Canis lupus familiaris (dog): 477498 Help Entry 477498            CDS       T01007                                  Symbol NOS1 Name (RefSeq) nitric oxide synthase, brain   KO K13240   nitric-oxide synthase, brain [EC:1.14.13.39] Organism cfa  Canis lupus familiaris (dog) Pathway cfa00220   Arginine biosynthesis cfa00330   Arginine and proline metabolism cfa01100   Metabolic pathways cfa04020   Calcium signaling pathway cfa04081   Hormone signaling cfa04145   Phagosome cfa04371   Apelin signaling pathway cfa04713   Circadian entrainment cfa04730   Long-term depression cfa04926   Relaxin signaling pathway cfa04970   Salivary secretion cfa05010   Alzheimer disease cfa05014   Amyotrophic lateral sclerosis cfa05022   Pathways of neurodegeneration - multiple diseases cfa05410   Hypertrophic cardiomyopathy cfa05412   Arrhythmogenic right ventricular cardiomyopathy cfa05414   Dilated cardiomyopathy cfa05416   Viral myocarditis Brite KEGG Orthology (KO) [BR:cfa00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     477498 (NOS1)    00330 Arginine and proline metabolism     477498 (NOS1)  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     477498 (NOS1)    04020 Calcium signaling pathway     477498 (NOS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     477498 (NOS1)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     477498 (NOS1)  09150 Organismal Systems   09152 Endocrine system    04926 Relaxin signaling pathway     477498 (NOS1)   09154 Digestive system    04970 Salivary secretion     477498 (NOS1)   09156 Nervous system    04730 Long-term depression     477498 (NOS1)   09159 Environmental adaptation    04713 Circadian entrainment     477498 (NOS1)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     477498 (NOS1)    05014 Amyotrophic lateral sclerosis     477498 (NOS1)    05022 Pathways of neurodegeneration - multiple diseases     477498 (NOS1)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     477498 (NOS1)    05412 Arrhythmogenic right ventricular cardiomyopathy     477498 (NOS1)    05414 Dilated cardiomyopathy     477498 (NOS1)    05416 Viral myocarditis     477498 (NOS1) Enzymes [BR:cfa01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      477498 (NOS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 PDZ PDZ_6 PDZ_2 Motif Other DBs NCBI-GeneID:  477498 NCBI-ProteinID:  NP_001182074 Ensembl:  ENSCAFG00000009820 VGNC:  43894 UniProt:  A0A8C0PPA5 A0A8I3PUD9 LinkDB All DBs Position 26:complement(13781845..13865309) Genome browser AA seq 1431 aa AA seqDB search MESQVFSVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA GDIILAVNGQPLVDLNYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI RVTRPLGPPTTAVDLSHQSSASKEHTPDGATGPGNGPQHIQDSGQQASSLLNTNSLAPRP PSQDSTKKSTGVALQDSQNNELLKEIEPVLSLLTSGNKGINGVGPSKAETKDAEVQVDRG MDSKSHKPLPLGVENDRVFSDLWGKGHVPVVLNNPYSEKEQPPASGKQSPTKNGSPSKCP RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQQIRRPEDVRTKEQLFPLA KEFIDQYYSSIKRSGSKAHTERLEEVNKEIETTGTYQLKDTELIYGAKHAWRNASRCVGR IQWSKLQVFDARDCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQ LIRYAGYKQPDGSILGDPANVEFTEICTQQGWKPPRGRFDVLPLLLQANGNDPELFQIPP ELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDY CDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESF IKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPEPWNTHVWKG TNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFK HAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVHEER KSYKVRFNSVSSYSDSHKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHA VDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLI SNDRSWKRNKFRLTYVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLH TNGNQELQYQPGDHLGVFPGNREDLVNALMERLEDAPPVNQLVKVELLEERNTALGVISN WTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEW KWGKNPTIVEVLEEFPSIQMPSTLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYR TGDGEGPIHHGVCSSWLNRIQADEVVPCFVRGAPSFHLPRNPQVPCILIGPGTGIAPFRS FWQQRQFDIQHKGMSPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDK PKKYVQDILQEQLAEPVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSVEDAG VFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS NT seq 4296 nt NT seq  +upstreamnt  +downstreamnt atggagagtcaggtgttcagtgttcagcaaatccaacccaacgtcatttctgtccgcctc ttcaagcgcaaggtggggggtctgggcttcctggtgaaggagcgagtgagcaagccgccc gtgatcatctctgacctgattcgggggggtgctgcggagcagagcggcctcatccaggcc ggcgacatcatcctcgcagtcaacggccagcccttggtggacctgaactatgacagtgcc ctggaggtgctcaggggcattgcctctgagacacatgtagtcctcattctgaggggccct gaaggcttcaccactcacctggagaccactttcactggggatgggacccccaagaccatc cgggtaacacggcccctgggtccccccaccacagctgtggatctgtctcaccagtcatcc gccagcaaagagcacacaccggacggggccacaggtcctggcaatgggccacagcatatc caagacagtggccagcaagccagctcactcttgaataccaacagcctggctcccagaccc ccgagccaggactctaccaagaagagtaccggggttgctctccaggacagccagaacaat gaattgctcaaagagatagagcctgtgctgagtcttctcaccagtggaaacaaagggatc aatggagtgggaccttccaaagcagagacaaaagatgcagaagtccaggtggacagaggt atggacagcaagtcacacaaaccactgccccttggcgtggagaatgaccgagtcttcagt gacctgtgggggaagggccatgtgcctgtcgtcctcaacaacccgtattcagagaaggag cagccccctgcctcgggaaaacagtctcccacaaagaatggaagcccctccaagtgcccc cgcttcctcaaggtcaagaactgggagacggatgtggttctcactgacaccctccacctt aagagcacattggaaacgggatgcaccgagcacatctgtatgggctccatcatgctccct tctcagcaaatacgaaggcctgaagacgtccgcacaaaagaacagctctttcctctcgcc aaagagttcattgatcagtactactcgtcaattaaaagatctggctccaaagcccacaca gagaggctggaagaggtgaacaaagagatcgaaaccacaggcacctaccagctcaaagac acggagctcatctatggggcaaagcacgcctggcggaatgcctcccgctgcgtcggcagg atccagtggtccaagctgcaggtgttcgatgcccgtgactgcaccacagctcatgggatg ttcaactacatctgcaaccacatcaagtatgccaccaacaaagggaacctccggtctgcc atcaccatatttccccagaggactgacggcaagcacgatttccgagtctggaactctcag ctcatccgctatgccggctacaagcagcccgacggttccatcctaggggacccagccaac gtggaattcacagagatctgcacacagcagggctggaaacccccaagaggccgcttcgat gtcctgccactcctgctccaggccaacggcaacgaccccgagctcttccagattcctcca gagctggtgttggaagtacccattaggcaccccaagtttgagtggttcaaggatctgggc ctgaagtggtacggcctccccgctgtgtccaacatgctgctggagatcggcggcctggag ttcagcgcctgtcccttcagcggctggtacatgggcacagagattggcgtccgcgactac tgtgacaactctcgatacaacatcctggaggaagtggccaagaagatgaacttggacatg aggaagacatcctccctgtggaaggaccaggcactggtggaaattaacattgctgtcctc tatagcttccagagtgacaaagttaccatcgttgaccaccactctgccaccgagtccttc attaagcacatggagaatgaataccgctgccgagggggctgccctgctgactgggtgtgg attgtgccccccatgtctggcagcatcacccctgtcttccaccaggagatgctcaactac cggcttaccccctccttcgaataccagccggagccttggaacacccatgtctggaaaggt accaatgggacccccacaaagcggcgagccatcggtttcaagaagctggcagaagccgtc aagttctcggccaagctcatggggcaagcaatggccaagagggtcaaggcgaccatcctt tatgccactgagacgggcaagtcacaggcctatgctaaaaccttgtgtgagatcttcaaa catgcttttgatgccaaggtgatgtccatggaagaatatgacattgtacacctggagcat gaaactctggtcctggtggttaccagcacttttggcaatggagacccacctgagaatggg gagaaattcggctgtgctttgatggaaatgaggcatcccaactctgtgcatgaggaaagg aagagctacaaagtccggttcaatagtgtttcctcatattctgattctcataagtcatcg ggtgatgggccagacctcagagacaactttgagagtgctggacccctggcaaatgtgagg ttctctgtgtttggccttggctcccgggcttaccctcacttttgcgcctttggacatgct gtggacaccctcctggaggagctgggaggagagagaatcctgaagatgagggaaggggat gagctctgtggacaggaagaggctttcaggacttgggccaagaaggtcttcaaggcagcc tgtgatgtgttctgcgtgggagatgatgtcaacattgaaaaggccaacaactccctcatc agcaatgaccgcagctggaagagaaacaagttccgcctcacctatgtggccgaagctcca gaacttacacagggtctatccaacgtccacaaaaagcgggtctcagccgctcgactcctc agccgtcaaaaccttcagagtcctaaatccagccgatcaaccatcttcgtgcgtctccac accaatgggaatcaggagctgcagtaccagcctggggaccacctgggcgtcttccctggc aaccgcgaggaccttgtgaatgccctgatggagcggctagaggatgcaccccccgtcaac cagctggtgaaggtggagctactggaggagcgcaacacggctctgggagttatcagtaac tggacggatgagctccgcctcccaccctgcaccatcttccaggccttcaagtactacctg gacatcaccacgccgccaacgccactgcagctgcaacagtttgcctccctggccaccagc gagaaagagaagcagcgtctactggtcctcagcaagggtttacaggagtacgaggaatgg aaatggggtaagaaccccaccatcgtggaggtgctggaggagttcccgtccatccagatg ccttccaccctgctcctaacccagctgtcgctgctgcagccccgctactactccatcagc tcctccccagacatgtatccagatgaggtgcacctcaccgtggcaattgtctcctatcgc accggagatggagaaggaccaattcaccacggcgtgtgctcctcctggctcaaccggata caggctgacgaagtggtcccatgtttcgtgagaggagcacccagcttccacctgccccga aatccccaagtgccctgtatcctcattggcccaggcactggcatcgcccctttccgaagc ttctggcagcagcggcaatttgatatccaacacaaaggaatgagtccgtgccccatggtc ctggtgttcgggtgccggcagtccaagatagaccacatctacagggaggagactctacag gccaagaacaagggggtcttcagagaactgtacacggcctactcccgggagccagacaaa ccaaagaagtatgtgcaggacatcctgcaggagcagctagcagaacctgtgtaccgagcc ctgaaggagcaagggggccacatctatgtctgcggggacgtcaccatggccgccgatgtc ctcaaagccatccagcgcatcatgacccagcaggggaaactctctgtagaggacgcgggc gtgttcatcagcaggctgagggatgacaaccggtaccatgaggatattttcggggtcacc ctccgaacgtatgaagtgaccaaccgccttagatctgaatccattgccttcattgaagag agcaaaaaagacaccgatgaggttttcagctcctaa

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