KEGG   Canis lupus familiaris (dog): 477085
Entry
477085            CDS       T01007                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04081  Hormone signaling
cfa04140  Autophagy - animal
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04152  AMPK signaling pathway
cfa04210  Apoptosis
cfa04211  Longevity regulating pathway
cfa04213  Longevity regulating pathway - multiple species
cfa04218  Cellular senescence
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04517  IgSF CAM signaling
cfa04518  Integrin signaling
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
cfa04668  TNF signaling pathway
cfa04670  Leukocyte transendothelial migration
cfa04722  Neurotrophin signaling pathway
cfa04725  Cholinergic synapse
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04923  Regulation of lipolysis in adipocytes
cfa04926  Relaxin signaling pathway
cfa04929  GnRH secretion
cfa04930  Type II diabetes mellitus
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa04960  Aldosterone-regulated sodium reabsorption
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05017  Spinocerebellar ataxia
cfa05020  Prion disease
cfa05100  Bacterial invasion of epithelial cells
cfa05132  Salmonella infection
cfa05135  Yersinia infection
cfa05142  Chagas disease
cfa05146  Amoebiasis
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05162  Measles
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05168  Herpes simplex virus 1 infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05200  Pathways in cancer
cfa05203  Viral carcinogenesis
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05218  Melanoma
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05222  Small cell lung cancer
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    477085 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    477085 (PIK3CB)
   04014 Ras signaling pathway
    477085 (PIK3CB)
   04015 Rap1 signaling pathway
    477085 (PIK3CB)
   04370 VEGF signaling pathway
    477085 (PIK3CB)
   04630 JAK-STAT signaling pathway
    477085 (PIK3CB)
   04668 TNF signaling pathway
    477085 (PIK3CB)
   04066 HIF-1 signaling pathway
    477085 (PIK3CB)
   04068 FoxO signaling pathway
    477085 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    477085 (PIK3CB)
   04072 Phospholipase D signaling pathway
    477085 (PIK3CB)
   04071 Sphingolipid signaling pathway
    477085 (PIK3CB)
   04024 cAMP signaling pathway
    477085 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    477085 (PIK3CB)
   04152 AMPK signaling pathway
    477085 (PIK3CB)
   04150 mTOR signaling pathway
    477085 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    477085 (PIK3CB)
   04517 IgSF CAM signaling
    477085 (PIK3CB)
   04518 Integrin signaling
    477085 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    477085 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    477085 (PIK3CB)
   04218 Cellular senescence
    477085 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    477085 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    477085 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    477085 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    477085 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    477085 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    477085 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    477085 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    477085 (PIK3CB)
   04660 T cell receptor signaling pathway
    477085 (PIK3CB)
   04662 B cell receptor signaling pathway
    477085 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    477085 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    477085 (PIK3CB)
   04670 Leukocyte transendothelial migration
    477085 (PIK3CB)
   04062 Chemokine signaling pathway
    477085 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    477085 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    477085 (PIK3CB)
   04929 GnRH secretion
    477085 (PIK3CB)
   04915 Estrogen signaling pathway
    477085 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    477085 (PIK3CB)
   04917 Prolactin signaling pathway
    477085 (PIK3CB)
   04926 Relaxin signaling pathway
    477085 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    477085 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    477085 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    477085 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    477085 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    477085 (PIK3CB)
   04722 Neurotrophin signaling pathway
    477085 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    477085 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    477085 (PIK3CB)
   04380 Osteoclast differentiation
    477085 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    477085 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    477085 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    477085 (PIK3CB)
   05206 MicroRNAs in cancer
    477085 (PIK3CB)
   05205 Proteoglycans in cancer
    477085 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    477085 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    477085 (PIK3CB)
   05203 Viral carcinogenesis
    477085 (PIK3CB)
   05230 Central carbon metabolism in cancer
    477085 (PIK3CB)
   05231 Choline metabolism in cancer
    477085 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    477085 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    477085 (PIK3CB)
   05212 Pancreatic cancer
    477085 (PIK3CB)
   05225 Hepatocellular carcinoma
    477085 (PIK3CB)
   05226 Gastric cancer
    477085 (PIK3CB)
   05214 Glioma
    477085 (PIK3CB)
   05221 Acute myeloid leukemia
    477085 (PIK3CB)
   05220 Chronic myeloid leukemia
    477085 (PIK3CB)
   05218 Melanoma
    477085 (PIK3CB)
   05211 Renal cell carcinoma
    477085 (PIK3CB)
   05215 Prostate cancer
    477085 (PIK3CB)
   05213 Endometrial cancer
    477085 (PIK3CB)
   05224 Breast cancer
    477085 (PIK3CB)
   05222 Small cell lung cancer
    477085 (PIK3CB)
   05223 Non-small cell lung cancer
    477085 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    477085 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    477085 (PIK3CB)
   05161 Hepatitis B
    477085 (PIK3CB)
   05160 Hepatitis C
    477085 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    477085 (PIK3CB)
   05164 Influenza A
    477085 (PIK3CB)
   05162 Measles
    477085 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    477085 (PIK3CB)
   05163 Human cytomegalovirus infection
    477085 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    477085 (PIK3CB)
   05169 Epstein-Barr virus infection
    477085 (PIK3CB)
   05165 Human papillomavirus infection
    477085 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    477085 (PIK3CB)
   05135 Yersinia infection
    477085 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    477085 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    477085 (PIK3CB)
   05142 Chagas disease
    477085 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    477085 (PIK3CB)
   05017 Spinocerebellar ataxia
    477085 (PIK3CB)
   05020 Prion disease
    477085 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    477085 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    477085 (PIK3CB)
   05415 Diabetic cardiomyopathy
    477085 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    477085 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    477085 (PIK3CB)
   04931 Insulin resistance
    477085 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    477085 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    477085 (PIK3CB)
   01524 Platinum drug resistance
    477085 (PIK3CB)
   01522 Endocrine resistance
    477085 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    477085 (PIK3CB)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     477085 (PIK3CB)
Membrane trafficking [BR:cfa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    477085 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 LepB_N
Other DBs
NCBI-GeneID: 477085
NCBI-ProteinID: XP_038313250
Ensembl: ENSCAFG00000007579
VGNC: 44556
UniProt: A0A8C0N9K7 A0A8I3PWT3
LinkDB
Position
23:complement(34826488..35032061)
AA seq 1070 aa
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQILW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNDFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPNDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNASNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKNI
NPCKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNKAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaagcagattttatgg
aaacaagttcacaattatccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgatccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcctgaagtgaatgatttccgaataaaaatgcgcaaattcagtgaggaaaagatt
cagtcacttgtgggattgtcttggatggattggctgaagcagacatatccaccagaacat
gaaccatcgatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggacgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagccccaatgattatgtgttgcaagtcagtgggagagtagaatatgtatttggtgat
cacccactaattcaattccagtatatccggaactgtgtaatgaacaggactttgccccat
tttatgcttgtggaatgttgcaagattaagaagatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaatgcatcaaaccttcctcttcctttacccccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaatcctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggccggcctttttcatggt
actgaactcctctgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatacttgtgacctgccacgaatggctcgatta
tgttttgctgtttatgcagttttggataaagtgaaaacaaaaaagtcaactaaaaatatt
aatccctgtaaatatcagaccatccggaaatctgggaaagtgcattatcctgtggcatgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattatcctccctttgataagataatcgagaaggcagctgagattgcaagc
agtgacagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcctttgtctcaactttgtgagaatgaaatggatcttatatggact
ttgagacaagattgcagagagaattttccacagtcactgccaaaattactgctgtcgatc
aagtggaataagcttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctgcccccccgggaggccttagagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcagtatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctgtctagattccta
ttagaaagagcgcttgctaatcggaggatagggcagtttctattttggcaccttaggtca
gaagtgcatatccctgctgtctcagtacagtttggtgtcatccttgaagcatattgccgg
ggaagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagctaaacaaagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtcg
cctctgaatccatgtgttatactttcagaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaacaacaaagtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgctg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcgacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgccgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatataattctggggatgacctagaccgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgggtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaagtttggc
cgcttccgccagtgttgtgaggatgcatatctgatattacgacgacacgggaatctcttc
atcaccctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcgcacacagttcggaaagactacagatcttaa

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