KEGG   Canis lupus familiaris (dog): 478347
Entry
478347            CDS       T01007                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04114  Oocyte meiosis
cfa04140  Autophagy - animal
cfa04148  Efferocytosis
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04210  Apoptosis
cfa04218  Cellular senescence
cfa04270  Vascular smooth muscle contraction
cfa04370  VEGF signaling pathway
cfa04371  Apelin signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04517  IgSF CAM signaling
cfa04519  Cadherin signaling
cfa04540  Gap junction
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagosome formation
cfa04668  TNF signaling pathway
cfa04720  Long-term potentiation
cfa04722  Neurotrophin signaling pathway
cfa04725  Cholinergic synapse
cfa04726  Serotonergic synapse
cfa04730  Long-term depression
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04912  GnRH signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04926  Relaxin signaling pathway
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04929  GnRH secretion
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa05010  Alzheimer disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05034  Alcoholism
cfa05132  Salmonella infection
cfa05135  Yersinia infection
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05216  Thyroid cancer
cfa05218  Melanoma
cfa05219  Bladder cancer
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    478347 (MAP2K1)
   04012 ErbB signaling pathway
    478347 (MAP2K1)
   04014 Ras signaling pathway
    478347 (MAP2K1)
   04015 Rap1 signaling pathway
    478347 (MAP2K1)
   04370 VEGF signaling pathway
    478347 (MAP2K1)
   04371 Apelin signaling pathway
    478347 (MAP2K1)
   04668 TNF signaling pathway
    478347 (MAP2K1)
   04066 HIF-1 signaling pathway
    478347 (MAP2K1)
   04068 FoxO signaling pathway
    478347 (MAP2K1)
   04072 Phospholipase D signaling pathway
    478347 (MAP2K1)
   04071 Sphingolipid signaling pathway
    478347 (MAP2K1)
   04024 cAMP signaling pathway
    478347 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    478347 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    478347 (MAP2K1)
   04150 mTOR signaling pathway
    478347 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    478347 (MAP2K1)
   04519 Cadherin signaling
    478347 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    478347 (MAP2K1)
   04148 Efferocytosis
    478347 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    478347 (MAP2K1)
   04210 Apoptosis
    478347 (MAP2K1)
   04218 Cellular senescence
    478347 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    478347 (MAP2K1)
   04540 Gap junction
    478347 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    478347 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    478347 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    478347 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    478347 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    478347 (MAP2K1)
   04660 T cell receptor signaling pathway
    478347 (MAP2K1)
   04662 B cell receptor signaling pathway
    478347 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    478347 (MAP2K1)
   04666 Fc gamma R-mediated phagosome formation
    478347 (MAP2K1)
   04062 Chemokine signaling pathway
    478347 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    478347 (MAP2K1)
   04929 GnRH secretion
    478347 (MAP2K1)
   04912 GnRH signaling pathway
    478347 (MAP2K1)
   04915 Estrogen signaling pathway
    478347 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    478347 (MAP2K1)
   04917 Prolactin signaling pathway
    478347 (MAP2K1)
   04921 Oxytocin signaling pathway
    478347 (MAP2K1)
   04926 Relaxin signaling pathway
    478347 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    478347 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    478347 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    478347 (MAP2K1)
   04916 Melanogenesis
    478347 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    478347 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    478347 (MAP2K1)
   04726 Serotonergic synapse
    478347 (MAP2K1)
   04720 Long-term potentiation
    478347 (MAP2K1)
   04730 Long-term depression
    478347 (MAP2K1)
   04722 Neurotrophin signaling pathway
    478347 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    478347 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    478347 (MAP2K1)
   05206 MicroRNAs in cancer
    478347 (MAP2K1)
   05205 Proteoglycans in cancer
    478347 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    478347 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    478347 (MAP2K1)
   05230 Central carbon metabolism in cancer
    478347 (MAP2K1)
   05231 Choline metabolism in cancer
    478347 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    478347 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    478347 (MAP2K1)
   05212 Pancreatic cancer
    478347 (MAP2K1)
   05225 Hepatocellular carcinoma
    478347 (MAP2K1)
   05226 Gastric cancer
    478347 (MAP2K1)
   05214 Glioma
    478347 (MAP2K1)
   05216 Thyroid cancer
    478347 (MAP2K1)
   05221 Acute myeloid leukemia
    478347 (MAP2K1)
   05220 Chronic myeloid leukemia
    478347 (MAP2K1)
   05218 Melanoma
    478347 (MAP2K1)
   05211 Renal cell carcinoma
    478347 (MAP2K1)
   05219 Bladder cancer
    478347 (MAP2K1)
   05215 Prostate cancer
    478347 (MAP2K1)
   05213 Endometrial cancer
    478347 (MAP2K1)
   05224 Breast cancer
    478347 (MAP2K1)
   05223 Non-small cell lung cancer
    478347 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    478347 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    478347 (MAP2K1)
   05161 Hepatitis B
    478347 (MAP2K1)
   05160 Hepatitis C
    478347 (MAP2K1)
   05164 Influenza A
    478347 (MAP2K1)
   05163 Human cytomegalovirus infection
    478347 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    478347 (MAP2K1)
   05165 Human papillomavirus infection
    478347 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    478347 (MAP2K1)
   05135 Yersinia infection
    478347 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    478347 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    478347 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    478347 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    478347 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    478347 (MAP2K1)
   01522 Endocrine resistance
    478347 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    478347 (MAP2K1)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     478347 (MAP2K1)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: STE group
  STE7 family
   478347 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 478347
NCBI-ProteinID: NP_001041559
Ensembl: ENSCAFG00000017298
VGNC: 42960
LinkDB
Position
30
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDVAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtg
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaactgaaggatgacgacttcgagaagatcagtgagctgggtgctggcaacggtggc
gtggtgttcaaggtctcccacaagccgtccggcctagtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctacaggttctacatgag
tgcaactccccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattctaggaaaagttagcatcgctgtaataaaaggtctgacatacctg
agagagaagcacaagattatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcattgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggagg
tatcccatccctcctccggatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagacgtggctgagaccccacccagaccaaggaccccgggaagaccccttagctcttat
ggaatggacagccgaccgcccatggcaatttttgagctgttggattacatagtcaacgag
ccccctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttc
atcaagagatctgacggtgaagaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacgccgacccacgcagctggcgtctaa

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