDLSRCHLERVSQESFVSLPKLQEINMSHNSLLSLDTLAY EPLLSLQILDCSFNRIVAFKEQGQQHFPSNLVSLNLTRNNFACDCEHQSFLQWVKDHRQL LVEVEQMVCAKPLDMKDMPLLSFRNATCQRSKTIISVSVFTVLMVSLVAVLAYKFYFHLM LLAGCKRYNRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFYKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKSLL RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKPWSPEGTEDAEKS NT seq 2502 nt NT seq  +upstreamnt  +downstreamnt atgatgtctcctacccgcctggttgggatattgatcccagccatggccttcctctcctgc ctgagacctgagagctgggacccttgcatgcaggtggttgctaacactacttaccaatgc atggagctgaatctcagcaaaatccccaacaacatccccacatcaaccgagaaactggac ctgagctttaaccccctgaggcatttaggcagccattgcttctccaacttcccaaaactg caggtgctggatttatccaggtgtgaaattcaggtaattgaagatgatgcatatcagggc ctaaaccacctctccatcttgatattgacaggaaaccctatccagagattatttccaaga gccttttctggactatcaagtttaaagacgctggtggccaaggagacaaaactaacatct ctagaggatttccccattggacatctcaaaaccttgaaggagcttaatgtggctcacaat cttatccattccttcaagctacctgcgtatttctctaacatgcccaacctggagaacgtg gatctttccaataacaagatccaaaatatttatcgtgaagacttgcaggttctacatcac atgccactactcaacctttctttagacttgtccctgaaccctttatactttatccaacca ggttcctttaaagaaattaaactccataaactgactttgagaagtaattttaatagtaca gatgtaatgaaaacttttattcaaggtctggctggcttaaagatcaatcagttggttctg ggagaatttaaaaatgaaaggaagttggaaagctttgacaattctctcctggaaggactg tgcaatttgaccattgaaaaattccggatagcatactttgatagcttctcaaaggatact actaacttatttaaccagttggtaaacatttctgcaatttctttggcgcatctgtattta gacacaccaaaataccttcctaaaaatctcagatggcaacggttggaaatagttaattgt aacttagaacaatttcccgcatgggagctggactctctcaaggagtttgttctcacttcc aacaaaggtatgaacacttttgctgatatgaagatggaaagccttgagtttctagatctc agtagaaatcgcctgagtttcaagacttgctgctctcactctgattttgggacaaccaga ctgaagcatttagatctgagcttcaatgaaatcattaccatgagttcaaacttcttgggc ttagaacaactggaatatctagatttacagcattccagtttgaagcaggccagtgatttt tcagtattcttgtccctcagaaacctccgttaccttgatatttcttatactcgcactgaa gttgctttccagggcatttttgatggcttggtcagcctcgaagtcttgaaaatggctgat aattcctttccggacaactcccttccaaatattttcaaagggttgactaacttaaccatt ctggacctttctaggtgtcatctggaacgggtgtcccaggaatcatttgtctcacttcct aaacttcaggagataaatatgagtcacaatagcctcttgtcattggatacactagcttat gaacctctcctctccctccagatcctagattgcagtttcaatcgaatagtagccttcaag gaacaaggacaacagcattttccaagtaatctagtttccttaaatcttactcggaataac tttgcttgtgactgtgaacatcagagtttcctgcagtgggtcaaagaccacagacagctc ttggtggaagttgaacaaatggtgtgtgcaaaacctttagacatgaaggacatgcccttg ctaagttttaggaatgccacctgtcagaggagcaagactatcattagtgtgtcagttttc actgtgctcatggtttctctggtagcagttttagcgtataagttctattttcacctgatg cttctcgctggctgcaaaaggtataacagaggggaaagtacctatgatgcatttgttatc tactcaagccaggatgaagactgggtgaggaatgaattggtaaagaacttggaggaggga gtgcccccctttcagctctgccttcactacagagacttcattcctggtgtggccatcgcc gccaacatcatccaggaaggcttctacaaaagccggaaggttattgttgtggtgtcccaa cacttcatccagagtcgatggtgcatctttgagtatgagattgcccagacttggcagttt cttagcagtcgtgctggcatcatcttcattgtcctgcagaaggtggagaagtccctgctg cggcagcaggtggaactgtatcgcctcctcagcaggaacacttacctggaatgggaagac agtgtcctggggcggcacatcttctggagacggctccgaaaagccttgctggatggtaaa ccgtggagtccagaaggaacagaggatgcagaaaaaagctag

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