KEGG   Canis lupus familiaris (dog): 477746
Entry
477746            CDS       T01007                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01522  Endocrine resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04024  cAMP signaling pathway
cfa04068  FoxO signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04137  Mitophagy - animal
cfa04140  Autophagy - animal
cfa04141  Protein processing in endoplasmic reticulum
cfa04210  Apoptosis
cfa04215  Apoptosis - multiple species
cfa04217  Necroptosis
cfa04310  Wnt signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04530  Tight junction
cfa04620  Toll-like receptor signaling pathway
cfa04621  NOD-like receptor signaling pathway
cfa04622  RIG-I-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04657  IL-17 signaling pathway
cfa04658  Th1 and Th2 cell differentiation
cfa04659  Th17 cell differentiation
cfa04660  T cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04668  TNF signaling pathway
cfa04722  Neurotrophin signaling pathway
cfa04723  Retrograde endocannabinoid signaling
cfa04728  Dopaminergic synapse
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04910  Insulin signaling pathway
cfa04912  GnRH signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04917  Prolactin signaling pathway
cfa04920  Adipocytokine signaling pathway
cfa04926  Relaxin signaling pathway
cfa04930  Type II diabetes mellitus
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa04936  Alcoholic liver disease
cfa05010  Alzheimer disease
cfa05012  Parkinson disease
cfa05016  Huntington disease
cfa05017  Spinocerebellar ataxia
cfa05020  Prion disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05132  Salmonella infection
cfa05133  Pertussis
cfa05135  Yersinia infection
cfa05142  Chagas disease
cfa05145  Toxoplasmosis
cfa05152  Tuberculosis
cfa05161  Hepatitis B
cfa05162  Measles
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05200  Pathways in cancer
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05212  Pancreatic cancer
cfa05231  Choline metabolism in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    477746 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    477746 (MAPK8)
   04012 ErbB signaling pathway
    477746 (MAPK8)
   04014 Ras signaling pathway
    477746 (MAPK8)
   04310 Wnt signaling pathway
    477746 (MAPK8)
   04668 TNF signaling pathway
    477746 (MAPK8)
   04068 FoxO signaling pathway
    477746 (MAPK8)
   04071 Sphingolipid signaling pathway
    477746 (MAPK8)
   04024 cAMP signaling pathway
    477746 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    477746 (MAPK8)
   04137 Mitophagy - animal
    477746 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    477746 (MAPK8)
   04215 Apoptosis - multiple species
    477746 (MAPK8)
   04217 Necroptosis
    477746 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    477746 (MAPK8)
   04530 Tight junction
    477746 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    477746 (MAPK8)
   04621 NOD-like receptor signaling pathway
    477746 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    477746 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    477746 (MAPK8)
   04660 T cell receptor signaling pathway
    477746 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    477746 (MAPK8)
   04659 Th17 cell differentiation
    477746 (MAPK8)
   04657 IL-17 signaling pathway
    477746 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    477746 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    477746 (MAPK8)
   04920 Adipocytokine signaling pathway
    477746 (MAPK8)
   04912 GnRH signaling pathway
    477746 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    477746 (MAPK8)
   04917 Prolactin signaling pathway
    477746 (MAPK8)
   04926 Relaxin signaling pathway
    477746 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    477746 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    477746 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    477746 (MAPK8)
   04722 Neurotrophin signaling pathway
    477746 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    477746 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    477746 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    477746 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    477746 (MAPK8)
   05231 Choline metabolism in cancer
    477746 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    477746 (MAPK8)
   05212 Pancreatic cancer
    477746 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    477746 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    477746 (MAPK8)
   05161 Hepatitis B
    477746 (MAPK8)
   05171 Coronavirus disease - COVID-19
    477746 (MAPK8)
   05162 Measles
    477746 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    477746 (MAPK8)
   05169 Epstein-Barr virus infection
    477746 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    477746 (MAPK8)
   05135 Yersinia infection
    477746 (MAPK8)
   05133 Pertussis
    477746 (MAPK8)
   05152 Tuberculosis
    477746 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    477746 (MAPK8)
   05142 Chagas disease
    477746 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    477746 (MAPK8)
   05012 Parkinson disease
    477746 (MAPK8)
   05016 Huntington disease
    477746 (MAPK8)
   05017 Spinocerebellar ataxia
    477746 (MAPK8)
   05020 Prion disease
    477746 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    477746 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    477746 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    477746 (MAPK8)
   05415 Diabetic cardiomyopathy
    477746 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    477746 (MAPK8)
   04936 Alcoholic liver disease
    477746 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    477746 (MAPK8)
   04931 Insulin resistance
    477746 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    477746 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    477746 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    477746 (MAPK8)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     477746 (MAPK8)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   477746 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 477746
NCBI-ProteinID: XP_005637524
Ensembl: ENSCAFG00000006551
VGNC: 43001
UniProt: A0A8C0NSG4
LinkDB
Position
28:552432..639965
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattccacattt
acagtcttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaaactaagccggcca
tttcagaatcagactcatgctaaacgggcttacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggacgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctacctgctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacaccttatgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacagccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgttggtaattgatgcatctaaaaggatctctgtagatgaagctctccagcacccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatacctgacaag
cagttagatgaaagggaacatacaatagaagagtggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcgtcatcatctgtcaatgatgtgtct
tcaatgtcaacagatccaactttggcctcagatacagacagcagtttagaagcatcagct
ggacctctgggctgctgtagatga

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