Canis lupus familiaris (dog): 474995 Help Entry 474995            CDS       T01007                                  Symbol MDN1 Name (RefSeq) midasin isoform X1   KO K14572   midasin Organism cfa  Canis lupus familiaris (dog) Pathway cfa03008   Ribosome biogenesis in eukaryotes Brite KEGG Orthology (KO) [BR:cfa00001]  09120 Genetic Information Processing   09122 Translation    03008 Ribosome biogenesis in eukaryotes     474995 (MDN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03009 Ribosome biogenesis [BR:cfa03009]     474995 (MDN1) Ribosome biogenesis [BR:cfa03009]  Eukaryotic type   Pre-60S particles    Other pre-60S particles     474995 (MDN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AAA_5 AAA_lid_7 AAA_lid_5 AAA_16 AAA AAA_3 AAA_7 AAA_22 TsaE nSTAND3 Sigma54_activ_2 Sigma54_activat AAA_14 ABC_tran AAA_18 MDN1_4th AAA_2 AAA_6 DUF815 AAA_25 PduV-EutP ResIII TniB VWA Pus10_N_euk Motif Other DBs NCBI-GeneID:  474995 NCBI-ProteinID:  XP_005627692 Ensembl:  ENSCAFG00000003109 VGNC:  43108 UniProt:  A0A8C0MTL7 LinkDB All DBs Position 12:complement(48660995..48827798) Genome browser AA seq 5592 aa AA seqDB search MEHLFLEVAAAPLRLLAAKNEKSRSELGRFLAKQVWTPQDRQCILNTLAQLLLDKDCTVL VGRQLRPLLLDLLERNAEAIKAGGQVNHDLHERLCVSMSKLLCNHPDILPFALRYFKDTS PVFQRLFLESSDANPVRYGRRRMKLRDLMEAAYKFLQQDQSVFRELWDWSVCVPLLRSHD TLVRWYTANCLALVTCMNEEHKLSFLKKIFNSEELIHFRLRLLEEAQLQDLEKALVLANP ETSLWRNEKELQYLQGHLVSADLSSRVTAVCGVVLPGQPPVPGEQASNRNSSREQELAFR SYVLVDSICKNLQTLAMAVASQNAVLLEGPIGCGKTSLVEHLGAMTGRRKPPQLLKVQLG DQTDSKMLLGMYRCTDVPGEFVWQPGTLTQAVTKGHWILLEDIDYAPLDVVSVLIPLLEN GELLIPGRGDCLKVAPGFQFFATRRLLSCGGNWYRPLNSHATLLDKYWTKIHMDNMDKTE LNEVLQNRYPSLLAVTDHLLDIYIQLTGEKHHSRSDSSVTCEQVPEEFAEARRENKRLSL EGRELSLRDLLNWCNRIVHCFDSLSSSASLNIFQEALDCFTAMLSKHTSKLKMAEIIGSK LNISKKKAEFFCQLYKPEIVINELDVQVGRVRLLRKQSEAVHIQREKFTFAPTRPSSVLI EQLAVCVSKGEPVLLVGETGTGKTSTVQYLAHITGHRLRVVNMNQQSDTADLLGGYKPVD HKLIWLPLREAFEELFAQTFSKKQNFTFLGHIQTCYRQKRWQDLLRLMQHVHKSAVNKDE KESETGLLLKEKWEAFGLRLNHAQQQMKMTENALLFAFVEGTLAQAVKKGEWILLDEINL AAPETLECLSGLLEGSSGSLVLLDRGDTEPLVRHPDFRLFACMNPATDVGKRNLPPGIRN RFTELYVEELESKEDLQILIVDYLKGLSVNKTTVQGIISLYTALRKDSGTKLVDGTGHRP HYSLRTLCRALRFAASNPCGNIQRSLYEGFCLGFLTQLDRASHPIVQKLICQHIVSGNVK SLLKQPIPEPKGGRLIQVEGYWISVGDKEPTIDETYILTSSVKLNLRDIVRVVSAGTYPV LIQGETSVGKTSLIRWLAAATGNHCVRINNHEHTDIQEYIGCYTSDSSGKLVFKEGVLID AMRKGYWIILDELNLAPTDVLEALNRLLDDNRELLITETQEVVKAHPRFMLFATQNPPGL YGGRKVLSRAFRNRFVELHFDELPSSELETILHKRCSLPPSYCSKLVKVMLDLQSYRRSS SVFAGKQGFITLRDLFRWAERYRLAEQTEKEYDWLQHLANDGFMLLSGRVRKQEEIDVIQ EVLEKHFKKTLCPQSLFSRENVLKLLSKLSTQVSTLESTFRHIVWTESMRRLAMLVGRAL EFGEPVLLVGDTGCGKTTICQVFASLSNQKLYSVNCHLHMETSDFLGGLRPVRQMSKDKE EIDTSRLFEWHDGPLVLAMKEDGFFLLDEISLADDSVLERLNSVLEVEKSLVLAEKGSVE DKDNEVELLTAGKKFRILATMNPGGDFGKKELSPALRNRFTEIWCPQSTNREDLIQIIRH NLRPGLSLGRIDHKGADIAEVMLDFIYWLTHQEFGRRCVVSIRDILSWVNFMNTMEEEAA LKRPETISTVTSFVHAACLVYIDGIGSGVTSSGFGTALLARKECLKFLIKKLSKIVRLTE CQKNELKIYDRLKTKEFTGIDNLWGIHPFFIPRGPVLHRNNIADYALSAGTTAMNTQRLL RATKLNKPILLEGSPGVGKTSLVGALAKASGNILVRINLSEQTDITDLFGADLPVEGGKG GEFAWRDGPLLAALKAGHWVVLDELNLASQSVLEGLNACFDHRGEIYVPELGMSFQVQHE KTKIFGCQNPFRQGGGRKGLPRSFLNRFTQVFVDPLTVIDMEFIASTLFPAIDKNIVKKM VAFNNQIDHEVTVEKKWGQKGGPWEFNLRDLFRWCQLMLVDQSPGCYDPGQHVFLVYGER MRTKEDKEKVIAVFKDVFNSSSNPYLGTRLFHITPYDVQLGYSVLSRGSYVPLLSRRPLL LLHQSLQSLESIMKCVQMSWMVILVGPASVGKTSLVQLLAHLTGHTLKIMAMNSAMDTTE LLGGFEQVDLIRPWRQLLEKVEGTVRALLRDSLLISSDDAEVVLRAWSHFLLTYKPKCLG DAGKGITMEIVNKLEAVLLLMQRLNNKINSYSKAEFAKLVEEFRNFGVKLLQSTSGHSHG TFEWVDSMFVRALKSGDWLLMDNVNFCNPSVLDRLNALLEPGGVLTLSERGMIDGSTPTI TPNPNFRLFLSMDPVHGEISRAMRNRGLEIYISGEGDGNIPDDLDLKVLLHSLGLVGDSV CDSLLALHTEIQSTVVGSPTSSISTLIQTALFIVQYLQRGLSLDRAFSEVCWEAYVCSQH SPANQKLAQALLEKHVFSLRAHETWGNSILALGLWPDSLPSALFATEDSHLSVVRSDGQI LVYCLNRMSMKTSSWARIQPLTLPDLEKIMQSPNPESLKFSSVEVDTYWIDEPDVLAMAV KLLIERATNQDWMLRVKWLYHLAKNIPQGLESIQIHLEASAASLRNFYSNSLSAGVSNVI KVLQPNITDEFVILLDPRWNMQALDIIRNSMDFDPQTDQPEQLFALLESVANKTILYLDR EKRIFTEANLVSIGGKKLRNSVLRMSFEFHKDPESYHSLPHEIVVNLAAFFELCDALILL WVQSSQGVVSDAMVIKILDSVRWRDRFWTVADTVKVDTPGLALLALHWHWVLKHLVHQIP HLLMNHEDKYYKEVQTVSEHIQNCLGSPTGGFTGIKKLQKFLGRPFPFKNKLVVECFSQL KILNKALAIRERMPALGESGWWEDINRLQVVASEWTFKKSLLQAWGLVLRANILEDANPD ELKNLVNAHCLELRAKGISFGFLEKKHNEASSVFQPDFTSLIQLTRSVQLWPAMEYLAML WQYKVVADFMTQACLRRSSKNQQPQIDEISHHITFCLKYTPVAPQELRDLWSLLRHQKVS TEEITSLWSDLFNSMFGSFWSSTVTTNPEYWLTWSPLPDIQQREMPRSLLDSTLKGPSSL SRAIFSKCCFEVLTSSCRASPWDVSGLPILSSSHVILGEWVERAQQLQDISLALWTNMAV PSVTEFRRTDSQLQGLVLCRHLAGLTELLPEPQRQEYMQNCEQLLLGDRQAFQHVGQTLG DMAGQEPLPKELLCLLLTSLRHLFGEGDIKQDLSEPARRGSLWVSLGLLQIQTWLPQARF DPAVKREYKLKYAKEELHQLQCEWKTRKLSSQLLTGTDLEDEVIIRYSHPHIRLLRQRID HLENLICSLSKKQAFRPQVPAYESLVQEIHHYVTSIAKAPAVQDLLTRLLQALHMDGPWS AQVVQNLLKEEASWQQSHHQFRKRLAEEYALYPDSVTPLQASILQLQHGMRLVASEVYAS FHGSVVCADRLGSLATSLLAFPSVGPAFPTYYAHADTLCSVKSEEVLRGLGKLILKRSGG KELEGKGQRPCPTREQLLMNALLYLRSHVLCKGELDQRALQLFRHVCQEIINEWDEQERI AQEKAEQESSLYRYRSRNSRTALSEEEEEEREFRKQFPLHEKDFADILVEPTLDEKKGTS DVQEEGAATDPALFSQSSMQAVMLIHQQLCLNFARSLWYQQPLPPHETKHYLGLFMSCYQ TGASLVTHFYSLMGAELNDQLLGSQLLACTLSYNTLFGEATSDLIVKPDGPYDFYQHPNV PEARHCQPVLQGFSEAVSQLLQDWPEHPALEQLLVVMDRIRSFPLSSPISKFLNGLEILL AKAQDWEENASRALSLRKHLDLVSQMIIRWRKLELNCWSMSLDNTMKRHTEKSTKHWFSI YQMLEKHMQEQTEEQEDDKQMTLMLLVSTLQAFIEGSSLGEFHVRLQMLLVFHCHVLLMP QVEGKDSLCSVLWNLYHYYKQFFDRVQAKIVELRSPLEKELKEFVKISKWNDVSFWSIKQ SVEKTHRTLFKFMKKFEAVLSEPCRSSLVESHKEEQPDFLSQPTATSEASSIQSLNKALR ETLLARPAAAQAVIPEQCQGAPFPSEGELLRRLPKLMKRMRKMCLTFLKESRLPHLVESL DHFTGEVISSVGELQSLKVEPSAEKEKQRSEAKHILLRKQRALADLFQHLAKTGLSYRKG LAWARSKNPQEMLYLHPLDIRSALSIVSTQEADSRLLTEISSSWDGCQKYFFRSLARHAR LNAALAAPVKELGMSNVERCKGFSAHLMKMLIRQRRSLTTLTEQWILLRNLLGCVQEIHS RLTGPLVYPVAFPPQDGVQQWTERLQHLAMQSQILLEQLSWLLQCCPSAGPTPGRGDAQA QGRPSAAYPEGPDLTEGRLSRAVQDLVPSELSYPSPVPRNQLPSGCLMRKQDQVWQQSTA RLTEMLKTIKTVKADVDKIRQLSCETLFHSWKDFEVCSSGLSCLSQMSVHLQGLESLFII PGMEVEQTDQQMALVESLEYLRGEINKATDDFTTWKTHLLALGSQGGNQMLEEGFVEDFS EQVETAIRAILCAIQNLAERNCKKTEENADQTRPQEEDEAAGFERLQSGHLTKLLEDDLR ADVSALHVQKIISAVSELLERLKSYGEDGTASKHTFFSQSCCVLVRLVPMLSRYSDLVLF FLTVSLATHRSTAKLLSVLAQVFTELAQEGFCLPKEFMEDSAGEGATEFHDYEGGGIGEG EGMKDVSDQIENEEQAEDTFQKGQEKDKEDPNSKSDIKGEDNAIEMSEDFDGKMHGGELE EQEEDDGKSDSDGGDLDKQMGDLNGEEADKLDERLWGDDDEEEEEEEEDSKTEETGPGMD EEDCGLVAKDDNSDAGKSNKDKNQVKEEKEEAEVADDGQGQDKINEQIDEREYDENEVDP YHGNQEKLPEPEALDLPDDLNLDSEDKNGGEDTDHEEGEENPLEIKEKPMDTEEAGHEAE EIKEEIEADHSEGQGQHEPEEGPSEEEKGEEEEEMDTGTNGQDKDTAEHPEEDSEDEHHS LEDKDEEASKGSAENGVPVDQGLQPQEEEGGENSDTEEQVPEATERKEHDSCGQTGLESV QSAQAVELAGTAPEKEQGKEEHGSGAADANQAEGHESNFIARLASQKQTRKNTQSFKRKP GQADNERSMGDHSEHVHKRLKTVDMENHTEQGPAQPQPQAEDADAFEHIKQGSDPYDAQM YDVASKEQQQQSTEDSRRDQEEEVEDTFLDTEKEEELRAADIEQLKPEKVKSGTTPGFDE MEVETQAVKTEEDQDPRTDLSQEETENEKPERSRDSTIHTAHQFLMDTVFQPFLKDISEL RQELERQLEMWQPHESGNPEEEKAAAEMWQSYLALTAPLSQQLCEQLRLILEPTQAAKLK GDYRTGKRLNMRKVIPYIASQFRKDKIWLRRTKPSKRQYQICLAIDDSSSMVDNHTKQLA FESLAVIGNALTLLEVGQIAVCSFGESVKLLHPFHEQFSDSSGSQILRLCKFQQKKTKIA QFLESVASMFAAAQQPSQNTSPETAQLLLVVSDGRGLFLEGKDRVLAAVQAARNANIFVI FVVLDNPSSRDSILDIKVPIFKGPGEMPEIRSYMEEFPFPFYIILRDVNALPETLSDALR QWFELVAASDHL NT seq 16779 nt NT seq  +upstreamnt  +downstreamnt atggagcaccttttcctggaggtggcggctgccccgctgcgcttactcgctgccaagaac gagaagagccgtagcgaactgggcaggttcttggccaaacaggtgtggacacctcaagat cgccagtgtatcctgaataccttagcacaattacttctggataaagactgtactgtgctg gttggtcgccaactacgccctcttcttttggatttgctggaaaggaatgctgaggccatt aaagctggaggccaagtcaaccatgatttacacgaaaggctctgtgtgtcaatgagcaaa ctcctctgtaaccatcctgacatccttccgtttgccctgaggtacttcaaggacacttct ccagtctttcagagactcttcctagagagttcagatgctaatccagtccgctatggacgc aggcggatgaagctccgggacctaatggaagcagcttacaagtttctgcaacaagaccag tctgtgtttcgggagctctgggactggagtgtgtgtgtccctcttctcagaagccatgac accttggtccgctggtacacagccaattgtcttgctttggtcacttgtatgaatgaagag cacaagttatcattccttaagaagatttttaatagtgaggaactgattcatttcaggttg aggttactagaagaggcccagctgcaggacttggagaaggccttggttttggctaatcca gaaacctccctttggcgtaatgagaaggagctgcagtacttacagggacatcttgtttca gctgacctctcttccagagtgactgctgtctgtggtgtggtgctgcctgggcagccacca gtccctggagagcaggctagtaataggaattcttctcgtgaacaggagctggcctttaga tcttatgtgctggttgattcaatctgcaaaaatcttcagacactggctatggcagtggct tctcagaatgctgtgttgttggaaggaccaataggatgtggcaaaacttccttagttgaa cacttaggtgcaatgacaggtagaaggaagccccctcagcttcttaaagtccagcttgga gatcagaccgacagtaagatgctgttgggaatgtatcggtgtacagatgtcccaggagag tttgtgtggcaacctggtactctcacacaggcagtcacaaagggacactggatccttctg gaggatattgactatgcccccttagacgtggtttccgtgctgatccctcttttggagaat ggagagctcttgattcctggccgaggtgactgtctgaaagtggctcctggatttcagttc tttgcaactaggagactcttgagctgtggaggaaattggtatcgacctctaaatagtcat gctactctgctagacaaatactggacaaaaattcacatggataacatggataagaccgaa ctgaatgaggttcttcagaatagatatcccagcctcttggcagtaactgatcacctgctt gacatttacatccaacttactggagagaaacatcactctcgcagtgatagttctgttaca tgtgaacaggtacctgaagaatttgcagaagccagaagagaaaacaaaagactaagcctt gagggaagagaattgtctctaagggatctactgaattggtgtaataggattgtccattgt tttgacagtctgtcttcatcagcatccttaaatatttttcaagaggctctggactgtttc acagcaatgctttctaagcatacaagcaaactgaaaatggcagaaataattggaagcaaa ttgaacatttccaagaaaaaggccgaattcttctgtcagctttataaacccgaaattgtg atcaatgagctagatgtgcaagtgggtcgagtacggcttctacggaaacaaagtgaggct gtccacatacagagggagaagttcacttttgctcctacaaggccgtcctctgttcttatt gaacagcttgcagtgtgtgttagtaaaggggagcctgtgttgctggtgggagagacaggg actggcaagacctctactgtccagtacttggctcacattacaggccaccgtttgagggtt gtcaatatgaatcaacaaagtgacactgcagacttgcttgggggttacaaaccagtggac cataagcttatttggctgcccttacgggaggcatttgaagaactctttgcccagacattt tctaagaagcaaaactttacgttcttgggacatattcagacctgttacaggcagaaacgg tggcaggatctcctcagactaatgcagcatgtgcacaagtcggctgtcaacaaggatgaa aaagagagtgaaactgggttactcctaaaagagaaatgggaagcatttggtcttagactc aaccatgctcaacaacagatgaaaatgactgaaaatgccctattgtttgcatttgtagag ggtacactagctcaagccgtaaagaaaggagagtggatcttgttggatgagattaatctg gctgctccagaaacattagaatgtctcagtggtttacttgaaggttcttctggctcccta gtgttgctggatcgaggagacacagaacccctggttcgtcatcctgacttccgtttattt gcttgtatgaacccagcaacagacgtgggcaaaagaaatctcccaccaggaataagaaac aggttcacagaactttatgtagaagaattggaaagtaaagaagatttacaaattcttatt gtggattatctgaaaggactgagtgtaaataagaccacagtgcaaggaatcatcagcttg tacacagctctccggaaagactctgggacaaaattggtggatggaactggccatagacct cattacagccttcggaccctttgcagggctctgcgatttgcagcttccaatccgtgtggc aacatccagcgctcgctctatgagggcttttgtttgggtttcttaacacagcttgacagg gcatcacacccaatagttcagaagctcatttgtcaacacattgtctctggcaatgtaaaa agtctgctgaagcagcctattccagaaccaaaaggaggacgacttatccaggttgaagga tattggatttcagtgggagacaaggagcctacaatagatgagacctacattcttacatct tctgttaagctgaacctgagagacattgtccgagtggtttctgcgggaacctatccagtg ttgattcagggagagacgtcagttggtaaaacaagccttatccggtggctggctgcagct actggtaaccactgtgtgcgtattaacaatcatgaacacacggatattcaggagtacatt ggttgttatacgtctgactcttcagggaagcttgtgtttaaagaaggtgttcttattgat gctatgagaaagggctactggattattttagatgaattaaatttggctcctactgatgtg ttagaagcactgaacagattgctagatgataatcgtgaattgctcatcacagaaacacaa gaagttgttaaagctcaccctcggttcatgctttttgctacccagaatcccccaggactt tatggaggcagaaaggtgctttctagagccttcaggaatcggtttgtggaattgcatttc gatgaattgcctagttctgagttggaaacaatcttgcataagcgctgtagtttgccaccc tcctattgtagcaagttggttaaagtcatgctggaccttcagtcctatcgcagaagttct tcagtgtttgctggaaaacagggtttcatcacccttcgtgatctttttcgatgggctgaa aggtacagactggctgaacagactgagaaagagtatgactggctacagcatttagccaat gatggttttatgcttctctcaggccgggtcaggaaacaggaagagattgatgtgattcaa gaagtccttgaaaaacatttcaagaaaacattgtgtcctcagtccctcttctccagggaa aatgtcctaaaattactgagtaaattgtccactcaggtatccactttggaatctacattc agacacattgtgtggactgaaagcatgcggagactggcgatgctggtgggaagggcgctg gaatttggtgaaccagtgttgctggttggagacactgggtgtgggaaaactactatctgt caggtgtttgccagcttgtcaaatcagaaactatactctgtcaactgccacttacacatg gagacatcggatttcctgggggggctacggccagtgagacagatgtcaaaggacaaggaa gaaattgatacatcaagactttttgagtggcatgatggtcctctagttttggccatgaag gaagatggcttttttctcttggatgagatctcactggctgatgactctgtcctggaaaga ctcaatagtgtccttgaagtggaaaagtccctggtattagctgaaaagggcagtgtagag gacaaggataatgaggtagagctcttgactgctgggaaaaaattccgtatcttagcaacc atgaaccctgggggcgactttggaaaaaaagagctgtctcctgccttaagaaaccggttt acagaaatatggtgcccacaaagcacaaatcgtgaagatttaattcagattatcagacat aatcttcgtccaggattgtctctgggcagaatagatcataaaggggctgacatagctgag gtgatgctggatttcatttattggctgacccatcaggaatttggccgaagatgtgtggtc agtatcagagatatcctgtcctgggttaatttcatgaacacaatggaggaggaagctgct ttgaaaaggccagagaccatctccactgtgacgtcttttgtccatgctgcatgcctggtg tacatagatggaataggttcaggggtaacttcctcagggtttggtacagctctcttggct cgcaaagaatgtctgaaattccttatcaagaaactttccaagatagtgcgacttacagag tgtcagaaaaatgaattgaagatttatgacagactcaaaaccaaagaatttactggaata gataacctttggggaattcatccattttttataccaaggggacctgtccttcacaggaat aatattgctgactatgcccttagtgcaggcaccacagctatgaacacccagagactctta agagctacaaaactgaacaaacctattctcctggagggctcccctggtgtgggcaagaca agtttggtgggagcattagccaaggcttcaggcaacatccttgttcgaatcaacttgtct gaacagacggacatcacagacctgtttggagcagatctacctgttgaaggtggcaaggga ggagagtttgcctggcgggatggccccttgctggcagctctgaaggcaggccattgggtt gtgttggatgagctcaacctggcttctcagtctgtattggaaggactcaatgcttgtttt gaccacagaggagaaatctatgttcctgagttaggaatgagttttcaagtacagcatgaa aagacgaagattttcgggtgtcaaaatccttttagacaaggaggtgggaggaagggcttg ccaaggtctttccttaacagattcactcaggtctttgtggatccccttacagtaattgac atggagttcattgctagtactctgtttccagccattgacaaaaatattgttaagaagatg gttgctttcaataaccaaattgatcatgaagtgactgttgaaaagaaatgggggcaaaaa ggaggaccctgggaattcaaccttcgggaccttttccgctggtgtcagttgatgctagtt gaccagtctcccgggtgttatgatcctggtcaacatgtgtttttggtctatggtgagaga atgagaaccaaggaagacaaagaaaaggtcattgctgtgttcaaggatgtgtttaattca agttccaacccttacttgggaaccagactatttcacatcactccttatgatgttcagctg ggctactctgtcctttcccgtggtagttacgttcctctcctgtcccgccgtcccctgttg ctcctgcaccagtcattacagtctctggagtctattatgaaatgtgtgcagatgagctgg atggtcatccttgtgggtccagcctctgtgggcaagaccagcctggtccagcttctggca caccttactggtcacacgttaaagatcatggctatgaacagtgcaatggatactacagag cttctgggtggatttgagcaggttgatcttatacggccatggaggcagctgctagaaaag gtggaaggcactgtaagggcactgttaagagacagccttcttatcagttctgatgatgca gaagtagtgctacgagcctggagtcactttcttctgacttataagcccaagtgtcttgga gatgctggtaaaggtatcacgatggagattgtcaacaagctggaagcagtattattgctt atgcagcgactcaacaacaaaatcaactcctactccaaggcagaatttgccaaacttgtg gaagagttccgaaattttggggtgaagcttctgcagtccaccagtggccacagccatggc acatttgaatgggttgacagcatgtttgttcgggctctgaagtctggagattggcttttg atggacaatgttaacttctgcaacccatcggtgctggatcgtttgaatgctttgcttgaa cctggaggtgttctcacccttagtgagagggggatgatagatggatccactcccaccata acaccaaatcccaatttcagactttttctctcgatggatcctgttcatggagaaatatcc cgagctatgaggaatcgtggacttgaaatctacatttcaggagaaggagatggaaacatc ccagatgacctggatctgaaagttctgctgcacagccttgggttggtgggggatagtgtg tgtgatagcctcttggctctacacacagagatccaaagcactgtagtaggttctccaacg tcctctatttcaactctaattcagacagccttattcattgtgcagtacctacagcgaggg ctgagtttagacagagccttttctgaagtatgctgggaagcatatgtctgctcccagcat tcaccagcaaaccagaagcttgcacaggctttactggagaaacatgttttttctcttcga gcacatgaaacctggggtaactccatccttgctctgggcctgtggccagattctctgccc tcagctctctttgctacagaagactctcacctgtctgtagtccgaagtgatggacagatc ttagtatattgccttaacaggatgagcatgaaaaccagcagctgggccaggattcagcct cttaccttacccgatttagagaaaattatgcagtctcctaaccccgagagcttgaaattc agttcagtcgaagtggatacttactggattgatgaaccagatgttctggccatggctgtt aaattgcttatagaacgagcaaccaatcaagattggatgctcagagttaaatggctttat catttagccaagaatataccacaggggttggaatcaatacagattcatttggaagccagt gctgcatctcttaggaatttttactcaaattctctctcagctggggtcagtaatgtcatc aaagtattacaaccaaatataacagatgaatttgtgattcttttggatccccgatggaat atgcaggctttggacatcattagaaattcaatggactttgatccacaaacagaccagcct gagcagctctttgcccttttagagtctgttgcgaacaagacaatcctatatcttgaccgg gaaaaacggatttttactgaagcaaatttggtttccattggtggcaaaaagctaagaaat agtgttttgagaatgtcctttgaattccataaagatccagagagctatcacagcctgccc catgaaattgtggtcaaccttgctgctttttttgaactttgcgatgcactaatcctgctc tgggtacagtcctctcagggggtggtgtctgatgccatggtcattaagatcttggattct gtgcggtggcgggaccggttttggactgtggctgacacagtaaaagtggataccccgggc ttggccctgcttgccctgcactggcactgggttttaaaacatttggtccatcaaatcccc cacctcctaatgaaccatgaagacaaatactacaaagaggttcagacggtctcagaacat attcagaattgcttggggagcccgactggtggcttcactggtataaagaagttgcagaag ttcctgggacgaccatttccttttaagaacaagctggtggtggaatgtttttctcagttg aaaatccttaacaaagcgcttgccataagggagcggatgcctgcccttggggaaagtgga tggtgggaagacattaatcgtctccaagtggttgcttctgaatggacttttaaaaaaagt ctcttgcaggcctggggattggtcctcagagctaatattctggaagatgccaatccagat gagttgaagaatcttgtgaatgctcattgtttagaactaagagccaaaggaatttcattt ggttttctggagaaaaagcacaatgaagcttcctccgtgttccaaccagactttacctcc ttaatccagcttaccaggagtgttcagttgtggcctgcaatggagtacctggctatgctt tggcagtacaaagtggtagctgattttatgacacaggcctgtctaagaagatccagcaaa aatcagcaaccccagatagatgagataagtcatcacatcacattttgtcttaagtacaca ccagttgctccgcaagagcttcgagacctttggtccttactgcgccatcagaaggtgtct accgaagaaattacttcgttgtggtctgacttatttaattccatgtttgggtctttttgg agcagtactgtgactacaaatccagagtactggctaacgtggagccctctgcctgatata cagcagagggagatgcctaggtcccttctggactccacattgaagggccccagcagtctc agtagagccatattctccaagtgctgctttgaagtcttgaccagcagctgcagagcaagt ccttgggatgtgagtggcctccctatcctgtcctcctcacatgtcatcctgggagaatgg gttgaaagagcccagcagctccaggacatcagcctggcactttggaccaacatggctgtg ccttcagtcacagaattcagacgcacggattcccagctccaggggcttgtgctgtgtcgg cacctggcaggtttgacagagctgctccctgaaccccagcggcaggagtatatgcagaac tgcgaacagctgctgctcggggacagacaagccttccagcatgtgggccagactcttgga gacatggctggacaggagcctctgcccaaagagctgctatgcctcttgcttacttccttg cgccacttgtttggggaaggggatattaaacaggacctctccgagccagcccgtcgtggg agcctctgggtgagccttggcttgctccagattcagacatggcttccacaggcacgcttt gaccctgcagtgaagagggaatacaagctcaagtatgctaaggaagagttacaccagttg cagtgtgagtggaagacccgaaagctctcgtcccagctactgactggaacagacttggaa gatgaagtcattatccgttactctcatcctcacatcagactacttcgccaaagaattgat catctggagaatttaatctgcagcctgtcaaagaagcaggccttcagaccccaggtccct gcctatgagtccctggtgcaggagatccaccactatgtcaccagcattgccaaggcccct gctgttcaggatctgctcacacggctcctgcaggccctccacatggatggaccttggtct gcccaggtggtccagaaccttctgaaagaggaagcctcctggcagcaatcccaccaccag ttcaggaagcggctggccgaggaatatgccctgtatccagactctgtgaccccactgcag gcatccatcttgcagttgcagcatgggatgaggctggtggcatctgaagtctatgcttca ttccatggcagtgtagtctgtgcagacaggctgggtagcctggccacatccttgttggct tttccatcggtgggccctgccttccccacttactatgctcatgcagatactttatgctca gtgaagtcagaagaggttcttcgaggccttggaaagttgatcctcaagcgctcaggagga aaggaactagaaggcaagggccagagaccttgcccaacgcgagagcagctgctgatgaat gcacttctttacctgcgctcccatgtgttgtgcaagggagagctggaccagagggctctg cagcttttcaggcacgtgtgccaggaaattatcaatgagtgggatgaacaggaacgcata gcccaagagaaggccgagcaggagagcagcctatacagatataggagcagaaactccagg acagccctgagcgaggaggaggaggaagaacgggagttcagaaagcagttcccacttcat gaaaaggattttgcagatattctagtagaaccaacactggacgagaagaagggaacttca gatgtgcaagaagagggagcagccacagaccctgccctcttctcccagagctcaatgcag gctgtgatgttgattcaccagcagctttgcctcaacttcgctcggtccctctggtaccaa cagcctctaccgccacatgagacaaagcattaccttggcctgtttatgtcctgctatcaa actggggcatctcttgtgacacacttctactctctgatgggagctgagctgaatgaccaa ctcttgggcagccaacttttggcttgcaccctctcctataacactctgtttggtgaggca acctcggatctaatagtgaagcctgatgggccctatgacttctaccagcaccccaatgtc ccagaagcaaggcattgtcaacctgtgcttcagggtttctcagaggctgttagtcagcta ctgcaggattggccggaacacccagctctcgaacagctgctggttgtaatggataggatt cgtagtttcccactttccagtcccatctcaaagttcctgaatggcttagaaatccttctc gcaaaggcacaggattgggaggagaatgcaagtcgagctctctctctgaggaagcatctc gatttagtcagtcagatgatcattcgttggcgtaaactggaactgaactgctggtctatg agtttggataatactatgaagcgccatactgagaaatccactaaacactggttctctatc tatcagatgcttgagaagcacatgcaggaacaaacagaggagcaggaagatgacaaacag atgaccttgatgttgctggtcagcacattacaagcatttattgaaggatcctcactggga gaattccacgtacgacttcagatgttactggttttccattgtcatgtcttgttgatgcct caagttgaaggaaaggattcactttgcagtgttctgtggaatctgtaccattattacaag caattctttgaccgggtccaagccaaaattgtggaacttcgttctccccttgaaaaagaa cttaaagaatttgttaaaatatccaagtggaatgatgtcagcttctggtccattaaacaa tctgtggaaaagacacacaggaccctctttaagttcatgaagaaatttgaagctgtcctg agtgaaccctgccggtcatccttggtggagagtcacaaggaggagcagcctgactttttg tcacagccaacagccactagtgaggcatcctccattcagagtctgaacaaggcactgagg gagaccctgttggcccggccggcagctgcacaggctgtgattccagaacagtgtcagggt gctccttttccttcagagggagagctgctgcgtcgcctgccaaagctcatgaaacgaatg aggaagatgtgcctgacattcctgaaggaaagccgtctgcctcacctagtggagagcctc gatcacttcactggtgaagtgatttcctctgtaggtgaactgcagagcttaaaggtggag ccctctgcagagaaggagaagcaacgatcagaagccaagcacattcttctgcggaagcag cgagctttagcagacctctttcaacaccttgcaaaaactggtttgtcatatcgcaaaggt cttgcctgggcccgttcaaaaaaccctcaagagatgctttatcttcacccattagatatc cggagcgcgttgtctatagtcagcactcaggaagctgattctagactccttacagaaatc tcatcttcatgggatggatgccagaaatacttctttcgctctcttgcacggcatgccaga cttaatgcagccttagcagctcctgtcaaggagttgggcatgagcaacgttgagcggtgc aaagggttctcggcacatttgatgaagatgcttattcgacagcggcgctccctgactacg ctgactgagcagtggatcctcctcaggaacctccttggctgtgtgcaggagattcatagc aggctgactggcccattggtgtacccagtggccttccctcctcaggatggtgtgcagcag tggacagaaaggctgcagcacctagccatgcagagccagatcctgctggagcagctctcc tggctcctccagtgctgccccagtgcagggccaactccaggccgaggtgatgcccaagca cagggtcggccttctgctgcctacccagaaggaccagacctcaccgagggacggctttcc agagcagtacaggacctcgtcccatcagaactgagttatccatccccagtacctcgaaat cagttgccctctggttgcttgatgcgtaaacaagaccaagtttggcaacagtcaactgca agattaacagagatgctgaaaactattaaaacagtaaaagctgatgtggacaaaatcagg cagctgtcctgtgagactctctttcattcttggaaagattttgaagtttgctcttctggg ctgagttgcctatcccagatgtcagttcatttgcaaggcctagagtccttgttcattatt ccagggatggaggttgagcaaacagatcaacaaatggcattagttgagagcctggaatat ttaagaggagaaatcaataaagccacagatgactttactacctggaagacacatctactt gctttaggcagccaaggcggaaaccaaatgttggaggaagggtttgtggaagatttttca gagcaagtggaaactgccatcagggccatcctttgtgccatccagaatttagcagaaaga aactgtaaaaagacagaggagaacgctgaccaaacaagaccacaagaagaggatgaggca gcaggctttgagagattgcaatcaggacatctaacaaaactcttagaggatgacttacgg gccgatgtgagcgctctgcatgttcagaaaataatttccgctgtctctgagctgttggag aggctgaaatcatatggcgaggatggcacagcatcaaagcacacgttcttcagccagtcc tgctgcgtgttggtgcgtctggtgcccatgctctccagatactcagatcttgtcctcttc ttcctgactgtgtctctggcaactcaccgtagcactgcaaagctgctctctgtgcttgcc caggtctttacagagttggcccaggagggattttgcctgcctaaagaattcatggaagat tcagcaggagaaggagcaactgaattccatgactatgagggaggtggaattggggaaggc gagggcatgaaagatgtgagtgaccagatagaaaatgaagaacaggcagaagatacattt cagaaaggtcaagaaaaggataaagaggatcctaactcaaaatcagacattaagggcgag gataatgccattgagatgtcagaagactttgatgggaaaatgcatggtggcgaacttgaa gaacaagaagaggatgatgggaaatcagatagtgatggtggagacctggataaacagatg ggcgatctgaatggtgaggaagctgataaactagatgagaggctttggggtgatgatgat gaggaagaagaggaggaggaagaagacagtaaaactgaagaaacaggaccaggaatggat gaggaagattgtggacttgttgccaaagatgacaactcagatgctgggaaatcaaacaaa gataaaaaccaagttaaggaagaaaaggaagaagcagaagttgctgatgatggacaaggc caggacaaaattaatgaacaaatagatgagagggaatatgatgaaaatgaggtggaccct taccatggcaatcaggagaagctgccagaacctgaggccttggaccttccagacgacttg aacctagacagtgaagacaagaacggtggtgaggacacagaccatgaagaaggagaagaa aatcctttggaaattaaagaaaaaccaatggatactgaagaagcaggtcatgaagctgag gaaataaaggaagagatcgaggctgaccacagtgaagggcaaggccaacatgagcctgag gaaggccccagtgaagaggaaaagggcgaggaggaggaagagatggacacgggaactaac ggccaagacaaagatactgctgaacatcctgaagaagactcagaggatgagcatcattct ctggaagacaaggacgaggaagccagtaagggaagtgcagagaatggcgttcctgttgac caaggtctccagccccaggaagaagaaggcggagagaattctgacacagaggagcaggtg ccagaggccacggagaggaaagagcatgactcttgcggacagactgggttggagagtgtg cagagtgcacaagctgtggagctggctgggactgcgcctgagaaggagcaggggaaggag gaacacggaagtggagctgcagacgcaaatcaggcagaaggccatgaatccaacttcatc gctcggttggcttcccagaaacagaccaggaaaaacacacagagtttcaagaggaaacct ggacaggccgacaatgaacgctccatgggtgatcacagtgagcatgtgcataagcggctg aagactgtggatatggagaaccacactgagcaggggccagcccagccccagccgcaggca gaagacgcagatgcctttgagcacattaagcaaggcagtgacccctatgatgcacagatg tatgatgtggccagcaaggagcagcagcaacagtctacagaagattccaggagggatcag gaagaggaggtggaggataccttcctggacacagagaaggaggaggagctccgagcagca gacatagagcagctgaaaccagagaaggtcaagtcagggaccacgccgggctttgatgag atggaggtggagactcaagctgttaaaacagaagaagaccaagatcccaggactgaccta tcacaggaggagacagagaatgagaaaccagagagaagccgagattcgaccattcacaca gcccatcagttcctcatggacacagttttccagccctttttaaaagatatcagcgagcta agacaggaactggagagacagctggaaatgtggcagccacatgagtctggaaacccagaa gaagaaaaggctgcagctgagatgtggcagagttacctggccttaactgcgcctctttca cagcagttgtgtgaacagcttcgcctcatattagagcctacccaggcagccaagctgaaa ggagactatcgaaccgggaagcggctaaacatgaggaaggtcattccatacattgctagt caatttcggaaagacaagatttggcttcgaaggaccaagcccagtaaacgccagtatcag atttgtttggctatcgatgactcttctagcatggtggacaaccataccaaacagctggca tttgaatctttggctgtgattggaaatgctcttacactcctggaagtgggtcagattgct gtgtgcagttttggagagtccgtaaagctgttacatccattccatgaacagttcagtgac tcctcggggtcccagattctgcgactttgcaaattccaacagaagaaaaccaagattgct cagtttctggagtctgtagccagcatgtttgcagctgctcagcagccctcacagaacacc agtccagaaaccgcacaactcctcctggtggtctctgatggacgtggccttttcctcgag ggtaaagacagagtactggcagccgtccaggccgcccggaatgctaacatctttgtcatt tttgttgtattggacaatcccagttcacgggattctatcttggatattaaagtgccaata tttaaaggacctggagagatgcccgaaatccgatcatacatggaagagttcccattccca ttctacatcattcttcgcgatgtgaatgccctccctgagacactcagcgatgctctgagg cagtggtttgagttggtggcagcctccgatcacctgtag

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