Canis lupus familiaris (dog): 403715
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Entry
403715 CDS
T01007
Symbol
SRD5A2
Name
(RefSeq) 3-oxo-5-alpha-steroid 4-dehydrogenase 2
KO
K12344
3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:
1.3.1.22
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00140
Steroid hormone biosynthesis
cfa01100
Metabolic pathways
cfa05215
Prostate cancer
Module
cfa_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
403715 (SRD5A2)
09160 Human Diseases
09162 Cancer: specific types
05215 Prostate cancer
403715 (SRD5A2)
Enzymes [BR:
cfa01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
403715 (SRD5A2)
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Motif
Pfam:
Steroid_dh
DUF1295
DUF6832
Motif
Other DBs
NCBI-GeneID:
403715
NCBI-ProteinID:
NP_001273993
Ensembl:
ENSCAFG00000032023
VGNC:
46794
UniProt:
A0A8C0NNA6
A0A8I3NQ64
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Position
17:complement(24811155..24850233)
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AA seq
254 aa
AA seq
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MPIRCQQSPVLAGSAALAAMGALFLYLAKPSGYGKYSEGLTPAAPRLPARAAWLLQELPS
FAVPAGILARQPRALLGQPATVLLGLFCAHYFHRTFIYSLLTRGRPFPVVFVVRGFIFCA
GNGLLQGYYLIYCAEYPAEWYMDVRFSLGIFLFILGMGINIHSDYILRQLRKPGEVIYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFLF
NT seq
765 nt
NT seq
+upstream
nt +downstream
nt
atgcccattcgctgccagcagagcccggtgctggcaggcagcgccgctttggcggccatg
ggggcactgttcctgtacctggccaagccctcgggctacgggaagtactcggagggcctg
acgcccgccgccccccgcctgcccgcgcgcgccgcctggttgctgcaggagctgccctcc
ttcgcggtgcccgcggggatcctcgcccggcagccgcgcgctctcctcggccagcctgcg
acggtgctcctgggcctcttctgcgcgcattacttccacaggacatttatttactcattg
ctcactagagggaggccttttccagttgtgttcgtggtcagaggatttatcttctgcgca
ggaaatggacttctccaaggctactatctgatttactgcgctgagtaccctgctgagtgg
tacatggacgtacggtttagcctgggtatcttcttatttattttgggaatgggaatcaac
attcatagtgactatatattgcgccagctcaggaagcctggagaagtcatctataggatt
ccacaaggtggcttgtttacgtatgtttctggagccaatttccttggtgagatcattgaa
tggatcggctatgccctggctacttggtccctcccagcacttgcatttgcgtttttctca
ctttgcttcctggggctgcgagcttttcaccaccataggttctacctcaagatgtttgag
gactaccccaaatctcggaaggccctcattccatttctcttttaa
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