Canis lupus familiaris (dog): 477625 Help Entry 477625            CDS       T01007                                  Symbol ADCY6 Name (RefSeq) adenylate cyclase type 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism cfa  Canis lupus familiaris (dog) Pathway cfa00230   Purine metabolism cfa01100   Metabolic pathways cfa01522   Endocrine resistance cfa04015   Rap1 signaling pathway cfa04022   cGMP-PKG signaling pathway cfa04024   cAMP signaling pathway cfa04062   Chemokine signaling pathway cfa04072   Phospholipase D signaling pathway cfa04081   Hormone signaling cfa04082   Neuroactive ligand signaling cfa04114   Oocyte meiosis cfa04211   Longevity regulating pathway cfa04213   Longevity regulating pathway - multiple species cfa04261   Adrenergic signaling in cardiomyocytes cfa04270   Vascular smooth muscle contraction cfa04371   Apelin signaling pathway cfa04540   Gap junction cfa04611   Platelet activation cfa04713   Circadian entrainment cfa04714   Thermogenesis cfa04723   Retrograde endocannabinoid signaling cfa04724   Glutamatergic synapse cfa04725   Cholinergic synapse cfa04727   GABAergic synapse cfa04742   Taste transduction cfa04750   Inflammatory mediator regulation of TRP channels cfa04911   Insulin secretion cfa04912   GnRH signaling pathway cfa04913   Ovarian steroidogenesis cfa04914   Progesterone-mediated oocyte maturation cfa04915   Estrogen signaling pathway cfa04916   Melanogenesis cfa04918   Thyroid hormone synthesis cfa04921   Oxytocin signaling pathway cfa04923   Regulation of lipolysis in adipocytes cfa04924   Renin secretion cfa04925   Aldosterone synthesis and secretion cfa04926   Relaxin signaling pathway cfa04927   Cortisol synthesis and secretion cfa04928   Parathyroid hormone synthesis, secretion and action cfa04934   Cushing syndrome cfa04935   Growth hormone synthesis, secretion and action cfa04961   Endocrine and other factor-regulated calcium reabsorption cfa04962   Vasopressin-regulated water reabsorption cfa04970   Salivary secretion cfa04971   Gastric acid secretion cfa04972   Pancreatic secretion cfa04976   Bile secretion cfa05032   Morphine addiction cfa05163   Human cytomegalovirus infection cfa05166   Human T-cell leukemia virus 1 infection cfa05200   Pathways in cancer cfa05207   Chemical carcinogenesis - receptor activation cfa05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:cfa00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     477625 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     477625 (ADCY6)    04072 Phospholipase D signaling pathway     477625 (ADCY6)    04024 cAMP signaling pathway     477625 (ADCY6)    04022 cGMP-PKG signaling pathway     477625 (ADCY6)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     477625 (ADCY6)    04081 Hormone signaling     477625 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     477625 (ADCY6)    04062 Chemokine signaling pathway     477625 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     477625 (ADCY6)    04923 Regulation of lipolysis in adipocytes     477625 (ADCY6)    04913 Ovarian steroidogenesis     477625 (ADCY6)    04915 Estrogen signaling pathway     477625 (ADCY6)    04921 Oxytocin signaling pathway     477625 (ADCY6)    04926 Relaxin signaling pathway     477625 (ADCY6)    04935 Growth hormone synthesis, secretion and action     477625 (ADCY6)    04918 Thyroid hormone synthesis     477625 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     477625 (ADCY6)    04924 Renin secretion     477625 (ADCY6)    04925 Aldosterone synthesis and secretion     477625 (ADCY6)    04927 Cortisol synthesis and secretion     477625 (ADCY6)   09154 Digestive system    04970 Salivary secretion     477625 (ADCY6)    04971 Gastric acid secretion     477625 (ADCY6)    04972 Pancreatic secretion     477625 (ADCY6)    04976 Bile secretion     477625 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     477625 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     477625 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     477625 (ADCY6)    04727 GABAergic synapse     477625 (ADCY6)    04725 Cholinergic synapse     477625 (ADCY6)    04723 Retrograde endocannabinoid signaling     477625 (ADCY6)   09157 Sensory system    04742 Taste transduction     477625 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     477625 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     477625 (ADCY6)    04213 Longevity regulating pathway - multiple species     477625 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     477625 (ADCY6)    04714 Thermogenesis     477625 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     477625 (ADCY6)    05207 Chemical carcinogenesis - receptor activation     477625 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     477625 (ADCY6)    05163 Human cytomegalovirus infection     477625 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     477625 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     477625 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     477625 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     477625 (ADCY6) Enzymes [BR:cfa01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      477625 (ADCY6) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  477625 NCBI-ProteinID:  NP_001182076 Ensembl:  ENSCAFG00000008907 VGNC:  37623 UniProt:  A0A8C0P6Z2 LinkDB All DBs Position 27:complement(40504946..40518306) Genome browser AA seq 1166 aa AA seqDB search MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRTSGFCTPRYMSCLRDAQPPSPTPAAPP RCPWQDEAFIRRGGPGKGTELGLRAVALGFEDTEAMSAVGAAEVAPDVTPGSRRSCWRRL AQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVA LLACAATLFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPRSPSVGLWCP VFFVYITYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQLGANMLLFLCTNVI GICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKK EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLR IKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHC GVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYL KEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQM GIDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS RKVDPRFGAYVACALLVFCFICFIQLLVFPHSTVMLGIYASIFVLLLITVLTCAVYSCGS LFPKALRRLSRSIVRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNVTPA DITACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAMI FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNDTFDGLDCPAAGRVALKYMTPVIL LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLA RERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEE RFRQLEKIKTIGSTYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQ MKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQ LECRGVVKVKGKGEMTTYFLNGGPPS NT seq 3501 nt NT seq  +upstreamnt  +downstreamnt atgtcgtggtttagtggcctcctggtccccaaagtggatgaacggaagacagcctggggt gaacgcaatgggcagaagcgtccacgccgcgggactcggaccagtggcttctgcacgccc cgctatatgagctgcctccgggatgcgcagccccccagtcccacccctgcggctccccct cggtgcccctggcaggatgaggccttcatccggagaggcggcccgggcaagggcacggag ctggggctgcgggcggtggccctgggcttcgaggacactgaggccatgtcagcggttggg gcagctgaggtggcccctgacgtgacccccgggagtaggcgatcctgctggcgccgtctg gcccaggtgttccagtcgaagcagttccgctcggccaagctggagcgcctgtaccagcgg tacttctttcagatgaaccagagcagcctgacgctgctgatggcggtgctggtgctgctg acagcggtgctgctagccttccatgctgcacctgcccgccctcagcctgcctacgtggcc ctgctggcctgtgccgccaccctcttcgtggcgctcatggtggtgtgtaaccggcacagc tttcgccaggactccatgtgggtggtgagctacgtggtgctgggcatcctggcagccgtt caggttgggggtgccctggcagccaacccccgcagcccctctgtgggcctctggtgccct gtgttttttgtctacatcacctacacgctcctacccatccgcatgcgggcagctgtcttc agtggcctgggcctgtccaccctgcatttgatcttggcctggcaactcaaccgcggtgac gccttcctctggaagcagctcggtgccaacatgctgctgttcctctgcaccaacgtcatt ggcatctgcacacactacccagctgaggtctctcagcgccaggcctttcaggagacccgc ggttacattcaggcccggctgcacctgcagcatgagaaccggcagcaggaacggctgctg ctgtccgtgttgccccagcatgttgccatggagatgaaagaagatatcaacacaaagaaa gaagacatgatgttccacaagatctacatccagaagcatgacaatgtcagcatcctgttt gcagacattgaaggcttcaccagcctggcgtcccagtgcaccgcgcaggagctggtcatg accctgaacgagctcttcgcccggtttgacaagctggctgcggaaaatcactgcctgagg atcaagatcttaggggactgttactactgtgtgtcggggctgccggaggcccgggcagac catgcccactgctgtgtggagatgggggtggacatgatcgaggccatctcgctggtgcgt gaggtgacaggtgtgaacgtgaacatgcgcgtgggcatccacagcgggcgtgtgcactgt ggcgtccttggcctgcggaaatggcagttcgacgtgtggtccaatgacgtgactctggcc aaccatatggaggcgggcggccgggccggccgcatccacatcacccgggccacgctgcag tacctgaacggggactacgaggtggagccgggccgcggtggcgagcggaacgcgtacctc aaggagcagcacatcgagaccttcctcatcctgggagccagccagaaacggaaagaggag aaggccatgctggccaagctgcagcggacgcgggccaactccatggaaggcctgatgcca cgctgggtgcccgaccgcgccttctcccggaccaaggactccaaggctttccgccagatg ggcattgatgattccagcaaagacaaccggggtgcccaagatgccctgaaccccgaggat gaggtcgatgagttcctgggccgtgccatcgatgcccgcagcatcgatcagctacggaag gaccatgtgcgccgcttcctgctcaccttccagagagaggatcttgaaaagaagtactca aggaaggtggacccccgcttcggagcctacgtggcctgtgcgctgttggtcttctgcttc atctgctttatccagctcctcgtcttcccacactcaaccgtgatgcttgggatctacgcc agtatctttgtgctgttgctgatcaccgtgctgacctgtgccgtgtactcctgtggctct ctcttccccaaggccctgcgacgtctttcccgcagcatcgtccgctctcgggcacacagc actgtggttggcattttttcagtcttgctagtgttcacctctgccatcgccaacatgttc acctgtaaccacacccccatccggacctgtgcagcccggatgctgaatgtaacacccgct gacatcactgcctgccacctgcagcagctcaattactctctgggcctggatgctccgctg tgtgagggcaccgcacccacttgcagcttccctgagtacttcgttgggaacatgctgctg agtctcttggccagctctgtcttcctgcacatcagtagcatcgggaagttggccatgatc tttgtcctggggctcatttatttggtgctgcttctgctgggccccccagccaccatcttt gacaactatgacctgctgcttggtgtccatggcttggcttcttccaatgacacctttgat gggctggactgcccagctgcggggagggtggcactgaaatacatgacccctgtgattctg ctggtgtttgccctggcgctgtatctgcacgcccagcaggtggaatcaactgcacgtctg gacttcctctggaaactgcaggcaacgggggagaaggaggagatggaggagctccaggcc tacaaccgaaggctgctgcataacattctgcctaaggacgtggctgcccacttcctggcc cgggagcgccggaacgatgagctctactaccagtcgtgtgagtgtgtggccgtcatgttt gcctccattgccaacttttctgagttctatgtggagctggaggcaaacaatgagggtgtc gagtgcctgcggctgctcaacgaaatcatcgccgactttgatgagatcatcagcgaggag cggttccggcagctggagaaaatcaagacgatcggtagcacgtacatggctgcgtcgggg ctgaacgccagcacctacgatcaggccggccgctcccacatcactgccctggccgactat gccatgcggctcatggagcagatgaaacacatcaacgagcactccttcaacaacttccag atgaagattgggctgaacatgggcccagttgtggcaggcgtcattggggctcggaagcca cagtatgacatctgggggaacacggtgaatgtctctagccgtatggacagcacgggggtt cctgaccgaatccaggtgaccacggacttgtaccaggttctagctgccaaaggctaccag ctggagtgtcgaggggtggtcaaggtgaagggcaagggggagatgaccacctacttcctc aatgggggcccccccagttag

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