Canis lupus familiaris (dog): 476714
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Entry
476714 CDS
T01007
Symbol
TYK2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X1
KO
K11219
non-receptor tyrosine-protein kinase TYK2 [EC:
2.7.10.2
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa04217
Necroptosis
cfa04380
Osteoclast differentiation
cfa04620
Toll-like receptor signaling pathway
cfa04621
NOD-like receptor signaling pathway
cfa04630
JAK-STAT signaling pathway
cfa04658
Th1 and Th2 cell differentiation
cfa04659
Th17 cell differentiation
cfa05145
Toxoplasmosis
cfa05160
Hepatitis C
cfa05161
Hepatitis B
cfa05162
Measles
cfa05164
Influenza A
cfa05165
Human papillomavirus infection
cfa05167
Kaposi sarcoma-associated herpesvirus infection
cfa05168
Herpes simplex virus 1 infection
cfa05169
Epstein-Barr virus infection
cfa05171
Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
476714 (TYK2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
476714 (TYK2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
476714 (TYK2)
04621 NOD-like receptor signaling pathway
476714 (TYK2)
04658 Th1 and Th2 cell differentiation
476714 (TYK2)
04659 Th17 cell differentiation
476714 (TYK2)
09158 Development and regeneration
04380 Osteoclast differentiation
476714 (TYK2)
09160 Human Diseases
09172 Infectious disease: viral
05161 Hepatitis B
476714 (TYK2)
05160 Hepatitis C
476714 (TYK2)
05171 Coronavirus disease - COVID-19
476714 (TYK2)
05164 Influenza A
476714 (TYK2)
05162 Measles
476714 (TYK2)
05168 Herpes simplex virus 1 infection
476714 (TYK2)
05167 Kaposi sarcoma-associated herpesvirus infection
476714 (TYK2)
05169 Epstein-Barr virus infection
476714 (TYK2)
05165 Human papillomavirus infection
476714 (TYK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
476714 (TYK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
cfa01001
]
476714 (TYK2)
Enzymes [BR:
cfa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
476714 (TYK2)
Protein kinases [BR:
cfa01001
]
Non-receptor tyrosine kinases
JAK family [OT]
476714 (TYK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
SH2_1
FERM_F1
Kinase-like
Kdo
RIO1
FERM_C_FAK1
ABC1
Motif
Other DBs
NCBI-GeneID:
476714
NCBI-ProteinID:
XP_022262766
Ensembl:
ENSCAFG00000017834
VGNC:
48024
UniProt:
A0A8C0T9X1
A0A8I3PUC3
LinkDB
All DBs
Position
20:50617718..50639776
Genome browser
AA seq
1180 aa
AA seq
DB search
MPLCHSGATTRDSRPDGDEAQPLATRGGLKVLLHWAGPGGGDPWVTFSEATLTAEDVCIH
IAHKVGITPSCFNLFALFDAEAQVWLPPNHILEVSGDMNLTLYFRMRFYFRNWHGTNSQE
PAVYRCGPTGTKSSSEQAEQGVQLLDPASFEYLFEQGKHEFVNDVASLWDLSSEEEIHHF
KNESLGMAFLHLCHLALSHGIPLEKVAKKISFKDCIPRSFRLQIRRHNALTRLRLRSIFR
RFVRAFQPGHISQQVIMVKYLATLEQLAPRFGTERVPVCHLELLAQAVGESCYIRDSGQA
PPEPELATGPPTHEVLVTGTGGIQWRPVQAESPRGDSSSRNRHADPFRKKTKAGEVGDQP
VDRPQEEPWVYFCDFQDITHVVLKERHISIHCQDNKSLELTLPSRAMALSWVSLVDGYFR
LTADSSHYLCHEVAPPRLVMSIQDGIHGPLMEPFVLAKLRSEDGLYLIHWSTSHLNRLIL
TVAQRDQSPGTQRLHLRKFPIELQAGVFRLEGWDRSFPSVRELRAALQGCSLRAGDDCFS
LRRCCLPRPGEISNLIIMRGPRAVTSPPNVSQLSFHRICQADVTQLSHLGQGTRTNVYEG
VLRVGARAPKEGAADGEDPPTPSEDSGLELRVVLKVLDPSHHDIALAFYETASLMSQVSH
VHLAFVHGICVYGSENIMVTEYVEHGPLDVWLRREKGHVPVAWKVAVAQQLASALSYLED
KSLVHGNVCGRNILLARLGLEEGTSPFIKLSDPGVGLGALSREERIERIPWIAPECLTGG
ANSLTTAADKWGFGATLLEICFDGEAPLQGRGPSEKECFYQKQHLLPQPSCPELATLISQ
CLTYEPAQRPSFRTILRDLTQLQPQNLADVLAVNPDSPASDPTVFHKRYLKKIRDLGEGH
FGKVSLYCYDPTNDGTGEMVAVKAIKAGCGPQLRTCWRREIDILRTLHHKHIVKYKGCCE
DQGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHAQHYVHRDLAAR
NVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSF
GVTLYELLTYCDSSQSPPSKFIELIGLTQGQMTVLRLTELLERGERLPRPEKCPYEIYLL
MKNCWEAEASFRPTFQNLIPILKTVQEKYQGQAASVFNVC
NT seq
3543 nt
NT seq
+upstream
nt +downstream
nt
atgcctctgtgccattcgggtgccaccaccagggacagcaggcctgatggcgatgaagct
cagcccctggccaccaggggaggcctgaaggtccttctgcactgggctggccctggtggc
ggggacccatgggtcaccttcagcgaggccacactgaccgcagaggatgtctgcatccac
attgcacacaaagtcggcattactccatcctgcttcaatctctttgctctcttcgatgcc
gaggcccaggtctggctgcctccaaaccacatcttggaggtctccggagacatgaacctg
accctgtacttccgcatgaggttttatttccggaactggcatggcacaaattctcaggag
ccggctgtgtaccgctgtgggcccacagggaccaagtcctcctcagaacaagcagagcag
ggggtgcagctactggacccagcctcctttgaatacctctttgagcagggcaagcatgag
tttgtgaatgacgtggcgtcactgtgggatctgtcgagcgaggaggagatccaccatttt
aagaacgagagtctgggcatggcctttctgcacctctgccaccttgctctctcccatggc
atccccctggagaaggtggccaagaagatcagcttcaaggactgcattccacgctccttc
cggctgcagatccggcggcacaatgcgttgacccggctgcgtctgcggagcatcttccgc
aggttcgtgcgggccttccagccgggccacatctcgcagcaggtcatcatggtcaaatac
ctggccacgctcgagcagctggcgccccgcttcggcacggagcgcgtgcctgtgtgccac
ctggagctcctggcccaggccgtgggggagtcctgctacatccgggacagcgggcaggcc
cctccagagcctgagctggccaccggaccccccactcatgaggtgctggtgacaggcact
ggtggcatccagtggcggccggtacaggcagagagtcccagaggcgacagcagcagcagg
aatcgccatgctgacccatttaggaagaaaaccaaggccggagaggtgggcgaccagcca
gtggacaggcctcaggaagagccatgggtctacttctgtgacttccaggatatcacccac
gtggtgctcaaggaacgccacatcagcatccactgtcaggacaacaagagcctggagctg
accctgccttcccgggctatggccctgtcctgggtgtcgctggtggacggctacttccgc
ctgacagccgactcaagccactacctgtgccatgaggtggcccctccacggctagtgatg
agcatccaggacggtatccatggacccttgatggagccctttgtgctggccaagctgcgg
tctgaggatggcctctacctcatccactggagcaccagccacctcaaccgcctcatcctg
acggtggcccagcgggaccagagcccgggcacacagcgcttgcacctgcgtaaattcccc
attgagctgcaggccggggtcttcaggctggagggctgggaccggtccttccccagcgtg
cgggagctgcgagccgccctgcagggctgctccctgcgcgccggggatgactgcttctcc
ctgcgccgctgctgcctgcctcggcccggagagatctccaacctcatcattatgcggggg
ccccgggctgtcacaagtccacccaacgtcagccagctcagcttccaccggatctgccag
gctgatgtcacccagctgtcccacctgggccaaggcacgaggaccaatgtgtatgagggc
gtgttacgagtgggggcaagagcccccaaggagggcgcggcggacggtgaggaccccccc
acacccagtgaggactctgggctggagctccgagtggtactcaaggtgctagaccctagt
caccacgacatcgccctggccttctacgagacagccagcctcatgagccaggtctcccat
gtgcacctggccttcgtacacggcatctgcgtgtatggctctgagaacatcatggtgaca
gagtacgtggagcacgggcccctggacgtgtggctgcggcgagagaagggccatgtgccc
gtggcctggaaggtggcagtggcccaacagctggccagcgccctcagctacctggaagac
aagagcctggttcacggtaatgtgtgtggtcggaacatcctgctggcgcggctggggctg
gaggagggcaccagccccttcatcaagctgagtgaccccggtgtgggcttgggtgccctt
tccagagaggagcggatcgagcggatcccctggatagcccccgagtgcctgactggcggg
gccaacagcctaaccactgctgccgataaatggggcttcggtgctaccctcctggagatc
tgcttcgacggggaggcccccctgcagggccgtggcccctccgagaaagagtgcttctac
cagaagcagcacctgcttcctcagccctcctgcccggagctggccacactcatcagccag
tgcctgacctacgaaccagctcagcggccctccttccgcaccatcctgcgtgacctcact
cagctgcagccccagaatcttgctgacgtcttggctgtgaaccccgactcacctgcatca
gaccccaccgtcttccacaagcgctatttgaaaaagatccgggatctgggcgagggccat
ttcggcaaggtcagtctgtattgctacgacccaaccaacgacggcactggtgagatggtg
gcggtgaaggccatcaaggccggctgcggcccccagctccgcacctgctggaggagggag
atagacatcctgcggacgctccatcacaagcacatcgtcaaatacaagggctgctgtgag
gaccaaggagagaagtcggtgcagctcgtcatggagtacgtgcccctgggaagcctacga
gactacctgccccggcacagcgtcggactggcccagctgcttctcttcgctcagcagatc
tgtgagggcatggcctaccttcacgcacagcactacgtgcatcgagacctggctgcccgc
aacgtgctgctggacaacgacagactggtcaaaatcggggactttggcctagccaaggct
gtgcccgaaggccacgagtactaccgcgtgcgcgaagatggggacagccccgtgttctgg
tatgctccagagtgcctgaaagagtgtaaattctactatgcatccgacgtctggtccttc
ggggtcaccctgtacgagctactgacctactgtgactccagccagagccccccctcgaaa
ttcatcgagctcataggcctcacccaggggcagatgacggtgctgaggctcacagagctg
ctggaacgaggggagaggctgccccggccagagaaatgtccttatgagatctatctcctc
atgaagaactgctgggaggcagaagcttcattccgccccaccttccagaacctcataccc
attctcaagacggtccaggagaaataccaaggccaggccgcctcagtgttcaatgtctgc
tga
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