Canis lupus familiaris (dog): 442952 Help Entry 442952            CDS       T01007                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism cfa  Canis lupus familiaris (dog) Pathway cfa01521   EGFR tyrosine kinase inhibitor resistance cfa04151   PI3K-Akt signaling pathway cfa04217   Necroptosis cfa04380   Osteoclast differentiation cfa04550   Signaling pathways regulating pluripotency of stem cells cfa04620   Toll-like receptor signaling pathway cfa04621   NOD-like receptor signaling pathway cfa04630   JAK-STAT signaling pathway cfa04658   Th1 and Th2 cell differentiation cfa04659   Th17 cell differentiation cfa05140   Leishmaniasis cfa05145   Toxoplasmosis cfa05152   Tuberculosis cfa05160   Hepatitis C cfa05161   Hepatitis B cfa05162   Measles cfa05163   Human cytomegalovirus infection cfa05164   Influenza A cfa05165   Human papillomavirus infection cfa05166   Human T-cell leukemia virus 1 infection cfa05167   Kaposi sarcoma-associated herpesvirus infection cfa05168   Herpes simplex virus 1 infection cfa05169   Epstein-Barr virus infection cfa05171   Coronavirus disease - COVID-19 cfa05200   Pathways in cancer cfa05203   Viral carcinogenesis cfa05212   Pancreatic cancer cfa05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     442952 (JAK1)    04151 PI3K-Akt signaling pathway     442952 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     442952 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     442952 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     442952 (JAK1)    04621 NOD-like receptor signaling pathway     442952 (JAK1)    04658 Th1 and Th2 cell differentiation     442952 (JAK1)    04659 Th17 cell differentiation     442952 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     442952 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     442952 (JAK1)    05203 Viral carcinogenesis     442952 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     442952 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     442952 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     442952 (JAK1)    05161 Hepatitis B     442952 (JAK1)    05160 Hepatitis C     442952 (JAK1)    05171 Coronavirus disease - COVID-19     442952 (JAK1)    05164 Influenza A     442952 (JAK1)    05162 Measles     442952 (JAK1)    05168 Herpes simplex virus 1 infection     442952 (JAK1)    05163 Human cytomegalovirus infection     442952 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     442952 (JAK1)    05169 Epstein-Barr virus infection     442952 (JAK1)    05165 Human papillomavirus infection     442952 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     442952 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     442952 (JAK1)    05140 Leishmaniasis     442952 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     442952 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:cfa01001]     442952 (JAK1) Enzymes [BR:cfa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      442952 (JAK1) Protein kinases [BR:cfa01001]  Non-receptor tyrosine kinases   JAK family [OT]    442952 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  442952 NCBI-ProteinID:  NP_001274055 Ensembl:  ENSCAFG00000018615 VGNC:  42175 LinkDB All DBs Position 5:45310150..45467121 Genome browser AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPNDSGNILYYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEMLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT LVDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPHCPEEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagactgaggtgaatctggaggcccctgaaccaggggtggaagtgctcttc tatctttctgatagagagcccctccggctgggcagcggagagtacacagcagaggagcta tgcatcagggccgcgcaggaatgctgtatctctccactttgtcacaacctctttgccctg tatgatgagaacaccaagctctggtatgctccgaatcgcaccatcaccgttgatgacaag acatcgctccggctccactaccggatgaggttctatttcaccaactggcatgggactaat gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa aaaaaagttccagatgctacccctcttcttgatgccagttctttggagtatctctttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagactgagcag gatgggcacgatattgagaatgagtgtctgggaatggctgtcctggccatctcccactat gccatgatgaagaagatgcagttgccagaacttcccaaggacatcagctataagcgatat attccagagaccttgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggatttcctgaaggaatttaataacaagactatttgtgacagtagt gtatctactcatgacctaaaggtgaaatatctggctaccttggaaactttgacaaagcat tatggcgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat tggtttcatccgaacgacagtggaaacattctctactatgaagtgatggtaactggaaat cttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggacgaggagaaaaacaaaatccgg gaagagtggaacaatttttcttacttccctgaaatcacacacattgtaataaaggagtct gtggtcagcatcaataagcaggacaacaaaaaaatggaactgaagctctcatcccatgag gaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcagatgcccat cattacctctgcactgatgtggctcccccattgatcgtccacaacatacagaatggttgt cacggtccaatctgcacagaatacgccatcaataagttgcggcaagaaggaagcgaggag gggatgtatgtgctgaggtggagctgtaccgacttcgacaatattctcatgactgtcacc tgctttgaaaaatctgagatgctgggtggccagaaacagttcaagaattttcagattgag gtgcagaagggccgctatagcctgcacggctcagaccgcagcttccccagcctaggggac ctgatgagccacctcaagaagcagatcctgcgtacggacaacatcagcttcgtgctgaag cgctgctgccagcccaagccccgagagatctccaatctgctggtggctactaagaaagcc caagagtggcagccagtctaccccatgagccagctgagttttgaccggatcctcaagaag gatattgtgcaaggagagcaccttgggagaggcacacggacacacatctactccggtact ctggtggattataaggatgatgaaggaacctctgaagaaaagagaataaaagtcatcctc aaagtcttagaccccagccacagggacatttctctggctttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctacggcgtctgtgtccgagacgtg gagaatatcatggtggaagagtttgtggagggggggcctctagatctcttcatgcaccgg aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaaacagctggccagcgcc ctgagttacttggaggataaagacctagttcatggaaatgtgtgcactaaaaaccttctc ctggcccgtgagggcattgacagcgagtgcggcccgttcatcaagctcagtgaccctggc atccccatcactgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcct gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc acattgtgggaaatctgctacaatggcgagatccctctgaaagacaagaccctgattgag aaagagagattctacgaaagccggtgccggccagtgacaccatcttgtaaggagctggct gaccttatgacccgctgcatgaactatgaccccaaccagagacccttcttccgagccatc atgagagacatcaataaactggaagagcagaatccagacattgtttccgaaagaaagcca gcaaccgaagtggatcccacacattttgaaaagcggttcttgaagaggatccgtgacctg ggagagggccactttgggaaggttgagctctgcaggtatgaccctgagggggataatact ggagagcaggtggctgtcaaatccctgaagcctgagagtggaggtaaccacatagctgat ctgaagaaggaaatcgaaattctaaggaacctttatcatgagaacattgtgaagtacaaa ggcatctgtacagaagacggaggaaatggtattaagctcatcatggaatttctgccttca ggaagtcttaaggaatatcttccaaagaataagaacaaaattaacctcaaacaacagtta aaatatgctgttcagatttgtaaggggatggactatttaggttctcggcaatatgttcac cgggacttagcagcaaggaatgtccttgttgagagtgaacaccaagtgaaaattggagac tttggtttgaccaaagcaattgaaactgacaaggagtactacacagtcaaggatgatcgg gacagccctgtgttttggtatgctcctgaatgtttaattcaatgtaaattttatatcgcc tctgatgtctggtcgtttggagtgaccctgcatgagttgcttacttattgtgactcagat tccagccccatggcgttgtttctgaaaatgataggcccaactcatggccagatgacagta acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacctcactgtcca gaagaggtttatcaacttatgagaaaatgctgggaattccagccatctaatcggacaact tttcagaaccttattgaaggatttgaagcacttttaaaataa

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