KEGG   Canis lupus familiaris (dog): 477160
Entry
477160            CDS       T01007                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04062  Chemokine signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04081  Hormone signaling
cfa04082  Neuroactive ligand signaling
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04270  Vascular smooth muscle contraction
cfa04310  Wnt signaling pathway
cfa04371  Apelin signaling pathway
cfa04540  Gap junction
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04621  NOD-like receptor signaling pathway
cfa04713  Circadian entrainment
cfa04720  Long-term potentiation
cfa04723  Retrograde endocannabinoid signaling
cfa04724  Glutamatergic synapse
cfa04725  Cholinergic synapse
cfa04726  Serotonergic synapse
cfa04728  Dopaminergic synapse
cfa04730  Long-term depression
cfa04742  Taste transduction
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04911  Insulin secretion
cfa04912  GnRH signaling pathway
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04918  Thyroid hormone synthesis
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04922  Glucagon signaling pathway
cfa04924  Renin secretion
cfa04925  Aldosterone synthesis and secretion
cfa04926  Relaxin signaling pathway
cfa04927  Cortisol synthesis and secretion
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04929  GnRH secretion
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa04961  Endocrine and other factor-regulated calcium reabsorption
cfa04970  Salivary secretion
cfa04971  Gastric acid secretion
cfa04972  Pancreatic secretion
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05016  Huntington disease
cfa05017  Spinocerebellar ataxia
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05142  Chagas disease
cfa05143  African trypanosomiasis
cfa05146  Amoebiasis
cfa05163  Human cytomegalovirus infection
cfa05200  Pathways in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
Module
cfa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    477160 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    477160 (PLCB4)
   04310 Wnt signaling pathway
    477160 (PLCB4)
   04371 Apelin signaling pathway
    477160 (PLCB4)
   04020 Calcium signaling pathway
    477160 (PLCB4)
   04070 Phosphatidylinositol signaling system
    477160 (PLCB4)
   04072 Phospholipase D signaling pathway
    477160 (PLCB4)
   04071 Sphingolipid signaling pathway
    477160 (PLCB4)
   04022 cGMP-PKG signaling pathway
    477160 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    477160 (PLCB4)
   04081 Hormone signaling
    477160 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    477160 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    477160 (PLCB4)
   04613 Neutrophil extracellular trap formation
    477160 (PLCB4)
   04621 NOD-like receptor signaling pathway
    477160 (PLCB4)
   04062 Chemokine signaling pathway
    477160 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    477160 (PLCB4)
   04922 Glucagon signaling pathway
    477160 (PLCB4)
   04929 GnRH secretion
    477160 (PLCB4)
   04912 GnRH signaling pathway
    477160 (PLCB4)
   04915 Estrogen signaling pathway
    477160 (PLCB4)
   04921 Oxytocin signaling pathway
    477160 (PLCB4)
   04926 Relaxin signaling pathway
    477160 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    477160 (PLCB4)
   04918 Thyroid hormone synthesis
    477160 (PLCB4)
   04919 Thyroid hormone signaling pathway
    477160 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    477160 (PLCB4)
   04916 Melanogenesis
    477160 (PLCB4)
   04924 Renin secretion
    477160 (PLCB4)
   04925 Aldosterone synthesis and secretion
    477160 (PLCB4)
   04927 Cortisol synthesis and secretion
    477160 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    477160 (PLCB4)
   04270 Vascular smooth muscle contraction
    477160 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    477160 (PLCB4)
   04971 Gastric acid secretion
    477160 (PLCB4)
   04972 Pancreatic secretion
    477160 (PLCB4)
   04973 Carbohydrate digestion and absorption
    477160 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    477160 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    477160 (PLCB4)
   04725 Cholinergic synapse
    477160 (PLCB4)
   04728 Dopaminergic synapse
    477160 (PLCB4)
   04726 Serotonergic synapse
    477160 (PLCB4)
   04720 Long-term potentiation
    477160 (PLCB4)
   04730 Long-term depression
    477160 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    477160 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    477160 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    477160 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    477160 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    477160 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    477160 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    477160 (PLCB4)
   05142 Chagas disease
    477160 (PLCB4)
   05143 African trypanosomiasis
    477160 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    477160 (PLCB4)
   05016 Huntington disease
    477160 (PLCB4)
   05017 Spinocerebellar ataxia
    477160 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    477160 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    477160 (PLCB4)
   05415 Diabetic cardiomyopathy
    477160 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    477160 (PLCB4)
   04934 Cushing syndrome
    477160 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    477160 (PLCB4)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     477160 (PLCB4)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    477160 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    477160 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 477160
NCBI-ProteinID: XP_013962517
Ensembl: ENSCAFG00000005760
VGNC: 44646
UniProt: A0A8C0QFL9
LinkDB
Position
24:complement(12575552..12993940)
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAAMGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSV
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gccatttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtattcgattgggagccaccccaaaggatcccaaaatcttg
gccgctcttgaggctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgagaatccagaa
gtaactaagcaatgggtagaaggattgagatcaatcatacataacttcagagccaacaat
gttagtccaatgacctgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagtcaggagtattactagaacgtttgcgtcggggaaaacagaaaaa
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgagaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgcaaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccaccctctggcc
cactacttcatcagttcttcacataacacctatctcactggccgacagtttggtgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgttgggacggaaaaggtgaagaccaagaaccaataataactcatggaaaagctatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgccccagttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaggctgttgcaaatagtgtcaagaaggcgtcggat
gaccttgaacatgaaatcaacaaaaagggcctggttactgtagaagatgagcaggcatgg
atggcatcatataagtatgtaggtgctaccactaatatccatccatatttgtctacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaacgagtccgttggtctaggctacttgaagacacatgca
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccgg
gttgattccagtaattacatgcctcaaattttctggaatgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgtgggtacctcctcaaaccagatttcatgagacggcccgatcgaacctttgat
ccattctctgaaacgcctgtcgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaagattggtacgtacgtagaagtggatatgtatggg
ttgcccaccgacactatccgtaaggaattccgaactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgacgacaacaataggctgataggccagaggattcttcca
ctggatggcctccaagcaggctatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagcgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaatgtgaccccacag
agcagctccgagctcagaccaaccaccacagcagccatggggtctggtgtggaagccaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ctgaagcacttaaagaagcaacagaaggagctaaattctttaaagaagaaacatgcgaag
gaacacagcaccatgcagaagttgcactgcacacaagttgacaaaattgtggcacagtat
gacaaagagaagtcgacacatgagaaaatcctagagaaggcgatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctgcaccttagccagcagtgtgag
ctcctgagaaagctactgatcagtgcccatgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctagagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtgtg
aaactccaaaatgcaaactga

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