KEGG   Canis lupus familiaris (dog): 485773
Entry
485773            CDS       T01007                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04062  Chemokine signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04081  Hormone signaling
cfa04082  Neuroactive ligand signaling
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04270  Vascular smooth muscle contraction
cfa04310  Wnt signaling pathway
cfa04371  Apelin signaling pathway
cfa04540  Gap junction
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04621  NOD-like receptor signaling pathway
cfa04713  Circadian entrainment
cfa04720  Long-term potentiation
cfa04723  Retrograde endocannabinoid signaling
cfa04724  Glutamatergic synapse
cfa04725  Cholinergic synapse
cfa04726  Serotonergic synapse
cfa04728  Dopaminergic synapse
cfa04730  Long-term depression
cfa04742  Taste transduction
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04911  Insulin secretion
cfa04912  GnRH signaling pathway
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04918  Thyroid hormone synthesis
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04922  Glucagon signaling pathway
cfa04924  Renin secretion
cfa04925  Aldosterone synthesis and secretion
cfa04926  Relaxin signaling pathway
cfa04927  Cortisol synthesis and secretion
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04929  GnRH secretion
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa04961  Endocrine and other factor-regulated calcium reabsorption
cfa04970  Salivary secretion
cfa04971  Gastric acid secretion
cfa04972  Pancreatic secretion
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05016  Huntington disease
cfa05017  Spinocerebellar ataxia
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05142  Chagas disease
cfa05143  African trypanosomiasis
cfa05146  Amoebiasis
cfa05163  Human cytomegalovirus infection
cfa05200  Pathways in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
Module
cfa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    485773 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    485773 (PLCB1)
   04310 Wnt signaling pathway
    485773 (PLCB1)
   04371 Apelin signaling pathway
    485773 (PLCB1)
   04020 Calcium signaling pathway
    485773 (PLCB1)
   04070 Phosphatidylinositol signaling system
    485773 (PLCB1)
   04072 Phospholipase D signaling pathway
    485773 (PLCB1)
   04071 Sphingolipid signaling pathway
    485773 (PLCB1)
   04022 cGMP-PKG signaling pathway
    485773 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    485773 (PLCB1)
   04081 Hormone signaling
    485773 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    485773 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    485773 (PLCB1)
   04613 Neutrophil extracellular trap formation
    485773 (PLCB1)
   04621 NOD-like receptor signaling pathway
    485773 (PLCB1)
   04062 Chemokine signaling pathway
    485773 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    485773 (PLCB1)
   04922 Glucagon signaling pathway
    485773 (PLCB1)
   04929 GnRH secretion
    485773 (PLCB1)
   04912 GnRH signaling pathway
    485773 (PLCB1)
   04915 Estrogen signaling pathway
    485773 (PLCB1)
   04921 Oxytocin signaling pathway
    485773 (PLCB1)
   04926 Relaxin signaling pathway
    485773 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    485773 (PLCB1)
   04918 Thyroid hormone synthesis
    485773 (PLCB1)
   04919 Thyroid hormone signaling pathway
    485773 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    485773 (PLCB1)
   04916 Melanogenesis
    485773 (PLCB1)
   04924 Renin secretion
    485773 (PLCB1)
   04925 Aldosterone synthesis and secretion
    485773 (PLCB1)
   04927 Cortisol synthesis and secretion
    485773 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    485773 (PLCB1)
   04270 Vascular smooth muscle contraction
    485773 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    485773 (PLCB1)
   04971 Gastric acid secretion
    485773 (PLCB1)
   04972 Pancreatic secretion
    485773 (PLCB1)
   04973 Carbohydrate digestion and absorption
    485773 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    485773 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    485773 (PLCB1)
   04725 Cholinergic synapse
    485773 (PLCB1)
   04728 Dopaminergic synapse
    485773 (PLCB1)
   04726 Serotonergic synapse
    485773 (PLCB1)
   04720 Long-term potentiation
    485773 (PLCB1)
   04730 Long-term depression
    485773 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    485773 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    485773 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    485773 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    485773 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    485773 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    485773 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    485773 (PLCB1)
   05142 Chagas disease
    485773 (PLCB1)
   05143 African trypanosomiasis
    485773 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    485773 (PLCB1)
   05016 Huntington disease
    485773 (PLCB1)
   05017 Spinocerebellar ataxia
    485773 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    485773 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    485773 (PLCB1)
   05415 Diabetic cardiomyopathy
    485773 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    485773 (PLCB1)
   04934 Cushing syndrome
    485773 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    485773 (PLCB1)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     485773 (PLCB1)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    485773 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    485773 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 485773
NCBI-ProteinID: XP_038313473
Ensembl: ENSCAFG00000005856
VGNC: 44644
UniProt: A0A8C0QN93 A0A8I3PN52
LinkDB
Position
24:complement(13161289..13837418)
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQVSNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEAGTNPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEESNHSSAPPSLASDPGKLNHKPPSS
EELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtgactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaaacatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcggacgcctggagcat
cgcatgataacggtggtgtatgggcctgacttagttaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtcaagagatgcatttctggaaaaagcctatactaagcttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataatatcttttccgaatttggtgccaaaagcaaaccatacctt
accgttgatcagatgatggattttatcaaccttaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagaacaagtccaagtattgattgagaagtatgaaccc
aacaatagcctcgccaaaaaaggacagatttcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgta
gagttggactgctggaagggtcgaactgctgaagaggaaccagtcatcacccatgggttc
accatgacaaccgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcccacaagtcgtcagaaggaagtggcaaaaag
aagctctcagaacaagtctccaacacgtacagtgactcctccagcatgtttgagccctca
tctccaggagccggggaagctgataccgagagtgatgatgatgatgatgatgatgactgt
aaaaaatcttctatggatgaggggactgccgggagtgaggccatggccacagaagagatg
tctaacctggtgaactatattcaaccagtcaagtttgagtcatttgaaatttcaaaaaaa
agaaatagaagttttgaaatgtcttctttcgtggaaaccaaaggactagagcaactgaca
aagtctccagtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacccgtgtggattcatctaactacatgcctcagctcttctggaatgcaggttgtcaa
atggttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtat
gaatacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaag
cattttgatccattcaccgaaggcatcgtggatgggatagtggccaatactttatctgtc
aagattatttcaggtcagtttctctctgataagaaagttgggacttacgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttatcggtcaccgg
atcttgccagtacaggcaattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctgatgcttccagctgtgtttgtctacatagaggtgaaagactatgtccca
gatacctatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatg
gaacagagagctaaacaactggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccgtcagaagctccaagtgaagctgggacaaatccagca
gaaaacggagtgaatcacactacatctctggcacccaaaccaccctcccaggccctccac
agccaaccagctccaggctctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtggaagcacagaccattgaagagctaaagcaacagaaatcgtttgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggttaaaagacaccacaagaaa
accacagaccttatcaaagaacacactacaaaatataatgaaattcagaatgactacttg
agaaggagggcagctttggaaaagacagccaaaaaggacagtaagaaaaaatcagatccc
agcagtcctgaccatggttcatcaacaattgagcaagatcttgctgcccttgatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagagcagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aaattgacggatgttgctgaagaatgtcagaacaatcagttgaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaaaaggcaggagaagata
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatatatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggatgaaaagccc
aagctgcagatggacttggagcaagagtaccaagacaagttcaaaagactgcccctggag
atcttggagtttgtgcaggaagccatgaaagggaagatcagtgaagagagcaatcacagt
tctgcccctccatccctggcctcagaccctggaaaactgaaccacaagcctccctccagt
gaggagctagagggagacaacccaggaaaagagtttgatactcctctgtga

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